DUS2 (dihydrouridine synthase 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54920
Gene name Gene Name - the full gene name approved by the HGNC.
Dihydrouridine synthase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DUS2
Synonyms (NCBI Gene) Gene synonyms aliases
DUS2L, SMM1, URLC8
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of tran
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT727847 hsa-miR-92a-3p HITS-CLIP 22473208
MIRT727846 hsa-miR-92b-3p HITS-CLIP 22473208
MIRT727845 hsa-miR-32-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0002943 Process TRNA dihydrouridine synthesis IBA 21873635
GO:0002943 Process TRNA dihydrouridine synthesis IDA 26429968
GO:0003725 Function Double-stranded RNA binding IDA 18096616
GO:0004860 Function Protein kinase inhibitor activity IDA 18096616
GO:0005515 Function Protein binding IPI 18096616
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
609707 26014 ENSG00000167264
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9NX74
Protein name tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2)
Protein function Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (P
PDB 4WFS , 4WFT , 4XP7 , 5OC4 , 5OC5 , 5OC6 , 6EI8 , 6EZA , 6EZB , 6EZC , 6F00
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01207 Dus 15 → 342 Dihydrouridine synthase (Dus) Family
PF00035 dsrm 370 → 433 Double-stranded RNA binding motif Domain
Tissue specificity TISSUE SPECIFICITY: Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level). {ECO:0000269|PubMed:15994936}.
Sequence
Sequence length 493
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Coronary heart disease Coronary heart disease 21347282 ClinVar
Biliary Cholangitis Biliary Cholangitis GWAS
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 36551188
Carcinogenesis Associate 26143927
Hypertension Associate 28562329
Lung Neoplasms Associate 26143927
Neoplasms Associate 26143927, 36551188