Gene Gene information from NCBI Gene database.
Entrez ID 54905
Gene name Cytochrome P450 family 2 subfamily W member 1
Gene symbol CYP2W1
Synonyms (NCBI Gene)
-
Chromosome 7
Chromosome location 7p22.3
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSe
miRNA miRNA information provided by mirtarbase database.
534
miRTarBase ID miRNA Experiments Reference
MIRT646976 hsa-miR-4524b-3p HITS-CLIP 23824327
MIRT646967 hsa-miR-411-5p HITS-CLIP 23824327
MIRT646975 hsa-miR-4781-3p HITS-CLIP 23824327
MIRT646974 hsa-miR-6823-5p HITS-CLIP 23824327
MIRT646973 hsa-miR-4716-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0001972 Function Retinoic acid binding IDA 26936974
GO:0004497 Function Monooxygenase activity IEA
GO:0004497 Function Monooxygenase activity TAS
GO:0005503 Function All-trans retinal binding IDA 26936974
GO:0005506 Function Iron ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615967 20243 ENSG00000073067
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TAV3
Protein name Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1)
Protein function A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hyd
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00067 p450 32 486 Cytochrome P450 Domain
Tissue specificity TISSUE SPECIFICITY: Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors. {ECO:0000269|PubMed:16426568}.
Sequence
Sequence length 490
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Retinol metabolism
Metabolic pathways
  Miscellaneous substrates
Xenobiotics
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BRONCHOPULMONARY DYSPLASIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adrenal Gland Neoplasms Associate 25144458
★☆☆☆☆
Found in Text Mining only
Aicardi Syndrome Associate 25144458
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 22631658, 22938436
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Stimulate 35902379
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 24801906, 38113974
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Associate 26787547, 27598485
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 26787547, 27598485, 31740522
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Associate 38051303
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Associate 34716287
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 27598485
★☆☆☆☆
Found in Text Mining only