Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54898
Gene name Gene Name - the full gene name approved by the HGNC.	ELOVL fatty acid elongase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ELOVL2
Synonyms (NCBI Gene) Gene synonyms aliases	SSC2
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p24.2

Show/Hide all(165)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025624	hsa-miR-10a-5p	Sequencing	20371350
MIRT029052	hsa-miR-26b-5p	Microarray	19088304
MIRT050775	hsa-miR-17-3p	CLASH	23622248
MIRT961176	hsa-let-7a	CLIP-seq
MIRT961177	hsa-let-7b	CLIP-seq
MIRT961178	hsa-let-7c	CLIP-seq
MIRT961179	hsa-let-7d	CLIP-seq
MIRT961180	hsa-let-7e	CLIP-seq
MIRT961181	hsa-let-7f	CLIP-seq
MIRT961182	hsa-let-7g	CLIP-seq
MIRT961183	hsa-let-7i	CLIP-seq
MIRT961184	hsa-miR-1225-5p	CLIP-seq
MIRT961185	hsa-miR-1258	CLIP-seq
MIRT961186	hsa-miR-1273g	CLIP-seq
MIRT961187	hsa-miR-140-5p	CLIP-seq
MIRT961188	hsa-miR-181a	CLIP-seq
MIRT961189	hsa-miR-181b	CLIP-seq
MIRT961190	hsa-miR-181c	CLIP-seq
MIRT961191	hsa-miR-181d	CLIP-seq
MIRT961192	hsa-miR-202	CLIP-seq
MIRT961193	hsa-miR-22	CLIP-seq
MIRT961194	hsa-miR-3200-5p	CLIP-seq
MIRT961195	hsa-miR-323b-5p	CLIP-seq
MIRT961196	hsa-miR-34c-3p	CLIP-seq
MIRT961197	hsa-miR-3613-3p	CLIP-seq
MIRT961198	hsa-miR-374c	CLIP-seq
MIRT961199	hsa-miR-3908	CLIP-seq
MIRT961200	hsa-miR-3919	CLIP-seq
MIRT961201	hsa-miR-3942-5p	CLIP-seq
MIRT961202	hsa-miR-3978	CLIP-seq
MIRT961203	hsa-miR-4262	CLIP-seq
MIRT961204	hsa-miR-4265	CLIP-seq
MIRT961205	hsa-miR-4296	CLIP-seq
MIRT961206	hsa-miR-4312	CLIP-seq
MIRT961207	hsa-miR-4314	CLIP-seq
MIRT961208	hsa-miR-4322	CLIP-seq
MIRT961209	hsa-miR-4433	CLIP-seq
MIRT961210	hsa-miR-4457	CLIP-seq
MIRT961211	hsa-miR-4458	CLIP-seq
MIRT961212	hsa-miR-4459	CLIP-seq
MIRT961213	hsa-miR-4500	CLIP-seq
MIRT961214	hsa-miR-455-5p	CLIP-seq
MIRT961215	hsa-miR-4643	CLIP-seq
MIRT961216	hsa-miR-4648	CLIP-seq
MIRT961217	hsa-miR-4649-3p	CLIP-seq
MIRT961218	hsa-miR-4654	CLIP-seq
MIRT961219	hsa-miR-466	CLIP-seq
MIRT961220	hsa-miR-4703-5p	CLIP-seq
MIRT961221	hsa-miR-4756-3p	CLIP-seq
MIRT961222	hsa-miR-4766-3p	CLIP-seq
MIRT961223	hsa-miR-4768-3p	CLIP-seq
MIRT961224	hsa-miR-4769-5p	CLIP-seq
MIRT961225	hsa-miR-4773	CLIP-seq
MIRT961226	hsa-miR-4789-3p	CLIP-seq
MIRT961227	hsa-miR-498	CLIP-seq
MIRT961228	hsa-miR-5096	CLIP-seq
MIRT961229	hsa-miR-513a-3p	CLIP-seq
MIRT961230	hsa-miR-513b	CLIP-seq
MIRT961231	hsa-miR-524-3p	CLIP-seq
MIRT961232	hsa-miR-525-3p	CLIP-seq
MIRT961233	hsa-miR-548c-3p	CLIP-seq
MIRT961234	hsa-miR-548l	CLIP-seq
MIRT961235	hsa-miR-549	CLIP-seq
MIRT961236	hsa-miR-622	CLIP-seq
MIRT961237	hsa-miR-655	CLIP-seq
MIRT961238	hsa-miR-656	CLIP-seq
MIRT961239	hsa-miR-935	CLIP-seq
MIRT961240	hsa-miR-98	CLIP-seq
MIRT1984823	hsa-miR-105	CLIP-seq
MIRT1984824	hsa-miR-1244	CLIP-seq
MIRT1984825	hsa-miR-1245b-3p	CLIP-seq
MIRT1984826	hsa-miR-1264	CLIP-seq
MIRT1984827	hsa-miR-128	CLIP-seq
MIRT1984828	hsa-miR-1299	CLIP-seq
MIRT1984829	hsa-miR-132	CLIP-seq
MIRT1984830	hsa-miR-1913	CLIP-seq
MIRT1984831	hsa-miR-194	CLIP-seq
MIRT1984832	hsa-miR-212	CLIP-seq
MIRT1984833	hsa-miR-27a	CLIP-seq
MIRT1984834	hsa-miR-27b	CLIP-seq
MIRT1984835	hsa-miR-3120-5p	CLIP-seq
MIRT1984836	hsa-miR-3125	CLIP-seq
MIRT1984837	hsa-miR-3126-3p	CLIP-seq
MIRT1984838	hsa-miR-3140-5p	CLIP-seq
MIRT1984839	hsa-miR-3162-5p	CLIP-seq
MIRT1984840	hsa-miR-3174	CLIP-seq
MIRT1984841	hsa-miR-324-3p	CLIP-seq
MIRT1984842	hsa-miR-361-3p	CLIP-seq
MIRT1984843	hsa-miR-3662	CLIP-seq
MIRT1984844	hsa-miR-3684	CLIP-seq
MIRT1984845	hsa-miR-377	CLIP-seq
MIRT1984846	hsa-miR-378	CLIP-seq
MIRT1984847	hsa-miR-378b	CLIP-seq
MIRT1984848	hsa-miR-378c	CLIP-seq
MIRT1984849	hsa-miR-378d	CLIP-seq
MIRT1984850	hsa-miR-378e	CLIP-seq
MIRT1984851	hsa-miR-378f	CLIP-seq
MIRT1984852	hsa-miR-378h	CLIP-seq
MIRT1984853	hsa-miR-378i	CLIP-seq
MIRT1984854	hsa-miR-3916	CLIP-seq
MIRT1984855	hsa-miR-3920	CLIP-seq
MIRT1984856	hsa-miR-3928	CLIP-seq
MIRT1984857	hsa-miR-3943	CLIP-seq
MIRT961202	hsa-miR-3978	CLIP-seq
MIRT1984858	hsa-miR-422a	CLIP-seq
MIRT1984859	hsa-miR-4261	CLIP-seq
MIRT1984860	hsa-miR-4263	CLIP-seq
MIRT1984861	hsa-miR-4419a	CLIP-seq
MIRT1984862	hsa-miR-4481	CLIP-seq
MIRT1984863	hsa-miR-4510	CLIP-seq
MIRT1984864	hsa-miR-4638-3p	CLIP-seq
MIRT1984865	hsa-miR-4641	CLIP-seq
MIRT961215	hsa-miR-4643	CLIP-seq
MIRT961217	hsa-miR-4649-3p	CLIP-seq
MIRT961219	hsa-miR-466	CLIP-seq
MIRT1984866	hsa-miR-4680-3p	CLIP-seq
MIRT1984867	hsa-miR-4687-3p	CLIP-seq
MIRT1984868	hsa-miR-4694-3p	CLIP-seq
MIRT1984869	hsa-miR-4727-5p	CLIP-seq
MIRT1984870	hsa-miR-4729	CLIP-seq
MIRT1984871	hsa-miR-4745-5p	CLIP-seq
MIRT1984872	hsa-miR-4758-5p	CLIP-seq
MIRT1984873	hsa-miR-4762-3p	CLIP-seq
MIRT961226	hsa-miR-4789-3p	CLIP-seq
MIRT1984874	hsa-miR-4789-5p	CLIP-seq
MIRT1984875	hsa-miR-4792	CLIP-seq
MIRT1984876	hsa-miR-521	CLIP-seq
MIRT961236	hsa-miR-622	CLIP-seq
MIRT1984877	hsa-miR-642b	CLIP-seq
MIRT1984878	hsa-miR-802	CLIP-seq
MIRT1984879	hsa-miR-875-3p	CLIP-seq
MIRT1984880	hsa-miR-9	CLIP-seq
MIRT1984881	hsa-miR-921	CLIP-seq
MIRT2219712	hsa-miR-103a	CLIP-seq
MIRT2219713	hsa-miR-107	CLIP-seq
MIRT1984825	hsa-miR-1245b-3p	CLIP-seq
MIRT1984829	hsa-miR-132	CLIP-seq
MIRT2219714	hsa-miR-15a	CLIP-seq
MIRT2219715	hsa-miR-15b	CLIP-seq
MIRT2219716	hsa-miR-16	CLIP-seq
MIRT2219717	hsa-miR-195	CLIP-seq
MIRT1984832	hsa-miR-212	CLIP-seq
MIRT1984839	hsa-miR-3162-5p	CLIP-seq
MIRT2219718	hsa-miR-338-3p	CLIP-seq
MIRT961200	hsa-miR-3919	CLIP-seq
MIRT2219719	hsa-miR-3929	CLIP-seq
MIRT2219720	hsa-miR-424	CLIP-seq
MIRT1984859	hsa-miR-4261	CLIP-seq
MIRT2219721	hsa-miR-4329	CLIP-seq
MIRT1984861	hsa-miR-4419a	CLIP-seq
MIRT2219722	hsa-miR-4419b	CLIP-seq
MIRT2219723	hsa-miR-4478	CLIP-seq
MIRT1984863	hsa-miR-4510	CLIP-seq
MIRT2219724	hsa-miR-4530	CLIP-seq
MIRT961221	hsa-miR-4756-3p	CLIP-seq
MIRT2219725	hsa-miR-4786-5p	CLIP-seq
MIRT1984874	hsa-miR-4789-5p	CLIP-seq
MIRT2219726	hsa-miR-497	CLIP-seq
MIRT2219727	hsa-miR-501-3p	CLIP-seq
MIRT2219728	hsa-miR-502-3p	CLIP-seq
MIRT961228	hsa-miR-5096	CLIP-seq
MIRT2219729	hsa-miR-570	CLIP-seq
MIRT2219730	hsa-miR-607	CLIP-seq
MIRT2219731	hsa-miR-645	CLIP-seq
MIRT2219732	hsa-miR-769-5p	CLIP-seq

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IEA
GO:0005515	Function	Protein binding	IPI	20937905, 32296183, 38422897
GO:0005783	Component	Endoplasmic reticulum	IDA	20937905
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0006636	Process	Unsaturated fatty acid biosynthetic process	IEA
GO:0009922	Function	Fatty acid elongase activity	EXP	10970790
GO:0009922	Function	Fatty acid elongase activity	IBA
GO:0009922	Function	Fatty acid elongase activity	IDA	12371743
GO:0009922	Function	Fatty acid elongase activity	IEA
GO:0009922	Function	Fatty acid elongase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016747	Function	Acyltransferase activity, transferring groups other than amino-acyl groups	IEA
GO:0019367	Process	Fatty acid elongation, saturated fatty acid	IBA
GO:0019367	Process	Fatty acid elongation, saturated fatty acid	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	IBA
GO:0030497	Process	Fatty acid elongation	IEA
GO:0034625	Process	Fatty acid elongation, monounsaturated fatty acid	IBA
GO:0034626	Process	Fatty acid elongation, polyunsaturated fatty acid	IBA
GO:0034626	Process	Fatty acid elongation, polyunsaturated fatty acid	IDA	12371743, 20937905
GO:0034626	Process	Fatty acid elongation, polyunsaturated fatty acid	IEA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0036109	Process	Alpha-linolenic acid metabolic process	IEA
GO:0036109	Process	Alpha-linolenic acid metabolic process	TAS
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IEA
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IBA
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IDA	12371743, 20937905
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IEA
GO:0043651	Process	Linoleic acid metabolic process	IEA
GO:0043651	Process	Linoleic acid metabolic process	TAS
GO:1901570	Process	Fatty acid derivative biosynthetic process	IEA

MIM	HGNC	e!Ensembl
611814	14416	ENSG00000197977

Protein

UniProt ID

Q9NXB9

Protein name

Very long chain fatty acid elongase 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Elongation of very long chain fatty acids protein 2) (Very long chain 3-ketoacyl-CoA synthase 2) (Very long chain 3

Protein function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01151	ELO	30 → 265	GNS1/SUR4 family	Family

Tissue specificity

TISSUE SPECIFICITY: Liver and testis. {ECO:0000269|PubMed:20937905}.

Sequence

MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRP
ALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYY
FSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIH
ILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSS
YMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ

Sequence length

296

Interactions

View interactions

	KEGG		Reactome
	Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism		Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs

ELOVL2 (ELOVL fatty acid elongase 2)