Gene Gene information from NCBI Gene database.
Entrez ID 54890
Gene name AlkB homolog 5, RNA demethylase
Gene symbol ALKBH5
Synonyms (NCBI Gene)
ABH5OFOXDOFOXD1
Chromosome 17
Chromosome location 17p11.2|17p11.2
miRNA miRNA information provided by mirtarbase database.
483
miRTarBase ID miRNA Experiments Reference
MIRT049251 hsa-miR-92a-3p CLASH 23622248
MIRT049251 hsa-miR-92a-3p CLASH 23622248
MIRT048722 hsa-miR-96-5p CLASH 23622248
MIRT042009 hsa-miR-484 CLASH 23622248
MIRT039912 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IDA 21264265
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 21264265
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613303 25996 ENSG00000091542
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6P6C2
Protein name RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)
Protein function Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572
PDB 4NJ4 , 4NRM , 4NRO , 4NRP , 4NRQ , 4O61 , 4O7X , 4OCT , 7V4G , 7WKV , 7WL0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13532 2OG-FeII_Oxy_2 93 297 2OG-Fe(II) oxygenase superfamily Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary. {ECO:0000269|PubMed:17979886}.
Sequence
MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGAKRKY
QEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYN
EHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHR
VIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVS
EPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSL
SSS
VLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRG
SFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Reversal of alkylation damage by DNA dioxygenases
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRE-ECLAMPSIA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Abortion Habitual Associate 31281518
★☆☆☆☆
Found in Text Mining only
Acute Kidney Injury Associate 39287046
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Associate 36133437
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 32258108
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Inhibit 32884942
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Associate 40225569
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Associate 32402250
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 27001847, 30953473, 32402250
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 32402250, 34759347, 35318440, 36239338, 37480971
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 34221187, 34647424, 35982895, 36335087, 36419136, 38501918
★☆☆☆☆
Found in Text Mining only