CWC25 (CWC25 spliceosome associated protein)

Gene

• Entrez ID: 54883
• Gene name: CWC25 spliceosome associated protein
• Gene symbol: CWC25
• Synonyms (NCBI Gene): CCDC49
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041008	hsa-miR-505-3p	CLASH	23622248
MIRT632155	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT632154	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT632153	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT632152	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT632151	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT632150	hsa-miR-4454	HITS-CLIP	23824327
MIRT632149	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632148	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT462322	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT462321	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT462320	hsa-miR-3622b-5p	PAR-CLIP	23592263
MIRT462319	hsa-miR-3653-3p	PAR-CLIP	23592263
MIRT462318	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT462317	hsa-miR-1271-5p	PAR-CLIP	23592263
MIRT462316	hsa-miR-96-5p	PAR-CLIP	23592263
MIRT632155	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT632154	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT632153	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT632152	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT632151	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT632150	hsa-miR-4454	HITS-CLIP	23824327
MIRT632149	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632148	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT462322	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT462321	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT462320	hsa-miR-3622b-5p	PAR-CLIP	23592263
MIRT462319	hsa-miR-3653-3p	PAR-CLIP	23592263
MIRT462318	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT462317	hsa-miR-1271-5p	PAR-CLIP	23592263
MIRT462316	hsa-miR-96-5p	PAR-CLIP	23592263
MIRT917399	hsa-miR-141	CLIP-seq
MIRT917400	hsa-miR-200a	CLIP-seq
MIRT917401	hsa-miR-3149	CLIP-seq
MIRT917402	hsa-miR-3160-3p	CLIP-seq
MIRT917403	hsa-miR-3180-5p	CLIP-seq
MIRT917404	hsa-miR-371-5p	CLIP-seq
MIRT917405	hsa-miR-371b-5p	CLIP-seq
MIRT917406	hsa-miR-4487	CLIP-seq
MIRT917407	hsa-miR-520a-5p	CLIP-seq
MIRT917408	hsa-miR-525-5p	CLIP-seq
MIRT917409	hsa-miR-558	CLIP-seq
MIRT1547698	hsa-miR-1297	CLIP-seq
MIRT1547699	hsa-miR-26a	CLIP-seq
MIRT1547700	hsa-miR-26b	CLIP-seq
MIRT1547701	hsa-miR-4465	CLIP-seq
MIRT1547702	hsa-miR-4799-5p	CLIP-seq
MIRT1547703	hsa-miR-579	CLIP-seq
MIRT2207686	hsa-miR-1182	CLIP-seq
MIRT2207687	hsa-miR-1252	CLIP-seq
MIRT2207688	hsa-miR-1260	CLIP-seq
MIRT2207689	hsa-miR-1260b	CLIP-seq
MIRT2207690	hsa-miR-1267	CLIP-seq
MIRT2207691	hsa-miR-1271	CLIP-seq
MIRT2207692	hsa-miR-1273f	CLIP-seq
MIRT2207693	hsa-miR-1280	CLIP-seq
MIRT2207694	hsa-miR-1296	CLIP-seq
MIRT1547698	hsa-miR-1297	CLIP-seq
MIRT2207695	hsa-miR-132	CLIP-seq
MIRT917399	hsa-miR-141	CLIP-seq
MIRT2207696	hsa-miR-1915	CLIP-seq
MIRT2207697	hsa-miR-192	CLIP-seq
MIRT917400	hsa-miR-200a	CLIP-seq
MIRT2207698	hsa-miR-212	CLIP-seq
MIRT2207699	hsa-miR-215	CLIP-seq
MIRT2207700	hsa-miR-224	CLIP-seq
MIRT2207701	hsa-miR-23a	CLIP-seq
MIRT2207702	hsa-miR-23b	CLIP-seq
MIRT2207703	hsa-miR-23c	CLIP-seq
MIRT1547699	hsa-miR-26a	CLIP-seq
MIRT1547700	hsa-miR-26b	CLIP-seq
MIRT2207704	hsa-miR-2909	CLIP-seq
MIRT2207705	hsa-miR-3119	CLIP-seq
MIRT2207706	hsa-miR-3144-3p	CLIP-seq
MIRT2207707	hsa-miR-3158-3p	CLIP-seq
MIRT917402	hsa-miR-3160-3p	CLIP-seq
MIRT2207708	hsa-miR-3179	CLIP-seq
MIRT917403	hsa-miR-3180-5p	CLIP-seq
MIRT2207709	hsa-miR-323-5p	CLIP-seq
MIRT2207710	hsa-miR-330-3p	CLIP-seq
MIRT2207711	hsa-miR-34a	CLIP-seq
MIRT2207712	hsa-miR-34c-5p	CLIP-seq
MIRT2207713	hsa-miR-3545-3p	CLIP-seq
MIRT2207714	hsa-miR-3614-3p	CLIP-seq
MIRT2207715	hsa-miR-3653	CLIP-seq
MIRT2207716	hsa-miR-3671	CLIP-seq
MIRT917404	hsa-miR-371-5p	CLIP-seq
MIRT917405	hsa-miR-371b-5p	CLIP-seq
MIRT2207717	hsa-miR-3913-3p	CLIP-seq
MIRT2207718	hsa-miR-4264	CLIP-seq
MIRT2207719	hsa-miR-4287	CLIP-seq
MIRT2207720	hsa-miR-4297	CLIP-seq
MIRT2207721	hsa-miR-4299	CLIP-seq
MIRT2207722	hsa-miR-4436a	CLIP-seq
MIRT2207723	hsa-miR-4446-3p	CLIP-seq
MIRT2207724	hsa-miR-4456	CLIP-seq
MIRT1547701	hsa-miR-4465	CLIP-seq
MIRT917406	hsa-miR-4487	CLIP-seq
MIRT2207725	hsa-miR-449a	CLIP-seq
MIRT2207726	hsa-miR-449b	CLIP-seq
MIRT2207727	hsa-miR-4523	CLIP-seq
MIRT2207728	hsa-miR-4659a-5p	CLIP-seq
MIRT2207729	hsa-miR-4659b-5p	CLIP-seq
MIRT2207730	hsa-miR-4661-5p	CLIP-seq
MIRT2207731	hsa-miR-4677-3p	CLIP-seq
MIRT2207732	hsa-miR-4678	CLIP-seq
MIRT2207733	hsa-miR-4679	CLIP-seq
MIRT2207734	hsa-miR-4680-5p	CLIP-seq
MIRT2207735	hsa-miR-4685-3p	CLIP-seq
MIRT2207736	hsa-miR-4704-5p	CLIP-seq
MIRT2207737	hsa-miR-4719	CLIP-seq
MIRT2207738	hsa-miR-4729	CLIP-seq
MIRT2207739	hsa-miR-4761-5p	CLIP-seq
MIRT2207740	hsa-miR-4762-3p	CLIP-seq
MIRT2207741	hsa-miR-4776-3p	CLIP-seq
MIRT2207742	hsa-miR-4778-5p	CLIP-seq
MIRT2207743	hsa-miR-4780	CLIP-seq
MIRT2207744	hsa-miR-4797-3p	CLIP-seq
MIRT1547702	hsa-miR-4799-5p	CLIP-seq
MIRT2207745	hsa-miR-483-3p	CLIP-seq
MIRT2207746	hsa-miR-489	CLIP-seq
MIRT2207747	hsa-miR-490-3p	CLIP-seq
MIRT2207748	hsa-miR-499-3p	CLIP-seq
MIRT2207749	hsa-miR-499a-3p	CLIP-seq
MIRT2207750	hsa-miR-5096	CLIP-seq
MIRT2207751	hsa-miR-513b	CLIP-seq
MIRT2207752	hsa-miR-514	CLIP-seq
MIRT2207753	hsa-miR-514b-3p	CLIP-seq
MIRT917407	hsa-miR-520a-5p	CLIP-seq
MIRT917408	hsa-miR-525-5p	CLIP-seq
MIRT2207754	hsa-miR-532-3p	CLIP-seq
MIRT2207755	hsa-miR-548q	CLIP-seq
MIRT917409	hsa-miR-558	CLIP-seq
MIRT1547703	hsa-miR-579	CLIP-seq
MIRT2207756	hsa-miR-590-3p	CLIP-seq
MIRT2207757	hsa-miR-623	CLIP-seq
MIRT2207758	hsa-miR-649	CLIP-seq
MIRT2207759	hsa-miR-668	CLIP-seq
MIRT2207760	hsa-miR-759	CLIP-seq
MIRT2207761	hsa-miR-875-5p	CLIP-seq
MIRT2207762	hsa-miR-876-3p	CLIP-seq
MIRT2207763	hsa-miR-96	CLIP-seq
MIRT2207687	hsa-miR-1252	CLIP-seq
MIRT917399	hsa-miR-141	CLIP-seq
MIRT917400	hsa-miR-200a	CLIP-seq
MIRT2386597	hsa-miR-3155	CLIP-seq
MIRT2386598	hsa-miR-3155b	CLIP-seq
MIRT2207709	hsa-miR-323-5p	CLIP-seq
MIRT2207715	hsa-miR-3653	CLIP-seq
MIRT2386599	hsa-miR-4268	CLIP-seq
MIRT2207724	hsa-miR-4456	CLIP-seq
MIRT2386600	hsa-miR-484	CLIP-seq
MIRT2207762	hsa-miR-876-3p	CLIP-seq
MIRT2207686	hsa-miR-1182	CLIP-seq
MIRT2207687	hsa-miR-1252	CLIP-seq
MIRT2207688	hsa-miR-1260	CLIP-seq
MIRT2207689	hsa-miR-1260b	CLIP-seq
MIRT2207690	hsa-miR-1267	CLIP-seq
MIRT2510996	hsa-miR-1270	CLIP-seq
MIRT2207691	hsa-miR-1271	CLIP-seq
MIRT2207692	hsa-miR-1273f	CLIP-seq
MIRT2510997	hsa-miR-1276	CLIP-seq
MIRT2207693	hsa-miR-1280	CLIP-seq
MIRT2510998	hsa-miR-1323	CLIP-seq
MIRT2510999	hsa-miR-1825	CLIP-seq
MIRT2511000	hsa-miR-1827	CLIP-seq
MIRT2511001	hsa-miR-199a-5p	CLIP-seq
MIRT2511002	hsa-miR-199b-5p	CLIP-seq
MIRT2511003	hsa-miR-2276	CLIP-seq
MIRT2511004	hsa-miR-2682	CLIP-seq
MIRT2207706	hsa-miR-3144-3p	CLIP-seq
MIRT2207708	hsa-miR-3179	CLIP-seq
MIRT2207711	hsa-miR-34a	CLIP-seq
MIRT2207712	hsa-miR-34c-5p	CLIP-seq
MIRT2207715	hsa-miR-3653	CLIP-seq
MIRT2511005	hsa-miR-371b-3p	CLIP-seq
MIRT2207721	hsa-miR-4299	CLIP-seq
MIRT2511006	hsa-miR-4311	CLIP-seq
MIRT2207724	hsa-miR-4456	CLIP-seq
MIRT2207725	hsa-miR-449a	CLIP-seq
MIRT2207726	hsa-miR-449b	CLIP-seq
MIRT2511007	hsa-miR-449c	CLIP-seq
MIRT2207727	hsa-miR-4523	CLIP-seq
MIRT2511008	hsa-miR-4531	CLIP-seq
MIRT2511009	hsa-miR-4649-3p	CLIP-seq
MIRT2511010	hsa-miR-4668-3p	CLIP-seq
MIRT2207740	hsa-miR-4762-3p	CLIP-seq
MIRT2207754	hsa-miR-532-3p	CLIP-seq
MIRT2511011	hsa-miR-548o	CLIP-seq
MIRT2207755	hsa-miR-548q	CLIP-seq
MIRT2511012	hsa-miR-583	CLIP-seq
MIRT2511013	hsa-miR-620	CLIP-seq
MIRT2207761	hsa-miR-875-5p	CLIP-seq
MIRT2207763	hsa-miR-96	CLIP-seq
MIRT2207686	hsa-miR-1182	CLIP-seq
MIRT2207688	hsa-miR-1260	CLIP-seq
MIRT2207689	hsa-miR-1260b	CLIP-seq
MIRT2207690	hsa-miR-1267	CLIP-seq
MIRT2510996	hsa-miR-1270	CLIP-seq
MIRT2207691	hsa-miR-1271	CLIP-seq
MIRT2207692	hsa-miR-1273f	CLIP-seq
MIRT2207693	hsa-miR-1280	CLIP-seq
MIRT2510999	hsa-miR-1825	CLIP-seq
MIRT2511000	hsa-miR-1827	CLIP-seq
MIRT2511001	hsa-miR-199a-5p	CLIP-seq
MIRT2511002	hsa-miR-199b-5p	CLIP-seq
MIRT2511003	hsa-miR-2276	CLIP-seq
MIRT2511004	hsa-miR-2682	CLIP-seq
MIRT2207706	hsa-miR-3144-3p	CLIP-seq
MIRT2207708	hsa-miR-3179	CLIP-seq
MIRT2207711	hsa-miR-34a	CLIP-seq
MIRT2207712	hsa-miR-34c-5p	CLIP-seq
MIRT2207715	hsa-miR-3653	CLIP-seq
MIRT2511005	hsa-miR-371b-3p	CLIP-seq
MIRT2207721	hsa-miR-4299	CLIP-seq
MIRT2207724	hsa-miR-4456	CLIP-seq
MIRT2207725	hsa-miR-449a	CLIP-seq
MIRT2207726	hsa-miR-449b	CLIP-seq
MIRT2511007	hsa-miR-449c	CLIP-seq
MIRT2678828	hsa-miR-4519	CLIP-seq
MIRT2207727	hsa-miR-4523	CLIP-seq
MIRT2511008	hsa-miR-4531	CLIP-seq
MIRT2511009	hsa-miR-4649-3p	CLIP-seq
MIRT2511010	hsa-miR-4668-3p	CLIP-seq
MIRT2207740	hsa-miR-4762-3p	CLIP-seq
MIRT2207754	hsa-miR-532-3p	CLIP-seq
MIRT2207755	hsa-miR-548q	CLIP-seq
MIRT2511013	hsa-miR-620	CLIP-seq
MIRT2207761	hsa-miR-875-5p	CLIP-seq
MIRT2207763	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	29301961
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	29301961
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005684	Component	U2-type spliceosomal complex	IBA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IDA	29301961

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9NXE8
• Protein name: Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25)
• Protein function: Involved in pre-mRNA splicing as component of the spliceosome.
• PDB: 5YZG, 6ZYM, 8I0W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10197	Cir_N	11 → 47	N-terminal domain of CBF1 interacting co-repressor CIR	Domain
  PF12542	CWC25	66 → 157	Pre-mRNA splicing factor	Family

• Sequence:

  MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDV
  GAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFA
  PSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKK
  EKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGL
  QGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSK
  LHNSKVNRRETGQTRSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERL
  NILKRHAKDEEREQRLEKLDSRDGKFIHRMKLESASTSSLEDRVKRNIYSLQRTSVALEK
  NFMKR

• Sequence length: 425

Pathways

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations