Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54861
Gene name Gene Name - the full gene name approved by the HGNC.
SNF related kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SNRK
Synonyms (NCBI Gene) Gene synonyms aliases
HSNFRK
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022051 hsa-miR-128-3p Microarray 17612493
MIRT031002 hsa-miR-21-5p Microarray 18591254
MIRT041578 hsa-miR-193b-3p CLASH 23622248
MIRT721142 hsa-miR-4422 HITS-CLIP 19536157
MIRT721141 hsa-miR-154-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 12234663
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 12234663
GO:0005524 Function ATP binding IDA 12234663
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612760 30598 ENSG00000163788
Protein
UniProt ID Q9NRH2
Protein name SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)
Protein function May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
PDB 5YKS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 16 269 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis. {ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:8654423}.
Sequence
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL
FQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYF
AQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY
SAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK
ECKDLITRMLQRDPKRRASLEEIENHPWL
QGVDPSPATKYNIPLVSYKNLSEEEHNSIIQ
RMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFR
QSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA
GPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSR
KSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSS
SETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSE
NNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHG
STKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELER
IKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI
Sequence length 765
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GWAS
Oligodendroglioma Oligodendroglioma GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Colonic Neoplasms Inhibit 22874833
Colorectal Neoplasms Inhibit 22874833
Inflammation Associate 28722495
Ovarian Neoplasms Associate 28722495