Gene Gene information from NCBI Gene database.
Entrez ID 54858
Gene name Pyroglutamyl-peptidase I
Gene symbol PGPEP1
Synonyms (NCBI Gene)
PAP-IPGIPGPPGP-IPGPIPcp
Chromosome 19
Chromosome location 19p13.11
Summary The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression
miRNA miRNA information provided by mirtarbase database.
1419
miRTarBase ID miRNA Experiments Reference
MIRT708264 hsa-miR-6854-5p HITS-CLIP 19536157
MIRT708263 hsa-miR-1228-3p HITS-CLIP 19536157
MIRT708262 hsa-miR-383-3p HITS-CLIP 19536157
MIRT708261 hsa-miR-342-3p HITS-CLIP 19536157
MIRT708260 hsa-miR-7106-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IEA
GO:0006508 Process Proteolysis IEA
GO:0008233 Function Peptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610694 13568 ENSG00000130517
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NXJ5
Protein name Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase)
Protein function Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01470 Peptidase_C15 6 188 Pyroglutamyl peptidase Domain
Sequence
Sequence length 209
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193921074 RCV000149246
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Renal Cell Associate 37722013
Colorectal Neoplasms Associate 26078706, 37424115
Neoplasm Metastasis Associate 37722013
Neoplasms Inhibit 26078706
Pancreatic Neoplasms Associate 31917448