Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54856
Gene name	Gon-4 like
Gene symbol	GON4L
Synonyms (NCBI Gene)	GON-4GON4LTMSYARP
Chromosome	1
Chromosome location	1q22

Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044248	hsa-miR-106b-5p	CLASH	23622248
MIRT1027321	hsa-miR-1269	CLIP-seq
MIRT1027322	hsa-miR-1269b	CLIP-seq
MIRT1027323	hsa-miR-1283	CLIP-seq
MIRT1027324	hsa-miR-1825	CLIP-seq
MIRT1027325	hsa-miR-1976	CLIP-seq
MIRT1027326	hsa-miR-28-5p	CLIP-seq
MIRT1027327	hsa-miR-3123	CLIP-seq
MIRT1027328	hsa-miR-3124-5p	CLIP-seq
MIRT1027329	hsa-miR-3136-3p	CLIP-seq
MIRT1027330	hsa-miR-3139	CLIP-seq
MIRT1027331	hsa-miR-3160-3p	CLIP-seq
MIRT1027332	hsa-miR-3176	CLIP-seq
MIRT1027333	hsa-miR-3613-3p	CLIP-seq
MIRT1027334	hsa-miR-370	CLIP-seq
MIRT1027335	hsa-miR-3922-3p	CLIP-seq
MIRT1027336	hsa-miR-3925-3p	CLIP-seq
MIRT1027337	hsa-miR-3925-5p	CLIP-seq
MIRT1027338	hsa-miR-3936	CLIP-seq
MIRT1027339	hsa-miR-4529-3p	CLIP-seq
MIRT1027340	hsa-miR-4539	CLIP-seq
MIRT1027341	hsa-miR-4633-3p	CLIP-seq
MIRT1027342	hsa-miR-4639-3p	CLIP-seq
MIRT1027343	hsa-miR-4661-5p	CLIP-seq
MIRT1027344	hsa-miR-4680-5p	CLIP-seq
MIRT1027345	hsa-miR-4699-3p	CLIP-seq
MIRT1027346	hsa-miR-4757-5p	CLIP-seq
MIRT1027347	hsa-miR-4797-5p	CLIP-seq
MIRT1027348	hsa-miR-501-3p	CLIP-seq
MIRT1027349	hsa-miR-502-3p	CLIP-seq
MIRT1027350	hsa-miR-520d-5p	CLIP-seq
MIRT1027351	hsa-miR-524-5p	CLIP-seq
MIRT1027352	hsa-miR-548n	CLIP-seq
MIRT1027353	hsa-miR-653	CLIP-seq
MIRT1027354	hsa-miR-708	CLIP-seq
MIRT1027355	hsa-miR-766	CLIP-seq
MIRT1027356	hsa-miR-934	CLIP-seq
MIRT2004737	hsa-miR-1287	CLIP-seq
MIRT2004738	hsa-miR-1293	CLIP-seq
MIRT2004739	hsa-miR-3135b	CLIP-seq
MIRT2004740	hsa-miR-4328	CLIP-seq
MIRT2004741	hsa-miR-4483	CLIP-seq
MIRT2004742	hsa-miR-490-5p	CLIP-seq
MIRT1027353	hsa-miR-653	CLIP-seq
MIRT2237504	hsa-miR-122	CLIP-seq
MIRT2004737	hsa-miR-1287	CLIP-seq
MIRT2004739	hsa-miR-3135b	CLIP-seq
MIRT2004742	hsa-miR-490-5p	CLIP-seq
MIRT2237504	hsa-miR-122	CLIP-seq
MIRT2004737	hsa-miR-1287	CLIP-seq
MIRT2004739	hsa-miR-3135b	CLIP-seq
MIRT2004742	hsa-miR-490-5p	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0016604	Component	Nuclear body	IDA

MIM	HGNC	e!Ensembl
610393	25973	ENSG00000116580

Q3T8J9

Protein name

GON-4-like protein (GON-4 homolog)

Protein function

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02671	PAH	1647 → 1693	Paired amphipathic helix repeat	Repeat

Sequence

MLPCKKRRTTVTESLQHKGNQEENNVDLESAVKPESDQVKDLSSVSLSWDPSHGRVAGFE
VQSLQDAGNQLGMEDTSLSSGMLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGK
GKLHATGSKRGKKMTLRPGPVTQEDRCDHLTLKEPFSGEPSEEVKEEGGKPQMNSEGEIP
SLPSGSQSAKPVSQPRKSTQPDVCASPQEKPLRTLFHQPEEEIEDGGLFIPMEEQDNEES
EKRRKKKKGTKRKRDGRGQEGTLAYDLKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVIT
NEHVVAMMKAAISETEDMPMFEPKMTRSKLKEVVEKGVVIPTWNISPIKKANEIKPPQFV
DIHLEEDDSSDEEYQPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQSSEMTETDE
ESGILSEAEKVTTPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM
DSFQPMDDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKMWLGGL
MNDDVGNEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNELMEELFETFQDE
MGFSNMEDDGPEEEECVAEPRPNFNTPQALRFEEPLANLLNEQHRTVKELFEQLKMKKSS
AKQLQEVEKVKPQSEKVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEAT
TTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTV
KKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGLKH
FEGTEFPNPLISKYLLTCKTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEI
QPHQWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDRSLEKDN
LELGSESRYPLLLPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPSPSLQPSFNPGK
TPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAVPPEAR
TSFPLSESQTLLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASPCMKPAPVIHHP
ASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPITTLLVNPTSFPCPLNQSLVA
SSVSPLIVSGNSVNLPIPSTPEDKAHVNVDIACAVADGENAFQGLEPKLEPQELSPLSAT
VFPKVEHSPGPPLADAECQEGLSENSACRWTVVKTEEGRQALEPLPQGIQESLNNPTPGD
LEEIVKMEPEEAREEISGSPERDICDDIKVEHAVELDTGAPSEELSSAGEVTKQTVLQKE
EERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSSVDGQ
SVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEEDEMSSASEESVLSVPELQETMEKLTWL
ASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVGDSAEKPPTFA
SPETAPEVETSRTPPGESIKAAGKGRNNHRARNKRGSRARASKDTSKLLLLYDEDILERD
PLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRRTAVDLYKSLQILLQ
DWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQG
CADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEF
DGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKETEWPDGAKDCACSCHEGGPD
SKLKKSKRRSCSHCSSKVCDSKSYKSKEPHELVGSSPHREASPMPGAKEAGQGKDMMEEE
APEERESTEATQSRTVRTTRKGEMPVSAGLAVGSTLPSPREVTVTERLLLDGPPPHSPET
PQFPPTTGAVLYTVKRNQVGPEVRSCPKASPRLQKEREGQKAVSESEALMLVWDASETEK
LPGTVEPPASFLSPVSSKTRDAGRRHVSGKPDTQERWLPSSRARVKTRDRTCPVHESPSG
IDTSETSPKAPRGGLAKDSGTQAKGPEGEQQPKAAEATVCANNSKVSSTGEKVVLWTREA
DRVILTMCQEQGAQPQTFNIISQQLGNKTPAEVSHRFRELMQLFHTACEASSEDEDDATS
TSNADQLSDHGDLLSEEELDE

Sequence length

2241

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ependymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GON4L-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

GON4L (gon-4 like)