SIDT1 (SID1 transmembrane family member 1)

Gene

• Entrez ID: 54847
• Gene name: SID1 transmembrane family member 1
• Gene symbol: SIDT1
• Synonyms (NCBI Gene): SID-1, SID1
• Chromosome: 3
• Chromosome location: 3q13.2
• Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028748	hsa-miR-26b-5p	Microarray	19088304
MIRT1348315	hsa-miR-103a	CLIP-seq
MIRT1348316	hsa-miR-106a	CLIP-seq
MIRT1348317	hsa-miR-106b	CLIP-seq
MIRT1348318	hsa-miR-107	CLIP-seq
MIRT1348319	hsa-miR-1179	CLIP-seq
MIRT1348320	hsa-miR-1207-5p	CLIP-seq
MIRT1348321	hsa-miR-122	CLIP-seq
MIRT1348322	hsa-miR-1231	CLIP-seq
MIRT1348323	hsa-miR-1245	CLIP-seq
MIRT1348324	hsa-miR-1245b-3p	CLIP-seq
MIRT1348325	hsa-miR-125a-5p	CLIP-seq
MIRT1348326	hsa-miR-125b	CLIP-seq
MIRT1348327	hsa-miR-1324	CLIP-seq
MIRT1348328	hsa-miR-142-3p	CLIP-seq
MIRT1348329	hsa-miR-149	CLIP-seq
MIRT1348330	hsa-miR-150	CLIP-seq
MIRT1348331	hsa-miR-15a	CLIP-seq
MIRT1348332	hsa-miR-15b	CLIP-seq
MIRT1348333	hsa-miR-16	CLIP-seq
MIRT1348334	hsa-miR-17	CLIP-seq
MIRT1348335	hsa-miR-18a	CLIP-seq
MIRT1348336	hsa-miR-18b	CLIP-seq
MIRT1348337	hsa-miR-1909	CLIP-seq
MIRT1348338	hsa-miR-195	CLIP-seq
MIRT1348339	hsa-miR-1976	CLIP-seq
MIRT1348340	hsa-miR-20a	CLIP-seq
MIRT1348341	hsa-miR-20b	CLIP-seq
MIRT1348342	hsa-miR-22	CLIP-seq
MIRT1348343	hsa-miR-3064-5p	CLIP-seq
MIRT1348344	hsa-miR-3120-5p	CLIP-seq
MIRT1348345	hsa-miR-3126-5p	CLIP-seq
MIRT1348346	hsa-miR-3135b	CLIP-seq
MIRT1348347	hsa-miR-3140-5p	CLIP-seq
MIRT1348348	hsa-miR-3147	CLIP-seq
MIRT1348349	hsa-miR-3605-3p	CLIP-seq
MIRT1348350	hsa-miR-3609	CLIP-seq
MIRT1348351	hsa-miR-3652	CLIP-seq
MIRT1348352	hsa-miR-3657	CLIP-seq
MIRT1348353	hsa-miR-3664-5p	CLIP-seq
MIRT1348354	hsa-miR-3689a-3p	CLIP-seq
MIRT1348355	hsa-miR-3689c	CLIP-seq
MIRT1348356	hsa-miR-3714	CLIP-seq
MIRT1348357	hsa-miR-3918	CLIP-seq
MIRT1348358	hsa-miR-3920	CLIP-seq
MIRT1348359	hsa-miR-3944-5p	CLIP-seq
MIRT1348360	hsa-miR-424	CLIP-seq
MIRT1348361	hsa-miR-4302	CLIP-seq
MIRT1348362	hsa-miR-4310	CLIP-seq
MIRT1348363	hsa-miR-4316	CLIP-seq
MIRT1348364	hsa-miR-4319	CLIP-seq
MIRT1348365	hsa-miR-4421	CLIP-seq
MIRT1348366	hsa-miR-4425	CLIP-seq
MIRT1348367	hsa-miR-4430	CLIP-seq
MIRT1348368	hsa-miR-4438	CLIP-seq
MIRT1348369	hsa-miR-4504	CLIP-seq
MIRT1348370	hsa-miR-450b-3p	CLIP-seq
MIRT1348371	hsa-miR-4512	CLIP-seq
MIRT1348372	hsa-miR-4639-3p	CLIP-seq
MIRT1348373	hsa-miR-4645-5p	CLIP-seq
MIRT1348374	hsa-miR-4673	CLIP-seq
MIRT1348375	hsa-miR-4688	CLIP-seq
MIRT1348376	hsa-miR-4693-3p	CLIP-seq
MIRT1348377	hsa-miR-4710	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq
MIRT1348379	hsa-miR-4728-5p	CLIP-seq
MIRT1348380	hsa-miR-4732-3p	CLIP-seq
MIRT1348381	hsa-miR-4735-3p	CLIP-seq
MIRT1348382	hsa-miR-4763-3p	CLIP-seq
MIRT1348383	hsa-miR-4794	CLIP-seq
MIRT1348384	hsa-miR-4796-3p	CLIP-seq
MIRT1348385	hsa-miR-497	CLIP-seq
MIRT1348386	hsa-miR-5095	CLIP-seq
MIRT1348387	hsa-miR-519d	CLIP-seq
MIRT1348388	hsa-miR-520g	CLIP-seq
MIRT1348389	hsa-miR-520h	CLIP-seq
MIRT1348390	hsa-miR-542-3p	CLIP-seq
MIRT1348391	hsa-miR-548ah	CLIP-seq
MIRT1348392	hsa-miR-549	CLIP-seq
MIRT1348393	hsa-miR-558	CLIP-seq
MIRT1348394	hsa-miR-595	CLIP-seq
MIRT1348395	hsa-miR-604	CLIP-seq
MIRT1348396	hsa-miR-615-5p	CLIP-seq
MIRT1348397	hsa-miR-647	CLIP-seq
MIRT1348398	hsa-miR-648	CLIP-seq
MIRT1348399	hsa-miR-670	CLIP-seq
MIRT1348400	hsa-miR-720	CLIP-seq
MIRT1348401	hsa-miR-765	CLIP-seq
MIRT1348402	hsa-miR-769-3p	CLIP-seq
MIRT1348403	hsa-miR-93	CLIP-seq
MIRT2103220	hsa-miR-1200	CLIP-seq
MIRT1348321	hsa-miR-122	CLIP-seq
MIRT2103221	hsa-miR-1225-3p	CLIP-seq
MIRT2103222	hsa-miR-1233	CLIP-seq
MIRT2103223	hsa-miR-1237	CLIP-seq
MIRT1348323	hsa-miR-1245	CLIP-seq
MIRT2103224	hsa-miR-1257	CLIP-seq
MIRT2103225	hsa-miR-1275	CLIP-seq
MIRT2103226	hsa-miR-129-3p	CLIP-seq
MIRT1348327	hsa-miR-1324	CLIP-seq
MIRT2103227	hsa-miR-1343	CLIP-seq
MIRT1348330	hsa-miR-150	CLIP-seq
MIRT2103228	hsa-miR-185	CLIP-seq
MIRT1348337	hsa-miR-1909	CLIP-seq
MIRT2103229	hsa-miR-1912	CLIP-seq
MIRT1348339	hsa-miR-1976	CLIP-seq
MIRT1348342	hsa-miR-22	CLIP-seq
MIRT2103230	hsa-miR-3123	CLIP-seq
MIRT1348346	hsa-miR-3135b	CLIP-seq
MIRT2103231	hsa-miR-3150a-3p	CLIP-seq
MIRT2103232	hsa-miR-3175	CLIP-seq
MIRT1348351	hsa-miR-3652	CLIP-seq
MIRT2103233	hsa-miR-3665	CLIP-seq
MIRT2103234	hsa-miR-3668	CLIP-seq
MIRT1348354	hsa-miR-3689a-3p	CLIP-seq
MIRT1348355	hsa-miR-3689c	CLIP-seq
MIRT2103235	hsa-miR-378g	CLIP-seq
MIRT2103236	hsa-miR-3960	CLIP-seq
MIRT1348361	hsa-miR-4302	CLIP-seq
MIRT2103237	hsa-miR-4306	CLIP-seq
MIRT2103238	hsa-miR-4324	CLIP-seq
MIRT2103239	hsa-miR-4330	CLIP-seq
MIRT2103240	hsa-miR-4420	CLIP-seq
MIRT1348367	hsa-miR-4430	CLIP-seq
MIRT2103241	hsa-miR-4437	CLIP-seq
MIRT2103242	hsa-miR-4502	CLIP-seq
MIRT2103243	hsa-miR-4525	CLIP-seq
MIRT2103244	hsa-miR-4644	CLIP-seq
MIRT1348373	hsa-miR-4645-5p	CLIP-seq
MIRT2103245	hsa-miR-4659a-3p	CLIP-seq
MIRT2103246	hsa-miR-4659b-3p	CLIP-seq
MIRT2103247	hsa-miR-4663	CLIP-seq
MIRT2103248	hsa-miR-4665-5p	CLIP-seq
MIRT2103249	hsa-miR-4667-5p	CLIP-seq
MIRT1348374	hsa-miR-4673	CLIP-seq
MIRT2103250	hsa-miR-4674	CLIP-seq
MIRT1348375	hsa-miR-4688	CLIP-seq
MIRT1348376	hsa-miR-4693-3p	CLIP-seq
MIRT2103251	hsa-miR-4700-5p	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq
MIRT2103252	hsa-miR-4723-5p	CLIP-seq
MIRT2103253	hsa-miR-4727-5p	CLIP-seq
MIRT2103254	hsa-miR-4728-3p	CLIP-seq
MIRT1348379	hsa-miR-4728-5p	CLIP-seq
MIRT2103255	hsa-miR-4762-3p	CLIP-seq
MIRT2103256	hsa-miR-483-3p	CLIP-seq
MIRT1348388	hsa-miR-520g	CLIP-seq
MIRT1348389	hsa-miR-520h	CLIP-seq
MIRT2103257	hsa-miR-544b	CLIP-seq
MIRT1348393	hsa-miR-558	CLIP-seq
MIRT2103258	hsa-miR-625	CLIP-seq
MIRT2103259	hsa-miR-637	CLIP-seq
MIRT2103260	hsa-miR-939	CLIP-seq
MIRT2103220	hsa-miR-1200	CLIP-seq
MIRT1348321	hsa-miR-122	CLIP-seq
MIRT2103221	hsa-miR-1225-3p	CLIP-seq
MIRT1348322	hsa-miR-1231	CLIP-seq
MIRT2103222	hsa-miR-1233	CLIP-seq
MIRT2103223	hsa-miR-1237	CLIP-seq
MIRT1348323	hsa-miR-1245	CLIP-seq
MIRT2103224	hsa-miR-1257	CLIP-seq
MIRT2103226	hsa-miR-129-3p	CLIP-seq
MIRT1348327	hsa-miR-1324	CLIP-seq
MIRT2103227	hsa-miR-1343	CLIP-seq
MIRT2327488	hsa-miR-139-5p	CLIP-seq
MIRT1348329	hsa-miR-149	CLIP-seq
MIRT1348330	hsa-miR-150	CLIP-seq
MIRT1348331	hsa-miR-15a	CLIP-seq
MIRT1348332	hsa-miR-15b	CLIP-seq
MIRT1348333	hsa-miR-16	CLIP-seq
MIRT1348337	hsa-miR-1909	CLIP-seq
MIRT2327489	hsa-miR-1914	CLIP-seq
MIRT1348338	hsa-miR-195	CLIP-seq
MIRT1348339	hsa-miR-1976	CLIP-seq
MIRT1348342	hsa-miR-22	CLIP-seq
MIRT2327490	hsa-miR-2467-3p	CLIP-seq
MIRT1348343	hsa-miR-3064-5p	CLIP-seq
MIRT2327491	hsa-miR-3126-3p	CLIP-seq
MIRT1348346	hsa-miR-3135b	CLIP-seq
MIRT1348351	hsa-miR-3652	CLIP-seq
MIRT2327492	hsa-miR-3667-3p	CLIP-seq
MIRT2327493	hsa-miR-3678-3p	CLIP-seq
MIRT1348354	hsa-miR-3689a-3p	CLIP-seq
MIRT1348355	hsa-miR-3689c	CLIP-seq
MIRT2103235	hsa-miR-378g	CLIP-seq
MIRT2103236	hsa-miR-3960	CLIP-seq
MIRT1348360	hsa-miR-424	CLIP-seq
MIRT2327494	hsa-miR-4268	CLIP-seq
MIRT1348361	hsa-miR-4302	CLIP-seq
MIRT2103238	hsa-miR-4324	CLIP-seq
MIRT2103240	hsa-miR-4420	CLIP-seq
MIRT1348367	hsa-miR-4430	CLIP-seq
MIRT2103241	hsa-miR-4437	CLIP-seq
MIRT1348368	hsa-miR-4438	CLIP-seq
MIRT2327495	hsa-miR-4464	CLIP-seq
MIRT2327496	hsa-miR-4481	CLIP-seq
MIRT2103242	hsa-miR-4502	CLIP-seq
MIRT1348373	hsa-miR-4645-5p	CLIP-seq
MIRT1348374	hsa-miR-4673	CLIP-seq
MIRT2103250	hsa-miR-4674	CLIP-seq
MIRT1348375	hsa-miR-4688	CLIP-seq
MIRT1348376	hsa-miR-4693-3p	CLIP-seq
MIRT2327497	hsa-miR-4715-5p	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq
MIRT1348379	hsa-miR-4728-5p	CLIP-seq
MIRT2327498	hsa-miR-4745-5p	CLIP-seq
MIRT2327499	hsa-miR-4748	CLIP-seq
MIRT2327500	hsa-miR-4749-3p	CLIP-seq
MIRT2327501	hsa-miR-4758-5p	CLIP-seq
MIRT2103255	hsa-miR-4762-3p	CLIP-seq
MIRT1348383	hsa-miR-4794	CLIP-seq
MIRT2327502	hsa-miR-4797-5p	CLIP-seq
MIRT2103256	hsa-miR-483-3p	CLIP-seq
MIRT1348385	hsa-miR-497	CLIP-seq
MIRT1348386	hsa-miR-5095	CLIP-seq
MIRT1348388	hsa-miR-520g	CLIP-seq
MIRT1348389	hsa-miR-520h	CLIP-seq
MIRT2103257	hsa-miR-544b	CLIP-seq
MIRT1348393	hsa-miR-558	CLIP-seq
MIRT2327503	hsa-miR-571	CLIP-seq
MIRT2327504	hsa-miR-584	CLIP-seq
MIRT1348395	hsa-miR-604	CLIP-seq
MIRT1348397	hsa-miR-647	CLIP-seq
MIRT2327505	hsa-miR-760	CLIP-seq
MIRT1348378	hsa-miR-4722-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
STAT6	Unknown	18342537

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0005764	Component	Lysosome	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0015485	Function	Cholesterol binding	IDA	28785058
GO:0016020	Component	Membrane	IEA
GO:0050658	Process	RNA transport	IBA
GO:0051033	Function	RNA transmembrane transporter activity	IBA

Other IDs

• MIM: 606816
• HGNC: 25967
• e!Ensembl: ENSG00000072858

Protein

• UniProt ID: Q9NXL6
• Protein name: SID1 transmembrane family member 1
• Protein function: In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. {ECO
• PDB: 8J6M, 8JUL, 8JUN, 8K13, 8K1B, 8K1D, 8KCW, 8KCX, 8V38, 8WOQ, 8WOR, 8WOS, 8WOT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13965	SID-1_RNA_chan	184 → 827	dsRNA-gated channel SID-1	Family

• Sequence:

  MRGCLRLALLCALPWLLLAASPGHPAKSPRQPPAPRRDPFDAARGADFDHVYSGVVNLST
  ENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSY
  NYQEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRTNVAFHFT
  ASPSQPQYFLYKFPKDVDSVIIKVVSEMAYPCSVVSVQNIMCPVYDLDHNVEFNGVYQSM
  TKKAAITLQKKDFPGEQFFVVFVIKPEDYACGGSFFIQEKENQTWNLQRKKNLEVTIVPS
  IKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRFQRKSIDGSFGSNDGSGNMVASHPIA
  ASTPEGSNYGTIDESSSSPGRQMSSSDGGPPGQSDTDSSVEESDFDTMPDIESDKNIIRT
  KMFLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICY
  YNFLCAHPLGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRALEAKDIFAVEYGIPK
  HFGLFYAMGIALMMEGVLSACYHVCPNYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINAS
  AYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYYMGRFKIDLGIF
  RRAAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICN
  LLLYLAFYIIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNR
  ECILLDFFDDHDIWHFLSATALFFSFLVLLTLDDDLDVVRRDQIPVF

• Sequence length: 827

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Long QT syndrome	Likely benign	rs531258462	RCV000190207
Marfanoid habitus and intellectual disability	Uncertain significance	rs374060767	RCV000850428

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	40644891
Neoplasms	Associate	22174421
Squamous Cell Carcinoma of Head and Neck	Associate	33758106