MFSD6 (major facilitator superfamily domain containing 6)

Gene

• Entrez ID: 54842
• Gene name: Major facilitator superfamily domain containing 6
• Gene symbol: MFSD6
• Synonyms (NCBI Gene): MMR2, SLC73A1, hMMR2
• Chromosome: 2
• Chromosome location: 2q32.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019038	hsa-miR-335-5p	Microarray	18185580
MIRT027391	hsa-miR-101-3p	Sequencing	20371350
MIRT038299	hsa-miR-130b-5p	CLASH	23622248
MIRT717015	hsa-miR-5587-3p	HITS-CLIP	19536157
MIRT717014	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT717013	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT717012	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT717011	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT717010	hsa-miR-1976	HITS-CLIP	19536157
MIRT717009	hsa-miR-1913	HITS-CLIP	19536157
MIRT717008	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT717007	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT656232	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT656231	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT667415	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656230	hsa-miR-6730-3p	HITS-CLIP	23824327
MIRT656229	hsa-miR-3660	HITS-CLIP	23824327
MIRT656228	hsa-miR-4526	HITS-CLIP	23824327
MIRT656227	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT667414	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656226	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT667413	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT667412	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT667411	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT656225	hsa-miR-5096	HITS-CLIP	23824327
MIRT656244	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT656243	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT656242	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT656241	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT656240	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT656239	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT656238	hsa-miR-3123	HITS-CLIP	23824327
MIRT656237	hsa-miR-3976	HITS-CLIP	23824327
MIRT656236	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT656235	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT656234	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT656233	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT656232	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT656231	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT656230	hsa-miR-6730-3p	HITS-CLIP	23824327
MIRT656229	hsa-miR-3660	HITS-CLIP	23824327
MIRT656228	hsa-miR-4526	HITS-CLIP	23824327
MIRT656227	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT656226	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT656225	hsa-miR-5096	HITS-CLIP	23824327
MIRT086422	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT503950	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT503949	hsa-miR-4801	PAR-CLIP	20371350
MIRT027391	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT503948	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT086419	hsa-miR-617	PAR-CLIP	20371350
MIRT503947	hsa-miR-6505-3p	PAR-CLIP	20371350
MIRT027391	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT503948	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT027391	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT086422	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT503950	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT503949	hsa-miR-4801	PAR-CLIP	21572407
MIRT027391	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT086419	hsa-miR-617	PAR-CLIP	21572407
MIRT503947	hsa-miR-6505-3p	PAR-CLIP	21572407
MIRT086422	hsa-miR-6882-5p	PAR-CLIP	23446348
MIRT503950	hsa-miR-4731-3p	PAR-CLIP	23446348
MIRT503949	hsa-miR-4801	PAR-CLIP	23446348
MIRT027391	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT503948	hsa-miR-144-3p	PAR-CLIP	23446348
MIRT086419	hsa-miR-617	PAR-CLIP	23446348
MIRT503947	hsa-miR-6505-3p	PAR-CLIP	23446348
MIRT027391	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT086398	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT086399	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT717015	hsa-miR-5587-3p	HITS-CLIP	19536157
MIRT717014	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT717013	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT717012	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT717011	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT717010	hsa-miR-1976	HITS-CLIP	19536157
MIRT717009	hsa-miR-1913	HITS-CLIP	19536157
MIRT717008	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT717007	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT656232	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT656231	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT667415	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656230	hsa-miR-6730-3p	HITS-CLIP	23824327
MIRT656229	hsa-miR-3660	HITS-CLIP	23824327
MIRT656228	hsa-miR-4526	HITS-CLIP	23824327
MIRT656227	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT667414	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656226	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT667413	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT667412	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT667411	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT656225	hsa-miR-5096	HITS-CLIP	23824327
MIRT656244	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT656243	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT656242	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT656241	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT656240	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT656239	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT656238	hsa-miR-3123	HITS-CLIP	23824327
MIRT656237	hsa-miR-3976	HITS-CLIP	23824327
MIRT656236	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT656235	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT656234	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT656233	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT656232	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT656231	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT656230	hsa-miR-6730-3p	HITS-CLIP	23824327
MIRT656229	hsa-miR-3660	HITS-CLIP	23824327
MIRT656228	hsa-miR-4526	HITS-CLIP	23824327
MIRT656227	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT656226	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT656225	hsa-miR-5096	HITS-CLIP	23824327
MIRT086422	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT503950	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT503949	hsa-miR-4801	PAR-CLIP	20371350
MIRT027391	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT503948	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT086419	hsa-miR-617	PAR-CLIP	20371350
MIRT503947	hsa-miR-6505-3p	PAR-CLIP	20371350
MIRT027391	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT503948	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT027391	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT086422	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT503950	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT503949	hsa-miR-4801	PAR-CLIP	21572407
MIRT027391	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT086419	hsa-miR-617	PAR-CLIP	21572407
MIRT503947	hsa-miR-6505-3p	PAR-CLIP	21572407
MIRT086422	hsa-miR-6882-5p	PAR-CLIP	23446348
MIRT503950	hsa-miR-4731-3p	PAR-CLIP	23446348
MIRT503949	hsa-miR-4801	PAR-CLIP	23446348
MIRT027391	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT503948	hsa-miR-144-3p	PAR-CLIP	23446348
MIRT086419	hsa-miR-617	PAR-CLIP	23446348
MIRT503947	hsa-miR-6505-3p	PAR-CLIP	23446348
MIRT027391	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT1146508	hsa-miR-101	CLIP-seq
MIRT1146509	hsa-miR-1244	CLIP-seq
MIRT1146510	hsa-miR-1297	CLIP-seq
MIRT1146511	hsa-miR-1305	CLIP-seq
MIRT1146512	hsa-miR-130a	CLIP-seq
MIRT1146513	hsa-miR-130b	CLIP-seq
MIRT1146514	hsa-miR-144	CLIP-seq
MIRT1146515	hsa-miR-146a	CLIP-seq
MIRT1146516	hsa-miR-199a-3p	CLIP-seq
MIRT1146517	hsa-miR-199b-3p	CLIP-seq
MIRT1146518	hsa-miR-19a	CLIP-seq
MIRT1146519	hsa-miR-19b	CLIP-seq
MIRT1146520	hsa-miR-214	CLIP-seq
MIRT1146521	hsa-miR-217	CLIP-seq
MIRT1146522	hsa-miR-26a	CLIP-seq
MIRT1146523	hsa-miR-26b	CLIP-seq
MIRT1146524	hsa-miR-301a	CLIP-seq
MIRT1146525	hsa-miR-301b	CLIP-seq
MIRT1146526	hsa-miR-3119	CLIP-seq
MIRT1146527	hsa-miR-3129-5p	CLIP-seq
MIRT1146528	hsa-miR-3163	CLIP-seq
MIRT1146529	hsa-miR-3619-5p	CLIP-seq
MIRT1146530	hsa-miR-3652	CLIP-seq
MIRT1146531	hsa-miR-3662	CLIP-seq
MIRT1146532	hsa-miR-3666	CLIP-seq
MIRT1146533	hsa-miR-3974	CLIP-seq
MIRT1146534	hsa-miR-421	CLIP-seq
MIRT1146535	hsa-miR-4277	CLIP-seq
MIRT1146536	hsa-miR-4295	CLIP-seq
MIRT1146537	hsa-miR-4327	CLIP-seq
MIRT1146538	hsa-miR-433	CLIP-seq
MIRT1146539	hsa-miR-4430	CLIP-seq
MIRT1146540	hsa-miR-4453	CLIP-seq
MIRT1146541	hsa-miR-4457	CLIP-seq
MIRT1146542	hsa-miR-4465	CLIP-seq
MIRT1146543	hsa-miR-4538	CLIP-seq
MIRT1146544	hsa-miR-454	CLIP-seq
MIRT1146545	hsa-miR-4643	CLIP-seq
MIRT1146546	hsa-miR-466	CLIP-seq
MIRT1146547	hsa-miR-4690-5p	CLIP-seq
MIRT1146548	hsa-miR-4711-3p	CLIP-seq
MIRT1146549	hsa-miR-4789-3p	CLIP-seq
MIRT1146550	hsa-miR-505	CLIP-seq
MIRT1146551	hsa-miR-513b	CLIP-seq
MIRT1146552	hsa-miR-519a	CLIP-seq
MIRT1146553	hsa-miR-519b-3p	CLIP-seq
MIRT1146554	hsa-miR-519c-3p	CLIP-seq
MIRT1146555	hsa-miR-548c-3p	CLIP-seq
MIRT1146556	hsa-miR-548m	CLIP-seq
MIRT1146557	hsa-miR-579	CLIP-seq
MIRT1146558	hsa-miR-582-5p	CLIP-seq
MIRT1146559	hsa-miR-589	CLIP-seq
MIRT1146560	hsa-miR-607	CLIP-seq
MIRT1146561	hsa-miR-664	CLIP-seq
MIRT1146562	hsa-miR-761	CLIP-seq
MIRT1146563	hsa-miR-875-3p	CLIP-seq
MIRT1146564	hsa-miR-892a	CLIP-seq
MIRT1146565	hsa-miR-943	CLIP-seq
MIRT1146521	hsa-miR-217	CLIP-seq
MIRT1146530	hsa-miR-3652	CLIP-seq
MIRT1146539	hsa-miR-4430	CLIP-seq
MIRT1146541	hsa-miR-4457	CLIP-seq
MIRT1146563	hsa-miR-875-3p	CLIP-seq
MIRT1146521	hsa-miR-217	CLIP-seq
MIRT1146530	hsa-miR-3652	CLIP-seq
MIRT1146539	hsa-miR-4430	CLIP-seq
MIRT1146541	hsa-miR-4457	CLIP-seq
MIRT1146563	hsa-miR-875-3p	CLIP-seq
MIRT1146508	hsa-miR-101	CLIP-seq
MIRT1146511	hsa-miR-1305	CLIP-seq
MIRT1146514	hsa-miR-144	CLIP-seq
MIRT2041735	hsa-miR-3117-3p	CLIP-seq
MIRT2041736	hsa-miR-3169	CLIP-seq
MIRT2041737	hsa-miR-3685	CLIP-seq
MIRT2041738	hsa-miR-4719	CLIP-seq
MIRT2041739	hsa-miR-4759	CLIP-seq
MIRT1146558	hsa-miR-582-5p	CLIP-seq
MIRT1146508	hsa-miR-101	CLIP-seq
MIRT2271259	hsa-miR-128	CLIP-seq
MIRT1146510	hsa-miR-1297	CLIP-seq
MIRT2271260	hsa-miR-1298	CLIP-seq
MIRT1146511	hsa-miR-1305	CLIP-seq
MIRT1146514	hsa-miR-144	CLIP-seq
MIRT2271261	hsa-miR-181a	CLIP-seq
MIRT2271262	hsa-miR-181b	CLIP-seq
MIRT2271263	hsa-miR-181c	CLIP-seq
MIRT2271264	hsa-miR-181d	CLIP-seq
MIRT2271265	hsa-miR-1825	CLIP-seq
MIRT2271266	hsa-miR-199a-5p	CLIP-seq
MIRT2271267	hsa-miR-199b-5p	CLIP-seq
MIRT1146520	hsa-miR-214	CLIP-seq
MIRT1146522	hsa-miR-26a	CLIP-seq
MIRT1146523	hsa-miR-26b	CLIP-seq
MIRT2271268	hsa-miR-27a	CLIP-seq
MIRT2271269	hsa-miR-27b	CLIP-seq
MIRT2271270	hsa-miR-30a	CLIP-seq
MIRT2271271	hsa-miR-30b	CLIP-seq
MIRT2271272	hsa-miR-30c	CLIP-seq
MIRT2271273	hsa-miR-30d	CLIP-seq
MIRT2271274	hsa-miR-30e	CLIP-seq
MIRT1146526	hsa-miR-3119	CLIP-seq
MIRT2271275	hsa-miR-3607-3p	CLIP-seq
MIRT1146529	hsa-miR-3619-5p	CLIP-seq
MIRT1146531	hsa-miR-3662	CLIP-seq
MIRT2271276	hsa-miR-3938	CLIP-seq
MIRT1146533	hsa-miR-3974	CLIP-seq
MIRT2271277	hsa-miR-4262	CLIP-seq
MIRT1146535	hsa-miR-4277	CLIP-seq
MIRT2271278	hsa-miR-4280	CLIP-seq
MIRT2271279	hsa-miR-4328	CLIP-seq
MIRT1146541	hsa-miR-4457	CLIP-seq
MIRT1146542	hsa-miR-4465	CLIP-seq
MIRT1146547	hsa-miR-4690-5p	CLIP-seq
MIRT2041738	hsa-miR-4719	CLIP-seq
MIRT1146556	hsa-miR-548m	CLIP-seq
MIRT1146558	hsa-miR-582-5p	CLIP-seq
MIRT2271280	hsa-miR-587	CLIP-seq
MIRT1146560	hsa-miR-607	CLIP-seq
MIRT2271281	hsa-miR-626	CLIP-seq
MIRT1146562	hsa-miR-761	CLIP-seq
MIRT1146564	hsa-miR-892a	CLIP-seq
MIRT1146521	hsa-miR-217	CLIP-seq
MIRT1146530	hsa-miR-3652	CLIP-seq
MIRT1146539	hsa-miR-4430	CLIP-seq
MIRT1146563	hsa-miR-875-3p	CLIP-seq
MIRT1146511	hsa-miR-1305	CLIP-seq
MIRT1146534	hsa-miR-421	CLIP-seq
MIRT1146550	hsa-miR-505	CLIP-seq
MIRT1146515	hsa-miR-146a	CLIP-seq
MIRT2684950	hsa-miR-3978	CLIP-seq
MIRT1146538	hsa-miR-433	CLIP-seq
MIRT1146548	hsa-miR-4711-3p	CLIP-seq
MIRT2684951	hsa-miR-548l	CLIP-seq
MIRT1146559	hsa-miR-589	CLIP-seq
MIRT2684952	hsa-miR-616	CLIP-seq
MIRT1146564	hsa-miR-892a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0042590	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I	IBA

Other IDs

• MIM: 613476
• HGNC: 24711
• e!Ensembl: ENSG00000151690

Protein

• UniProt ID: Q6ZSS7
• Protein name: Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12832	MFS_1_like	68 → 605	MFS_1 like family	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all. {ECO:0000269|PubMed:20123006}.
• Sequence:

  MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKH
  CVKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPF
  WGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
  TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDL
  TLNSSTATPVSPGSVTKETTTVIVTTTKSLPSDQVMLVYDQQEVEAIFLVILVVVIIGEF
  FSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
  KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESS
  EETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT
  LFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
  VLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAA
  ATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATIDLVQQQTED
  VMPRIEPRLPPKKTKHQEEQEDVNKPAWGVSSSPWVTFVYALYQIKEMMQLTRDNRASEI
  QPLQGTNENRENSPAGRAQPVPCETHSDPSRNQPSPDAAASQTQTSPAHPSVDPCTEESE
  EQQAQLAAGGH

• Sequence length: 791

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOIMMUNE DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE IDIOPATHIC ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations