Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5481
Gene name	Peptidylprolyl isomerase D
Gene symbol	PPID
Synonyms (NCBI Gene)	CYP-40CYPD
Chromosome	4
Chromosome location	4q32.1
Summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028395	hsa-miR-30a-5p	Proteomics	18668040
MIRT032229	hsa-let-7b-5p	Proteomics	18668040
MIRT635610	hsa-miR-496	HITS-CLIP	22927820
MIRT635609	hsa-miR-223-5p	HITS-CLIP	22927820
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT706392	hsa-miR-6818-5p	HITS-CLIP	22927820
MIRT706391	hsa-miR-147a	HITS-CLIP	22927820
MIRT706390	hsa-miR-5010-3p	HITS-CLIP	22927820
MIRT635607	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT635610	hsa-miR-496	HITS-CLIP	23313552
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT706391	hsa-miR-147a	HITS-CLIP	27418678
MIRT635609	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT635609	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT635609	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT635610	hsa-miR-496	HITS-CLIP	27418678
MIRT635610	hsa-miR-496	HITS-CLIP	27418678
MIRT635610	hsa-miR-496	HITS-CLIP	27418678
MIRT706390	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT635607	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT635607	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT635607	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT706392	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT733887	hsa-miR-1203	Luciferase reporter assayWestern blottingqRT-PCR	32041924
MIRT635610	hsa-miR-496	HITS-CLIP	22927820
MIRT635609	hsa-miR-223-5p	HITS-CLIP	22927820
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT706392	hsa-miR-6818-5p	HITS-CLIP	22927820
MIRT706391	hsa-miR-147a	HITS-CLIP	22927820
MIRT706390	hsa-miR-5010-3p	HITS-CLIP	22927820
MIRT635607	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT635610	hsa-miR-496	HITS-CLIP	23313552
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT756194	hsa-miR-25-3p	Luciferase reporter assayWestern blottingqRT-PCRImmunoprecipitaion (IP)	36276499
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT1252879	hsa-miR-1908	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT1252882	hsa-miR-3122	CLIP-seq
MIRT1252883	hsa-miR-3165	CLIP-seq
MIRT1252884	hsa-miR-3689a-3p	CLIP-seq
MIRT1252885	hsa-miR-3689c	CLIP-seq
MIRT1252886	hsa-miR-3913-5p	CLIP-seq
MIRT1252887	hsa-miR-3974	CLIP-seq
MIRT1252888	hsa-miR-4433	CLIP-seq
MIRT1252889	hsa-miR-4457	CLIP-seq
MIRT1252890	hsa-miR-4459	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252893	hsa-miR-4651	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT1252895	hsa-miR-4728-5p	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT1252899	hsa-miR-513b	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252903	hsa-miR-608	CLIP-seq
MIRT1252904	hsa-miR-624	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252906	hsa-miR-663	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT2074475	hsa-miR-24	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT2074476	hsa-miR-342-3p	CLIP-seq
MIRT2074477	hsa-miR-371-5p	CLIP-seq
MIRT2074478	hsa-miR-371b-5p	CLIP-seq
MIRT2074479	hsa-miR-4284	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT2074481	hsa-miR-4743	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT2074482	hsa-miR-495	CLIP-seq
MIRT2074483	hsa-miR-548c-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT2301470	hsa-miR-1262	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT2074475	hsa-miR-24	CLIP-seq
MIRT2301471	hsa-miR-2467-3p	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT2074476	hsa-miR-342-3p	CLIP-seq
MIRT2301472	hsa-miR-3605-5p	CLIP-seq
MIRT2301473	hsa-miR-3612	CLIP-seq
MIRT2074479	hsa-miR-4284	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT2301474	hsa-miR-451b	CLIP-seq
MIRT2301475	hsa-miR-4537	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT2301476	hsa-miR-4696	CLIP-seq
MIRT2301477	hsa-miR-4701-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT2074481	hsa-miR-4743	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT2301478	hsa-miR-542-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT2301479	hsa-miR-650	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT2301470	hsa-miR-1262	CLIP-seq
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT1252879	hsa-miR-1908	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT1252882	hsa-miR-3122	CLIP-seq
MIRT1252883	hsa-miR-3165	CLIP-seq
MIRT2598191	hsa-miR-3675-3p	CLIP-seq
MIRT1252884	hsa-miR-3689a-3p	CLIP-seq
MIRT1252885	hsa-miR-3689c	CLIP-seq
MIRT2074477	hsa-miR-371-5p	CLIP-seq
MIRT2074478	hsa-miR-371b-5p	CLIP-seq
MIRT1252886	hsa-miR-3913-5p	CLIP-seq
MIRT1252887	hsa-miR-3974	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT1252888	hsa-miR-4433	CLIP-seq
MIRT1252889	hsa-miR-4457	CLIP-seq
MIRT1252890	hsa-miR-4459	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT2301474	hsa-miR-451b	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252893	hsa-miR-4651	CLIP-seq
MIRT2598192	hsa-miR-4684-5p	CLIP-seq
MIRT2301476	hsa-miR-4696	CLIP-seq
MIRT2301477	hsa-miR-4701-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT1252895	hsa-miR-4728-5p	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT2074482	hsa-miR-495	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT1252899	hsa-miR-513b	CLIP-seq
MIRT2301478	hsa-miR-542-3p	CLIP-seq
MIRT2598193	hsa-miR-548aa	CLIP-seq
MIRT2074483	hsa-miR-548c-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252903	hsa-miR-608	CLIP-seq
MIRT1252904	hsa-miR-624	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252906	hsa-miR-663	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT2301470	hsa-miR-1262	CLIP-seq
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT1252879	hsa-miR-1908	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT1252882	hsa-miR-3122	CLIP-seq
MIRT1252883	hsa-miR-3165	CLIP-seq
MIRT2598191	hsa-miR-3675-3p	CLIP-seq
MIRT1252884	hsa-miR-3689a-3p	CLIP-seq
MIRT1252885	hsa-miR-3689c	CLIP-seq
MIRT2074477	hsa-miR-371-5p	CLIP-seq
MIRT2074478	hsa-miR-371b-5p	CLIP-seq
MIRT1252886	hsa-miR-3913-5p	CLIP-seq
MIRT1252887	hsa-miR-3974	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT1252888	hsa-miR-4433	CLIP-seq
MIRT1252889	hsa-miR-4457	CLIP-seq
MIRT1252890	hsa-miR-4459	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT2301474	hsa-miR-451b	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252893	hsa-miR-4651	CLIP-seq
MIRT2598192	hsa-miR-4684-5p	CLIP-seq
MIRT2301476	hsa-miR-4696	CLIP-seq
MIRT2301477	hsa-miR-4701-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT1252895	hsa-miR-4728-5p	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT2074482	hsa-miR-495	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT1252899	hsa-miR-513b	CLIP-seq
MIRT2301478	hsa-miR-542-3p	CLIP-seq
MIRT2598193	hsa-miR-548aa	CLIP-seq
MIRT2074483	hsa-miR-548c-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252903	hsa-miR-608	CLIP-seq
MIRT1252904	hsa-miR-624	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252906	hsa-miR-663	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	18708059
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IBA
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IDA	11350175, 20676357
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0005515	Function	Protein binding	IPI	9659917, 16507998, 18806802, 21146485, 28514442, 30266287, 33961781
GO:0005634	Component	Nucleus	IDA	11525244
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	11525244
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11525244
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005929	Component	Cilium	IDA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IDA	11350175
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	ISS
GO:0006915	Process	Apoptotic process	IEA
GO:0008134	Function	Transcription factor binding	IDA	9659917
GO:0015031	Process	Protein transport	IEA
GO:0016018	Function	Cyclosporin A binding	IBA
GO:0016018	Function	Cyclosporin A binding	TAS	7744028, 8812478
GO:0016853	Function	Isomerase activity	IEA
GO:0019076	Process	Viral release from host cell	TAS	21711559
GO:0030331	Function	Nuclear estrogen receptor binding	ISS
GO:0030544	Function	Hsp70 protein binding	ISS
GO:0031072	Function	Heat shock protein binding	IPI	9660753
GO:0034389	Process	Lipid droplet organization	IMP	21711559
GO:0043065	Process	Positive regulation of apoptotic process	IMP	23220213
GO:0045070	Process	Positive regulation of viral genome replication	IMP	19932913
GO:0050714	Process	Positive regulation of protein secretion	IMP	21711559
GO:0051879	Function	Hsp90 protein binding	IDA	12145316
GO:0065003	Process	Protein-containing complex assembly	IDA	18708059
GO:0071492	Process	Cellular response to UV-A	IMP	23220213

MIM	HGNC	e!Ensembl
601753	9257	ENSG00000171497

Q08752

Protein name

Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)

Protein function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unlig

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00160	Pro_isomerase	19 → 183	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Domain
PF13176	TPR_7	226 → 258	Tetratricopeptide repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGH
TTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSM
ANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAE
CGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWE
MAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEAL
ELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDK
EKAVYAKMFA

Sequence length

370

Interactions

View interactions

	KEGG		Reactome
	Necroptosis Cellular senescence Alzheimer disease Pathways of neurodegeneration - multiple diseases Shigellosis		ESR-mediated signaling

PPID (peptidylprolyl isomerase D)