Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5481
Gene name Gene Name - the full gene name approved by the HGNC.	Peptidylprolyl isomerase D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPID
Synonyms (NCBI Gene) Gene synonyms aliases	CYP-40, CYPD
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q32.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028395	hsa-miR-30a-5p	Proteomics	18668040
MIRT032229	hsa-let-7b-5p	Proteomics	18668040
MIRT635610	hsa-miR-496	HITS-CLIP	22927820
MIRT635609	hsa-miR-223-5p	HITS-CLIP	22927820
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT706392	hsa-miR-6818-5p	HITS-CLIP	22927820
MIRT706391	hsa-miR-147a	HITS-CLIP	22927820
MIRT706390	hsa-miR-5010-3p	HITS-CLIP	22927820
MIRT635607	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT635610	hsa-miR-496	HITS-CLIP	23313552
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT706391	hsa-miR-147a	HITS-CLIP	27418678
MIRT635609	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT635609	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT635609	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT635610	hsa-miR-496	HITS-CLIP	27418678
MIRT635610	hsa-miR-496	HITS-CLIP	27418678
MIRT635610	hsa-miR-496	HITS-CLIP	27418678
MIRT706390	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT635607	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT635607	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT635607	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT706392	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT733887	hsa-miR-1203	Luciferase reporter assay, Western blotting, qRT-PCR	32041924
MIRT635610	hsa-miR-496	HITS-CLIP	22927820
MIRT635609	hsa-miR-223-5p	HITS-CLIP	22927820
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT706392	hsa-miR-6818-5p	HITS-CLIP	22927820
MIRT706391	hsa-miR-147a	HITS-CLIP	22927820
MIRT706390	hsa-miR-5010-3p	HITS-CLIP	22927820
MIRT635607	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT635610	hsa-miR-496	HITS-CLIP	23313552
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT635610	hsa-miR-496	HITS-CLIP	23824327
MIRT635609	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT635608	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635607	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT756194	hsa-miR-25-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	36276499
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT1252879	hsa-miR-1908	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT1252882	hsa-miR-3122	CLIP-seq
MIRT1252883	hsa-miR-3165	CLIP-seq
MIRT1252884	hsa-miR-3689a-3p	CLIP-seq
MIRT1252885	hsa-miR-3689c	CLIP-seq
MIRT1252886	hsa-miR-3913-5p	CLIP-seq
MIRT1252887	hsa-miR-3974	CLIP-seq
MIRT1252888	hsa-miR-4433	CLIP-seq
MIRT1252889	hsa-miR-4457	CLIP-seq
MIRT1252890	hsa-miR-4459	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252893	hsa-miR-4651	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT1252895	hsa-miR-4728-5p	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT1252899	hsa-miR-513b	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252903	hsa-miR-608	CLIP-seq
MIRT1252904	hsa-miR-624	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252906	hsa-miR-663	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT2074475	hsa-miR-24	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT2074476	hsa-miR-342-3p	CLIP-seq
MIRT2074477	hsa-miR-371-5p	CLIP-seq
MIRT2074478	hsa-miR-371b-5p	CLIP-seq
MIRT2074479	hsa-miR-4284	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT2074481	hsa-miR-4743	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT2074482	hsa-miR-495	CLIP-seq
MIRT2074483	hsa-miR-548c-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT2301470	hsa-miR-1262	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT2074475	hsa-miR-24	CLIP-seq
MIRT2301471	hsa-miR-2467-3p	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT2074476	hsa-miR-342-3p	CLIP-seq
MIRT2301472	hsa-miR-3605-5p	CLIP-seq
MIRT2301473	hsa-miR-3612	CLIP-seq
MIRT2074479	hsa-miR-4284	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT2301474	hsa-miR-451b	CLIP-seq
MIRT2301475	hsa-miR-4537	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT2301476	hsa-miR-4696	CLIP-seq
MIRT2301477	hsa-miR-4701-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT2074481	hsa-miR-4743	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT2301478	hsa-miR-542-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT2301479	hsa-miR-650	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT2301470	hsa-miR-1262	CLIP-seq
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT1252879	hsa-miR-1908	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT1252882	hsa-miR-3122	CLIP-seq
MIRT1252883	hsa-miR-3165	CLIP-seq
MIRT2598191	hsa-miR-3675-3p	CLIP-seq
MIRT1252884	hsa-miR-3689a-3p	CLIP-seq
MIRT1252885	hsa-miR-3689c	CLIP-seq
MIRT2074477	hsa-miR-371-5p	CLIP-seq
MIRT2074478	hsa-miR-371b-5p	CLIP-seq
MIRT1252886	hsa-miR-3913-5p	CLIP-seq
MIRT1252887	hsa-miR-3974	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT1252888	hsa-miR-4433	CLIP-seq
MIRT1252889	hsa-miR-4457	CLIP-seq
MIRT1252890	hsa-miR-4459	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT2301474	hsa-miR-451b	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252893	hsa-miR-4651	CLIP-seq
MIRT2598192	hsa-miR-4684-5p	CLIP-seq
MIRT2301476	hsa-miR-4696	CLIP-seq
MIRT2301477	hsa-miR-4701-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT1252895	hsa-miR-4728-5p	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT2074482	hsa-miR-495	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT1252899	hsa-miR-513b	CLIP-seq
MIRT2301478	hsa-miR-542-3p	CLIP-seq
MIRT2598193	hsa-miR-548aa	CLIP-seq
MIRT2074483	hsa-miR-548c-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252903	hsa-miR-608	CLIP-seq
MIRT1252904	hsa-miR-624	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252906	hsa-miR-663	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq
MIRT2074474	hsa-miR-1228	CLIP-seq
MIRT2301470	hsa-miR-1262	CLIP-seq
MIRT1252875	hsa-miR-1268	CLIP-seq
MIRT1252876	hsa-miR-1268b	CLIP-seq
MIRT1252877	hsa-miR-1273e	CLIP-seq
MIRT1252878	hsa-miR-1827	CLIP-seq
MIRT1252879	hsa-miR-1908	CLIP-seq
MIRT1252880	hsa-miR-2964a-3p	CLIP-seq
MIRT1252881	hsa-miR-302f	CLIP-seq
MIRT1252882	hsa-miR-3122	CLIP-seq
MIRT1252883	hsa-miR-3165	CLIP-seq
MIRT2598191	hsa-miR-3675-3p	CLIP-seq
MIRT1252884	hsa-miR-3689a-3p	CLIP-seq
MIRT1252885	hsa-miR-3689c	CLIP-seq
MIRT2074477	hsa-miR-371-5p	CLIP-seq
MIRT2074478	hsa-miR-371b-5p	CLIP-seq
MIRT1252886	hsa-miR-3913-5p	CLIP-seq
MIRT1252887	hsa-miR-3974	CLIP-seq
MIRT2074480	hsa-miR-4432	CLIP-seq
MIRT1252888	hsa-miR-4433	CLIP-seq
MIRT1252889	hsa-miR-4457	CLIP-seq
MIRT1252890	hsa-miR-4459	CLIP-seq
MIRT1252891	hsa-miR-4486	CLIP-seq
MIRT2301474	hsa-miR-451b	CLIP-seq
MIRT1252892	hsa-miR-4649-3p	CLIP-seq
MIRT1252893	hsa-miR-4651	CLIP-seq
MIRT2598192	hsa-miR-4684-5p	CLIP-seq
MIRT2301476	hsa-miR-4696	CLIP-seq
MIRT2301477	hsa-miR-4701-3p	CLIP-seq
MIRT1252894	hsa-miR-4722-5p	CLIP-seq
MIRT1252895	hsa-miR-4728-5p	CLIP-seq
MIRT1252896	hsa-miR-4747-5p	CLIP-seq
MIRT1252897	hsa-miR-4768-3p	CLIP-seq
MIRT2074482	hsa-miR-495	CLIP-seq
MIRT1252898	hsa-miR-508-5p	CLIP-seq
MIRT1252899	hsa-miR-513b	CLIP-seq
MIRT2301478	hsa-miR-542-3p	CLIP-seq
MIRT2598193	hsa-miR-548aa	CLIP-seq
MIRT2074483	hsa-miR-548c-3p	CLIP-seq
MIRT1252900	hsa-miR-550a	CLIP-seq
MIRT1252901	hsa-miR-564	CLIP-seq
MIRT1252902	hsa-miR-585	CLIP-seq
MIRT1252903	hsa-miR-608	CLIP-seq
MIRT1252904	hsa-miR-624	CLIP-seq
MIRT1252905	hsa-miR-661	CLIP-seq
MIRT1252906	hsa-miR-663	CLIP-seq
MIRT1252907	hsa-miR-766	CLIP-seq
MIRT1252908	hsa-miR-890	CLIP-seq
MIRT1252909	hsa-miR-940	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	18708059
GO:0000413	Process	Protein peptidyl-prolyl isomerization	IBA	21873635
GO:0000413	Process	Protein peptidyl-prolyl isomerization	IDA	20676357
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IBA	21873635
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IDA	11350175, 20676357
GO:0005515	Function	Protein binding	IPI	9659917, 16507998, 18806802, 21146485, 30266287
GO:0005634	Component	Nucleus	IDA	11525244
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	11525244
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	11525244
GO:0005829	Component	Cytosol	IDA
GO:0006457	Process	Protein folding	IBA	21873635
GO:0006457	Process	Protein folding	ISS
GO:0006915	Process	Apoptotic process	IEA
GO:0008134	Function	Transcription factor binding	IDA	9659917
GO:0015031	Process	Protein transport	IEA
GO:0016018	Function	Cyclosporin A binding	IBA	21873635
GO:0016018	Function	Cyclosporin A binding	IDA	20676357
GO:0016018	Function	Cyclosporin A binding	TAS	7744028
GO:0019076	Process	Viral release from host cell	TAS	21711559
GO:0030331	Function	Estrogen receptor binding	ISS
GO:0030544	Function	Hsp70 protein binding	ISS
GO:0031072	Function	Heat shock protein binding	IPI	9660753
GO:0034389	Process	Lipid droplet organization	IMP	21711559
GO:0043065	Process	Positive regulation of apoptotic process	IMP	23220213
GO:0045070	Process	Positive regulation of viral genome replication	IMP	19932913
GO:0050714	Process	Positive regulation of protein secretion	IMP	21711559
GO:0051879	Function	Hsp90 protein binding	IDA	12145316
GO:0061077	Process	Chaperone-mediated protein folding	IDA	11350175
GO:0065003	Process	Protein-containing complex assembly	IDA	18708059
GO:0071492	Process	Cellular response to UV-A	IMP	23220213

MIM	HGNC	e!Ensembl
601753	9257	ENSG00000171497

Protein

UniProt ID

Q08752

Protein name

Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)

Protein function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unlig

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00160	Pro_isomerase	19 → 183	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Domain
PF13176	TPR_7	226 → 258	Tetratricopeptide repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGH
TTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSM
ANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAE
CGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWE
MAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEAL
ELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDK
EKAVYAKMFA

Sequence length

370

Interactions

View interactions

	KEGG		Reactome
	Necroptosis Cellular senescence Alzheimer disease Pathways of neurodegeneration - multiple diseases Shigellosis		ESR-mediated signaling

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Insomnia	Insomnia			GWAS

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Kidney Injury	Associate	31733829
Brain Injuries	Associate	21121808
Breast Neoplasms	Associate	11216911, 23598413
Colorectal Neoplasms	Associate	15004035
Death	Inhibit	16507998
Dental Pulp Diseases	Associate	31089403
Drug Related Side Effects and Adverse Reactions	Associate	19187006
Heart Diseases	Associate	38412332
Huntington Disease	Associate	21257639
Lateral Medullary Syndrome	Associate	38412332
Lymphoma Large Cell Anaplastic	Associate	22681779
Meningioma	Associate	24603329
Mitochondrial Diseases	Associate	23108666, 31089403
Myopathy with Giant Abnormal Mitochondria	Associate	21121808
Neoplasms	Associate	11216911, 19187006, 20080742
Nerve Degeneration	Associate	21257639
Neurodegenerative Diseases	Associate	21121808
Pancreatitis	Associate	38050301
Prostatic Neoplasms	Associate	17615153
Prostatic Neoplasms	Stimulate	20023700
Schizophrenia	Associate	38412332

PPID (peptidylprolyl isomerase D)