Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5480
Gene name Gene Name - the full gene name approved by the HGNC.
Peptidylprolyl isomerase C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPIC
Synonyms (NCBI Gene) Gene synonyms aliases
CYPC
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to othe
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030019 hsa-miR-26b-5p Microarray 19088304
MIRT608424 hsa-miR-8485 HITS-CLIP 19536157
MIRT608423 hsa-miR-329-3p HITS-CLIP 19536157
MIRT608422 hsa-miR-362-3p HITS-CLIP 19536157
MIRT608420 hsa-miR-6801-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000413 Process Protein peptidyl-prolyl isomerization IBA 21873635
GO:0000413 Process Protein peptidyl-prolyl isomerization IDA 20676357
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IBA 21873635
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IDA 20676357
GO:0005515 Function Protein binding IPI 25416956, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
123842 9256 ENSG00000168938
Protein
UniProt ID P45877
Protein name Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C)
Protein function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
PDB 2ESL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00160 Pro_isomerase 41 198 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in kidney, skeletal muscle, pancreas, heart, lung, liver and to a lower extent in brain. {ECO:0000269|PubMed:8031755}.
Sequence
Sequence length 212
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
16367923
Unknown
Disease term Disease name Evidence References Source
Mental Depression Mental Depression GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Stimulate 15165699
Alzheimer Disease Associate 19647891
Glioma Stimulate 27801851
Stomach Neoplasms Associate 16367923, 23442884
Wolf Hirschhorn Syndrome Associate 17576924