Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54798
Gene name Gene Name - the full gene name approved by the HGNC.	Dachsous cadherin-related 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DCHS2
Synonyms (NCBI Gene) Gene synonyms aliases	CDH27, CDHJ, CDHR7, PCDH23, PCDHJ
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q31.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer`s disease, compressive strength index, and appendicular lean

Show/Hide all(22)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017262	hsa-miR-335-5p	Microarray	18185580
MIRT029174	hsa-miR-26b-5p	Microarray	19088304
MIRT926006	hsa-miR-3065-5p	CLIP-seq
MIRT926007	hsa-miR-3180-5p	CLIP-seq
MIRT926008	hsa-miR-3616-5p	CLIP-seq
MIRT926009	hsa-miR-3647-5p	CLIP-seq
MIRT926010	hsa-miR-3713	CLIP-seq
MIRT926011	hsa-miR-383	CLIP-seq
MIRT926012	hsa-miR-3926	CLIP-seq
MIRT926013	hsa-miR-421	CLIP-seq
MIRT926014	hsa-miR-4772-5p	CLIP-seq
MIRT926015	hsa-miR-520a-5p	CLIP-seq
MIRT926016	hsa-miR-525-5p	CLIP-seq
MIRT926017	hsa-miR-548s	CLIP-seq
MIRT926018	hsa-miR-573	CLIP-seq
MIRT926019	hsa-miR-587	CLIP-seq
MIRT926020	hsa-miR-643	CLIP-seq
MIRT926021	hsa-miR-1206	CLIP-seq
MIRT926022	hsa-miR-1298	CLIP-seq
MIRT926023	hsa-miR-375	CLIP-seq
MIRT926024	hsa-miR-433	CLIP-seq
MIRT926025	hsa-miR-664	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence
GO:0003674	Function	Molecular_function	ND
GO:0005509	Function	Calcium ion binding	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005886	Component	Plasma membrane	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0008150	Process	Biological_process	ND
GO:0016021	Component	Integral component of membrane	IEA
GO:0072006	Process	Nephron development	IEA
GO:0072137	Process	Condensed mesenchymal cell proliferation	IEA

MIM	HGNC	e!Ensembl
612486	23111	ENSG00000197410

Protein

UniProt ID

Q6V1P9

Protein name

Protocadherin-23 (Cadherin-27) (Cadherin-like protein CDHJ) (Cadherin-like protein VR8) (Protein dachsous homolog 2) (Protocadherin PCDHJ)

Protein function

Calcium-dependent cell-adhesion protein.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00028	Cadherin	64 → 154	Cadherin domain	Domain
PF00028	Cadherin	382 → 471	Cadherin domain	Domain
PF00028	Cadherin	485 → 575	Cadherin domain	Domain
PF00028	Cadherin	590 → 683	Cadherin domain	Domain
PF00028	Cadherin	848 → 939	Cadherin domain	Domain
PF00028	Cadherin	953 → 1046	Cadherin domain	Domain
PF00028	Cadherin	1060 → 1156	Cadherin domain	Domain
PF00028	Cadherin	1169 → 1260	Cadherin domain	Domain
PF00028	Cadherin	1274 → 1365	Cadherin domain	Domain
PF00028	Cadherin	1379 → 1469	Cadherin domain	Domain
PF00028	Cadherin	1483 → 1574	Cadherin domain	Domain
PF00028	Cadherin	1589 → 1676	Cadherin domain	Domain
PF00028	Cadherin	1689 → 1778	Cadherin domain	Domain
PF00028	Cadherin	1792 → 1883	Cadherin domain	Domain
PF00028	Cadherin	1896 → 1983	Cadherin domain	Domain
PF00028	Cadherin	1997 → 2085	Cadherin domain	Domain
PF00028	Cadherin	2099 → 2201	Cadherin domain	Domain
PF00028	Cadherin	2215 → 2305	Cadherin domain	Domain
PF00028	Cadherin	2319 → 2416	Cadherin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Cerebral cortex and testis. {ECO:0000269|PubMed:15003449}.

Sequence

MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS
GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP
DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS
PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS
SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE
YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE
LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE
GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL
LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS
QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA
ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE
PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH
DGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI
SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST
TLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA
REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC
SSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS
PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP
SWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG
WIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV
EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHH
EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV
FAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGV
PPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLH
FSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDV
EDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPF
LIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF
ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTC
PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPG
EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVL
VRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNN
RAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQ
VRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAF
TIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQ
NPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPS
SEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVT
VKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESS
GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYS
ILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDI
NDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTG
VVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESI
PVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVE
ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR
ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDS
GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI
IYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVL
DDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY
DHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIF
TQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRA
LPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVV
SFLVFLILICILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSN
EVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSD
SALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQN
NVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSW
EPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVN
LGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTC
HELKAEDEVQI

Sequence length

3371

Interactions

View interactions

	KEGG
	Hippo signaling pathway - multiple species

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	22005931

Show/Hide Unknown Diseases (5)

Disease term	Disease name	References	Source
Unknown
Thyrotoxic periodic paralysis	Thyrotoxic periodic paralysis	31050781	ClinVar
Diabetes	Diabetes		GWAS
Dermatitis	Dermatitis		GWAS
Oligodendroglioma	Oligodendroglioma		GWAS
Schizophrenia	Schizophrenia		GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Colorectal Neoplasms	Associate	24898286, 35975176
Microsatellite Instability	Associate	24898286
Neoplasms	Associate	24898286

DCHS2 (dachsous cadherin-related 2)