Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54790
Gene name	Tet methylcytosine dioxygenase 2
Gene symbol	TET2
Synonyms (NCBI Gene)	IMD75KIAA1546MDS
Chromosome	4
Chromosome location	4q24
Summary	The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myelop

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016981	hsa-miR-335-5p	Microarray	18185580
MIRT049648	hsa-miR-92a-3p	CLASH	23622248
MIRT042185	hsa-miR-484	CLASH	23622248
MIRT053224	hsa-miR-22-3p	Luciferase reporter assayqRT-PCR	23830207
MIRT210981	hsa-miR-26a-5p	Luciferase reporter assay	24114270
MIRT438630	hsa-miR-125b-5p	Luciferase reporter assay	24120864
MIRT210969	hsa-miR-29b-3p	Luciferase reporter assay	24120864
MIRT210970	hsa-miR-29c-3p	Luciferase reporter assay	24120864
MIRT210927	hsa-miR-101-3p	Luciferase reporter assay	24120864
MIRT438629	hsa-miR-7-5p	Luciferase reporter assay	24120864
MIRT210968	hsa-miR-29a-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	23820384
MIRT210968	hsa-miR-29a-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	23820384
MIRT053224	hsa-miR-22-3p	FlowImmunofluorescenceImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	23827711
MIRT053224	hsa-miR-22-3p	FlowImmunofluorescenceImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	23827711
MIRT210981	hsa-miR-26a-5p	Luciferase reporter assay	24114270
MIRT438630	hsa-miR-125b-5p	Luciferase reporter assay	24120864
MIRT210969	hsa-miR-29b-3p	Luciferase reporter assay	24120864
MIRT210970	hsa-miR-29c-3p	Luciferase reporter assay	24120864
MIRT210927	hsa-miR-101-3p	Luciferase reporter assay	24120864
MIRT438629	hsa-miR-7-5p	Luciferase reporter assay	24120864
MIRT210968	hsa-miR-29a-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	23820384
MIRT210968	hsa-miR-29a-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	23820384
MIRT053224	hsa-miR-22-3p	FlowImmunofluorescenceImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	23827711
MIRT053224	hsa-miR-22-3p	FlowImmunofluorescenceImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	23827711
MIRT390320	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503331	hsa-miR-3924	HITS-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508338	hsa-miR-4775	HITS-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503331	hsa-miR-3924	HITS-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT508338	hsa-miR-4775	HITS-CLIP	22927820
MIRT503332	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT503331	hsa-miR-3924	HITS-CLIP	22927820
MIRT503330	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT508339	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508338	hsa-miR-4775	PAR-CLIP	20371350
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503331	hsa-miR-3924	PAR-CLIP	20371350
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508338	hsa-miR-4775	PAR-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503331	hsa-miR-3924	PAR-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503331	hsa-miR-3924	PAR-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT508338	hsa-miR-4775	PAR-CLIP	22012620
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT508339	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508338	hsa-miR-4775	PAR-CLIP	23446348
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503331	hsa-miR-3924	PAR-CLIP	23446348
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT508339	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508338	hsa-miR-4775	PAR-CLIP	23446348
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503331	hsa-miR-3924	PAR-CLIP	23446348
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503331	hsa-miR-3924	PAR-CLIP	23446348
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT210968	hsa-miR-29a-3p	MicroarrayqRT-PCR	26251039
MIRT210968	hsa-miR-29a-3p	Luciferase reporter assayqRT-PCRWestern blot	26404510
MIRT210969	hsa-miR-29b-3p	Luciferase reporter assayqRT-PCRWestern blot	26404510
MIRT390320	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503331	hsa-miR-3924	HITS-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508338	hsa-miR-4775	HITS-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503331	hsa-miR-3924	HITS-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT508338	hsa-miR-4775	HITS-CLIP	22927820
MIRT503332	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT503331	hsa-miR-3924	HITS-CLIP	22927820
MIRT503330	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT508339	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508338	hsa-miR-4775	PAR-CLIP	20371350
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503331	hsa-miR-3924	PAR-CLIP	20371350
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508338	hsa-miR-4775	PAR-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503331	hsa-miR-3924	PAR-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503331	hsa-miR-3924	PAR-CLIP	21572407
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT508338	hsa-miR-4775	PAR-CLIP	22012620
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT508339	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508338	hsa-miR-4775	PAR-CLIP	23446348
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503331	hsa-miR-3924	PAR-CLIP	23446348
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT508339	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508338	hsa-miR-4775	PAR-CLIP	23446348
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503331	hsa-miR-3924	PAR-CLIP	23446348
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT390320	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503332	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503331	hsa-miR-3924	PAR-CLIP	23446348
MIRT503330	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1418632	hsa-let-7a	CLIP-seq
MIRT1418633	hsa-let-7b	CLIP-seq
MIRT1418634	hsa-let-7c	CLIP-seq
MIRT1418635	hsa-let-7d	CLIP-seq
MIRT1418636	hsa-let-7e	CLIP-seq
MIRT1418637	hsa-let-7f	CLIP-seq
MIRT1418638	hsa-let-7g	CLIP-seq
MIRT1418639	hsa-let-7i	CLIP-seq
MIRT1418640	hsa-miR-101	CLIP-seq
MIRT1418641	hsa-miR-1208	CLIP-seq
MIRT1418642	hsa-miR-1257	CLIP-seq
MIRT1418643	hsa-miR-1264	CLIP-seq
MIRT1418644	hsa-miR-1273e	CLIP-seq
MIRT1418645	hsa-miR-1276	CLIP-seq
MIRT1418646	hsa-miR-1284	CLIP-seq
MIRT1418647	hsa-miR-1294	CLIP-seq
MIRT1418648	hsa-miR-1297	CLIP-seq
MIRT1418649	hsa-miR-1303	CLIP-seq
MIRT1418650	hsa-miR-1305	CLIP-seq
MIRT1418651	hsa-miR-132	CLIP-seq
MIRT1418652	hsa-miR-133a	CLIP-seq
MIRT1418653	hsa-miR-133b	CLIP-seq
MIRT1418654	hsa-miR-139-5p	CLIP-seq
MIRT1418655	hsa-miR-142-5p	CLIP-seq
MIRT1418656	hsa-miR-144	CLIP-seq
MIRT1418657	hsa-miR-148a	CLIP-seq
MIRT1418658	hsa-miR-148b	CLIP-seq
MIRT1418659	hsa-miR-152	CLIP-seq
MIRT1418660	hsa-miR-200b	CLIP-seq
MIRT1418661	hsa-miR-200c	CLIP-seq
MIRT1418662	hsa-miR-202	CLIP-seq
MIRT1418663	hsa-miR-203	CLIP-seq
MIRT1418664	hsa-miR-204	CLIP-seq
MIRT1418665	hsa-miR-2054	CLIP-seq
MIRT1418666	hsa-miR-210	CLIP-seq
MIRT1418667	hsa-miR-211	CLIP-seq
MIRT1418668	hsa-miR-2116	CLIP-seq
MIRT1418669	hsa-miR-212	CLIP-seq
MIRT1418670	hsa-miR-22	CLIP-seq
MIRT1418671	hsa-miR-23a	CLIP-seq
MIRT1418672	hsa-miR-23b	CLIP-seq
MIRT1418673	hsa-miR-23c	CLIP-seq
MIRT1418674	hsa-miR-26a	CLIP-seq
MIRT1418675	hsa-miR-26b	CLIP-seq
MIRT1418676	hsa-miR-29a	CLIP-seq
MIRT1418677	hsa-miR-29b	CLIP-seq
MIRT1418678	hsa-miR-29c	CLIP-seq
MIRT1418679	hsa-miR-300	CLIP-seq
MIRT1418680	hsa-miR-3065-3p	CLIP-seq
MIRT1418681	hsa-miR-3065-5p	CLIP-seq
MIRT1418682	hsa-miR-30a	CLIP-seq
MIRT1418683	hsa-miR-30b	CLIP-seq
MIRT1418684	hsa-miR-30c	CLIP-seq
MIRT1418685	hsa-miR-30d	CLIP-seq
MIRT1418686	hsa-miR-30e	CLIP-seq
MIRT1418687	hsa-miR-3121-3p	CLIP-seq
MIRT1418688	hsa-miR-3160-5p	CLIP-seq
MIRT1418689	hsa-miR-3163	CLIP-seq
MIRT1418690	hsa-miR-3187-3p	CLIP-seq
MIRT1418691	hsa-miR-326	CLIP-seq
MIRT1418692	hsa-miR-330-5p	CLIP-seq
MIRT1418693	hsa-miR-33a	CLIP-seq
MIRT1418694	hsa-miR-33b	CLIP-seq
MIRT1418695	hsa-miR-340	CLIP-seq
MIRT1418696	hsa-miR-3614-5p	CLIP-seq
MIRT1418697	hsa-miR-3646	CLIP-seq
MIRT1418698	hsa-miR-3647-3p	CLIP-seq
MIRT1418699	hsa-miR-3658	CLIP-seq
MIRT1418700	hsa-miR-3660	CLIP-seq
MIRT1418701	hsa-miR-3662	CLIP-seq
MIRT1418702	hsa-miR-3674	CLIP-seq
MIRT1418703	hsa-miR-3682-3p	CLIP-seq
MIRT1418704	hsa-miR-3685	CLIP-seq
MIRT1418705	hsa-miR-3689a-3p	CLIP-seq
MIRT1418706	hsa-miR-3689c	CLIP-seq
MIRT1418707	hsa-miR-3714	CLIP-seq
MIRT1418708	hsa-miR-371-5p	CLIP-seq
MIRT1418709	hsa-miR-380	CLIP-seq
MIRT1418710	hsa-miR-381	CLIP-seq
MIRT1418711	hsa-miR-384	CLIP-seq
MIRT1418712	hsa-miR-3910	CLIP-seq
MIRT1418713	hsa-miR-3929	CLIP-seq
MIRT1418714	hsa-miR-3977	CLIP-seq
MIRT1418715	hsa-miR-425	CLIP-seq
MIRT1418716	hsa-miR-4255	CLIP-seq
MIRT1418717	hsa-miR-4264	CLIP-seq
MIRT1418718	hsa-miR-4277	CLIP-seq
MIRT1418719	hsa-miR-429	CLIP-seq
MIRT1418720	hsa-miR-4291	CLIP-seq
MIRT1418721	hsa-miR-4300	CLIP-seq
MIRT1418722	hsa-miR-433	CLIP-seq
MIRT1418723	hsa-miR-4419b	CLIP-seq
MIRT1418724	hsa-miR-4421	CLIP-seq
MIRT1418725	hsa-miR-4422	CLIP-seq
MIRT1418726	hsa-miR-4435	CLIP-seq
MIRT1418727	hsa-miR-4446-5p	CLIP-seq
MIRT1418728	hsa-miR-4452	CLIP-seq
MIRT1418729	hsa-miR-4458	CLIP-seq
MIRT1418730	hsa-miR-4465	CLIP-seq
MIRT1418731	hsa-miR-4478	CLIP-seq
MIRT1418732	hsa-miR-4484	CLIP-seq
MIRT1418733	hsa-miR-4494	CLIP-seq
MIRT1418734	hsa-miR-4495	CLIP-seq
MIRT1418735	hsa-miR-4500	CLIP-seq
MIRT1418736	hsa-miR-4526	CLIP-seq
MIRT1418737	hsa-miR-4530	CLIP-seq
MIRT1418738	hsa-miR-4639-3p	CLIP-seq
MIRT1418739	hsa-miR-4666-3p	CLIP-seq
MIRT1418740	hsa-miR-4676-5p	CLIP-seq
MIRT1418741	hsa-miR-4677-3p	CLIP-seq
MIRT1418742	hsa-miR-4677-5p	CLIP-seq
MIRT1418743	hsa-miR-4679	CLIP-seq
MIRT1418744	hsa-miR-4690-5p	CLIP-seq
MIRT1418745	hsa-miR-4699-3p	CLIP-seq
MIRT1418746	hsa-miR-4701-5p	CLIP-seq
MIRT1418747	hsa-miR-4705	CLIP-seq
MIRT1418748	hsa-miR-4738-3p	CLIP-seq
MIRT1418749	hsa-miR-4755-5p	CLIP-seq
MIRT1418750	hsa-miR-4769-3p	CLIP-seq
MIRT1418751	hsa-miR-4771	CLIP-seq
MIRT1418752	hsa-miR-4797-3p	CLIP-seq
MIRT1418753	hsa-miR-494	CLIP-seq
MIRT1418754	hsa-miR-498	CLIP-seq
MIRT1418755	hsa-miR-499-3p	CLIP-seq
MIRT1418756	hsa-miR-499a-3p	CLIP-seq
MIRT1418757	hsa-miR-513a-3p	CLIP-seq
MIRT1418758	hsa-miR-520d-5p	CLIP-seq
MIRT1418759	hsa-miR-524-5p	CLIP-seq
MIRT1418760	hsa-miR-548an	CLIP-seq
MIRT1418761	hsa-miR-548m	CLIP-seq
MIRT1418762	hsa-miR-548s	CLIP-seq
MIRT1418763	hsa-miR-548u	CLIP-seq
MIRT1418764	hsa-miR-561	CLIP-seq
MIRT1418765	hsa-miR-575	CLIP-seq
MIRT1418766	hsa-miR-578	CLIP-seq
MIRT1418767	hsa-miR-588	CLIP-seq
MIRT1418768	hsa-miR-593	CLIP-seq
MIRT1418769	hsa-miR-623	CLIP-seq
MIRT1418770	hsa-miR-640	CLIP-seq
MIRT1418771	hsa-miR-668	CLIP-seq
MIRT1418772	hsa-miR-767-5p	CLIP-seq
MIRT1418773	hsa-miR-9	CLIP-seq
MIRT1418774	hsa-miR-920	CLIP-seq
MIRT1418775	hsa-miR-98	CLIP-seq
MIRT1418642	hsa-miR-1257	CLIP-seq
MIRT1418714	hsa-miR-3977	CLIP-seq
MIRT1418728	hsa-miR-4452	CLIP-seq
MIRT1418632	hsa-let-7a	CLIP-seq
MIRT1418633	hsa-let-7b	CLIP-seq
MIRT1418634	hsa-let-7c	CLIP-seq
MIRT1418635	hsa-let-7d	CLIP-seq
MIRT1418636	hsa-let-7e	CLIP-seq
MIRT1418637	hsa-let-7f	CLIP-seq
MIRT1418638	hsa-let-7g	CLIP-seq
MIRT1418639	hsa-let-7i	CLIP-seq
MIRT1418640	hsa-miR-101	CLIP-seq
MIRT2125552	hsa-miR-103a	CLIP-seq
MIRT2125553	hsa-miR-107	CLIP-seq
MIRT2125554	hsa-miR-1179	CLIP-seq
MIRT2125555	hsa-miR-1184	CLIP-seq
MIRT2125556	hsa-miR-1205	CLIP-seq
MIRT1418641	hsa-miR-1208	CLIP-seq
MIRT2125557	hsa-miR-1224-3p	CLIP-seq
MIRT2125558	hsa-miR-1236	CLIP-seq
MIRT2125559	hsa-miR-1248	CLIP-seq
MIRT1418642	hsa-miR-1257	CLIP-seq
MIRT1418648	hsa-miR-1297	CLIP-seq
MIRT2125560	hsa-miR-1301	CLIP-seq
MIRT1418650	hsa-miR-1305	CLIP-seq
MIRT2125561	hsa-miR-135a	CLIP-seq
MIRT2125562	hsa-miR-135b	CLIP-seq
MIRT1418654	hsa-miR-139-5p	CLIP-seq
MIRT2125563	hsa-miR-143	CLIP-seq
MIRT1418656	hsa-miR-144	CLIP-seq
MIRT2125564	hsa-miR-145	CLIP-seq
MIRT1418660	hsa-miR-200b	CLIP-seq
MIRT1418661	hsa-miR-200c	CLIP-seq
MIRT1418662	hsa-miR-202	CLIP-seq
MIRT1418664	hsa-miR-204	CLIP-seq
MIRT2125565	hsa-miR-2052	CLIP-seq
MIRT1418665	hsa-miR-2054	CLIP-seq
MIRT1418667	hsa-miR-211	CLIP-seq
MIRT2125566	hsa-miR-2113	CLIP-seq
MIRT2125567	hsa-miR-217	CLIP-seq
MIRT2125568	hsa-miR-2355-5p	CLIP-seq
MIRT1418671	hsa-miR-23a	CLIP-seq
MIRT1418672	hsa-miR-23b	CLIP-seq
MIRT1418673	hsa-miR-23c	CLIP-seq
MIRT1418674	hsa-miR-26a	CLIP-seq
MIRT1418675	hsa-miR-26b	CLIP-seq
MIRT1418676	hsa-miR-29a	CLIP-seq
MIRT1418677	hsa-miR-29b	CLIP-seq
MIRT1418678	hsa-miR-29c	CLIP-seq
MIRT2125569	hsa-miR-302a	CLIP-seq
MIRT2125570	hsa-miR-302b	CLIP-seq
MIRT2125571	hsa-miR-302c	CLIP-seq
MIRT2125572	hsa-miR-302d	CLIP-seq
MIRT2125573	hsa-miR-302e	CLIP-seq
MIRT1418680	hsa-miR-3065-3p	CLIP-seq
MIRT1418682	hsa-miR-30a	CLIP-seq
MIRT1418683	hsa-miR-30b	CLIP-seq
MIRT1418684	hsa-miR-30c	CLIP-seq
MIRT1418685	hsa-miR-30d	CLIP-seq
MIRT1418686	hsa-miR-30e	CLIP-seq
MIRT2125574	hsa-miR-3138	CLIP-seq
MIRT2125575	hsa-miR-3143	CLIP-seq
MIRT2125576	hsa-miR-3145-3p	CLIP-seq
MIRT2125577	hsa-miR-3158-5p	CLIP-seq
MIRT1418688	hsa-miR-3160-5p	CLIP-seq
MIRT2125578	hsa-miR-323-3p	CLIP-seq
MIRT2125579	hsa-miR-338-5p	CLIP-seq
MIRT1418693	hsa-miR-33a	CLIP-seq
MIRT1418694	hsa-miR-33b	CLIP-seq
MIRT1418695	hsa-miR-340	CLIP-seq
MIRT2125580	hsa-miR-3613-3p	CLIP-seq
MIRT1418698	hsa-miR-3647-3p	CLIP-seq
MIRT1418699	hsa-miR-3658	CLIP-seq
MIRT1418701	hsa-miR-3662	CLIP-seq
MIRT2125581	hsa-miR-3663-3p	CLIP-seq
MIRT2125582	hsa-miR-3671	CLIP-seq
MIRT1418702	hsa-miR-3674	CLIP-seq
MIRT1418704	hsa-miR-3685	CLIP-seq
MIRT2125583	hsa-miR-369-3p	CLIP-seq
MIRT2125584	hsa-miR-372	CLIP-seq
MIRT2125585	hsa-miR-373	CLIP-seq
MIRT2125586	hsa-miR-374a	CLIP-seq
MIRT2125587	hsa-miR-374b	CLIP-seq
MIRT1418709	hsa-miR-380	CLIP-seq
MIRT2125588	hsa-miR-382	CLIP-seq
MIRT1418713	hsa-miR-3929	CLIP-seq
MIRT2125589	hsa-miR-3938	CLIP-seq
MIRT1418714	hsa-miR-3977	CLIP-seq
MIRT1418716	hsa-miR-4255	CLIP-seq
MIRT1418717	hsa-miR-4264	CLIP-seq
MIRT2125590	hsa-miR-4276	CLIP-seq
MIRT1418718	hsa-miR-4277	CLIP-seq
MIRT2125591	hsa-miR-4286	CLIP-seq
MIRT1418719	hsa-miR-429	CLIP-seq
MIRT1418720	hsa-miR-4291	CLIP-seq
MIRT2125592	hsa-miR-4307	CLIP-seq
MIRT1418722	hsa-miR-433	CLIP-seq
MIRT2125593	hsa-miR-4330	CLIP-seq
MIRT1418723	hsa-miR-4419b	CLIP-seq
MIRT1418725	hsa-miR-4422	CLIP-seq
MIRT1418728	hsa-miR-4452	CLIP-seq
MIRT1418729	hsa-miR-4458	CLIP-seq
MIRT1418730	hsa-miR-4465	CLIP-seq
MIRT2125594	hsa-miR-4477a	CLIP-seq
MIRT1418731	hsa-miR-4478	CLIP-seq
MIRT1418734	hsa-miR-4495	CLIP-seq
MIRT1418735	hsa-miR-4500	CLIP-seq
MIRT1418738	hsa-miR-4639-3p	CLIP-seq
MIRT2125595	hsa-miR-4659a-3p	CLIP-seq
MIRT2125596	hsa-miR-4659b-3p	CLIP-seq
MIRT2125597	hsa-miR-4660	CLIP-seq
MIRT2125598	hsa-miR-4661-5p	CLIP-seq
MIRT2125599	hsa-miR-4668-3p	CLIP-seq
MIRT1418744	hsa-miR-4690-5p	CLIP-seq
MIRT2125600	hsa-miR-4712-5p	CLIP-seq
MIRT2125601	hsa-miR-4752	CLIP-seq
MIRT2125602	hsa-miR-4753-3p	CLIP-seq
MIRT1418749	hsa-miR-4755-5p	CLIP-seq
MIRT2125603	hsa-miR-4770	CLIP-seq
MIRT2125604	hsa-miR-4773	CLIP-seq
MIRT2125605	hsa-miR-4780	CLIP-seq
MIRT1418752	hsa-miR-4797-3p	CLIP-seq
MIRT2125606	hsa-miR-4800-5p	CLIP-seq
MIRT2125607	hsa-miR-490-3p	CLIP-seq
MIRT1418754	hsa-miR-498	CLIP-seq
MIRT1418755	hsa-miR-499-3p	CLIP-seq
MIRT1418756	hsa-miR-499a-3p	CLIP-seq
MIRT2125608	hsa-miR-5047	CLIP-seq
MIRT1418757	hsa-miR-513a-3p	CLIP-seq
MIRT2125609	hsa-miR-520a-3p	CLIP-seq
MIRT2125610	hsa-miR-520b	CLIP-seq
MIRT2125611	hsa-miR-520c-3p	CLIP-seq
MIRT2125612	hsa-miR-520d-3p	CLIP-seq
MIRT2125613	hsa-miR-520e	CLIP-seq
MIRT2125614	hsa-miR-543	CLIP-seq
MIRT2125615	hsa-miR-548aa	CLIP-seq
MIRT2125616	hsa-miR-548ac	CLIP-seq
MIRT2125617	hsa-miR-548ae	CLIP-seq
MIRT2125618	hsa-miR-548aj	CLIP-seq
MIRT2125619	hsa-miR-548am	CLIP-seq
MIRT1418760	hsa-miR-548an	CLIP-seq
MIRT2125620	hsa-miR-548d-3p	CLIP-seq
MIRT2125621	hsa-miR-548x	CLIP-seq
MIRT2125622	hsa-miR-548z	CLIP-seq
MIRT2125623	hsa-miR-556-3p	CLIP-seq
MIRT1418764	hsa-miR-561	CLIP-seq
MIRT2125624	hsa-miR-570	CLIP-seq
MIRT2125625	hsa-miR-582-5p	CLIP-seq
MIRT2125626	hsa-miR-600	CLIP-seq
MIRT2125627	hsa-miR-607	CLIP-seq
MIRT1418769	hsa-miR-623	CLIP-seq
MIRT2125628	hsa-miR-627	CLIP-seq
MIRT2125629	hsa-miR-633	CLIP-seq
MIRT1418770	hsa-miR-640	CLIP-seq
MIRT2125630	hsa-miR-649	CLIP-seq
MIRT2125631	hsa-miR-653	CLIP-seq
MIRT2125632	hsa-miR-656	CLIP-seq
MIRT1418772	hsa-miR-767-5p	CLIP-seq
MIRT2125633	hsa-miR-770-5p	CLIP-seq
MIRT2125634	hsa-miR-924	CLIP-seq
MIRT2125635	hsa-miR-942	CLIP-seq
MIRT2125636	hsa-miR-944	CLIP-seq
MIRT1418775	hsa-miR-98	CLIP-seq
MIRT1418632	hsa-let-7a	CLIP-seq
MIRT1418633	hsa-let-7b	CLIP-seq
MIRT1418634	hsa-let-7c	CLIP-seq
MIRT1418635	hsa-let-7d	CLIP-seq
MIRT1418636	hsa-let-7e	CLIP-seq
MIRT1418637	hsa-let-7f	CLIP-seq
MIRT1418638	hsa-let-7g	CLIP-seq
MIRT1418639	hsa-let-7i	CLIP-seq
MIRT1418640	hsa-miR-101	CLIP-seq
MIRT2125552	hsa-miR-103a	CLIP-seq
MIRT2125553	hsa-miR-107	CLIP-seq
MIRT2125555	hsa-miR-1184	CLIP-seq
MIRT2125556	hsa-miR-1205	CLIP-seq
MIRT1418641	hsa-miR-1208	CLIP-seq
MIRT2347906	hsa-miR-1255a	CLIP-seq
MIRT2347907	hsa-miR-1255b	CLIP-seq
MIRT1418642	hsa-miR-1257	CLIP-seq
MIRT2347908	hsa-miR-125a-3p	CLIP-seq
MIRT1418648	hsa-miR-1297	CLIP-seq
MIRT2125560	hsa-miR-1301	CLIP-seq
MIRT1418650	hsa-miR-1305	CLIP-seq
MIRT2347909	hsa-miR-1321	CLIP-seq
MIRT2125561	hsa-miR-135a	CLIP-seq
MIRT2125562	hsa-miR-135b	CLIP-seq
MIRT1418654	hsa-miR-139-5p	CLIP-seq
MIRT1418656	hsa-miR-144	CLIP-seq
MIRT2125564	hsa-miR-145	CLIP-seq
MIRT1418657	hsa-miR-148a	CLIP-seq
MIRT1418658	hsa-miR-148b	CLIP-seq
MIRT1418659	hsa-miR-152	CLIP-seq
MIRT2347910	hsa-miR-1827	CLIP-seq
MIRT1418660	hsa-miR-200b	CLIP-seq
MIRT1418661	hsa-miR-200c	CLIP-seq
MIRT1418662	hsa-miR-202	CLIP-seq
MIRT1418664	hsa-miR-204	CLIP-seq
MIRT1418665	hsa-miR-2054	CLIP-seq
MIRT1418666	hsa-miR-210	CLIP-seq
MIRT1418667	hsa-miR-211	CLIP-seq
MIRT1418674	hsa-miR-26a	CLIP-seq
MIRT1418675	hsa-miR-26b	CLIP-seq
MIRT1418676	hsa-miR-29a	CLIP-seq
MIRT1418677	hsa-miR-29b	CLIP-seq
MIRT1418678	hsa-miR-29c	CLIP-seq
MIRT1418680	hsa-miR-3065-3p	CLIP-seq
MIRT2125575	hsa-miR-3143	CLIP-seq
MIRT2125576	hsa-miR-3145-3p	CLIP-seq
MIRT2125577	hsa-miR-3158-5p	CLIP-seq
MIRT2347911	hsa-miR-3162-5p	CLIP-seq
MIRT2347912	hsa-miR-337-3p	CLIP-seq
MIRT1418695	hsa-miR-340	CLIP-seq
MIRT2347913	hsa-miR-3545-3p	CLIP-seq
MIRT2347914	hsa-miR-3591-5p	CLIP-seq
MIRT1418701	hsa-miR-3662	CLIP-seq
MIRT2125582	hsa-miR-3671	CLIP-seq
MIRT1418704	hsa-miR-3685	CLIP-seq
MIRT1418708	hsa-miR-371-5p	CLIP-seq
MIRT1418709	hsa-miR-380	CLIP-seq
MIRT1418711	hsa-miR-384	CLIP-seq
MIRT2347915	hsa-miR-3914	CLIP-seq
MIRT1418714	hsa-miR-3977	CLIP-seq
MIRT1418715	hsa-miR-425	CLIP-seq
MIRT1418716	hsa-miR-4255	CLIP-seq
MIRT1418717	hsa-miR-4264	CLIP-seq
MIRT2125590	hsa-miR-4276	CLIP-seq
MIRT1418718	hsa-miR-4277	CLIP-seq
MIRT1418719	hsa-miR-429	CLIP-seq
MIRT1418720	hsa-miR-4291	CLIP-seq
MIRT2125593	hsa-miR-4330	CLIP-seq
MIRT1418724	hsa-miR-4421	CLIP-seq
MIRT1418727	hsa-miR-4446-5p	CLIP-seq
MIRT1418728	hsa-miR-4452	CLIP-seq
MIRT1418729	hsa-miR-4458	CLIP-seq
MIRT1418730	hsa-miR-4465	CLIP-seq
MIRT2125594	hsa-miR-4477a	CLIP-seq
MIRT1418735	hsa-miR-4500	CLIP-seq
MIRT1418738	hsa-miR-4639-3p	CLIP-seq
MIRT2347916	hsa-miR-4642	CLIP-seq
MIRT2125597	hsa-miR-4660	CLIP-seq
MIRT2125598	hsa-miR-4661-5p	CLIP-seq
MIRT2347917	hsa-miR-4698	CLIP-seq
MIRT1418745	hsa-miR-4699-3p	CLIP-seq
MIRT2347918	hsa-miR-4700-3p	CLIP-seq
MIRT1418747	hsa-miR-4705	CLIP-seq
MIRT2125600	hsa-miR-4712-5p	CLIP-seq
MIRT2347919	hsa-miR-4714-3p	CLIP-seq
MIRT2347920	hsa-miR-4724-3p	CLIP-seq
MIRT2347921	hsa-miR-4731-3p	CLIP-seq
MIRT2347922	hsa-miR-4736	CLIP-seq
MIRT2347923	hsa-miR-4739	CLIP-seq
MIRT1418749	hsa-miR-4755-5p	CLIP-seq
MIRT2347924	hsa-miR-4756-5p	CLIP-seq
MIRT2125604	hsa-miR-4773	CLIP-seq
MIRT2347925	hsa-miR-4781-3p	CLIP-seq
MIRT1418752	hsa-miR-4797-3p	CLIP-seq
MIRT2347926	hsa-miR-4801	CLIP-seq
MIRT2125607	hsa-miR-490-3p	CLIP-seq
MIRT1418754	hsa-miR-498	CLIP-seq
MIRT1418755	hsa-miR-499-3p	CLIP-seq
MIRT1418756	hsa-miR-499a-3p	CLIP-seq
MIRT2125608	hsa-miR-5047	CLIP-seq
MIRT2347927	hsa-miR-5095	CLIP-seq
MIRT2125614	hsa-miR-543	CLIP-seq
MIRT2125616	hsa-miR-548ac	CLIP-seq
MIRT2125617	hsa-miR-548ae	CLIP-seq
MIRT2125618	hsa-miR-548aj	CLIP-seq
MIRT2125619	hsa-miR-548am	CLIP-seq
MIRT1418760	hsa-miR-548an	CLIP-seq
MIRT2125620	hsa-miR-548d-3p	CLIP-seq
MIRT2347928	hsa-miR-548p	CLIP-seq
MIRT1418763	hsa-miR-548u	CLIP-seq
MIRT2125621	hsa-miR-548x	CLIP-seq
MIRT2125622	hsa-miR-548z	CLIP-seq
MIRT2347929	hsa-miR-552	CLIP-seq
MIRT2347930	hsa-miR-556-5p	CLIP-seq
MIRT1418764	hsa-miR-561	CLIP-seq
MIRT2125625	hsa-miR-582-5p	CLIP-seq
MIRT2347931	hsa-miR-599	CLIP-seq
MIRT2125627	hsa-miR-607	CLIP-seq
MIRT1418769	hsa-miR-623	CLIP-seq
MIRT2125628	hsa-miR-627	CLIP-seq
MIRT2125630	hsa-miR-649	CLIP-seq
MIRT2125631	hsa-miR-653	CLIP-seq
MIRT2125632	hsa-miR-656	CLIP-seq
MIRT2347932	hsa-miR-657	CLIP-seq
MIRT1418771	hsa-miR-668	CLIP-seq
MIRT1418772	hsa-miR-767-5p	CLIP-seq
MIRT2125633	hsa-miR-770-5p	CLIP-seq
MIRT2347933	hsa-miR-873	CLIP-seq
MIRT2347934	hsa-miR-888	CLIP-seq
MIRT2125634	hsa-miR-924	CLIP-seq
MIRT2347935	hsa-miR-940	CLIP-seq
MIRT2125636	hsa-miR-944	CLIP-seq
MIRT1418775	hsa-miR-98	CLIP-seq
MIRT1418642	hsa-miR-1257	CLIP-seq
MIRT1418648	hsa-miR-1297	CLIP-seq
MIRT1418671	hsa-miR-23a	CLIP-seq
MIRT1418672	hsa-miR-23b	CLIP-seq
MIRT1418673	hsa-miR-23c	CLIP-seq
MIRT1418674	hsa-miR-26a	CLIP-seq
MIRT1418675	hsa-miR-26b	CLIP-seq
MIRT1418676	hsa-miR-29a	CLIP-seq
MIRT1418677	hsa-miR-29b	CLIP-seq
MIRT1418678	hsa-miR-29c	CLIP-seq
MIRT1418680	hsa-miR-3065-3p	CLIP-seq
MIRT1418707	hsa-miR-3714	CLIP-seq
MIRT1418714	hsa-miR-3977	CLIP-seq
MIRT1418720	hsa-miR-4291	CLIP-seq
MIRT1418728	hsa-miR-4452	CLIP-seq
MIRT1418730	hsa-miR-4465	CLIP-seq
MIRT1418733	hsa-miR-4494	CLIP-seq
MIRT1418750	hsa-miR-4769-3p	CLIP-seq
MIRT1418751	hsa-miR-4771	CLIP-seq
MIRT2395668	hsa-miR-4781-5p	CLIP-seq
MIRT1418760	hsa-miR-548an	CLIP-seq
MIRT2395669	hsa-miR-664	CLIP-seq
MIRT2347906	hsa-miR-1255a	CLIP-seq
MIRT2347907	hsa-miR-1255b	CLIP-seq
MIRT1418648	hsa-miR-1297	CLIP-seq
MIRT1418650	hsa-miR-1305	CLIP-seq
MIRT2125561	hsa-miR-135a	CLIP-seq
MIRT2125562	hsa-miR-135b	CLIP-seq
MIRT1418674	hsa-miR-26a	CLIP-seq
MIRT1418675	hsa-miR-26b	CLIP-seq
MIRT2125576	hsa-miR-3145-3p	CLIP-seq
MIRT2347912	hsa-miR-337-3p	CLIP-seq
MIRT2640726	hsa-miR-3653	CLIP-seq
MIRT1418699	hsa-miR-3658	CLIP-seq
MIRT2125582	hsa-miR-3671	CLIP-seq
MIRT1418730	hsa-miR-4465	CLIP-seq
MIRT2125594	hsa-miR-4477a	CLIP-seq
MIRT2347919	hsa-miR-4714-3p	CLIP-seq
MIRT2640727	hsa-miR-4766-3p	CLIP-seq
MIRT1418754	hsa-miR-498	CLIP-seq
MIRT2347928	hsa-miR-548p	CLIP-seq
MIRT2640728	hsa-miR-642b	CLIP-seq
MIRT2125632	hsa-miR-656	CLIP-seq
MIRT1418648	hsa-miR-1297	CLIP-seq
MIRT1418650	hsa-miR-1305	CLIP-seq
MIRT2125561	hsa-miR-135a	CLIP-seq
MIRT2125562	hsa-miR-135b	CLIP-seq
MIRT1418674	hsa-miR-26a	CLIP-seq
MIRT1418675	hsa-miR-26b	CLIP-seq
MIRT2125576	hsa-miR-3145-3p	CLIP-seq
MIRT2640726	hsa-miR-3653	CLIP-seq
MIRT1418699	hsa-miR-3658	CLIP-seq
MIRT2125582	hsa-miR-3671	CLIP-seq
MIRT1418730	hsa-miR-4465	CLIP-seq
MIRT2125594	hsa-miR-4477a	CLIP-seq
MIRT2347919	hsa-miR-4714-3p	CLIP-seq
MIRT1418754	hsa-miR-498	CLIP-seq
MIRT2640728	hsa-miR-642b	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002521	Process	Leukocyte differentiation	IMP	32518946
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	23222540, 23353889, 25601757, 28514442, 29735542, 32814053, 33961781, 34667079
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006493	Process	Protein O-linked glycosylation	IDA	23222540
GO:0006493	Process	Protein O-linked glycosylation	IMP	23353889
GO:0008198	Function	Ferrous iron binding	IDA	24315485
GO:0008270	Function	Zinc ion binding	IDA	24315485
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010557	Process	Positive regulation of macromolecule biosynthetic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016706	Function	2-oxoglutarate-dependent dioxygenase activity	IEA
GO:0030099	Process	Myeloid cell differentiation	IBA
GO:0030099	Process	Myeloid cell differentiation	IMP	21057493
GO:0040029	Process	Epigenetic regulation of gene expression	IEA
GO:0044029	Process	Positive regulation of gene expression via chromosomal CpG island demethylation	IDA	24315485
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	23222540, 23353889
GO:0046872	Function	Metal ion binding	IEA
GO:0051213	Function	Dioxygenase activity	IEA
GO:0070579	Function	DNA 5-methylcytosine dioxygenase activity	IBA
GO:0070579	Function	DNA 5-methylcytosine dioxygenase activity	IDA	24315485
GO:0070579	Function	DNA 5-methylcytosine dioxygenase activity	IEA
GO:0070579	Function	DNA 5-methylcytosine dioxygenase activity	IMP	21057493, 23222540, 32518946
GO:0070579	Function	DNA 5-methylcytosine dioxygenase activity	ISS

MIM	HGNC	e!Ensembl
612839	25941	ENSG00000168769

Q6N021

Protein name

Methylcytosine dioxygenase TET2 (EC 1.14.11.80)

Protein function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also

PDB

4NM6 , 5D9Y , 5DEU , 7NE3 , 7NE6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12851	Tet_JBP	1290 → 1905	Oxygenase domain of the 2OGFeDO superfamily	Domain

Tissue specificity

TISSUE SPECIFICITY: Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes. {ECO:0000269|PubMed

Sequence

MEQDRTNHVEGNRLSPFLIPSPPICQTEPLATKLQNGSPLPERAHPEVNGDTKWHSFKSY
YGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPSLSGLLQIKKLKQDQKANG
ERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAVKDFTSFSTHNCSGPENPELQ
ILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSVEHTHGELLEKTLSQYYPDCVSI
AVQKTTSHINAINSQATNELSCEITHPSHTSGQINSAQTSNSELPPKPAAVVSEACDADD
ADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPSPAENNIQGTTKLASGEEFCSGSSSNL
QAPGGSSERYLKQNEMNGAYFKQSSVFTKDSFSATTTPPPPSQLLLSPPPPLPQVPQLPS
EGKSTLNGGVLEEHHHYPNQSNTTLLREVKIEGKPEAPPSQSPNPSTHVCSPSPMLSERP
QNNCVNRNDIQTAGTMTVPLCSEKTRPMSEHLKHNPPIFGSSGELQDNCQQLMRNKEQEI
LKGRDKEQTRDLVPPTQHYLKPGWIELKAPRFHQAESHLKRNEASLPSILQYQPNLSNQM
TSKQYTGNSNMPGGLPRQAYTQKTTQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQV
HFSKTDHLPKAHVQSLCGTRFHFQQRADSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQ
HKPHKQAAQTQPSQSSHLPQNQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTK
VEECFHGENQYSKSSEFETHNVQMGLEEVQNINRRNSPYSQTMKSSACKIQVSCSNNTHL
VSENKEQTTHPELFAGNKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYK
NRNQDMSGQQAAQLAQQRYLIHNHANVFPVPDQGGSHTQTPPQKDTQKHAALRWHLLQKQ
EQQQTQQPQTESCHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQ
QKSIIETMEQHLKQFHAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPA
LEQQTTSSEKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVEQII
EKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVV
RRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTN
RRCALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEE
KLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAH
AHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKR
SGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKSAPSRTK
QTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSY
SASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPG
LLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQSQPMDLYRYPSQDPLSKLSLPPIHTLYQ
PRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPTHEMDGHFMGATSRL
PPNLSNPNMDYKNGEHHSPSHIIHNYSAAPGMFNSSLHALHLQNKENDMLSHTANGLSKM
LPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGAEDNDEVWSDSEQSFLDPDIG
GVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAK
MAEKAREKEEECEKYGPDYVPQKSHGKKVKREPAEPHETSEPTYLRFIKSLAERTMSVTT
DSTVTTSPYAFTRVTGPYNRYI

Sequence length

2002

Interactions

View interactions

Show/Hide Causal Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Angioimmunoblastic T-cell lymphoma	Pathogenic	rs1352258641, rs1245041497	RCV003447637 RCV003447657
Clonal hematopoiesis	Pathogenic	rs2476537310	RCV003126394
EBV-positive nodal T- and NK-cell lymphoma	Likely pathogenic; Pathogenic	rs772634266, rs575928986, rs1242089483, rs2476493944, rs2476750584, rs1730329392, rs1728692644, rs1729381211, rs2110232389, rs1322900367, rs2476498425, rs572712965, rs2476480900, rs2110315013, rs771408533, rs1728711651, rs2476494544 View all (2 more)	RCV004557990 RCV004557991 RCV004557992 RCV004557993 RCV004557994 RCV004557995 RCV004557996 RCV004557997 RCV004557999 RCV004558000 RCV004558001 RCV004558003 RCV004558004 RCV004558005 RCV004558006 RCV004558007 RCV004558008
Immunodeficiency 75	Likely pathogenic	rs2476498043, rs1242089483	RCV003150599 RCV005036827
Multiple myeloma	Likely pathogenic	rs1578264146	RCV000984135
Myelodysplastic syndrome	Pathogenic; Likely pathogenic	rs2110231198, rs1242089483	RCV002246770 RCV005036827
TET2-related disorder	Likely pathogenic	rs771168522	RCV003408319
Third degree atrioventricular block	Pathogenic	rs2476533556	RCV002305645

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Atypical chronic myeloid leukemia, BCR-ABL1 negative	Uncertain significance	rs116519313, rs771761785	RCV003232849 RCV003232904
Familial cancer of breast	Likely benign; Uncertain significance	rs748776247, rs869025296	RCV005932093 RCV000207332
Neoplasm	Uncertain significance	rs765803723	RCV005233035
Nephroblastoma	other	rs1553918194	RCV000505569
Squamous cell carcinoma	Uncertain significance	rs2476500760	RCV003129703
Thyroid cancer, nonmedullary, 1	Likely benign	rs201837804	RCV005930377
Uterine corpus endometrial carcinoma	Uncertain significance	rs2110249348	RCV005929886

Show/Hide Text Mining Associations (232)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Accessory Nerve Injuries	Associate	35892263
Adenocarcinoma of Lung	Associate	37667220
Aging Premature	Associate	34210413
Anemia	Associate	32243522
Anemia	Stimulate	38225226
Anemia Aplastic	Associate	34587721, 37087521
Anemia Macrocytic	Associate	35126364
Anemia Refractory	Associate	26874914
Aneurysm	Associate	39382597
Aortic Valve Stenosis	Associate	31504400, 32639511, 36680616
Arthritis Rheumatoid	Associate	34125889, 40305610
Ataxia Telangiectasia	Associate	20334914, 27203213, 35299281, 36796016
Atherosclerosis	Associate	31990036, 33779075, 35385050, 36835370, 37197843
Atrial Fibrillation	Associate	35724849, 38598228
Atypical Squamous Cells of the Cervix	Associate	34663818, 35352484
Autoimmune Diseases	Associate	36314527
Autoimmune Lymphoproliferative Syndrome	Associate	32518946
Behcet Syndrome	Associate	36864496
Beta ketothiolase deficiency	Associate	27997762
Bipolar Disorder	Associate	34282735
Bjornstad syndrome	Associate	37558665
Bohring syndrome	Associate	22186017
Bone Marrow Diseases	Associate	30709865, 35427424
Bone Marrow Diseases	Stimulate	35185048
Brain Diseases	Associate	35235761
Brain Neoplasms	Associate	37423059
Breast Neoplasms	Associate	26207381, 26354892, 29316957, 30385776, 31704974, 33146288, 34689714, 35351824, 39261937
Calcinosis Cutis	Associate	23636849
Carcinogenesis	Inhibit	25601757, 30385776, 37667220
Carcinogenesis	Associate	26880370, 30917865, 32390600, 34689714, 34905094, 35109986
Carcinoma Hepatocellular	Inhibit	35651922
Carcinoma Hepatocellular	Associate	38470216
Carcinoma in Situ	Associate	24292451
Carcinoma Non Small Cell Lung	Associate	27528220, 32554069, 36593050, 38190582
Carcinoma Renal Cell	Associate	34551979, 35173532
Carcinoma Squamous Cell	Associate	28099906
Carcinoma Squamous Cell	Inhibit	35109986
Cardiomyopathy Dilated	Associate	35979940
Cardiovascular Diseases	Associate	30890702, 32639511, 35339897, 35931086, 36441964, 39382597
Cell Transformation Neoplastic	Associate	37667220
Cell Transformation Viral	Stimulate	20068184
Cell Transformation Viral	Associate	22431577, 34449560, 35013795, 37399248
Cerebral Infarction	Associate	34743536
Cholangiocarcinoma	Associate	34905094
Chromosomal Instability	Associate	32066746
Cleft Palate	Associate	37399248
Colitis Ulcerative	Associate	28524162
Colonic Neoplasms	Stimulate	30013992
Colorectal Neoplasms	Associate	25557833, 25853800, 26816554, 28675510, 29641532, 30013992, 35660018, 37620362
Colorectal Neoplasms	Inhibit	36806702
Corneal Endothelial Cell Loss	Associate	31990036
Coronary Artery Disease	Associate	36097025, 39460851
Coronary Disease	Associate	34125889
Cyclic neutropenia	Associate	27497531, 29866652, 31707836, 32442302, 32639511, 34050697, 34210413, 34413458, 34663818, 34793200, 34963005, 36097025, 36281508, 37934948, 39287426, 39382597, 39456832, 39849426 View all (3 more)
Cytokine Release Syndrome	Associate	32639511
Death	Associate	25092778, 30566180, 33779075, 33832602, 33877299, 34239136, 35339897, 36441964
Dental Leakage	Associate	38172938
Depressive Disorder Major	Associate	34282735
Developmental Disabilities	Associate	22186017
Diabetes Gestational	Associate	27005421
Diabetes Mellitus	Stimulate	38305890
Diabetes Mellitus Type 2	Associate	26356709
Diabetic Retinopathy	Associate	38172938
Disease	Associate	35279121
Down Syndrome	Associate	26317209
Drug Related Side Effects and Adverse Reactions	Associate	35533245, 35962345
Drug Resistant Epilepsy	Associate	35235761
Dyserythropoiesis Congenital with Internuclear Chromatin Bridges and Ultrastructurally Normal Erythroblast Heterochromatin	Associate	28167661
Endometrial Neoplasms	Associate	28349832
Endometriosis	Associate	32658928
Enterocolitis Neutropenic	Associate	28655780
Enteropathy Associated T Cell Lymphoma	Associate	33579790
Epstein Barr Virus Infections	Inhibit	27829228
Epstein Barr Virus Infections	Associate	31311407, 35021606
Erdheim Chester Disease	Associate	33067622
Esophageal Squamous Cell Carcinoma	Associate	26093090, 26873401, 27050164
Essential Hypertension	Associate	25695618
Essential Tremor	Associate	27447873
GATA2 Deficiency	Associate	25614448, 31311407, 32321919
Genomic Instability	Associate	32397113
Giant Cell Arteritis	Associate	37909388
Glioblastoma	Associate	30888082
Glioma	Associate	34905094, 38547058
Granulosa Cell Tumor	Associate	32203090
Heart Failure	Associate	30566180, 32639511, 33779075, 33832602, 35339897
Heart Failure	Stimulate	34210413
Hematologic Diseases	Associate	27389314, 27717004, 30709865, 31350794, 33786584
Hematologic Neoplasms	Associate	20061559, 24693539, 30475948, 33512451, 34050697, 34120595, 34239136, 34570179, 36639817, 37774069
Hematologic Neoplasms	Inhibit	30371677
Hemoglobinuria Paroxysmal	Associate	25244093
Hemophilia B	Associate	35185048
Hemorrhage	Associate	38003211
Hemorrhagic Stroke	Stimulate	34743536
Hereditary Autoinflammatory Diseases	Associate	35126364
Hereditary Breast and Ovarian Cancer Syndrome	Associate	28115406, 39261937
Hippocampal Sclerosis	Stimulate	35235761
Histiocytic Sarcoma	Associate	37839675
Histiocytosis Langerhans Cell	Associate	36064398, 37839675
HIV Infections	Inhibit	35319230
HIV Infections	Associate	36473831
Hodgkin Disease	Associate	36639817
Holoprosencephaly recurrent infections and monocytosis	Associate	19262599, 24970933, 28370365, 30709865
Hypereosinophilic Syndrome	Associate	27174585
Hyperglycemia	Inhibit	36806702
Hypotension	Stimulate	36485103
Hypoxia	Stimulate	25794157
Hypoxia	Associate	39292770
Immune System Diseases	Associate	37325673
Immunologic Deficiency Syndromes	Associate	32518946
Infections	Associate	32639511
Inflammation	Associate	29138803, 31504400, 32639511, 35339897, 35533245, 35581740, 39456832
Intracranial Aneurysm	Associate	39382597
Kidney Neoplasms	Associate	35173532
Leprosy Paucibacillary	Associate	27927582
Leukemia	Associate	23996483, 24373966, 25326804, 25972343, 31707836, 35345350, 35973983, 36065607, 37467321, 37541212, 37591941
Leukemia	Inhibit	25601757
Leukemia Basophilic Acute	Associate	34132463
Leukemia Erythroblastic Acute	Associate	33172974
Leukemia Large Granular Lymphocytic	Associate	29148541, 31311407, 33786584, 35015834
Leukemia Lymphocytic Chronic B Cell	Associate	24693539, 27980696, 31845905, 37985171
Leukemia Lymphoma Adult T Cell	Associate	26880370, 34413196
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	21346257, 28452984, 28533480, 39327604
Leukemia Myeloid	Associate	20693430, 22186017, 22395470, 24693539, 25972343, 28973458, 35345350, 36065607, 37586297
Leukemia Myeloid Acute	Associate	19420352, 20678218, 21130701, 21343549, 21504050, 21828143, 21881046, 22234698, 22343920, 22507776, 22535592, 22581002, 22912701, 22976956, 23349305 View all (70 more)
Leukemia Myeloid Acute	Stimulate	36371552
Leukemia Myeloid Acute	Inhibit	37884893
Leukemia Myeloid Chronic Atypical BCR ABL Negative	Associate	28314085, 30635983, 36375042, 36601682, 38066919
Leukemia Myeloid Chronic Phase	Associate	40295826
Leukemia Myelomonocytic Chronic	Associate	19420352, 20693430, 21828135, 22017486, 22328940, 22395470, 23065512, 23319568, 24817963, 24970933, 25972343, 26648538, 26771811, 27164004, 28548124 View all (13 more)
Leukemia Myelomonocytic Chronic	Stimulate	22511494
Leukemia Myelomonocytic Juvenile	Associate	19372255, 20955399, 22912701, 35299281
Leukemia Neutrophilic Chronic	Associate	33822276, 36375042
Leukemia Promyelocytic Acute	Associate	29274134
Leukemia T Cell	Associate	34793200, 34905094
Lupus Erythematosus Systemic	Associate	35592687, 36314527
Lupus Nephritis	Associate	26509176
Lymphatic Metastasis	Inhibit	28349832
Lymphohistiocytosis Hemophagocytic	Associate	37985171
Lymphoma	Associate	25326804, 25671252, 30890702, 32518946, 35533245, 37475138, 38429084
Lymphoma B Cell Marginal Zone	Associate	29674500, 34021249, 35064935
Lymphoma Large B Cell Diffuse	Associate	23831920, 28731140, 29895903, 30683910, 32187361, 32469082, 36812290, 37032379
Lymphoma Non Hodgkin	Associate	33400376
Lymphoma T Cell	Associate	24345752, 26719098, 28148900, 29052597, 31859368, 32442302, 32945366, 33512451, 33739791, 34581268, 35064935, 35895386, 36093687, 36536430, 36567979
Lymphoma T Cell Peripheral	Associate	26268241, 30829413, 31859368, 34108263, 34980830, 35301414, 36093687
Lymphoproliferative Disorders	Associate	33512451, 37705050
Lysosomal Storage Diseases	Associate	35351824
Macrocytosis Familial	Associate	32761230
Mast Cell Activation Disorders	Associate	27310990
Mastocytosis	Associate	22905207, 24389310
Mastocytosis Systemic	Associate	19262599, 22905207, 23958953, 27214377
Melanoma	Associate	22980977, 27102770, 34843679, 39456832
Melanoma Cutaneous Malignant	Associate	29641532
Meningeal Neoplasms	Associate	32711494
Mucocutaneous Lymph Node Syndrome	Associate	31171909
Multiple Sclerosis	Associate	24735979
Myelodysplastic Myeloproliferative Diseases	Associate	19372255, 20955399, 21346257, 22180010, 32573691, 39337700
Myelodysplastic Syndromes	Associate	19388938, 20334914, 20678218, 20693430, 22017486, 22186017, 23319568, 23831921, 23996483, 24220272, 24962689, 25092778, 27389314, 27497531, 27717004 View all (39 more)
Myelodysplastic Syndromes	Inhibit	26617797
Myeloproliferative Disorders	Associate	29795413
Neoplasm Metastasis	Associate	23636849, 26816554, 28608921, 30888082, 32711494
Neoplasm Metastasis	Inhibit	37667220
Neoplasms	Inhibit	19262599, 25557833, 28349832, 29138803, 30371677, 30917865, 32066746, 34689714, 35109986, 36847506, 37286599, 38014648
Neoplasms	Associate	19372255, 19420352, 19957346, 20061559, 20068184, 21173100, 21531982, 21734233, 22017486, 22320381, 22980977, 23066032, 23319568, 23636849, 23781511 View all (68 more)
Neoplasms Second Primary	Associate	35803921
Neoplasms Squamous Cell	Associate	26105999, 26379152, 31811114, 33530792, 33687433, 37286599
Nerve Degeneration	Associate	30890702
Neural Tube Defects	Associate	19372255, 24970933, 28255022, 33512451
Neuroblastoma	Associate	38014648
Neurodegenerative Diseases	Associate	30323172
Neuroendocrine Tumors	Associate	30045709
Neurotoxicity Syndromes	Associate	35533245
Neutropenia	Associate	34115096
Neutropenia severe chronic	Associate	34166485
Obesity	Associate	36806702
Osteoporosis	Associate	31430471
Ovalocytosis Hereditary Hemolytic with Defective Erythropoiesis	Associate	30254129
Ovarian Neoplasms	Associate	28115406
Pancreatic Intraductal Neoplasms	Associate	35238112
Pancreatic Neoplasms	Associate	28099906, 35238112
Peripheral Nervous System Diseases	Associate	35504600
Peritonitis	Associate	33144643
Personality Disorders	Associate	27486019, 33008340
Philadelphia Chromosome	Associate	23781511
Plasmablastic Lymphoma	Associate	33297669, 33951889
Platelet Disorder Familial with Associated Myeloid Malignancy	Associate	27997762
Platyspondylic Lethal Skeletal Dysplasia Torrance Type	Associate	31311407
Pneumocephalus	Associate	29895903
Polycythemia	Associate	38244120
Polycythemia Vera	Associate	19262601, 21273266, 23781511, 27447873, 28218607, 28370365, 32066200
Pre Eclampsia	Associate	27005421
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	28245838
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22017486, 23521373, 27476855, 29767839, 31409822, 32174258, 32203209, 32856987, 33529373, 34132463, 34413196
Primary Myelofibrosis	Associate	19262601, 22180010, 23733509, 23996481, 26124496, 27447873, 28218607, 36000955
Prostatic Neoplasms	Associate	22219177, 23593118, 27486019, 29641532, 30917865
Prostatic Neoplasms	Inhibit	33008340
Prostatic Neoplasms Castration Resistant	Associate	23636849
Prostatitis	Associate	27486019, 28115406, 30917865
Protein S Deficiency	Associate	33008340
Pulmonary Arterial Hypertension	Inhibit	35581740
Pulmonary Arterial Hypertension	Stimulate	39849426
Pulmonary Disease Chronic Obstructive	Associate	26423011, 28655780
Pulmonary Fibrosis	Associate	37045913
Purpura	Associate	29069007
Purpura Thrombocytopenic Idiopathic	Associate	29069007
Red Cell Aplasia Pure	Associate	33500526
Retinal Dysplasia	Associate	29795413
Ring Chromosomes	Associate	30587503
Sarcoma Myeloid	Associate	35474239
Schizophrenia	Associate	34282735
Shock Cardiogenic	Associate	35729851
Sinonasal undifferentiated carcinoma	Associate	28084339
Skin Diseases	Associate	34671345
Splenomegaly	Associate	22180010
Squamous Cell Carcinoma of Head and Neck	Associate	30548484
ST Elevation Myocardial Infarction	Associate	35339897
Stomach Diseases	Associate	27829228
Stomach Neoplasms	Inhibit	27027260
Stroke	Associate	34507355, 34743536
Syndrome	Associate	29795413
Thrombocythemia Essential	Associate	19262601, 23781511, 28218607, 32732354
Thrombocytopenia	Associate	29069007, 33786584
Thrombocytosis	Associate	32761230
Thrombophilia	Associate	35733370
Thyroid Neoplasms	Associate	32390600
Trigger Finger Disorder	Associate	36065607
Tukel syndrome	Associate	23781511
Tyrosinemias	Associate	34768283
Uterine Cervical Neoplasms	Associate	26686387
Vascular Diseases	Associate	39382597
Vascular System Injuries	Associate	33067622
Vision Disorders	Associate	37909388
Waldenstrom Macroglobulinemia	Associate	34847227, 37839675

TET2 (tet methylcytosine dioxygenase 2)