UniProt ID |
P62937
|
Protein name |
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] |
Protein function |
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activati |
PDB |
1AK4
,
1AWQ
,
1AWR
,
1AWS
,
1AWT
,
1AWU
,
1AWV
,
1BCK
,
1CWA
,
1CWB
,
1CWC
,
1CWF
,
1CWH
,
1CWI
,
1CWJ
,
1CWK
,
1CWL
,
1CWM
,
1CWO
,
1FGL
,
1M63
,
1M9C
,
1M9D
,
1M9E
,
1M9F
,
1M9X
,
1M9Y
,
1MF8
,
1MIK
,
1NMK
,
1OCA
,
1RMH
,
1VBS
,
1VBT
,
1W8L
,
1W8M
,
1W8V
,
1YND
,
1ZKF
,
2ALF
,
2CPL
,
2CYH
,
2MS4
,
2MZU
,
2N0T
,
2RMA
,
2RMB
,
2X25
,
2X2A
,
2X2C
,
2X2D
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00160
|
Pro_isomerase |
7 → 163 |
Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
Domain |
|
Sequence |
|
Sequence length |
165 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Carcinoma |
Squamous cell carcinoma |
rs121912654, rs555607708, rs786202962, rs1564055259 |
15274141 |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 View all (244 more) |
19424620 |
Lung carcinoma |
Non-Small Cell Lung Carcinoma |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
17094902 |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
20073568 |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Acquired Immunodeficiency Syndrome |
Associate
|
17590083 |
Acrocephalosyndactylia |
Associate
|
19092998 |
Alzheimer Disease |
Associate
|
25757756 |
Amyotrophic Lateral Sclerosis |
Associate
|
34099711 |
Aneurysm |
Associate
|
29929532 |
Aortic Aneurysm Abdominal |
Associate
|
23558220, 31936351 |
Aortic Aneurysm Thoracic |
Associate
|
31936351 |
Arrhythmogenic Right Ventricular Dysplasia |
Associate
|
31096574 |
Arthritis Rheumatoid |
Associate
|
18567920, 37894839 |
Asthma |
Associate
|
21999750 |
Autism Spectrum Disorder |
Associate
|
38421723 |
Brain Injuries |
Associate
|
35008690 |
Breast Neoplasms |
Associate
|
18042273 |
Carcinogenesis |
Associate
|
23031673 |
Carcinoma Hepatocellular |
Associate
|
36231045 |
Carcinoma Non Small Cell Lung |
Associate
|
23031673, 35579671, 37298389 |
Carcinoma Pancreatic Ductal |
Associate
|
32185224 |
Carcinoma Renal Cell |
Associate
|
17559644, 21368578 |
Cardiomyopathies |
Associate
|
23243067 |
Cardiovascular Diseases |
Associate
|
31519036, 31936351 |
Cerebral Infarction |
Associate
|
31519036 |
Cholangiocarcinoma |
Associate
|
23480755 |
Colorectal Neoplasms |
Associate
|
20122155, 21059236 |
Coronary Artery Disease |
Associate
|
26084004, 31519036, 33191348 |
COVID 19 |
Associate
|
15688292, 24566223, 36377893 |
Cytomegalovirus Infections |
Associate
|
22238232 |
Death |
Associate
|
23243067, 31519036 |
Depressive Disorder |
Inhibit
|
23110234 |
Dermatitis Atopic |
Associate
|
28479159 |
Developmental Disabilities |
Associate
|
38421723 |
Diabetes Mellitus |
Stimulate
|
29364090 |
Diabetic Nephropathies |
Stimulate
|
26496315 |
Diffuse Intrinsic Pontine Glioma |
Stimulate
|
22492959 |
Dysmenorrhea |
Associate
|
29081463 |
Endometrial Neoplasms |
Associate
|
25473950, 32439920, 35805203 |
Endometriosis |
Associate
|
29081463 |
Epstein Barr Virus Infections |
Associate
|
31063269 |
Esophageal Neoplasms |
Associate
|
35840882 |
Esophageal Squamous Cell Carcinoma |
Associate
|
24351116, 36467891 |
Femur Head Necrosis |
Associate
|
27323096 |
Fibrosis |
Associate
|
31096574, 32708451 |
Gastrointestinal Stromal Tumors |
Associate
|
21171987 |
Glioma |
Stimulate
|
32775435 |
Glut1 Deficiency Syndrome |
Associate
|
25757756 |
Heart Failure |
Associate
|
23243067 |
Hematologic Neoplasms |
Associate
|
34360654 |
Hemorrhage |
Associate
|
31519036, 33191348 |
HIV Infections |
Associate
|
16188970, 17590083, 19092998, 22280894, 26865710, 27088296, 28077629, 30814280, 39480090 |
HTLV I Infections |
Associate
|
17715216 |
Hypercholesterolemia |
Stimulate
|
26084004 |
Hypercholesterolemia |
Associate
|
31519036 |
Hyperglycemia |
Associate
|
29364090 |
Hyperplasia |
Associate
|
35805203 |
Hypertension |
Stimulate
|
26084004 |
Hypertension |
Associate
|
31519036 |
Hypoxia |
Associate
|
35579671 |
Hypoxia Brain |
Associate
|
35579671 |
Infections |
Associate
|
15479848, 17267487, 17715216, 18829762, 19092998, 23325683, 33758083, 8648689 |
Inflammation |
Associate
|
22798670, 23243067, 29403273, 31096574 |
Inflammation |
Stimulate
|
29081463 |
Kidney Diseases |
Associate
|
32708451 |
Kidney Diseases |
Stimulate
|
33191348 |
Lung Neoplasms |
Associate
|
33393627 |
Lymphoma |
Associate
|
26752561 |
Lymphoma Non Hodgkin |
Associate
|
26752561 |
Lymphoma T Cell Cutaneous |
Associate
|
34360654 |
Malformations of Cortical Development Group I |
Inhibit
|
33393627 |
Marfan Syndrome |
Associate
|
31936351 |
Mycosis Fungoides |
Stimulate
|
34360654 |
Myocardial Infarction |
Inhibit
|
26084004 |
Myocardial Infarction |
Associate
|
31519036, 40305362 |
Nasopharyngeal Carcinoma |
Associate
|
28107202 |
Nasopharyngeal Carcinoma |
Stimulate
|
31063269 |
Necrosis |
Associate
|
23243067 |
Neoplasm Metastasis |
Associate
|
23031673, 24351116 |
Neoplasms |
Associate
|
16604531, 18401453, 22470562, 23031673, 34360654, 35579671, 36768889, 37166013, 37298389 |
Nerve Degeneration |
Associate
|
35058547 |
Neuroblastoma |
Associate
|
18797883 |
Non alcoholic Fatty Liver Disease |
Stimulate
|
29364090 |
Non ST Elevated Myocardial Infarction |
Associate
|
40305362 |
Oral Submucous Fibrosis |
Associate
|
27533088 |
Ovarian Diseases |
Associate
|
29081463 |
Ovarian Neoplasms |
Associate
|
29203663 |
Pancreatic Neoplasms |
Associate
|
16604531, 32185224 |
Parkinson Disease |
Associate
|
35008690 |
Periodontitis |
Associate
|
29116140 |
Persistent Infection |
Associate
|
27088296 |
Postural Orthostatic Tachycardia Syndrome |
Associate
|
40022872 |
Pulmonary Disease Chronic Obstructive |
Associate
|
29403273 |
Salivary Gland Neoplasms |
Associate
|
31098787 |
Sezary Syndrome |
Stimulate
|
34360654 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
24386210 |
Status Asthmaticus |
Associate
|
23110234 |
Stomach Neoplasms |
Associate
|
33804393, 37926757 |
Thoracic Outlet Syndrome |
Associate
|
35058547 |
Urinary Incontinence Stress |
Associate
|
27193112 |
Uterine Diseases |
Associate
|
29081463 |
Ventricular Remodeling |
Associate
|
31096574 |
Virus Diseases |
Associate
|
34533641 |
Wounds and Injuries |
Associate
|
33393627 |
|