Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5478
Gene name Gene Name - the full gene name approved by the HGNC.
Peptidylprolyl isomerase A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPIA
Synonyms (NCBI Gene) Gene synonyms aliases
CYPA, CYPH, HEL-S-69p
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclospor
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023905 hsa-miR-1-3p Proteomics 18668040
MIRT050789 hsa-miR-17-3p CLASH 23622248
MIRT050690 hsa-miR-18a-5p CLASH 23622248
MIRT050185 hsa-miR-26a-5p CLASH 23622248
MIRT048054 hsa-miR-197-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity IDA 15130913
GO:0000413 Process Protein peptidyl-prolyl isomerization IBA 21873635
GO:0000413 Process Protein peptidyl-prolyl isomerization IDA 14993672, 20676357
GO:0001933 Process Negative regulation of protein phosphorylation IDA 26095851
GO:0001934 Process Positive regulation of protein phosphorylation IDA 11943775
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
123840 9253 ENSG00000196262
Protein
UniProt ID P62937
Protein name Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Protein function Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activati
PDB 1AK4 , 1AWQ , 1AWR , 1AWS , 1AWT , 1AWU , 1AWV , 1BCK , 1CWA , 1CWB , 1CWC , 1CWF , 1CWH , 1CWI , 1CWJ , 1CWK , 1CWL , 1CWM , 1CWO , 1FGL , 1M63 , 1M9C , 1M9D , 1M9E , 1M9F , 1M9X , 1M9Y , 1MF8 , 1MIK , 1NMK , 1OCA , 1RMH , 1VBS , 1VBT , 1W8L , 1W8M , 1W8V , 1YND , 1ZKF , 2ALF , 2CPL , 2CYH , 2MS4 , 2MZU , 2N0T , 2RMA , 2RMB , 2X25 , 2X2A , 2X2C , 2X2D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00160 Pro_isomerase 7 163 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Domain
Sequence
Sequence length 165
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1
Necroptosis
  Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Basigin interactions
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 15274141
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
19424620
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
17094902
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
20073568
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 17590083
Acrocephalosyndactylia Associate 19092998
Alzheimer Disease Associate 25757756
Amyotrophic Lateral Sclerosis Associate 34099711
Aneurysm Associate 29929532
Aortic Aneurysm Abdominal Associate 23558220, 31936351
Aortic Aneurysm Thoracic Associate 31936351
Arrhythmogenic Right Ventricular Dysplasia Associate 31096574
Arthritis Rheumatoid Associate 18567920, 37894839
Asthma Associate 21999750