Gene Gene information from NCBI Gene database.
Entrez ID 5478
Gene name Peptidylprolyl isomerase A
Gene symbol PPIA
Synonyms (NCBI Gene)
CYPACYPHHEL-S-69p
Chromosome 7
Chromosome location 7p13
Summary This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclospor
miRNA miRNA information provided by mirtarbase database.
733
miRTarBase ID miRNA Experiments Reference
MIRT023905 hsa-miR-1-3p Proteomics 18668040
MIRT050789 hsa-miR-17-3p CLASH 23622248
MIRT050690 hsa-miR-18a-5p CLASH 23622248
MIRT050185 hsa-miR-26a-5p CLASH 23622248
MIRT048054 hsa-miR-197-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
68
GO ID Ontology Definition Evidence Reference
GO:0000413 Process Protein peptidyl-prolyl isomerization IDA 14993672
GO:0001933 Process Negative regulation of protein phosphorylation IDA 26095851
GO:0001934 Process Positive regulation of protein phosphorylation IDA 11943775
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
123840 9253 ENSG00000196262
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62937
Protein name Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Protein function Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activati
PDB 1AK4 , 1AWQ , 1AWR , 1AWS , 1AWT , 1AWU , 1AWV , 1BCK , 1CWA , 1CWB , 1CWC , 1CWF , 1CWH , 1CWI , 1CWJ , 1CWK , 1CWL , 1CWM , 1CWO , 1FGL , 1M63 , 1M9C , 1M9D , 1M9E , 1M9F , 1M9X , 1M9Y , 1MF8 , 1MIK , 1NMK , 1OCA , 1RMH , 1VBS , 1VBT , 1W8L , 1W8M , 1W8V , 1YND , 1ZKF , 2ALF , 2CPL , 2CYH , 2MS4 , 2MZU , 2N0T , 2RMA , 2RMB , 2X25 , 2X2A , 2X2C , 2X2D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00160 Pro_isomerase 7 163 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Domain
Sequence
Sequence length 165
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Viral life cycle - HIV-1
Necroptosis
  Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Basigin interactions
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation