Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54778
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger protein 111
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNF111
Synonyms (NCBI Gene) Gene synonyms aliases
ARK, hRNF111
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.1-q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negativ
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021196 hsa-miR-186-5p Sequencing 20371350
MIRT027713 hsa-miR-98-5p Microarray 19088304
MIRT029993 hsa-miR-26b-5p Microarray 19088304
MIRT031301 hsa-miR-19b-3p Sequencing 20371350
MIRT031911 hsa-miR-16-5p Microarray 21199864
Transcription factors
Transcription factor Regulation Reference
XPC Repression 23751493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IEA
GO:0005515 Function Protein binding IPI 16601693, 19549727, 19690564, 20936779, 21516116, 25260751, 25416956, 29892012, 31515488
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605840 17384 ENSG00000157450
Protein
UniProt ID Q6ZNA4
Protein name E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)
Protein function E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BM
PDB 2KIZ , 5LG0 , 5LG7 , 7P2K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15303 RNF111_N 18 292 E3 ubiquitin-protein ligase Arkadia N-terminus Family
PF13639 zf-RING_2 940 983 Ring finger domain Domain
Tissue specificity TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:14657019}.
Sequence
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKV
GNEFSHLCDDSQKQEKEMNGNQQEQEKSLVVRKKRKSQQAGPSYVQNCVKENQGILGLRQ
HLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKRE
VLARRKYALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSASENHQNNPAVP
SGSIDEDV
VVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSE
QASDTASAVTSSQPSTVSETSATLTSNSTTGTSIGDDSRRTTSSAVTETGPPAMPRLPSC
CPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQQALPVDLSNSGIRSHGSGSFHGASAFDPCCPVSSSRAA
IFGHQAAAAAPSQPLSSIDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRPLHHQ
ASACPHSHGNPPPQTQPPPQVDYVIPHPVHAFHSQISSHATSHPVAPPPPTHLASTAAPI
PQHLPPTHQPISHHIPATAPPAQRLHPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMH
PNYGHGHHIHVPQTMSSHPRQAPERSAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLH
HLQLGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQG
TIERCTYPHKYKKVTTDWFSQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPC
MHLFHQVCVDQWLITNKKCPICR
VDIEAQLPSES
Sequence length 994
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Formation of Incision Complex in GG-NER
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25865352
Jeune thoracic dystrophy Jeune thoracic dystrophy rs137853025, rs137853028, rs137853030, rs137853031, rs137853032, rs431905500, rs201188361, rs587776909, rs397514637, rs431905507, rs199952377, rs431905521, rs587777352, rs750396637, rs755338872
View all (122 more)
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 31213409
Carcinoma Renal Cell Associate 26522722
Eczema Associate 31213409
Neoplasms Associate 26522722, 33000178
Stomach Neoplasms Associate 33000178