Gene Gene information from NCBI Gene database.
Entrez ID 54764
Gene name Zinc finger RANBP2-type containing 1
Gene symbol ZRANB1
Synonyms (NCBI Gene)
TRABID
Chromosome 10
Chromosome location 10q26.13
miRNA miRNA information provided by mirtarbase database.
455
miRTarBase ID miRNA Experiments Reference
MIRT027006 hsa-miR-103a-3p Sequencing 20371350
MIRT030762 hsa-miR-21-5p Microarray 18591254
MIRT031505 hsa-miR-16-5p Sequencing 20371350
MIRT608354 hsa-miR-548ae-3p HITS-CLIP 24906430
MIRT608353 hsa-miR-548ah-3p HITS-CLIP 24906430
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IDA 33637724
GO:0003824 Function Catalytic activity IEA
GO:0004843 Function Cysteine-type deubiquitinase activity IBA
GO:0004843 Function Cysteine-type deubiquitinase activity IDA 18281465, 23827681, 25752573, 25752577
GO:0004843 Function Cysteine-type deubiquitinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611749 18224 ENSG00000019995
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UGI0
Protein name Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)
Protein function Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency com
PDB 3ZRH , 5AF6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00641 zf-RanBP 4 33 Zn-finger in Ran binding protein and others Domain
PF00641 zf-RanBP 149 178 Zn-finger in Ran binding protein and others Domain
PF18418 AnkUBD 246 341 Ankyrin ubiquitin-binding domain Domain
PF02338 OTU 438 586 OTU-like cysteine protease Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11463333}.
Sequence
MSERGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKSGSSDVGRDWDPSSTEG
GSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAIRCTQCLSQRRTRSPTESP
QSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSVCTYENWAKAKRCVVCDHPRPNNI
EAIELAETEEASSIINEQDRARWRGSCSSGNSQRRSPPATKRDSEVKMDFQRIELAGAVG
SKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEV
RLLNRPSAFDVGYTLVHLAIRFQRQDMLAILLTEVSQQAAK
CIPAMVCPELTEQIRREIA
ASLHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINW
SLELATRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLHDCSHWFYTR
WKDWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVY
GVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHF
SALVAMENDGYGNR
GAGANLNTDDDVTITFLPLVDSERKLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGV
LVAMQKSSRRRNHPLVTQMVEKWLDRYRQIRPCTSLSDGEEDEDDEDE
Sequence length 708
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Degradation of beta-catenin by the destruction complex
Ovarian tumor domain proteases
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HEARING LOSS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Chromosomal Instability Associate 37002234
★☆☆☆☆
Found in Text Mining only
Essential Tremor Associate 36183486
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Associate 37002234
★☆☆☆☆
Found in Text Mining only
Recombinant chromosome 8 syndrome Associate 37002234
★☆☆☆☆
Found in Text Mining only
Weight Loss Associate 33082492
★☆☆☆☆
Found in Text Mining only