XAF1 (XIAP associated factor 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 54739 |
| Gene name | XIAP associated factor 1 |
| Gene symbol | XAF1 |
| Synonyms (NCBI Gene) |
BIRC4BPHSXIAPAF1XIAPAF1
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| Chromosome | 17 |
| Chromosome location | 17p13.1 |
| Summary | This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and pro |
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miRNA
miRNA information provided by mirtarbase database.
501
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
1
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6GPH4 | ||||||||||
| Protein name | XIAP-associated factor 1 (BIRC4-binding protein) | ||||||||||
| Protein function | Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-in | ||||||||||
| PDB | 2LXW | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:16343440, ECO:0000269|PubMed:1732 | ||||||||||
| Sequence |
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| Sequence length | 301 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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