XAF1 (XIAP associated factor 1)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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54739 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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XIAP associated factor 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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XAF1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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BIRC4BP, HSXIAPAF1, XIAPAF1 |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17p13.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and pro |
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miRNA
miRNA information provided by mirtarbase database.
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| Transcription factors | |||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q6GPH4 | ||||||||||
| Protein name | XIAP-associated factor 1 (BIRC4-binding protein) | ||||||||||
| Protein function | Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-in | ||||||||||
| PDB | 2LXW | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:16343440, ECO:0000269|PubMed:1732 | ||||||||||
| Sequence |
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| Sequence length | 301 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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