Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54739
Gene name Gene Name - the full gene name approved by the HGNC.
XIAP associated factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
XAF1
Synonyms (NCBI Gene) Gene synonyms aliases
BIRC4BP, HSXIAPAF1, XIAPAF1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and pro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018358 hsa-miR-335-5p Microarray 18185580
MIRT020845 hsa-miR-155-5p Other 20584899
MIRT1495091 hsa-miR-1183 CLIP-seq
MIRT1495092 hsa-miR-1207-5p CLIP-seq
MIRT1495093 hsa-miR-122 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
STAT1 Unknown 18035482
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IC 36394357
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606717 30932 ENSG00000132530
Protein
UniProt ID Q6GPH4
Protein name XIAP-associated factor 1 (BIRC4-binding protein)
Protein function Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-in
PDB 2LXW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18608 XAF1_C 248 301 XIAP-associated factor 1 C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:16343440, ECO:0000269|PubMed:1732
Sequence
MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQVGCT
MCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIM
HRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKK
HFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKNKTLD
PLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNF
S
Sequence length 301
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Interferon alpha/beta signaling
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