Gene Gene information from NCBI Gene database.
Entrez ID 54737
Gene name M-phase phosphoprotein 8
Gene symbol MPHOSPH8
Synonyms (NCBI Gene)
HSMPP8TWA3mpp8
Chromosome 13
Chromosome location 13q12.11
miRNA miRNA information provided by mirtarbase database.
642
miRTarBase ID miRNA Experiments Reference
MIRT030337 hsa-miR-26b-5p Microarray 19088304
MIRT050509 hsa-miR-20a-5p CLASH 23622248
MIRT663250 hsa-miR-34b-3p HITS-CLIP 23313552
MIRT663249 hsa-miR-4695-5p HITS-CLIP 23313552
MIRT663248 hsa-miR-6511a-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IDA 20871592
GO:0000792 Component Heterochromatin IBA
GO:0000792 Component Heterochromatin IDA 20871592, 28581500
GO:0003682 Function Chromatin binding IBA
GO:0003682 Function Chromatin binding IDA 29211708
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611626 29810 ENSG00000196199
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99549
Protein name M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)
Protein function Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HU
PDB 3LWE , 3QO2 , 3R93 , 3SVM , 6V2S , 7M5U , 8QFB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00385 Chromo 59 109 Chromo (CHRromatin Organisation MOdifier) domain Domain
PF12796 Ank_2 570 664 Ankyrin repeats (3 copies) Repeat
Sequence
MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFE
VEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKK
IAENKAKAVRK
DIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKD
KSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT
KTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERA
GQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVP
KKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQ
KRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDD
HKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQL
EWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSS
GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV
NVQQ
SNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLK
NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGI
LLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRL
TEAPSAKVKLLIGAYRVQLQ
Sequence length 860
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinogenesis Associate 33596786
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 22022377, 25870236
★☆☆☆☆
Found in Text Mining only
Osteosarcoma Associate 33596786
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Associate 25870236
★☆☆☆☆
Found in Text Mining only