RBFOX1 (RNA binding fox-1 homolog 1)

Gene

• Entrez ID: 54715
• Gene name: RNA binding fox-1 homolog 1
• Gene symbol: RBFOX1
• Synonyms (NCBI Gene): 2BP1, A2BP1, FOX-1, FOX1, HRNBP1
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of atax

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs145873257	G>A,T	Likely-benign, pathogenic	Coding sequence variant, missense variant, synonymous variant
rs147023054	C>T	Likely-benign, pathogenic	Intron variant
rs372761949	G>A	Pathogenic	Missense variant, coding sequence variant, intron variant
rs974157467	GCTGCC>-,GCTGCCGCTGCC	Pathogenic	Coding sequence variant, inframe deletion, inframe insertion
rs1064794750	C>G,T	Likely-pathogenic	Synonymous variant, genic upstream transcript variant, coding sequence variant, intron variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028610	hsa-miR-30a-5p	Proteomics	18668040
MIRT032440	hsa-let-7b-5p	Proteomics	18668040
MIRT666725	hsa-miR-562	HITS-CLIP	23824327
MIRT666724	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT666723	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT666722	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT666721	hsa-miR-498	HITS-CLIP	23824327
MIRT666720	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT666719	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT666718	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT666717	hsa-miR-1305	HITS-CLIP	23824327
MIRT654401	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT654400	hsa-miR-935	HITS-CLIP	23824327
MIRT654399	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT654397	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT666725	hsa-miR-562	HITS-CLIP	23824327
MIRT666724	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT666723	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT666722	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT666721	hsa-miR-498	HITS-CLIP	23824327
MIRT666720	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT666719	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT666718	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT666717	hsa-miR-1305	HITS-CLIP	23824327
MIRT654401	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT654400	hsa-miR-935	HITS-CLIP	23824327
MIRT654399	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT654397	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT1294186	hsa-miR-129-5p	CLIP-seq
MIRT1294187	hsa-miR-1470	CLIP-seq
MIRT1294188	hsa-miR-3691-5p	CLIP-seq
MIRT1294189	hsa-miR-4446-5p	CLIP-seq
MIRT1294190	hsa-miR-450b-5p	CLIP-seq
MIRT1294191	hsa-miR-4667-3p	CLIP-seq
MIRT1294192	hsa-miR-4755-5p	CLIP-seq
MIRT1294193	hsa-miR-4764-5p	CLIP-seq
MIRT1294194	hsa-miR-507	CLIP-seq
MIRT1294195	hsa-miR-557	CLIP-seq
MIRT1294196	hsa-miR-642a	CLIP-seq
MIRT1294197	hsa-miR-1237	CLIP-seq
MIRT1294198	hsa-miR-1248	CLIP-seq
MIRT1294186	hsa-miR-129-5p	CLIP-seq
MIRT1294199	hsa-miR-2116	CLIP-seq
MIRT1294200	hsa-miR-3122	CLIP-seq
MIRT1294201	hsa-miR-3165	CLIP-seq
MIRT1294202	hsa-miR-324-5p	CLIP-seq
MIRT1294203	hsa-miR-3660	CLIP-seq
MIRT1294188	hsa-miR-3691-5p	CLIP-seq
MIRT1294204	hsa-miR-375	CLIP-seq
MIRT1294205	hsa-miR-3913-5p	CLIP-seq
MIRT1294206	hsa-miR-4256	CLIP-seq
MIRT1294207	hsa-miR-4273	CLIP-seq
MIRT1294208	hsa-miR-450b-3p	CLIP-seq
MIRT1294190	hsa-miR-450b-5p	CLIP-seq
MIRT1294209	hsa-miR-4526	CLIP-seq
MIRT1294210	hsa-miR-4677-5p	CLIP-seq
MIRT1294193	hsa-miR-4764-5p	CLIP-seq
MIRT1294194	hsa-miR-507	CLIP-seq
MIRT1294195	hsa-miR-557	CLIP-seq
MIRT1294211	hsa-miR-769-3p	CLIP-seq
MIRT1294186	hsa-miR-129-5p	CLIP-seq
MIRT2312200	hsa-miR-3978	CLIP-seq
MIRT2312201	hsa-miR-556-3p	CLIP-seq
MIRT2689420	hsa-miR-28-3p	CLIP-seq
MIRT2689421	hsa-miR-4640-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	10814712
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	10814712, 16713569, 24722188, 25416956, 26871637, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10814712
GO:0005737	Component	Cytoplasm	IEA
GO:0005802	Component	Trans-Golgi network	IDA	10814712
GO:0006397	Process	MRNA processing	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0010494	Component	Cytoplasmic stress granule	IDA	29358748
GO:0043484	Process	Regulation of RNA splicing	IEA
GO:0050658	Process	RNA transport	NAS	10814712
GO:0097165	Component	Nuclear stress granule	IDA	29358748

Other IDs

• MIM: 605104
• HGNC: 18222
• e!Ensembl: ENSG00000078328

Protein

• UniProt ID: Q9NWB1
• Protein name: RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1)
• Protein function: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. {ECO:0000269|PubMed:16537540}
• PDB: 2ERR, 2N82, 4ZKA, 7VRL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	119 → 187	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF12414	Fox-1_C	253 → 342	Calcitonin gene-related peptide regulator C terminal	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in muscle and brain.
• Sequence:

  MNCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPE
  HTLNLYPPAQTHSEQSPADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLH
  VSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTV
  VEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPEFYAGTVLLCQANQEGSSM
  YSAPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVY
  QDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHALAPAPTYGVGAMNAF
  APLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY

• Sequence length: 397

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Colorectal cancer	Pathogenic	rs2093621567	RCV001293843
Intellectual disability	Likely pathogenic	rs2510618048	RCV003329103

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Clear cell carcinoma of kidney	Likely benign	rs145873257	RCV005899819
Glioma susceptibility 1	Likely benign	rs371317235	RCV005869858
Idiopathic generalized epilepsy	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	rs998828744, rs766344856, rs750798420, rs113298071, rs371393737, rs769491451, rs905562885, rs372085042, rs1435955739, rs2083432188, rs138704494, rs2094181320, rs2094642843, rs1417087822, rs757319815, rs997305923, rs765974335, rs1242620682, rs139265655, rs752506752, rs751076623, rs1283928972, rs958684686, rs745880431, rs376877653, rs1315127050, rs775977215, rs1268768787, rs768579064, rs759738790, rs776577408, rs372365163, rs771567004, rs775667685, rs1378405539, rs372977736, rs764254377, rs2144803234, rs112339093, rs200198767, rs146803665, rs368442088, rs1159971428, rs781023213, rs2144461588, rs1351528483, rs1193035983, rs2152948676, rs577598050, rs182244522, rs141919506, rs749751319, rs148751394, rs2148629483, rs758714800, rs370887797, rs2152836590, rs1360100229, rs376061440, rs544967209, rs2146427156, rs2146426013, rs774774269, rs763604762, rs1403788049, rs760159651, rs751611395, rs2152958287, rs2152190628, rs1180011308, rs1325337150, rs1240585365, rs780839692, rs1257361531, rs761469568, rs527782263, rs781321986, rs764702003, rs773528139, rs2152189230, rs763620262, rs1352822587, rs780406377, rs2144810454, rs2152958333, rs371603385, rs781701289, rs760593868, rs201242998, rs1013691536, rs2073403458, rs760925781, rs2141262938, rs1603623680, rs774848304, rs765010942, rs781081302, rs2144812486, rs1304807131, rs753108920, rs2076811567, rs2094642630, rs768195911, rs754561652, rs1389613810, rs1196867548, rs766827645, rs1378738998, rs762873223, rs756935023, rs780351349, rs776439789, rs756984329, rs750150151, rs748651106, rs200892489, rs200394869, rs767678711, rs767972090, rs143601277, rs200813556, rs375075227, rs751549203, rs767727470, rs777768764, rs763250831, rs756360831, rs747421844, rs1285678739, rs1263847911, rs751374056, rs2065660205, rs1416883490, rs113881725, rs191016584, rs771443037, rs2302213, rs763792559, rs755253534, rs1347157111, rs2144802781, rs2152948167, rs772354139, rs1327343028, rs1355901802, rs371402357, rs368983711, rs770163669, rs770264923, rs2060799020, rs767190235, rs200846246, rs750342737, rs778547505, rs2083432841, rs759616730, rs2076772204, rs557383173, rs2094642425, rs772780511, rs2548521868, rs750258747, rs757494481, rs1261897218, rs2076793649, rs776368600, rs775318701, rs770947838, rs764886194, rs373349113, rs761520199, rs776822373, rs758785440, rs375042676, rs1006821072, rs542828240, rs371317235, rs1427959997, rs753003961, rs768548714, rs2509609375, rs752967236, rs2065688587, rs1282113144, rs1466309905, rs2509325920, rs1353751760, rs2509346925, rs2548523058, rs2510616894, rs889615462, rs768759230, rs1490574094, rs1351120730, rs749494970, rs745489912, rs754000952, rs780902521, rs766300841, rs371567019, rs777651404, rs776822682, rs1464709105, rs1259585181, rs765695547, rs2144802128, rs2548519268, rs768320667, rs771044128, rs2509879280, rs2509879358, rs757718956, rs1271196293, rs201490398, rs143573994, rs145861898, rs779034823, rs79369633, rs760846272, rs778728291, rs761874772, rs2509359590, rs2510617714, rs768320837, rs774467606, rs1370492285, rs2509825505, rs754708372, rs777211248, rs2508643639, rs746553919, rs1437060269, rs139251660, rs772995775, rs1192003172, rs184452994, rs2548524024, rs2509609326, rs772316128, rs2093615072, rs2510487380, rs2076806935, rs2076811340, rs2548520711, rs1568611039, rs1279254693, rs2509019879, rs2548524000, rs1352846497, rs748882469, rs762735864, rs2507160043, rs2095318021, rs965563468, rs2509879070, rs2509021983, rs768777551, rs2510616525, rs538050088, rs2509610886, rs2548519672, rs1359424859, rs2548519485, rs2548520763, rs1456446298, rs372098682, rs2507169671, rs760390213, rs1048084717, rs777939421, rs368263619, rs758822866, rs887302027, rs567736615, rs765283381, rs1406238959, rs1387893122, rs747612014, rs773859142, rs1465514323, rs1322833083, rs748133904, rs771083814, rs1239197769, rs62010201, rs1057521725, rs61742359, rs1060504699, rs199644500, rs143695164, rs17143930, rs748804086, rs140174146, rs1060504700, rs151214012, rs147023054, rs372761949, rs974157467, rs145873257, rs779418628, rs137880529, rs1555648980, rs761510301, rs150941982, rs376576588, rs1555542676, rs200053144, rs148594771, rs779321097, rs149974858, rs373077021, rs368113568, rs1312874997, rs766496349, rs147525462, rs1555812114, rs761205127, rs1567630819, rs778034989, rs1189994954, rs1567632409, rs146499343, rs1600686165, rs1600687118, rs771438834, rs890155302, rs767345247, rs139929599, rs1597853857, rs147306562, rs147261087, rs202136920, rs772611871, rs372725346, rs774530398, rs759837636, rs757485949, rs1478825837, rs1389267525, rs916986800, rs765683149, rs148909710, rs534312610, rs749403774, rs200006523, rs769265490, rs201549920, rs745729142, rs754737409, rs1217033932, rs1022794718, rs749852826, rs7187508, rs145006582, rs145351963, rs773668882, rs1037124321, rs201282652, rs772109063, rs921443679, rs1387824991, rs2094760665, rs1157311700, rs1312108862, rs767917479, rs200502098, rs535313416, rs369122393, rs2076775196, rs2076823058, rs375723096, rs750747492, rs772231726, rs2095316869, rs2065679298, rs1287710352, rs757066841, rs141994899, rs759654438, rs769785213, rs747242541, rs560607770, rs1597855236	RCV001321209 RCV001312759 RCV001314275 RCV001320553 RCV001313037 RCV001316942 RCV001324413 RCV001326589 RCV001325657 RCV001313482 RCV001317295 RCV001348516 RCV001340816 RCV001350861 RCV001347597 RCV001347389 RCV001368960 RCV001365170 RCV001395694 RCV001413384 RCV001393360 RCV001409004 RCV001393244 RCV001403491 RCV001441020 RCV001444787 RCV001449129 RCV001435445 RCV001447215 RCV001444658 RCV001444343 RCV001440288 RCV001451044 RCV001475432 RCV001469485 RCV001469686 RCV001453258 RCV001477078 RCV001469505 RCV001477224 RCV001450589 RCV001472724 RCV001501138 RCV001492546 RCV001500339 RCV001482634 RCV001480653 RCV001496980 RCV001497527 RCV001494701 RCV001496165 RCV001487907 RCV001513768 RCV002004464 RCV001922104 RCV002038973 RCV002039134 RCV001967915 RCV001972873 RCV001991621 RCV001864890 RCV002034392 RCV001934475 RCV001932054 RCV001905969 RCV002037062 RCV001891138 RCV001929979 RCV002044613 RCV002044683 RCV001896210 RCV001945700 RCV002047973 RCV001951806 RCV001955270 RCV001891393 RCV001872872 RCV002046271 RCV001870102 RCV001957887 RCV001986832 RCV002016722 RCV002044313 RCV001878512 RCV001932842 RCV001964697 RCV001871181 RCV001901424 RCV001927632 RCV001909079 RCV001898801 RCV002005922 RCV002045640 RCV001948591 RCV002020776 RCV001918377 RCV001903657 RCV002029575 RCV001935773 RCV001962387 RCV001983123 RCV002039800 RCV001892368 RCV001920349 RCV001916314 RCV001940112 RCV002038645 RCV002043946 RCV002189904 RCV002182407 RCV002137829 RCV002174832 RCV002082441 RCV002071358 RCV002175152 RCV002190577 RCV002164443 RCV002103311 RCV002130215 RCV002164873 RCV002161076 RCV002161222 RCV002166024 RCV002190874 RCV002130011 RCV002172524 RCV002160188 RCV002102780 RCV002200249 RCV002115307 RCV002096103 RCV002209189 RCV002204823 RCV002086215 RCV002112706 RCV002193872 RCV002209962 RCV002210057 RCV002097910 RCV002097939 RCV002199994 RCV002166905 RCV002208675 RCV002130370 RCV002142997 RCV002182300 RCV002075992 RCV002159630 RCV002181949 RCV002205294 RCV002219382 RCV002095289 RCV002203795 RCV002217810 RCV002211545 RCV002165371 RCV002190988 RCV002170955 RCV002089450 RCV002295783 RCV002295009 RCV003071595 RCV003056701 RCV003060277 RCV003077296 RCV003093422 RCV003072993 RCV003071985 RCV003089434 RCV002588177 RCV003090548 RCV002620089 RCV002638004 RCV002629558 RCV002638385 RCV002632978 RCV002640517 RCV002654757 RCV002624377 RCV002651855 RCV003108436 RCV002573986 RCV002576955 RCV002580386 RCV002601593 RCV002638851 RCV002671664 RCV002714905 RCV002710132 RCV002694982 RCV002686030 RCV002710548 RCV002691153 RCV002815605 RCV002815050 RCV002839064 RCV002851486 RCV002890995 RCV002885578 RCV002882187 RCV002919092 RCV002947775 RCV002947894 RCV002909398 RCV002927718 RCV002928170 RCV002928211 RCV002972001 RCV002962374 RCV002967756 RCV002999137 RCV003033663 RCV003006286 RCV003046336 RCV003017542 RCV003042656 RCV003057639 RCV003030219 RCV003053497 RCV003036316 RCV003052547 RCV003049962 RCV000227343 RCV000231227 RCV001086644 RCV000227797 RCV000233569 RCV005101221 RCV005102624 RCV005104105 RCV003525576 RCV003525658 RCV003525422 RCV003525647 RCV003525773 RCV003526719 RCV003525700 RCV003525763 RCV003526661 RCV003525783 RCV003525816 RCV003526656 RCV003526812 RCV003526819 RCV003526899 RCV003527009 RCV003526797 RCV003526876 RCV003527408 RCV003527326 RCV003526384 RCV003526259 RCV003526352 RCV003526457 RCV003639390 RCV003639463 RCV003639507 RCV003639509 RCV003639537 RCV003639650 RCV003639599 RCV003639743 RCV003639669 RCV003639955 RCV003639853 RCV003639942 RCV003639780 RCV003639823 RCV003640015 RCV003640038 RCV003640083 RCV003640084 RCV003640027 RCV003640201 RCV003640301 RCV003640358 RCV003638149 RCV003638307 RCV003638254 RCV003638323 RCV003638292 RCV003638294 RCV003638506 RCV003638444 RCV003638439 RCV003638412 RCV003638414 RCV003638453 RCV003639131 RCV003639176 RCV003639178 RCV003639196 RCV003639311 RCV003639333 RCV003639334 RCV003810857 RCV003836942 RCV003858333 RCV003859655 RCV003863787 RCV003866606 RCV003860160 RCV003875885 RCV003869780 RCV003878797 RCV003638654 RCV000459810 RCV000475990 RCV000462760 RCV000474526 RCV000471744 RCV001084850 RCV000461385 RCV000468947 RCV000476755 RCV000462654 RCV001471417 RCV000476699 RCV000473773 RCV001857032 RCV003638673 RCV001080369 RCV001061679 RCV000537804 RCV000543107 RCV000548157 RCV000536907 RCV000557941 RCV000529151 RCV000558134 RCV000533056 RCV000544023 RCV000634987 RCV000634995 RCV000634990 RCV000634976 RCV000634975 RCV000634977 RCV002060728 RCV000634981 RCV000634970 RCV000634972 RCV000634994 RCV000634973 RCV000634974 RCV000705424 RCV000696077 RCV000706404 RCV000706071 RCV000698463 RCV000685462 RCV000699976 RCV000694824 RCV000812474 RCV000803953 RCV000793535 RCV000820568 RCV000824646 RCV000820743 RCV000796549 RCV000813593 RCV000802765 RCV000805004 RCV000863008 RCV000862974 RCV000861554 RCV000862653 RCV000864060 RCV000863259 RCV002064584 RCV001498321 RCV000869413 RCV001451544 RCV001475427 RCV002064647 RCV000868333 RCV000870441 RCV001443896 RCV000871635 RCV002547177 RCV001413049 RCV000966691 RCV000909290 RCV001497593 RCV000936282 RCV000937016 RCV001430122 RCV000936271 RCV001506296 RCV000989518 RCV003639296 RCV001050203 RCV001044775 RCV001035472 RCV001043502 RCV001037186 RCV001071950 RCV001047207 RCV001069866 RCV001215877 RCV001214938 RCV001218689 RCV001208399 RCV001208400 RCV001210431 RCV001206022 RCV001207597 RCV001211549 RCV001218802 RCV001225931 RCV001226307 RCV001234860 RCV001226638 RCV001237735 RCV001232346 RCV001244841 RCV001242813 RCV001245835 RCV001294656 RCV001306314 RCV001302962 RCV001308394
Intellectual disability, autosomal dominant 46	Conflicting classifications of pathogenicity	rs1057521725	RCV005860077
Lung cancer	Likely benign	rs371317235, rs145873257	RCV005869859 RCV005899821
Malignant tumor of esophagus	Likely benign	rs145873257	RCV005899818
Neurodevelopmental disorder	Conflicting classifications of pathogenicity	rs1057521725	RCV006249633
Ovarian serous cystadenocarcinoma	Likely benign	rs145873257	RCV005899820
RBFOX1-related disorder	Likely benign; Conflicting classifications of pathogenicity; Uncertain significance; Benign	rs372365163, rs577598050, rs141919506, rs2152190628, rs1352822587, rs763792559, rs371317235, rs371567019, rs779034823, rs79369633, rs1165813698, rs1799717079, rs538050088, rs928189351, rs772780511, rs748804086, rs151214012, rs145873257, rs137880529, rs113881725, rs757485949	RCV003955960 RCV003956097 RCV003416363 RCV003401773 RCV003968599 RCV003911198 RCV003916483 RCV003936416 RCV003939897 RCV003977691 RCV003414371 RCV003904550 RCV003901831 RCV003899849 RCV003971510 RCV003960094 RCV003960034 RCV003915357 RCV003962486 RCV003960278 RCV003955648
Self-limited epilepsy with centrotemporal spikes	Likely benign; Uncertain significance	rs147023054, rs372761949, rs974157467, rs145873257	RCV000656039 RCV000656038 RCV000656040 RCV000656041

Associations from Text Mining
Disease Name	Relationship Type	References
16p11.2 Deletion Syndrome	Inhibit	37903506
Adenocarcinoma Mucinous	Associate	37768171
Adenoma	Associate	23301059
Alcoholism	Associate	31294817
Alzheimer Disease	Associate	35627222
Arthritis Rheumatoid	Associate	30423114
Attention Deficit Disorder with Hyperactivity	Associate	19546859, 22678932
Autism Spectrum Disorder	Associate	21614001, 22730494, 22952857, 32081867
Autistic Disorder	Associate	19546859, 21614001, 22678932, 23575222, 26174448, 27260404, 31294817, 34535545, 37903506
Bipolar Disorder	Associate	19567891, 39999946
Breast Neoplasms	Associate	25823661
Carcinogenesis	Associate	23301059
Carcinoma Hepatocellular	Associate	23236287
Carotid Stenosis	Associate	21309755
Cognition Disorders	Associate	22678932
Colorectal Neoplasms	Associate	23286373, 26222184
Dementia	Associate	37420130
Dermatitis Exfoliative	Associate	25950944, 28756411
Developmental Disabilities	Associate	23602712
Disease	Associate	22730494, 27264186
Epilepsies Partial	Associate	26174448
Epilepsy	Associate	23350840, 25950944, 26174448, 28756411
Epilepsy Idiopathic Generalized	Associate	23350840, 24039908, 25243798, 26174448
Epilepsy Rolandic	Associate	24039908, 26174448
Epilepsy Temporal Lobe	Associate	25243798, 26174448
Essential Tremor	Associate	36183486
Glioma	Associate	18474104
Heroin Dependence	Associate	31294817
Heterotaxy Syndrome	Associate	27637763
Hippocampal Sclerosis	Associate	26174448
Language Disorders	Associate	23602712
Liver Cirrhosis Biliary	Associate	20153395
Lung Neoplasms	Associate	31512508
Mental Disorders	Associate	23350840, 25950944, 39674387
Mesothelioma Malignant	Associate	23830731
Motor Neuron Disease	Associate	37903506
Muscular Atrophy Spinal	Associate	19396477
Myopia	Associate	27611182, 36395078
Neoplasms	Associate	18474104, 30984543
Neoplasms	Inhibit	23286373, 23830731
Neuralgia	Associate	39674387
Obesity	Associate	30547318, 37500688
Obesity Morbid	Associate	31852448
Osteoarthritis	Associate	19508968
Pain	Associate	39674387
Paresis	Associate	22678932
Parkinson Disease	Associate	27264186
Periodontitis	Associate	30547318
Prader Willi Syndrome	Associate	34535545
Pseudomyxoma Peritonei	Associate	37768171
Psychotic Disorders	Associate	19567891
Sarcoma Endometrial Stromal	Associate	38167455
Schizophrenia	Associate	19546859, 22952857, 30597088, 31294817, 36833409, 39999946
Seizures	Associate	23350840
Stomach Neoplasms	Associate	20331625
Tobacco Use Disorder	Associate	31294817
Tourette Syndrome	Associate	19546859