PPAT (phosphoribosyl pyrophosphate amidotransferase)

Gene

• Entrez ID: 5471
• Gene name: Phosphoribosyl pyrophosphate amidotransferase
• Gene symbol: PPAT
• Synonyms (NCBI Gene): ATASE, GPAT, PRAT
• Chromosome: 4
• Chromosome location: 4q12
• Summary: The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a b

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005010	hsa-miR-125b-5p	Microarray	17891175
MIRT024474	hsa-miR-215-5p	Microarray	19074876
MIRT026845	hsa-miR-192-5p	Microarray	19074876
MIRT027826	hsa-miR-98-5p	Microarray	19088304
MIRT030142	hsa-miR-26b-5p	Microarray	19088304
MIRT039332	hsa-miR-425-5p	CLASH	23622248
MIRT1252088	hsa-let-7a	CLIP-seq
MIRT1252089	hsa-let-7b	CLIP-seq
MIRT1252090	hsa-let-7c	CLIP-seq
MIRT1252091	hsa-let-7d	CLIP-seq
MIRT1252092	hsa-let-7e	CLIP-seq
MIRT1252093	hsa-let-7f	CLIP-seq
MIRT1252094	hsa-let-7g	CLIP-seq
MIRT1252095	hsa-let-7i	CLIP-seq
MIRT1252096	hsa-miR-105	CLIP-seq
MIRT1252097	hsa-miR-1183	CLIP-seq
MIRT1252098	hsa-miR-1184	CLIP-seq
MIRT1252099	hsa-miR-1197	CLIP-seq
MIRT1252100	hsa-miR-1205	CLIP-seq
MIRT1252101	hsa-miR-1246	CLIP-seq
MIRT1252102	hsa-miR-1256	CLIP-seq
MIRT1252103	hsa-miR-1273f	CLIP-seq
MIRT1252104	hsa-miR-128	CLIP-seq
MIRT1252105	hsa-miR-132	CLIP-seq
MIRT1252106	hsa-miR-139-5p	CLIP-seq
MIRT1252107	hsa-miR-144	CLIP-seq
MIRT1252108	hsa-miR-1827	CLIP-seq
MIRT1252109	hsa-miR-194	CLIP-seq
MIRT1252110	hsa-miR-200b	CLIP-seq
MIRT1252111	hsa-miR-200c	CLIP-seq
MIRT1252112	hsa-miR-202	CLIP-seq
MIRT1252113	hsa-miR-203	CLIP-seq
MIRT1252114	hsa-miR-208a	CLIP-seq
MIRT1252115	hsa-miR-208b	CLIP-seq
MIRT1252116	hsa-miR-21	CLIP-seq
MIRT1252117	hsa-miR-2110	CLIP-seq
MIRT1252118	hsa-miR-212	CLIP-seq
MIRT1252119	hsa-miR-219-1-3p	CLIP-seq
MIRT1252120	hsa-miR-224	CLIP-seq
MIRT1252121	hsa-miR-23a	CLIP-seq
MIRT1252122	hsa-miR-23b	CLIP-seq
MIRT1252123	hsa-miR-23c	CLIP-seq
MIRT1252124	hsa-miR-24	CLIP-seq
MIRT1252125	hsa-miR-25	CLIP-seq
MIRT1252126	hsa-miR-27a	CLIP-seq
MIRT1252127	hsa-miR-27b	CLIP-seq
MIRT1252128	hsa-miR-299-3p	CLIP-seq
MIRT1252129	hsa-miR-3064-3p	CLIP-seq
MIRT1252130	hsa-miR-3117-3p	CLIP-seq
MIRT1252131	hsa-miR-3117-5p	CLIP-seq
MIRT1252132	hsa-miR-3121-3p	CLIP-seq
MIRT1252133	hsa-miR-3127-5p	CLIP-seq
MIRT1252134	hsa-miR-3137	CLIP-seq
MIRT1252135	hsa-miR-3150a-3p	CLIP-seq
MIRT1252136	hsa-miR-3151	CLIP-seq
MIRT1252137	hsa-miR-3156-5p	CLIP-seq
MIRT1252138	hsa-miR-3158-5p	CLIP-seq
MIRT1252139	hsa-miR-3175	CLIP-seq
MIRT1252140	hsa-miR-32	CLIP-seq
MIRT1252141	hsa-miR-3200-5p	CLIP-seq
MIRT1252142	hsa-miR-338-5p	CLIP-seq
MIRT1252143	hsa-miR-3617	CLIP-seq
MIRT1252144	hsa-miR-3618	CLIP-seq
MIRT1252145	hsa-miR-363	CLIP-seq
MIRT1252146	hsa-miR-3658	CLIP-seq
MIRT1252147	hsa-miR-367	CLIP-seq
MIRT1252148	hsa-miR-3671	CLIP-seq
MIRT1252149	hsa-miR-369-3p	CLIP-seq
MIRT1252150	hsa-miR-371-5p	CLIP-seq
MIRT1252151	hsa-miR-371b-5p	CLIP-seq
MIRT1252152	hsa-miR-374a	CLIP-seq
MIRT1252153	hsa-miR-374b	CLIP-seq
MIRT1252154	hsa-miR-378	CLIP-seq
MIRT1252155	hsa-miR-378b	CLIP-seq
MIRT1252156	hsa-miR-378c	CLIP-seq
MIRT1252157	hsa-miR-378d	CLIP-seq
MIRT1252158	hsa-miR-378e	CLIP-seq
MIRT1252159	hsa-miR-378f	CLIP-seq
MIRT1252160	hsa-miR-378h	CLIP-seq
MIRT1252161	hsa-miR-378i	CLIP-seq
MIRT1252162	hsa-miR-3918	CLIP-seq
MIRT1252163	hsa-miR-3974	CLIP-seq
MIRT1252164	hsa-miR-3975	CLIP-seq
MIRT1252165	hsa-miR-422a	CLIP-seq
MIRT1252166	hsa-miR-425	CLIP-seq
MIRT1252167	hsa-miR-4256	CLIP-seq
MIRT1252168	hsa-miR-4263	CLIP-seq
MIRT1252169	hsa-miR-4265	CLIP-seq
MIRT1252170	hsa-miR-4271	CLIP-seq
MIRT1252171	hsa-miR-4272	CLIP-seq
MIRT1252172	hsa-miR-4284	CLIP-seq
MIRT1252173	hsa-miR-429	CLIP-seq
MIRT1252174	hsa-miR-4296	CLIP-seq
MIRT1252175	hsa-miR-4305	CLIP-seq
MIRT1252176	hsa-miR-4311	CLIP-seq
MIRT1252177	hsa-miR-4322	CLIP-seq
MIRT1252178	hsa-miR-4417	CLIP-seq
MIRT1252179	hsa-miR-4422	CLIP-seq
MIRT1252180	hsa-miR-4447	CLIP-seq
MIRT1252181	hsa-miR-4458	CLIP-seq
MIRT1252182	hsa-miR-4470	CLIP-seq
MIRT1252183	hsa-miR-4472	CLIP-seq
MIRT1252184	hsa-miR-4477a	CLIP-seq
MIRT1252185	hsa-miR-4500	CLIP-seq
MIRT1252186	hsa-miR-4517	CLIP-seq
MIRT1252187	hsa-miR-4638-3p	CLIP-seq
MIRT1252188	hsa-miR-4649-3p	CLIP-seq
MIRT1252189	hsa-miR-4663	CLIP-seq
MIRT1252190	hsa-miR-4668-3p	CLIP-seq
MIRT1252191	hsa-miR-4694-3p	CLIP-seq
MIRT1252192	hsa-miR-4719	CLIP-seq
MIRT1252193	hsa-miR-4725-3p	CLIP-seq
MIRT1252194	hsa-miR-4727-5p	CLIP-seq
MIRT1252195	hsa-miR-4732-5p	CLIP-seq
MIRT1252196	hsa-miR-4733-5p	CLIP-seq
MIRT1252197	hsa-miR-4738-3p	CLIP-seq
MIRT1252198	hsa-miR-4762-5p	CLIP-seq
MIRT1252199	hsa-miR-4769-3p	CLIP-seq
MIRT1252200	hsa-miR-4786-3p	CLIP-seq
MIRT1252201	hsa-miR-4795-3p	CLIP-seq
MIRT1252202	hsa-miR-4799-5p	CLIP-seq
MIRT1252203	hsa-miR-491-5p	CLIP-seq
MIRT1252204	hsa-miR-499-3p	CLIP-seq
MIRT1252205	hsa-miR-499-5p	CLIP-seq
MIRT1252206	hsa-miR-499a-3p	CLIP-seq
MIRT1252207	hsa-miR-511	CLIP-seq
MIRT1252208	hsa-miR-513b	CLIP-seq
MIRT1252209	hsa-miR-518a-5p	CLIP-seq
MIRT1252210	hsa-miR-522	CLIP-seq
MIRT1252211	hsa-miR-527	CLIP-seq
MIRT1252212	hsa-miR-548g	CLIP-seq
MIRT1252213	hsa-miR-548l	CLIP-seq
MIRT1252214	hsa-miR-548n	CLIP-seq
MIRT1252215	hsa-miR-570	CLIP-seq
MIRT1252216	hsa-miR-571	CLIP-seq
MIRT1252217	hsa-miR-576-5p	CLIP-seq
MIRT1252218	hsa-miR-582-5p	CLIP-seq
MIRT1252219	hsa-miR-590-5p	CLIP-seq
MIRT1252220	hsa-miR-605	CLIP-seq
MIRT1252221	hsa-miR-606	CLIP-seq
MIRT1252222	hsa-miR-607	CLIP-seq
MIRT1252223	hsa-miR-628-5p	CLIP-seq
MIRT1252224	hsa-miR-630	CLIP-seq
MIRT1252225	hsa-miR-641	CLIP-seq
MIRT1252226	hsa-miR-651	CLIP-seq
MIRT1252227	hsa-miR-671-5p	CLIP-seq
MIRT1252228	hsa-miR-7	CLIP-seq
MIRT1252229	hsa-miR-802	CLIP-seq
MIRT1252230	hsa-miR-92a	CLIP-seq
MIRT1252231	hsa-miR-92b	CLIP-seq
MIRT1252232	hsa-miR-934	CLIP-seq
MIRT1252233	hsa-miR-935	CLIP-seq
MIRT1252234	hsa-miR-939	CLIP-seq
MIRT1252235	hsa-miR-944	CLIP-seq
MIRT1252236	hsa-miR-98	CLIP-seq
MIRT1252096	hsa-miR-105	CLIP-seq
MIRT1252104	hsa-miR-128	CLIP-seq
MIRT1252107	hsa-miR-144	CLIP-seq
MIRT1252108	hsa-miR-1827	CLIP-seq
MIRT1252117	hsa-miR-2110	CLIP-seq
MIRT1252121	hsa-miR-23a	CLIP-seq
MIRT1252122	hsa-miR-23b	CLIP-seq
MIRT1252123	hsa-miR-23c	CLIP-seq
MIRT1252125	hsa-miR-25	CLIP-seq
MIRT1252126	hsa-miR-27a	CLIP-seq
MIRT1252127	hsa-miR-27b	CLIP-seq
MIRT1252128	hsa-miR-299-3p	CLIP-seq
MIRT1252131	hsa-miR-3117-5p	CLIP-seq
MIRT2074294	hsa-miR-3148	CLIP-seq
MIRT1252136	hsa-miR-3151	CLIP-seq
MIRT1252140	hsa-miR-32	CLIP-seq
MIRT1252145	hsa-miR-363	CLIP-seq
MIRT1252147	hsa-miR-367	CLIP-seq
MIRT1252149	hsa-miR-369-3p	CLIP-seq
MIRT1252152	hsa-miR-374a	CLIP-seq
MIRT1252153	hsa-miR-374b	CLIP-seq
MIRT1252166	hsa-miR-425	CLIP-seq
MIRT1252170	hsa-miR-4271	CLIP-seq
MIRT1252179	hsa-miR-4422	CLIP-seq
MIRT1252180	hsa-miR-4447	CLIP-seq
MIRT1252183	hsa-miR-4472	CLIP-seq
MIRT2074295	hsa-miR-4496	CLIP-seq
MIRT1252188	hsa-miR-4649-3p	CLIP-seq
MIRT1252192	hsa-miR-4719	CLIP-seq
MIRT1252193	hsa-miR-4725-3p	CLIP-seq
MIRT1252197	hsa-miR-4738-3p	CLIP-seq
MIRT1252198	hsa-miR-4762-5p	CLIP-seq
MIRT1252201	hsa-miR-4795-3p	CLIP-seq
MIRT1252203	hsa-miR-491-5p	CLIP-seq
MIRT2074296	hsa-miR-5096	CLIP-seq
MIRT2074297	hsa-miR-513a-5p	CLIP-seq
MIRT2074298	hsa-miR-520d-5p	CLIP-seq
MIRT2074299	hsa-miR-524-5p	CLIP-seq
MIRT2074300	hsa-miR-548ae	CLIP-seq
MIRT2074301	hsa-miR-548aj	CLIP-seq
MIRT2074302	hsa-miR-548am	CLIP-seq
MIRT1252213	hsa-miR-548l	CLIP-seq
MIRT1252214	hsa-miR-548n	CLIP-seq
MIRT2074303	hsa-miR-548x	CLIP-seq
MIRT2074304	hsa-miR-554	CLIP-seq
MIRT1252230	hsa-miR-92a	CLIP-seq
MIRT1252231	hsa-miR-92b	CLIP-seq
MIRT1252235	hsa-miR-944	CLIP-seq
MIRT1252088	hsa-let-7a	CLIP-seq
MIRT1252089	hsa-let-7b	CLIP-seq
MIRT1252090	hsa-let-7c	CLIP-seq
MIRT1252091	hsa-let-7d	CLIP-seq
MIRT1252092	hsa-let-7e	CLIP-seq
MIRT1252093	hsa-let-7f	CLIP-seq
MIRT1252094	hsa-let-7g	CLIP-seq
MIRT1252095	hsa-let-7i	CLIP-seq
MIRT1252096	hsa-miR-105	CLIP-seq
MIRT1252097	hsa-miR-1183	CLIP-seq
MIRT1252104	hsa-miR-128	CLIP-seq
MIRT1252107	hsa-miR-144	CLIP-seq
MIRT1252108	hsa-miR-1827	CLIP-seq
MIRT1252112	hsa-miR-202	CLIP-seq
MIRT1252117	hsa-miR-2110	CLIP-seq
MIRT1252120	hsa-miR-224	CLIP-seq
MIRT1252121	hsa-miR-23a	CLIP-seq
MIRT1252122	hsa-miR-23b	CLIP-seq
MIRT1252123	hsa-miR-23c	CLIP-seq
MIRT1252125	hsa-miR-25	CLIP-seq
MIRT1252126	hsa-miR-27a	CLIP-seq
MIRT1252127	hsa-miR-27b	CLIP-seq
MIRT1252128	hsa-miR-299-3p	CLIP-seq
MIRT1252136	hsa-miR-3151	CLIP-seq
MIRT1252140	hsa-miR-32	CLIP-seq
MIRT1252145	hsa-miR-363	CLIP-seq
MIRT1252147	hsa-miR-367	CLIP-seq
MIRT1252149	hsa-miR-369-3p	CLIP-seq
MIRT1252152	hsa-miR-374a	CLIP-seq
MIRT1252153	hsa-miR-374b	CLIP-seq
MIRT2301280	hsa-miR-3910	CLIP-seq
MIRT1252163	hsa-miR-3974	CLIP-seq
MIRT1252164	hsa-miR-3975	CLIP-seq
MIRT1252170	hsa-miR-4271	CLIP-seq
MIRT1252171	hsa-miR-4272	CLIP-seq
MIRT1252175	hsa-miR-4305	CLIP-seq
MIRT1252179	hsa-miR-4422	CLIP-seq
MIRT1252180	hsa-miR-4447	CLIP-seq
MIRT1252181	hsa-miR-4458	CLIP-seq
MIRT1252183	hsa-miR-4472	CLIP-seq
MIRT1252184	hsa-miR-4477a	CLIP-seq
MIRT1252185	hsa-miR-4500	CLIP-seq
MIRT1252188	hsa-miR-4649-3p	CLIP-seq
MIRT1252192	hsa-miR-4719	CLIP-seq
MIRT1252193	hsa-miR-4725-3p	CLIP-seq
MIRT1252195	hsa-miR-4732-5p	CLIP-seq
MIRT1252196	hsa-miR-4733-5p	CLIP-seq
MIRT1252197	hsa-miR-4738-3p	CLIP-seq
MIRT1252200	hsa-miR-4786-3p	CLIP-seq
MIRT1252201	hsa-miR-4795-3p	CLIP-seq
MIRT1252203	hsa-miR-491-5p	CLIP-seq
MIRT2074296	hsa-miR-5096	CLIP-seq
MIRT2074297	hsa-miR-513a-5p	CLIP-seq
MIRT2074298	hsa-miR-520d-5p	CLIP-seq
MIRT2074299	hsa-miR-524-5p	CLIP-seq
MIRT2074300	hsa-miR-548ae	CLIP-seq
MIRT2074301	hsa-miR-548aj	CLIP-seq
MIRT2074302	hsa-miR-548am	CLIP-seq
MIRT1252214	hsa-miR-548n	CLIP-seq
MIRT2074303	hsa-miR-548x	CLIP-seq
MIRT1252220	hsa-miR-605	CLIP-seq
MIRT1252221	hsa-miR-606	CLIP-seq
MIRT1252224	hsa-miR-630	CLIP-seq
MIRT1252227	hsa-miR-671-5p	CLIP-seq
MIRT1252230	hsa-miR-92a	CLIP-seq
MIRT1252231	hsa-miR-92b	CLIP-seq
MIRT1252235	hsa-miR-944	CLIP-seq
MIRT1252236	hsa-miR-98	CLIP-seq
MIRT1252104	hsa-miR-128	CLIP-seq
MIRT1252107	hsa-miR-144	CLIP-seq
MIRT1252126	hsa-miR-27a	CLIP-seq
MIRT1252127	hsa-miR-27b	CLIP-seq
MIRT1252201	hsa-miR-4795-3p	CLIP-seq
MIRT2074298	hsa-miR-520d-5p	CLIP-seq
MIRT2074299	hsa-miR-524-5p	CLIP-seq
MIRT1252104	hsa-miR-128	CLIP-seq
MIRT1252107	hsa-miR-144	CLIP-seq
MIRT1252126	hsa-miR-27a	CLIP-seq
MIRT1252127	hsa-miR-27b	CLIP-seq
MIRT1252201	hsa-miR-4795-3p	CLIP-seq
MIRT2074298	hsa-miR-520d-5p	CLIP-seq
MIRT2074299	hsa-miR-524-5p	CLIP-seq
MIRT2456988	hsa-miR-3622a-3p	CLIP-seq
MIRT2456989	hsa-miR-3622b-3p	CLIP-seq
MIRT2456990	hsa-miR-431	CLIP-seq
MIRT2456991	hsa-miR-4421	CLIP-seq
MIRT2456992	hsa-miR-4642	CLIP-seq
MIRT2597975	hsa-miR-1276	CLIP-seq
MIRT1252128	hsa-miR-299-3p	CLIP-seq
MIRT1252129	hsa-miR-3064-3p	CLIP-seq
MIRT1252141	hsa-miR-3200-5p	CLIP-seq
MIRT1252149	hsa-miR-369-3p	CLIP-seq
MIRT1252152	hsa-miR-374a	CLIP-seq
MIRT1252153	hsa-miR-374b	CLIP-seq
MIRT1252167	hsa-miR-4256	CLIP-seq
MIRT1252169	hsa-miR-4265	CLIP-seq
MIRT2597976	hsa-miR-4282	CLIP-seq
MIRT1252174	hsa-miR-4296	CLIP-seq
MIRT1252176	hsa-miR-4311	CLIP-seq
MIRT1252177	hsa-miR-4322	CLIP-seq
MIRT1252178	hsa-miR-4417	CLIP-seq
MIRT1252179	hsa-miR-4422	CLIP-seq
MIRT1252186	hsa-miR-4517	CLIP-seq
MIRT2456992	hsa-miR-4642	CLIP-seq
MIRT2597977	hsa-miR-4698	CLIP-seq
MIRT2597978	hsa-miR-583	CLIP-seq
MIRT2597979	hsa-miR-590-3p	CLIP-seq
MIRT2597975	hsa-miR-1276	CLIP-seq
MIRT1252128	hsa-miR-299-3p	CLIP-seq
MIRT1252129	hsa-miR-3064-3p	CLIP-seq
MIRT1252141	hsa-miR-3200-5p	CLIP-seq
MIRT1252167	hsa-miR-4256	CLIP-seq
MIRT1252169	hsa-miR-4265	CLIP-seq
MIRT2597976	hsa-miR-4282	CLIP-seq
MIRT1252174	hsa-miR-4296	CLIP-seq
MIRT1252176	hsa-miR-4311	CLIP-seq
MIRT1252177	hsa-miR-4322	CLIP-seq
MIRT1252178	hsa-miR-4417	CLIP-seq
MIRT2597977	hsa-miR-4698	CLIP-seq
MIRT2597978	hsa-miR-583	CLIP-seq
MIRT2597979	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004044	Function	Amidophosphoribosyltransferase activity	IBA
GO:0004044	Function	Amidophosphoribosyltransferase activity	IEA
GO:0004044	Function	Amidophosphoribosyltransferase activity	TAS	8106516
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA
GO:0006164	Process	Purine nucleotide biosynthetic process	IEA
GO:0006164	Process	Purine nucleotide biosynthetic process	TAS	8106516
GO:0006177	Process	GMP biosynthetic process	IEA
GO:0006189	Process	'de novo' IMP biosynthetic process	IEA
GO:0009113	Process	Purine nucleobase biosynthetic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0044208	Process	'de novo' AMP biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0097294	Process	'de novo' XMP biosynthetic process	IEA

Other IDs

• MIM: 172450
• HGNC: 9238
• e!Ensembl: ENSG00000128059

Protein

• UniProt ID: Q06203
• Protein name: Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)
• Protein function: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13522	GATase_6	64 → 216		Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:8380692}.
• Sequence:

  MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPT
  FKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVA
  HNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEA
  PTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFL
  SIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVY
  TVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQP
  NMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASP
  PIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKE
  KKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW

• Sequence length: 517

Pathways

KEGG:

Purine metabolism
Alanine, aspartate and glutamate metabolism
Metabolic pathways

Reactome:

Purine ribonucleoside monophosphate biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adenocarcinoma of Lung	Associate	39735553	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	30463022	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	33407546	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	35798250	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	20459617	★☆☆☆☆ Found in Text Mining only
Diabetic Foot	Associate	38287255	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	32256495	★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum	Associate	8512814	★☆☆☆☆ Found in Text Mining only