Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54700
Gene name Gene Name - the full gene name approved by the HGNC.
RNA polymerase I transcription factor RRN3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RRN3
Synonyms (NCBI Gene) Gene synonyms aliases
A-270G1.2, TIFIA
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028106 hsa-miR-93-5p Sequencing 20371350
MIRT045801 hsa-miR-191-5p CLASH 23622248
MIRT554563 hsa-miR-3609 PAR-CLIP 21572407
MIRT554562 hsa-miR-548ah-5p PAR-CLIP 21572407
MIRT554561 hsa-miR-106a-5p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001042 Function RNA polymerase I core binding IBA 21873635
GO:0001164 Function RNA polymerase I core promoter sequence-specific DNA binding IDA 22368283
GO:0001181 Function RNA polymerase I general transcription initiation factor activity IBA 21873635
GO:0001188 Process RNA polymerase I preinitiation complex assembly IEA
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605121 30346 ENSG00000085721
Protein
UniProt ID Q9NYV6
Protein name RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)
Protein function Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:112
PDB 7OBA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05327 RRN3 50 586 RNA polymerase I specific transcription initiation factor RRN3 Family
Sequence
Sequence length 651
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 27485818
Gallbladder Neoplasms Associate 31752867
Leukemia Myeloid Acute Associate 24850755
Medulloblastoma Associate 30901604
Neoplasms Associate 26506235, 32577795
von Willebrand Disease Type 2 Associate 32577795