CROT (carnitine O-octanoyltransferase)

Gene

• Entrez ID: 54677
• Gene name: Carnitine O-octanoyltransferase
• Gene symbol: CROT
• Synonyms (NCBI Gene): COT
• Chromosome: 7
• Chromosome location: 7q21.12
• Summary: This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007354	hsa-miR-33a-5p	Immunofluorescence, Luciferase reporter assay, Western blot	23547260
MIRT020476	hsa-miR-106b-5p	Microarray	17242205
MIRT046842	hsa-miR-221-3p	CLASH	23622248
MIRT440875	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT020476	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT222908	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440875	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT020476	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT222907	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT222917	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT222909	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT222927	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT222908	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT007354	hsa-miR-33a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27199118
MIRT735940	hsa-miR-33b-3p	qRT-PCR	31686542
MIRT910436	hsa-miR-106a	CLIP-seq
MIRT910437	hsa-miR-106b	CLIP-seq
MIRT910438	hsa-miR-1184	CLIP-seq
MIRT910439	hsa-miR-1208	CLIP-seq
MIRT910440	hsa-miR-1271	CLIP-seq
MIRT910441	hsa-miR-1273e	CLIP-seq
MIRT910442	hsa-miR-150	CLIP-seq
MIRT910443	hsa-miR-17	CLIP-seq
MIRT910444	hsa-miR-182	CLIP-seq
MIRT910445	hsa-miR-194	CLIP-seq
MIRT910446	hsa-miR-2053	CLIP-seq
MIRT910447	hsa-miR-20a	CLIP-seq
MIRT910448	hsa-miR-20b	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910454	hsa-miR-3130-3p	CLIP-seq
MIRT910455	hsa-miR-3200-3p	CLIP-seq
MIRT910456	hsa-miR-33a	CLIP-seq
MIRT910457	hsa-miR-33b	CLIP-seq
MIRT910458	hsa-miR-3609	CLIP-seq
MIRT910459	hsa-miR-3674	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT910462	hsa-miR-380	CLIP-seq
MIRT910463	hsa-miR-4252	CLIP-seq
MIRT910464	hsa-miR-4418	CLIP-seq
MIRT910465	hsa-miR-4426	CLIP-seq
MIRT910466	hsa-miR-4432	CLIP-seq
MIRT910467	hsa-miR-4639-5p	CLIP-seq
MIRT910468	hsa-miR-4647	CLIP-seq
MIRT910469	hsa-miR-4662b	CLIP-seq
MIRT910470	hsa-miR-4691-3p	CLIP-seq
MIRT910471	hsa-miR-4757-5p	CLIP-seq
MIRT910472	hsa-miR-4760-3p	CLIP-seq
MIRT910473	hsa-miR-4796-3p	CLIP-seq
MIRT910474	hsa-miR-4803	CLIP-seq
MIRT910475	hsa-miR-485-3p	CLIP-seq
MIRT910476	hsa-miR-488	CLIP-seq
MIRT910477	hsa-miR-495	CLIP-seq
MIRT910478	hsa-miR-499-3p	CLIP-seq
MIRT910479	hsa-miR-499-5p	CLIP-seq
MIRT910480	hsa-miR-499a-3p	CLIP-seq
MIRT910481	hsa-miR-509-3-5p	CLIP-seq
MIRT910482	hsa-miR-509-5p	CLIP-seq
MIRT910483	hsa-miR-519a	CLIP-seq
MIRT910484	hsa-miR-519b-3p	CLIP-seq
MIRT910485	hsa-miR-519c-3p	CLIP-seq
MIRT910486	hsa-miR-519d	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT910493	hsa-miR-520g	CLIP-seq
MIRT910494	hsa-miR-520h	CLIP-seq
MIRT910495	hsa-miR-548ah	CLIP-seq
MIRT910496	hsa-miR-561	CLIP-seq
MIRT910497	hsa-miR-636	CLIP-seq
MIRT910498	hsa-miR-885-3p	CLIP-seq
MIRT910499	hsa-miR-93	CLIP-seq
MIRT910500	hsa-miR-96	CLIP-seq
MIRT910436	hsa-miR-106a	CLIP-seq
MIRT910437	hsa-miR-106b	CLIP-seq
MIRT910501	hsa-miR-1231	CLIP-seq
MIRT910502	hsa-miR-1256	CLIP-seq
MIRT910503	hsa-miR-1269	CLIP-seq
MIRT910504	hsa-miR-1269b	CLIP-seq
MIRT910440	hsa-miR-1271	CLIP-seq
MIRT910505	hsa-miR-1273d	CLIP-seq
MIRT910441	hsa-miR-1273e	CLIP-seq
MIRT910506	hsa-miR-1297	CLIP-seq
MIRT910443	hsa-miR-17	CLIP-seq
MIRT910444	hsa-miR-182	CLIP-seq
MIRT910507	hsa-miR-188-5p	CLIP-seq
MIRT910508	hsa-miR-198	CLIP-seq
MIRT910447	hsa-miR-20a	CLIP-seq
MIRT910448	hsa-miR-20b	CLIP-seq
MIRT910509	hsa-miR-26a	CLIP-seq
MIRT910510	hsa-miR-26b	CLIP-seq
MIRT910511	hsa-miR-2964a-5p	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910512	hsa-miR-3154	CLIP-seq
MIRT910513	hsa-miR-339-5p	CLIP-seq
MIRT910456	hsa-miR-33a	CLIP-seq
MIRT910457	hsa-miR-33b	CLIP-seq
MIRT910458	hsa-miR-3609	CLIP-seq
MIRT910514	hsa-miR-3614-3p	CLIP-seq
MIRT910515	hsa-miR-3713	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT910516	hsa-miR-375	CLIP-seq
MIRT910517	hsa-miR-376c	CLIP-seq
MIRT910518	hsa-miR-3910	CLIP-seq
MIRT910519	hsa-miR-4257	CLIP-seq
MIRT910520	hsa-miR-4269	CLIP-seq
MIRT910521	hsa-miR-4288	CLIP-seq
MIRT910522	hsa-miR-4421	CLIP-seq
MIRT910465	hsa-miR-4426	CLIP-seq
MIRT910523	hsa-miR-4438	CLIP-seq
MIRT910524	hsa-miR-4453	CLIP-seq
MIRT910525	hsa-miR-4465	CLIP-seq
MIRT910526	hsa-miR-4529-3p	CLIP-seq
MIRT910527	hsa-miR-4538	CLIP-seq
MIRT910528	hsa-miR-4643	CLIP-seq
MIRT910468	hsa-miR-4647	CLIP-seq
MIRT910469	hsa-miR-4662b	CLIP-seq
MIRT910529	hsa-miR-4711-5p	CLIP-seq
MIRT910473	hsa-miR-4796-3p	CLIP-seq
MIRT910474	hsa-miR-4803	CLIP-seq
MIRT910476	hsa-miR-488	CLIP-seq
MIRT910530	hsa-miR-501-3p	CLIP-seq
MIRT910531	hsa-miR-502-3p	CLIP-seq
MIRT910532	hsa-miR-5095	CLIP-seq
MIRT910486	hsa-miR-519d	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910533	hsa-miR-520a-5p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT910534	hsa-miR-525-5p	CLIP-seq
MIRT910495	hsa-miR-548ah	CLIP-seq
MIRT910535	hsa-miR-562	CLIP-seq
MIRT910536	hsa-miR-632	CLIP-seq
MIRT910497	hsa-miR-636	CLIP-seq
MIRT910537	hsa-miR-643	CLIP-seq
MIRT910538	hsa-miR-767-5p	CLIP-seq
MIRT910498	hsa-miR-885-3p	CLIP-seq
MIRT910499	hsa-miR-93	CLIP-seq
MIRT910500	hsa-miR-96	CLIP-seq
MIRT910503	hsa-miR-1269	CLIP-seq
MIRT910504	hsa-miR-1269b	CLIP-seq
MIRT910506	hsa-miR-1297	CLIP-seq
MIRT1969913	hsa-miR-190	CLIP-seq
MIRT1969914	hsa-miR-190b	CLIP-seq
MIRT1969915	hsa-miR-2052	CLIP-seq
MIRT910509	hsa-miR-26a	CLIP-seq
MIRT910510	hsa-miR-26b	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910514	hsa-miR-3614-3p	CLIP-seq
MIRT1969916	hsa-miR-3660	CLIP-seq
MIRT1969917	hsa-miR-3680	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT1969918	hsa-miR-4256	CLIP-seq
MIRT1969919	hsa-miR-4307	CLIP-seq
MIRT910523	hsa-miR-4438	CLIP-seq
MIRT910524	hsa-miR-4453	CLIP-seq
MIRT910525	hsa-miR-4465	CLIP-seq
MIRT1969920	hsa-miR-4526	CLIP-seq
MIRT910526	hsa-miR-4529-3p	CLIP-seq
MIRT910527	hsa-miR-4538	CLIP-seq
MIRT910528	hsa-miR-4643	CLIP-seq
MIRT1969921	hsa-miR-4720-3p	CLIP-seq
MIRT1969922	hsa-miR-4804-3p	CLIP-seq
MIRT1969923	hsa-miR-483-3p	CLIP-seq
MIRT910530	hsa-miR-501-3p	CLIP-seq
MIRT910531	hsa-miR-502-3p	CLIP-seq
MIRT910532	hsa-miR-5095	CLIP-seq
MIRT910483	hsa-miR-519a	CLIP-seq
MIRT910484	hsa-miR-519b-3p	CLIP-seq
MIRT910485	hsa-miR-519c-3p	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT910535	hsa-miR-562	CLIP-seq
MIRT1969924	hsa-miR-633	CLIP-seq
MIRT910538	hsa-miR-767-5p	CLIP-seq
MIRT1969925	hsa-miR-941	CLIP-seq
MIRT910506	hsa-miR-1297	CLIP-seq
MIRT910509	hsa-miR-26a	CLIP-seq
MIRT910510	hsa-miR-26b	CLIP-seq
MIRT910514	hsa-miR-3614-3p	CLIP-seq
MIRT910522	hsa-miR-4421	CLIP-seq
MIRT910524	hsa-miR-4453	CLIP-seq
MIRT910525	hsa-miR-4465	CLIP-seq
MIRT910527	hsa-miR-4538	CLIP-seq
MIRT910535	hsa-miR-562	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT2436474	hsa-miR-129-5p	CLIP-seq
MIRT2436475	hsa-miR-4693-3p	CLIP-seq
MIRT2436476	hsa-miR-579	CLIP-seq
MIRT2436477	hsa-miR-580	CLIP-seq
MIRT2436474	hsa-miR-129-5p	CLIP-seq
MIRT2436475	hsa-miR-4693-3p	CLIP-seq
MIRT2436476	hsa-miR-579	CLIP-seq
MIRT2436477	hsa-miR-580	CLIP-seq
MIRT2509179	hsa-miR-1323	CLIP-seq
MIRT1969913	hsa-miR-190	CLIP-seq
MIRT1969914	hsa-miR-190b	CLIP-seq
MIRT910445	hsa-miR-194	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT1969919	hsa-miR-4307	CLIP-seq
MIRT2509180	hsa-miR-4328	CLIP-seq
MIRT2509181	hsa-miR-4719	CLIP-seq
MIRT910474	hsa-miR-4803	CLIP-seq
MIRT1969923	hsa-miR-483-3p	CLIP-seq
MIRT910477	hsa-miR-495	CLIP-seq
MIRT2509182	hsa-miR-513b	CLIP-seq
MIRT910483	hsa-miR-519a	CLIP-seq
MIRT910484	hsa-miR-519b-3p	CLIP-seq
MIRT910485	hsa-miR-519c-3p	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT2509183	hsa-miR-548o	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	21619872
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	NAS	10486279
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	IDA	10486279
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IMP	21619872
GO:0006635	Process	Fatty acid beta-oxidation	IDA	21619872
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0008458	Function	Carnitine O-octanoyltransferase activity	EXP	10486279
GO:0008458	Function	Carnitine O-octanoyltransferase activity	IBA
GO:0008458	Function	Carnitine O-octanoyltransferase activity	IDA	10486279, 21619872
GO:0008458	Function	Carnitine O-octanoyltransferase activity	IEA
GO:0009437	Process	Carnitine metabolic process	IEA
GO:0009437	Process	Carnitine metabolic process	ISS
GO:0015908	Process	Fatty acid transport	IEA
GO:0015936	Process	Coenzyme A metabolic process	IEA
GO:0015936	Process	Coenzyme A metabolic process	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	TAS
GO:0051791	Process	Medium-chain fatty acid metabolic process	IDA	10486279

Other IDs

• MIM: 606090
• HGNC: 2366
• e!Ensembl: ENSG00000005469

Protein

• UniProt ID: Q9UKG9
• Protein name: Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)
• Protein function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. {ECO:0000269|PubMed:104
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00755	Carn_acyltransf	20 → 604	Choline/Carnitine o-acyltransferase	Family

• Sequence:

  MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQS
  GIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGT
  QLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYF
  RTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAAL
  TSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIG
  DPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVR
  DIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFI
  QLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQ
  QKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFV
  LSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAF
  HDMIQLMNSTHL

• Sequence length: 612

Pathways

KEGG:

Peroxisome

Reactome:

Beta-oxidation of pristanoyl-CoA
Peroxisomal protein import

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Sarcoma	Uncertain significance	rs138191847	RCV005932378

Associations from Text Mining
Disease Name	Relationship Type	References
Neoplasms	Associate	36778142
Obesity	Associate	28445147
Ovarian Neoplasms	Inhibit	36120434
Paranoid Disorders	Associate	22832427
Prostatic Neoplasms	Associate	31295943, 36778142