Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54677
Gene name Gene Name - the full gene name approved by the HGNC.	Carnitine O-octanoyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CROT
Synonyms (NCBI Gene) Gene synonyms aliases	COT
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q21.12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of m

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007354	hsa-miR-33a-5p	Immunofluorescence, Luciferase reporter assay, Western blot	23547260
MIRT020476	hsa-miR-106b-5p	Microarray	17242205
MIRT046842	hsa-miR-221-3p	CLASH	23622248
MIRT440875	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT020476	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT222908	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440875	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT020476	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT222907	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT222917	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT222909	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT222927	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT222908	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT007354	hsa-miR-33a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27199118
MIRT735940	hsa-miR-33b-3p	qRT-PCR	31686542
MIRT910436	hsa-miR-106a	CLIP-seq
MIRT910437	hsa-miR-106b	CLIP-seq
MIRT910438	hsa-miR-1184	CLIP-seq
MIRT910439	hsa-miR-1208	CLIP-seq
MIRT910440	hsa-miR-1271	CLIP-seq
MIRT910441	hsa-miR-1273e	CLIP-seq
MIRT910442	hsa-miR-150	CLIP-seq
MIRT910443	hsa-miR-17	CLIP-seq
MIRT910444	hsa-miR-182	CLIP-seq
MIRT910445	hsa-miR-194	CLIP-seq
MIRT910446	hsa-miR-2053	CLIP-seq
MIRT910447	hsa-miR-20a	CLIP-seq
MIRT910448	hsa-miR-20b	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910454	hsa-miR-3130-3p	CLIP-seq
MIRT910455	hsa-miR-3200-3p	CLIP-seq
MIRT910456	hsa-miR-33a	CLIP-seq
MIRT910457	hsa-miR-33b	CLIP-seq
MIRT910458	hsa-miR-3609	CLIP-seq
MIRT910459	hsa-miR-3674	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT910462	hsa-miR-380	CLIP-seq
MIRT910463	hsa-miR-4252	CLIP-seq
MIRT910464	hsa-miR-4418	CLIP-seq
MIRT910465	hsa-miR-4426	CLIP-seq
MIRT910466	hsa-miR-4432	CLIP-seq
MIRT910467	hsa-miR-4639-5p	CLIP-seq
MIRT910468	hsa-miR-4647	CLIP-seq
MIRT910469	hsa-miR-4662b	CLIP-seq
MIRT910470	hsa-miR-4691-3p	CLIP-seq
MIRT910471	hsa-miR-4757-5p	CLIP-seq
MIRT910472	hsa-miR-4760-3p	CLIP-seq
MIRT910473	hsa-miR-4796-3p	CLIP-seq
MIRT910474	hsa-miR-4803	CLIP-seq
MIRT910475	hsa-miR-485-3p	CLIP-seq
MIRT910476	hsa-miR-488	CLIP-seq
MIRT910477	hsa-miR-495	CLIP-seq
MIRT910478	hsa-miR-499-3p	CLIP-seq
MIRT910479	hsa-miR-499-5p	CLIP-seq
MIRT910480	hsa-miR-499a-3p	CLIP-seq
MIRT910481	hsa-miR-509-3-5p	CLIP-seq
MIRT910482	hsa-miR-509-5p	CLIP-seq
MIRT910483	hsa-miR-519a	CLIP-seq
MIRT910484	hsa-miR-519b-3p	CLIP-seq
MIRT910485	hsa-miR-519c-3p	CLIP-seq
MIRT910486	hsa-miR-519d	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT910493	hsa-miR-520g	CLIP-seq
MIRT910494	hsa-miR-520h	CLIP-seq
MIRT910495	hsa-miR-548ah	CLIP-seq
MIRT910496	hsa-miR-561	CLIP-seq
MIRT910497	hsa-miR-636	CLIP-seq
MIRT910498	hsa-miR-885-3p	CLIP-seq
MIRT910499	hsa-miR-93	CLIP-seq
MIRT910500	hsa-miR-96	CLIP-seq
MIRT910436	hsa-miR-106a	CLIP-seq
MIRT910437	hsa-miR-106b	CLIP-seq
MIRT910501	hsa-miR-1231	CLIP-seq
MIRT910502	hsa-miR-1256	CLIP-seq
MIRT910503	hsa-miR-1269	CLIP-seq
MIRT910504	hsa-miR-1269b	CLIP-seq
MIRT910440	hsa-miR-1271	CLIP-seq
MIRT910505	hsa-miR-1273d	CLIP-seq
MIRT910441	hsa-miR-1273e	CLIP-seq
MIRT910506	hsa-miR-1297	CLIP-seq
MIRT910443	hsa-miR-17	CLIP-seq
MIRT910444	hsa-miR-182	CLIP-seq
MIRT910507	hsa-miR-188-5p	CLIP-seq
MIRT910508	hsa-miR-198	CLIP-seq
MIRT910447	hsa-miR-20a	CLIP-seq
MIRT910448	hsa-miR-20b	CLIP-seq
MIRT910509	hsa-miR-26a	CLIP-seq
MIRT910510	hsa-miR-26b	CLIP-seq
MIRT910511	hsa-miR-2964a-5p	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910512	hsa-miR-3154	CLIP-seq
MIRT910513	hsa-miR-339-5p	CLIP-seq
MIRT910456	hsa-miR-33a	CLIP-seq
MIRT910457	hsa-miR-33b	CLIP-seq
MIRT910458	hsa-miR-3609	CLIP-seq
MIRT910514	hsa-miR-3614-3p	CLIP-seq
MIRT910515	hsa-miR-3713	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT910516	hsa-miR-375	CLIP-seq
MIRT910517	hsa-miR-376c	CLIP-seq
MIRT910518	hsa-miR-3910	CLIP-seq
MIRT910519	hsa-miR-4257	CLIP-seq
MIRT910520	hsa-miR-4269	CLIP-seq
MIRT910521	hsa-miR-4288	CLIP-seq
MIRT910522	hsa-miR-4421	CLIP-seq
MIRT910465	hsa-miR-4426	CLIP-seq
MIRT910523	hsa-miR-4438	CLIP-seq
MIRT910524	hsa-miR-4453	CLIP-seq
MIRT910525	hsa-miR-4465	CLIP-seq
MIRT910526	hsa-miR-4529-3p	CLIP-seq
MIRT910527	hsa-miR-4538	CLIP-seq
MIRT910528	hsa-miR-4643	CLIP-seq
MIRT910468	hsa-miR-4647	CLIP-seq
MIRT910469	hsa-miR-4662b	CLIP-seq
MIRT910529	hsa-miR-4711-5p	CLIP-seq
MIRT910473	hsa-miR-4796-3p	CLIP-seq
MIRT910474	hsa-miR-4803	CLIP-seq
MIRT910476	hsa-miR-488	CLIP-seq
MIRT910530	hsa-miR-501-3p	CLIP-seq
MIRT910531	hsa-miR-502-3p	CLIP-seq
MIRT910532	hsa-miR-5095	CLIP-seq
MIRT910486	hsa-miR-519d	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910533	hsa-miR-520a-5p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT910534	hsa-miR-525-5p	CLIP-seq
MIRT910495	hsa-miR-548ah	CLIP-seq
MIRT910535	hsa-miR-562	CLIP-seq
MIRT910536	hsa-miR-632	CLIP-seq
MIRT910497	hsa-miR-636	CLIP-seq
MIRT910537	hsa-miR-643	CLIP-seq
MIRT910538	hsa-miR-767-5p	CLIP-seq
MIRT910498	hsa-miR-885-3p	CLIP-seq
MIRT910499	hsa-miR-93	CLIP-seq
MIRT910500	hsa-miR-96	CLIP-seq
MIRT910503	hsa-miR-1269	CLIP-seq
MIRT910504	hsa-miR-1269b	CLIP-seq
MIRT910506	hsa-miR-1297	CLIP-seq
MIRT1969913	hsa-miR-190	CLIP-seq
MIRT1969914	hsa-miR-190b	CLIP-seq
MIRT1969915	hsa-miR-2052	CLIP-seq
MIRT910509	hsa-miR-26a	CLIP-seq
MIRT910510	hsa-miR-26b	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910514	hsa-miR-3614-3p	CLIP-seq
MIRT1969916	hsa-miR-3660	CLIP-seq
MIRT1969917	hsa-miR-3680	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT1969918	hsa-miR-4256	CLIP-seq
MIRT1969919	hsa-miR-4307	CLIP-seq
MIRT910523	hsa-miR-4438	CLIP-seq
MIRT910524	hsa-miR-4453	CLIP-seq
MIRT910525	hsa-miR-4465	CLIP-seq
MIRT1969920	hsa-miR-4526	CLIP-seq
MIRT910526	hsa-miR-4529-3p	CLIP-seq
MIRT910527	hsa-miR-4538	CLIP-seq
MIRT910528	hsa-miR-4643	CLIP-seq
MIRT1969921	hsa-miR-4720-3p	CLIP-seq
MIRT1969922	hsa-miR-4804-3p	CLIP-seq
MIRT1969923	hsa-miR-483-3p	CLIP-seq
MIRT910530	hsa-miR-501-3p	CLIP-seq
MIRT910531	hsa-miR-502-3p	CLIP-seq
MIRT910532	hsa-miR-5095	CLIP-seq
MIRT910483	hsa-miR-519a	CLIP-seq
MIRT910484	hsa-miR-519b-3p	CLIP-seq
MIRT910485	hsa-miR-519c-3p	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT910535	hsa-miR-562	CLIP-seq
MIRT1969924	hsa-miR-633	CLIP-seq
MIRT910538	hsa-miR-767-5p	CLIP-seq
MIRT1969925	hsa-miR-941	CLIP-seq
MIRT910506	hsa-miR-1297	CLIP-seq
MIRT910509	hsa-miR-26a	CLIP-seq
MIRT910510	hsa-miR-26b	CLIP-seq
MIRT910514	hsa-miR-3614-3p	CLIP-seq
MIRT910522	hsa-miR-4421	CLIP-seq
MIRT910524	hsa-miR-4453	CLIP-seq
MIRT910525	hsa-miR-4465	CLIP-seq
MIRT910527	hsa-miR-4538	CLIP-seq
MIRT910535	hsa-miR-562	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT2436474	hsa-miR-129-5p	CLIP-seq
MIRT2436475	hsa-miR-4693-3p	CLIP-seq
MIRT2436476	hsa-miR-579	CLIP-seq
MIRT2436477	hsa-miR-580	CLIP-seq
MIRT2436474	hsa-miR-129-5p	CLIP-seq
MIRT2436475	hsa-miR-4693-3p	CLIP-seq
MIRT2436476	hsa-miR-579	CLIP-seq
MIRT2436477	hsa-miR-580	CLIP-seq
MIRT2509179	hsa-miR-1323	CLIP-seq
MIRT1969913	hsa-miR-190	CLIP-seq
MIRT1969914	hsa-miR-190b	CLIP-seq
MIRT910445	hsa-miR-194	CLIP-seq
MIRT910449	hsa-miR-302a	CLIP-seq
MIRT910450	hsa-miR-302b	CLIP-seq
MIRT910451	hsa-miR-302c	CLIP-seq
MIRT910452	hsa-miR-302d	CLIP-seq
MIRT910453	hsa-miR-302e	CLIP-seq
MIRT910460	hsa-miR-372	CLIP-seq
MIRT910461	hsa-miR-373	CLIP-seq
MIRT1969919	hsa-miR-4307	CLIP-seq
MIRT2509180	hsa-miR-4328	CLIP-seq
MIRT2509181	hsa-miR-4719	CLIP-seq
MIRT910474	hsa-miR-4803	CLIP-seq
MIRT1969923	hsa-miR-483-3p	CLIP-seq
MIRT910477	hsa-miR-495	CLIP-seq
MIRT2509182	hsa-miR-513b	CLIP-seq
MIRT910483	hsa-miR-519a	CLIP-seq
MIRT910484	hsa-miR-519b-3p	CLIP-seq
MIRT910485	hsa-miR-519c-3p	CLIP-seq
MIRT910487	hsa-miR-520a-3p	CLIP-seq
MIRT910488	hsa-miR-520b	CLIP-seq
MIRT910489	hsa-miR-520c-3p	CLIP-seq
MIRT910490	hsa-miR-520d-3p	CLIP-seq
MIRT910491	hsa-miR-520e	CLIP-seq
MIRT910492	hsa-miR-520f	CLIP-seq
MIRT2509183	hsa-miR-548o	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	21619872
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	NAS	10486279
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	IDA	10486279
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IMP	21619872
GO:0006635	Process	Fatty acid beta-oxidation	IDA	21619872
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0008458	Function	Carnitine O-octanoyltransferase activity	EXP	10486279
GO:0008458	Function	Carnitine O-octanoyltransferase activity	IBA
GO:0008458	Function	Carnitine O-octanoyltransferase activity	IDA	10486279, 21619872
GO:0008458	Function	Carnitine O-octanoyltransferase activity	IEA
GO:0009437	Process	Carnitine metabolic process	IEA
GO:0009437	Process	Carnitine metabolic process	ISS
GO:0015908	Process	Fatty acid transport	IEA
GO:0015936	Process	Coenzyme A metabolic process	IEA
GO:0015936	Process	Coenzyme A metabolic process	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	TAS
GO:0051791	Process	Medium-chain fatty acid metabolic process	IDA	10486279

MIM	HGNC	e!Ensembl
606090	2366	ENSG00000005469

Protein

UniProt ID

Q9UKG9

Protein name

Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)

Protein function

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. {ECO:0000269|PubMed:104

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00755	Carn_acyltransf	20 → 604	Choline/Carnitine o-acyltransferase	Family

Sequence

MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQS
GIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGT
QLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYF
RTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAAL
TSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIG
DPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVR
DIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFI
QLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQ
QKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFV
LSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAF
HDMIQLMNSTHL

Sequence length

612

Interactions

View interactions

	KEGG		Reactome
	Peroxisome		Beta-oxidation of pristanoyl-CoA Peroxisomal protein import

CROT (carnitine O-octanoyltransferase)