Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54675
Gene name	Cardiolipin synthase 1
Gene symbol	CRLS1
Synonyms (NCBI Gene)	C20orf155CLSCLS1COSPD57GCD10dJ967N21.6
Chromosome	20
Chromosome location	20p12.3
Summary	This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [

326

Show/Hide all (326)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025804	hsa-miR-7-5p	Sequencing	20371350
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	22927820
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	22927820
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	22927820
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	22927820
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	22927820
MIRT629469	hsa-miR-8485	HITS-CLIP	22927820
MIRT684105	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT684104	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT684103	hsa-miR-603	HITS-CLIP	22927820
MIRT629468	hsa-miR-1323	HITS-CLIP	22927820
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	22927820
MIRT684102	hsa-miR-3941	HITS-CLIP	22927820
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT629469	hsa-miR-8485	HITS-CLIP	23313552
MIRT684105	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT684104	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT684103	hsa-miR-603	HITS-CLIP	23313552
MIRT629468	hsa-miR-1323	HITS-CLIP	23313552
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT684102	hsa-miR-3941	HITS-CLIP	23313552
MIRT631416	hsa-miR-518a-5p	HITS-CLIP	23313552
MIRT631415	hsa-miR-527	HITS-CLIP	23313552
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT629469	hsa-miR-8485	HITS-CLIP	23313552
MIRT684105	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT684104	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT684103	hsa-miR-603	HITS-CLIP	23313552
MIRT629468	hsa-miR-1323	HITS-CLIP	23313552
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT684102	hsa-miR-3941	HITS-CLIP	23313552
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	23824327
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT662633	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT631417	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT631416	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT631415	hsa-miR-527	HITS-CLIP	23824327
MIRT662632	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT662631	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT630784	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT630783	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT630782	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT630781	hsa-miR-23c	HITS-CLIP	23824327
MIRT630780	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT630779	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	23824327
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT631417	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT631416	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT631415	hsa-miR-527	HITS-CLIP	23824327
MIRT630788	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT630787	hsa-miR-5688	HITS-CLIP	23824327
MIRT630786	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT630785	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT630784	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT630783	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT630782	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT630781	hsa-miR-23c	HITS-CLIP	23824327
MIRT630780	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT630779	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	23824327
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	27418678
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	27418678
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	27418678
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	27418678
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	27418678
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	27418678
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	27418678
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	27418678
MIRT629469	hsa-miR-8485	HITS-CLIP	27418678
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	22927820
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	22927820
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	22927820
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	22927820
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	22927820
MIRT629469	hsa-miR-8485	HITS-CLIP	22927820
MIRT684105	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT684104	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT684103	hsa-miR-603	HITS-CLIP	22927820
MIRT629468	hsa-miR-1323	HITS-CLIP	22927820
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	22927820
MIRT684102	hsa-miR-3941	HITS-CLIP	22927820
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT629469	hsa-miR-8485	HITS-CLIP	23313552
MIRT684105	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT684104	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT684103	hsa-miR-603	HITS-CLIP	23313552
MIRT629468	hsa-miR-1323	HITS-CLIP	23313552
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT684102	hsa-miR-3941	HITS-CLIP	23313552
MIRT631416	hsa-miR-518a-5p	HITS-CLIP	23313552
MIRT631415	hsa-miR-527	HITS-CLIP	23313552
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT629469	hsa-miR-8485	HITS-CLIP	23313552
MIRT684105	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT684104	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT684103	hsa-miR-603	HITS-CLIP	23313552
MIRT629468	hsa-miR-1323	HITS-CLIP	23313552
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT684102	hsa-miR-3941	HITS-CLIP	23313552
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	23824327
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT662633	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT631417	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT631416	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT631415	hsa-miR-527	HITS-CLIP	23824327
MIRT662632	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT662631	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT630784	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT630783	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT630782	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT630781	hsa-miR-23c	HITS-CLIP	23824327
MIRT630780	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT630779	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	23824327
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT631417	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT631416	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT631415	hsa-miR-527	HITS-CLIP	23824327
MIRT630788	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT630787	hsa-miR-5688	HITS-CLIP	23824327
MIRT630786	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT630785	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT630784	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT630783	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT630782	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT630781	hsa-miR-23c	HITS-CLIP	23824327
MIRT630780	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT630779	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT629475	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT629474	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT629473	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT629472	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT629471	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT629470	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT629469	hsa-miR-8485	HITS-CLIP	23824327
MIRT629468	hsa-miR-1323	HITS-CLIP	23824327
MIRT629467	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT910335	hsa-miR-154	CLIP-seq
MIRT910336	hsa-miR-15a	CLIP-seq
MIRT910337	hsa-miR-15b	CLIP-seq
MIRT910338	hsa-miR-16	CLIP-seq
MIRT910339	hsa-miR-195	CLIP-seq
MIRT910340	hsa-miR-3117-5p	CLIP-seq
MIRT910341	hsa-miR-3150b-3p	CLIP-seq
MIRT910342	hsa-miR-3194-5p	CLIP-seq
MIRT910343	hsa-miR-3646	CLIP-seq
MIRT910344	hsa-miR-3650	CLIP-seq
MIRT910345	hsa-miR-380	CLIP-seq
MIRT910346	hsa-miR-424	CLIP-seq
MIRT910347	hsa-miR-425	CLIP-seq
MIRT910348	hsa-miR-4293	CLIP-seq
MIRT910349	hsa-miR-4503	CLIP-seq
MIRT910350	hsa-miR-451b	CLIP-seq
MIRT910351	hsa-miR-4676-5p	CLIP-seq
MIRT910352	hsa-miR-4689	CLIP-seq
MIRT910353	hsa-miR-4691-3p	CLIP-seq
MIRT910354	hsa-miR-4747-5p	CLIP-seq
MIRT910355	hsa-miR-4784	CLIP-seq
MIRT910356	hsa-miR-497	CLIP-seq
MIRT910357	hsa-miR-544b	CLIP-seq
MIRT910358	hsa-miR-548e	CLIP-seq
MIRT910359	hsa-miR-548f	CLIP-seq
MIRT910360	hsa-miR-548o	CLIP-seq
MIRT910361	hsa-miR-575	CLIP-seq
MIRT910362	hsa-miR-890	CLIP-seq
MIRT910363	hsa-miR-1183	CLIP-seq
MIRT910364	hsa-miR-3140-3p	CLIP-seq
MIRT910365	hsa-miR-329	CLIP-seq
MIRT910366	hsa-miR-3653	CLIP-seq
MIRT910367	hsa-miR-3682-5p	CLIP-seq
MIRT910368	hsa-miR-4699-3p	CLIP-seq
MIRT910354	hsa-miR-4747-5p	CLIP-seq
MIRT910369	hsa-miR-488	CLIP-seq
MIRT910360	hsa-miR-548o	CLIP-seq
MIRT910370	hsa-miR-634	CLIP-seq
MIRT910371	hsa-miR-942	CLIP-seq
MIRT910363	hsa-miR-1183	CLIP-seq
MIRT1969879	hsa-miR-1226	CLIP-seq
MIRT910343	hsa-miR-3646	CLIP-seq
MIRT910366	hsa-miR-3653	CLIP-seq
MIRT910367	hsa-miR-3682-5p	CLIP-seq
MIRT1969880	hsa-miR-4267	CLIP-seq
MIRT910368	hsa-miR-4699-3p	CLIP-seq
MIRT1969881	hsa-miR-548ac	CLIP-seq
MIRT1969882	hsa-miR-548ae	CLIP-seq
MIRT1969883	hsa-miR-548aj	CLIP-seq
MIRT1969884	hsa-miR-548am	CLIP-seq
MIRT1969885	hsa-miR-548d-3p	CLIP-seq
MIRT910358	hsa-miR-548e	CLIP-seq
MIRT910359	hsa-miR-548f	CLIP-seq
MIRT1969886	hsa-miR-548x	CLIP-seq
MIRT1969887	hsa-miR-548z	CLIP-seq
MIRT1969888	hsa-miR-3662	CLIP-seq
MIRT910363	hsa-miR-1183	CLIP-seq
MIRT2205863	hsa-miR-1205	CLIP-seq
MIRT2205864	hsa-miR-1305	CLIP-seq
MIRT2205865	hsa-miR-132	CLIP-seq
MIRT2205866	hsa-miR-212	CLIP-seq
MIRT2205867	hsa-miR-3064-5p	CLIP-seq
MIRT2205868	hsa-miR-3126-5p	CLIP-seq
MIRT2205869	hsa-miR-3183	CLIP-seq
MIRT2205870	hsa-miR-323-3p	CLIP-seq
MIRT2205871	hsa-miR-323b-3p	CLIP-seq
MIRT910365	hsa-miR-329	CLIP-seq
MIRT2205872	hsa-miR-3622a-3p	CLIP-seq
MIRT2205873	hsa-miR-3622b-3p	CLIP-seq
MIRT910366	hsa-miR-3653	CLIP-seq
MIRT910367	hsa-miR-3682-5p	CLIP-seq
MIRT2205874	hsa-miR-3685	CLIP-seq
MIRT2205875	hsa-miR-384	CLIP-seq
MIRT2205876	hsa-miR-3909	CLIP-seq
MIRT2205877	hsa-miR-3924	CLIP-seq
MIRT2205878	hsa-miR-3938	CLIP-seq
MIRT2205879	hsa-miR-4292	CLIP-seq
MIRT2205880	hsa-miR-4308	CLIP-seq
MIRT2205881	hsa-miR-4324	CLIP-seq
MIRT2205882	hsa-miR-4419a	CLIP-seq
MIRT2205883	hsa-miR-4473	CLIP-seq
MIRT2205884	hsa-miR-448	CLIP-seq
MIRT2205885	hsa-miR-4510	CLIP-seq
MIRT910368	hsa-miR-4699-3p	CLIP-seq
MIRT2205886	hsa-miR-4714-3p	CLIP-seq
MIRT2205887	hsa-miR-4723-3p	CLIP-seq
MIRT2205888	hsa-miR-4753-3p	CLIP-seq
MIRT2205889	hsa-miR-486-5p	CLIP-seq
MIRT2205890	hsa-miR-495	CLIP-seq
MIRT2205891	hsa-miR-498	CLIP-seq
MIRT2205892	hsa-miR-512-3p	CLIP-seq
MIRT2205893	hsa-miR-513a-3p	CLIP-seq
MIRT2205894	hsa-miR-520f	CLIP-seq
MIRT2205895	hsa-miR-587	CLIP-seq
MIRT2205896	hsa-miR-604	CLIP-seq
MIRT2205897	hsa-miR-647	CLIP-seq
MIRT2205898	hsa-miR-7	CLIP-seq
MIRT2447655	hsa-miR-1276	CLIP-seq
MIRT2447656	hsa-miR-2052	CLIP-seq
MIRT2447657	hsa-miR-4670-3p	CLIP-seq
MIRT910369	hsa-miR-488	CLIP-seq
MIRT2447655	hsa-miR-1276	CLIP-seq
MIRT2465120	hsa-miR-139-5p	CLIP-seq
MIRT2447656	hsa-miR-2052	CLIP-seq
MIRT2205874	hsa-miR-3685	CLIP-seq
MIRT2205875	hsa-miR-384	CLIP-seq
MIRT2447657	hsa-miR-4670-3p	CLIP-seq
MIRT910369	hsa-miR-488	CLIP-seq
MIRT2465121	hsa-miR-582-5p	CLIP-seq
MIRT2205889	hsa-miR-486-5p	CLIP-seq
MIRT2678669	hsa-miR-1291	CLIP-seq
MIRT2205864	hsa-miR-1305	CLIP-seq
MIRT2678670	hsa-miR-146b-3p	CLIP-seq
MIRT2678671	hsa-miR-296-5p	CLIP-seq
MIRT2678672	hsa-miR-3591-3p	CLIP-seq
MIRT2678673	hsa-miR-3660	CLIP-seq
MIRT2678674	hsa-miR-4256	CLIP-seq
MIRT2678675	hsa-miR-4526	CLIP-seq
MIRT2205889	hsa-miR-486-5p	CLIP-seq
MIRT2205891	hsa-miR-498	CLIP-seq
MIRT2205895	hsa-miR-587	CLIP-seq
MIRT2678676	hsa-miR-642b	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	38322995
GO:0005739	Component	Mitochondrion	IDA	16716149
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	ISS
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016780	Function	Phosphotransferase activity, for other substituted phosphate groups	IEA
GO:0031966	Component	Mitochondrial membrane	ISS
GO:0032049	Process	Cardiolipin biosynthetic process	IBA
GO:0032049	Process	Cardiolipin biosynthetic process	IDA	16678169, 16716149
GO:0032049	Process	Cardiolipin biosynthetic process	IEA
GO:0032049	Process	Cardiolipin biosynthetic process	TAS	38322995
GO:0036148	Process	Phosphatidylglycerol acyl-chain remodeling	TAS
GO:0043337	Function	Cardiolipin synthase (CMP-forming)	IBA
GO:0043337	Function	Cardiolipin synthase (CMP-forming)	IDA	16678169, 16716149
GO:0043337	Function	Cardiolipin synthase (CMP-forming)	IEA
GO:0043337	Function	Cardiolipin synthase (CMP-forming)	IMP	35147173
GO:0043337	Function	Cardiolipin synthase (CMP-forming)	TAS
GO:0046474	Process	Glycerophospholipid biosynthetic process	IEA
GO:0047144	Function	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS

MIM	HGNC	e!Ensembl
608188	16148	ENSG00000088766

Q9UJA2

Protein name

Cardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41) (Protein GCD10 homolog)

Protein function

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG) (PubMed:16547353, PubMed:16678169, PubMed:16716149, PubMed:35147173). CL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01066	CDP-OH_P_transf	108 → 173	CDP-alcohol phosphatidyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in tissues such as heart, skeletal muscle and liver. {ECO:0000269|PubMed:16547353}.

Sequence

MLALRVARGSWGALRGAAWAPGTRPSKRRACWALLPPVPCCLGCLAERWRLRPAALGLRL
PGIGQRNHCSGAGKAAPRPAAGAGAAAEAPGGQWGPASTPSLYENPWTIPNMLSMTRIGL
APVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNWANQRSALGSALDPLADKILISIL
YVSLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATARLKPTF
ISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCFTAFTTAASAYSYYHYGRKTVQVIK
D

Sequence length

301

Interactions

View interactions

	KEGG		Reactome
	Glycerophospholipid metabolism Metabolic pathways		Acyl chain remodelling of PG Synthesis of CL

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Combined oxidative phosphorylation deficiency 57	Pathogenic	rs1568615047, rs759395960, rs764608497	RCV003152310 RCV003152311 RCV003152312	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Fatty Liver	Associate	30270343	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leigh Disease	Associate	19542079	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	34099597	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial complex I deficiency	Associate	19542079	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	37552373	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non alcoholic Fatty Liver Disease	Associate	30270343	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	37259036	★★★★★ ★☆☆☆☆ Found in Text Mining only

CRLS1 (cardiolipin synthase 1)