WDR74 (WD repeat domain 74)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54663
Gene name Gene Name - the full gene name approved by the HGNC.
WD repeat domain 74
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WDR74
Synonyms (NCBI Gene) Gene synonyms aliases
Nsa1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q12.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(17)
miRTarBase ID miRNA Experiments Reference
MIRT027617 hsa-miR-98-5p Microarray 19088304
MIRT028577 hsa-miR-30a-5p Proteomics 18668040
MIRT032316 hsa-let-7b-5p Proteomics 18668040
MIRT047671 hsa-miR-10a-5p CLASH 23622248
MIRT1491432 hsa-miR-214 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0000176 Component Nuclear exosome (RNase complex) IDA 26456651
GO:0001825 Process Blastocyst formation IEA
GO:0001825 Process Blastocyst formation ISS
GO:0005515 Function Protein binding IPI 25416956, 26456651, 28416111, 29107693
GO:0005634 Component Nucleus IDA 28416111
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
617947 25529 ENSG00000133316
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Q6RFH5
Protein name WD repeat-containing protein 74 (NOP seven-associated protein 1)
Protein function Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required fo
PDB 8FKP , 8FKR , 8FKT , 8FKV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 259 → 297 WD domain, G-beta repeat Repeat
Sequence 
MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLV
GCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTS
SDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDL
RVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGN
SVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN
PRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKL
SGLEQPQGALQTRRRKKKRPGSTSP
Sequence length 385
Interactions View interactions
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