WDR74 (WD repeat domain 74)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 54663
Gene name WD repeat domain 74
Gene symbol WDR74
Synonyms (NCBI Gene)
Nsa1
Chromosome 11
Chromosome location 11q12.3
miRNA miRNA information provided by mirtarbase database.
17
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (17)
miRTarBase ID miRNA Experiments Reference
MIRT027617 hsa-miR-98-5p Microarray 19088304
MIRT028577 hsa-miR-30a-5p Proteomics 18668040
MIRT032316 hsa-let-7b-5p Proteomics 18668040
MIRT047671 hsa-miR-10a-5p CLASH 23622248
MIRT1491432 hsa-miR-214 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (21)
GO ID Ontology Definition Evidence Reference
GO:0000176 Component Nuclear exosome (RNase complex) IDA 26456651
GO:0001825 Process Blastocyst formation IEA
GO:0001825 Process Blastocyst formation ISS
GO:0005515 Function Protein binding IPI 25416956, 26456651, 28416111, 29107693
GO:0005634 Component Nucleus IDA 28416111
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617947 25529 ENSG00000133316
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6RFH5
Protein name WD repeat-containing protein 74 (NOP seven-associated protein 1)
Protein function Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required fo
PDB 8FKP , 8FKR , 8FKT , 8FKV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 259 → 297 WD domain, G-beta repeat Repeat
Sequence 
MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLV
GCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTS
SDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDL
RVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGN
SVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN
PRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKL
SGLEQPQGALQTRRRKKKRPGSTSP
Sequence length 385
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Lung cancer Benign rs199550021 RCV005910451
Show/Hide Text Mining Associations (2)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Neoplasms Associate 25261935
Urinary Bladder Neoplasms Associate 36658180