Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5464
Gene name	Inorganic pyrophosphatase 1
Gene symbol	PPA1
Synonyms (NCBI Gene)	HEL-S-66pIOPPPPPPP1SID6-8061
Chromosome	10
Chromosome location	10q22.1
Summary	The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028424	hsa-miR-30a-5p	Proteomics	18668040
MIRT031461	hsa-miR-16-5p	Proteomics	18668040
MIRT044072	hsa-miR-361-5p	CLASH	23622248
MIRT438337	hsa-miR-518d-3p	Luciferase reporter assay	24639097
MIRT438337	hsa-miR-518d-3p	Luciferase reporter assay	24639097
MIRT573847	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT573846	hsa-miR-200a-5p	PAR-CLIP	20371350
MIRT573845	hsa-miR-200b-5p	PAR-CLIP	20371350
MIRT573847	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT573846	hsa-miR-200a-5p	PAR-CLIP	20371350
MIRT573845	hsa-miR-200b-5p	PAR-CLIP	20371350
MIRT1251140	hsa-miR-1245b-3p	CLIP-seq
MIRT1251141	hsa-miR-216a	CLIP-seq
MIRT1251142	hsa-miR-3074-3p	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT1251144	hsa-miR-3180-5p	CLIP-seq
MIRT1251145	hsa-miR-3682-5p	CLIP-seq
MIRT1251146	hsa-miR-3685	CLIP-seq
MIRT1251147	hsa-miR-374c	CLIP-seq
MIRT1251148	hsa-miR-384	CLIP-seq
MIRT1251149	hsa-miR-3908	CLIP-seq
MIRT1251150	hsa-miR-3919	CLIP-seq
MIRT1251151	hsa-miR-3942-5p	CLIP-seq
MIRT1251152	hsa-miR-4703-5p	CLIP-seq
MIRT1251153	hsa-miR-4766-3p	CLIP-seq
MIRT1251154	hsa-miR-4775	CLIP-seq
MIRT1251155	hsa-miR-4803	CLIP-seq
MIRT1251156	hsa-miR-520a-5p	CLIP-seq
MIRT1251157	hsa-miR-525-5p	CLIP-seq
MIRT1251158	hsa-miR-539	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT1251160	hsa-miR-576-5p	CLIP-seq
MIRT1251161	hsa-miR-590-3p	CLIP-seq
MIRT1251162	hsa-miR-630	CLIP-seq
MIRT1251163	hsa-miR-643	CLIP-seq
MIRT1251164	hsa-miR-655	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2074096	hsa-miR-3168	CLIP-seq
MIRT2074097	hsa-miR-323b-3p	CLIP-seq
MIRT1251146	hsa-miR-3685	CLIP-seq
MIRT1251148	hsa-miR-384	CLIP-seq
MIRT2074098	hsa-miR-4503	CLIP-seq
MIRT2074099	hsa-miR-455-5p	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT1251154	hsa-miR-4775	CLIP-seq
MIRT1251155	hsa-miR-4803	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT1251161	hsa-miR-590-3p	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT1251140	hsa-miR-1245b-3p	CLIP-seq
MIRT1251141	hsa-miR-216a	CLIP-seq
MIRT1251142	hsa-miR-3074-3p	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2301118	hsa-miR-3164	CLIP-seq
MIRT1251144	hsa-miR-3180-5p	CLIP-seq
MIRT1251145	hsa-miR-3682-5p	CLIP-seq
MIRT1251146	hsa-miR-3685	CLIP-seq
MIRT1251147	hsa-miR-374c	CLIP-seq
MIRT1251148	hsa-miR-384	CLIP-seq
MIRT1251149	hsa-miR-3908	CLIP-seq
MIRT1251150	hsa-miR-3919	CLIP-seq
MIRT1251151	hsa-miR-3942-5p	CLIP-seq
MIRT2301119	hsa-miR-4457	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT1251152	hsa-miR-4703-5p	CLIP-seq
MIRT1251153	hsa-miR-4766-3p	CLIP-seq
MIRT1251155	hsa-miR-4803	CLIP-seq
MIRT2301120	hsa-miR-496	CLIP-seq
MIRT2301121	hsa-miR-513b	CLIP-seq
MIRT1251156	hsa-miR-520a-5p	CLIP-seq
MIRT1251157	hsa-miR-525-5p	CLIP-seq
MIRT1251158	hsa-miR-539	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT1251160	hsa-miR-576-5p	CLIP-seq
MIRT1251161	hsa-miR-590-3p	CLIP-seq
MIRT2301122	hsa-miR-617	CLIP-seq
MIRT1251162	hsa-miR-630	CLIP-seq
MIRT1251163	hsa-miR-643	CLIP-seq
MIRT1251164	hsa-miR-655	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT2597669	hsa-miR-1261	CLIP-seq
MIRT2597670	hsa-miR-1283	CLIP-seq
MIRT2597671	hsa-miR-3134	CLIP-seq
MIRT2597672	hsa-miR-3143	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2074096	hsa-miR-3168	CLIP-seq
MIRT2597673	hsa-miR-320a	CLIP-seq
MIRT2597674	hsa-miR-320b	CLIP-seq
MIRT2597675	hsa-miR-320c	CLIP-seq
MIRT2597676	hsa-miR-320d	CLIP-seq
MIRT2597677	hsa-miR-4303	CLIP-seq
MIRT2597678	hsa-miR-4429	CLIP-seq
MIRT2074098	hsa-miR-4503	CLIP-seq
MIRT2597679	hsa-miR-4682	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT2597680	hsa-miR-4760-5p	CLIP-seq
MIRT2301120	hsa-miR-496	CLIP-seq
MIRT2597681	hsa-miR-543	CLIP-seq
MIRT2597682	hsa-miR-548n	CLIP-seq
MIRT2597683	hsa-miR-548t	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT2597669	hsa-miR-1261	CLIP-seq
MIRT2597671	hsa-miR-3134	CLIP-seq
MIRT2597672	hsa-miR-3143	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2074096	hsa-miR-3168	CLIP-seq
MIRT2597677	hsa-miR-4303	CLIP-seq
MIRT2074098	hsa-miR-4503	CLIP-seq
MIRT2597679	hsa-miR-4682	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT2597680	hsa-miR-4760-5p	CLIP-seq
MIRT2301120	hsa-miR-496	CLIP-seq
MIRT2597681	hsa-miR-543	CLIP-seq
MIRT2597682	hsa-miR-548n	CLIP-seq
MIRT2597683	hsa-miR-548t	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004427	Function	Inorganic diphosphate phosphatase activity	IBA
GO:0004427	Function	Inorganic diphosphate phosphatase activity	IEA
GO:0004427	Function	Inorganic diphosphate phosphatase activity	TAS	10542310
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	TAS
GO:0006796	Process	Phosphate-containing compound metabolic process	IBA
GO:0006796	Process	Phosphate-containing compound metabolic process	IEA
GO:0006796	Process	Phosphate-containing compound metabolic process	TAS	10542310
GO:0016462	Function	Pyrophosphatase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
179030	9226	ENSG00000180817

Q15181

Protein name

Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)

PDB

6C45 , 7BTN , 7CMO , 8J7Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00719	Pyrophosphatase	46 → 228	Inorganic pyrophosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed ubiquitously. {ECO:0000269|PubMed:10542310}.

Sequence

MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI
ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI
DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP
GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI
SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN

Sequence length

289

Interactions

View interactions

	KEGG		Reactome
	Oxidative phosphorylation		Cytosolic tRNA aminoacylation Pyrophosphate hydrolysis

PPA1 (inorganic pyrophosphatase 1)