PPA1 (inorganic pyrophosphatase 1)

Gene

• Entrez ID: 5464
• Gene name: Inorganic pyrophosphatase 1
• Gene symbol: PPA1
• Synonyms (NCBI Gene): HEL-S-66p, IOPPP, PP, PP1, SID6-8061
• Chromosome: 10
• Chromosome location: 10q22.1
• Summary: The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028424	hsa-miR-30a-5p	Proteomics	18668040
MIRT031461	hsa-miR-16-5p	Proteomics	18668040
MIRT044072	hsa-miR-361-5p	CLASH	23622248
MIRT438337	hsa-miR-518d-3p	Luciferase reporter assay	24639097
MIRT438337	hsa-miR-518d-3p	Luciferase reporter assay	24639097
MIRT573847	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT573846	hsa-miR-200a-5p	PAR-CLIP	20371350
MIRT573845	hsa-miR-200b-5p	PAR-CLIP	20371350
MIRT573847	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT573846	hsa-miR-200a-5p	PAR-CLIP	20371350
MIRT573845	hsa-miR-200b-5p	PAR-CLIP	20371350
MIRT1251140	hsa-miR-1245b-3p	CLIP-seq
MIRT1251141	hsa-miR-216a	CLIP-seq
MIRT1251142	hsa-miR-3074-3p	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT1251144	hsa-miR-3180-5p	CLIP-seq
MIRT1251145	hsa-miR-3682-5p	CLIP-seq
MIRT1251146	hsa-miR-3685	CLIP-seq
MIRT1251147	hsa-miR-374c	CLIP-seq
MIRT1251148	hsa-miR-384	CLIP-seq
MIRT1251149	hsa-miR-3908	CLIP-seq
MIRT1251150	hsa-miR-3919	CLIP-seq
MIRT1251151	hsa-miR-3942-5p	CLIP-seq
MIRT1251152	hsa-miR-4703-5p	CLIP-seq
MIRT1251153	hsa-miR-4766-3p	CLIP-seq
MIRT1251154	hsa-miR-4775	CLIP-seq
MIRT1251155	hsa-miR-4803	CLIP-seq
MIRT1251156	hsa-miR-520a-5p	CLIP-seq
MIRT1251157	hsa-miR-525-5p	CLIP-seq
MIRT1251158	hsa-miR-539	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT1251160	hsa-miR-576-5p	CLIP-seq
MIRT1251161	hsa-miR-590-3p	CLIP-seq
MIRT1251162	hsa-miR-630	CLIP-seq
MIRT1251163	hsa-miR-643	CLIP-seq
MIRT1251164	hsa-miR-655	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2074096	hsa-miR-3168	CLIP-seq
MIRT2074097	hsa-miR-323b-3p	CLIP-seq
MIRT1251146	hsa-miR-3685	CLIP-seq
MIRT1251148	hsa-miR-384	CLIP-seq
MIRT2074098	hsa-miR-4503	CLIP-seq
MIRT2074099	hsa-miR-455-5p	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT1251154	hsa-miR-4775	CLIP-seq
MIRT1251155	hsa-miR-4803	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT1251161	hsa-miR-590-3p	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT1251140	hsa-miR-1245b-3p	CLIP-seq
MIRT1251141	hsa-miR-216a	CLIP-seq
MIRT1251142	hsa-miR-3074-3p	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2301118	hsa-miR-3164	CLIP-seq
MIRT1251144	hsa-miR-3180-5p	CLIP-seq
MIRT1251145	hsa-miR-3682-5p	CLIP-seq
MIRT1251146	hsa-miR-3685	CLIP-seq
MIRT1251147	hsa-miR-374c	CLIP-seq
MIRT1251148	hsa-miR-384	CLIP-seq
MIRT1251149	hsa-miR-3908	CLIP-seq
MIRT1251150	hsa-miR-3919	CLIP-seq
MIRT1251151	hsa-miR-3942-5p	CLIP-seq
MIRT2301119	hsa-miR-4457	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT1251152	hsa-miR-4703-5p	CLIP-seq
MIRT1251153	hsa-miR-4766-3p	CLIP-seq
MIRT1251155	hsa-miR-4803	CLIP-seq
MIRT2301120	hsa-miR-496	CLIP-seq
MIRT2301121	hsa-miR-513b	CLIP-seq
MIRT1251156	hsa-miR-520a-5p	CLIP-seq
MIRT1251157	hsa-miR-525-5p	CLIP-seq
MIRT1251158	hsa-miR-539	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT1251160	hsa-miR-576-5p	CLIP-seq
MIRT1251161	hsa-miR-590-3p	CLIP-seq
MIRT2301122	hsa-miR-617	CLIP-seq
MIRT1251162	hsa-miR-630	CLIP-seq
MIRT1251163	hsa-miR-643	CLIP-seq
MIRT1251164	hsa-miR-655	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT2597669	hsa-miR-1261	CLIP-seq
MIRT2597670	hsa-miR-1283	CLIP-seq
MIRT2597671	hsa-miR-3134	CLIP-seq
MIRT2597672	hsa-miR-3143	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2074096	hsa-miR-3168	CLIP-seq
MIRT2597673	hsa-miR-320a	CLIP-seq
MIRT2597674	hsa-miR-320b	CLIP-seq
MIRT2597675	hsa-miR-320c	CLIP-seq
MIRT2597676	hsa-miR-320d	CLIP-seq
MIRT2597677	hsa-miR-4303	CLIP-seq
MIRT2597678	hsa-miR-4429	CLIP-seq
MIRT2074098	hsa-miR-4503	CLIP-seq
MIRT2597679	hsa-miR-4682	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT2597680	hsa-miR-4760-5p	CLIP-seq
MIRT2301120	hsa-miR-496	CLIP-seq
MIRT2597681	hsa-miR-543	CLIP-seq
MIRT2597682	hsa-miR-548n	CLIP-seq
MIRT2597683	hsa-miR-548t	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq
MIRT2597669	hsa-miR-1261	CLIP-seq
MIRT2597671	hsa-miR-3134	CLIP-seq
MIRT2597672	hsa-miR-3143	CLIP-seq
MIRT1251143	hsa-miR-3145-3p	CLIP-seq
MIRT2074096	hsa-miR-3168	CLIP-seq
MIRT2597677	hsa-miR-4303	CLIP-seq
MIRT2074098	hsa-miR-4503	CLIP-seq
MIRT2597679	hsa-miR-4682	CLIP-seq
MIRT2074100	hsa-miR-4699-3p	CLIP-seq
MIRT2597680	hsa-miR-4760-5p	CLIP-seq
MIRT2301120	hsa-miR-496	CLIP-seq
MIRT2597681	hsa-miR-543	CLIP-seq
MIRT2597682	hsa-miR-548n	CLIP-seq
MIRT2597683	hsa-miR-548t	CLIP-seq
MIRT1251159	hsa-miR-549	CLIP-seq
MIRT2074101	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IBA	21873635
GO:0004427	Function	Inorganic diphosphatase activity	IBA	21873635
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006418	Process	TRNA aminoacylation for protein translation	TAS
GO:0006796	Process	Phosphate-containing compound metabolic process	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071344	Process	Diphosphate metabolic process	TAS

Other IDs

• MIM: 179030
• HGNC: 9226
• e!Ensembl: ENSG00000180817

Protein

• UniProt ID: Q15181
• Protein name: Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)
• PDB: 6C45, 7BTN, 7CMO, 8J7Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00719	Pyrophosphatase	46 → 228	Inorganic pyrophosphatase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed ubiquitously. {ECO:0000269|PubMed:10542310}.
• Sequence:

  MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEI
  ATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPI
  DVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKP
  GYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGI
  SCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN

• Sequence length: 289

Pathways

KEGG:

Oxidative phosphorylation

Reactome:

Cytosolic tRNA aminoacylation
Pyrophosphate hydrolysis

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Autism Spectrum Disorder	Associate	37730588
Breast Neoplasms	Associate	17511879, 33991172
Carcinogenesis	Associate	27666431
Carcinoma Ovarian Epithelial	Associate	28202851
Cardiomyopathies	Associate	31705601
Colorectal Neoplasms	Associate	34821638
Drug Related Side Effects and Adverse Reactions	Associate	27631768
Gastrointestinal Neoplasms	Associate	26722435
Hereditary Breast and Ovarian Cancer Syndrome	Associate	17511879
Hyperthyroidism	Associate	34821638
Hypoxia	Associate	25967976
Leukemia B Cell	Associate	32138279
Lung Neoplasms	Associate	27666431, 34821638
Lymphatic Metastasis	Stimulate	22797819, 28202851
Melanoma	Associate	27631768
Neoplasm Metastasis	Stimulate	26722435
Neoplasm Metastasis	Associate	26948660
Neoplasms	Stimulate	22797819
Neoplasms	Associate	25923237, 26722435, 26948660, 27666431, 33991172, 34821638
Neoplasms	Inhibit	28202851
Osteoarthritis	Associate	15958763
Ovarian Neoplasms	Associate	24831101, 25923237, 28202851
Ovarian Neoplasms	Stimulate	27666431
Squamous Cell Carcinoma of Head and Neck	Associate	26948660
Stomach Neoplasms	Associate	22797819, 25923237, 26722435