Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	54629
Gene name	MINDY lysine 48 deubiquitinase 2
Gene symbol	MINDY2
Synonyms (NCBI Gene)	FAM63B
Chromosome	15
Chromosome location	15q21.3-q22.1

Show/Hide all (48)

miRTarBase ID	miRNA	Experiments	Reference
MIRT658372	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT658366	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT658369	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT668407	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT658370	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT668406	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT658367	hsa-miR-5580-5p	HITS-CLIP	23824327
MIRT658368	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT658366	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT658365	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT668405	hsa-miR-4435	HITS-CLIP	23824327
MIRT658364	hsa-miR-5096	HITS-CLIP	23824327
MIRT658372	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT658366	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT658369	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT658370	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT658367	hsa-miR-5580-5p	HITS-CLIP	23824327
MIRT658368	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT658366	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT658365	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT658364	hsa-miR-5096	HITS-CLIP	23824327
MIRT537477	hsa-miR-494-3p	PAR-CLIP	22012620
MIRT537476	hsa-miR-4802-3p	PAR-CLIP	22012620
MIRT537475	hsa-miR-3185	PAR-CLIP	22012620
MIRT537474	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT537473	hsa-miR-6759-3p	PAR-CLIP	22012620
MIRT537472	hsa-miR-7-5p	PAR-CLIP	22012620
MIRT537471	hsa-miR-6077	PAR-CLIP	22012620
MIRT537470	hsa-miR-510-3p	PAR-CLIP	22012620
MIRT523797	hsa-miR-409-3p	PAR-CLIP	23446348
MIRT523796	hsa-miR-4438	PAR-CLIP	23446348
MIRT523795	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT523794	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523793	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT523792	hsa-miR-4252	PAR-CLIP	23446348
MIRT523791	hsa-miR-6851-3p	PAR-CLIP	23446348
MIRT523790	hsa-miR-4425	PAR-CLIP	23446348
MIRT523789	hsa-miR-3147	PAR-CLIP	23446348
MIRT523788	hsa-miR-5095	PAR-CLIP	23446348
MIRT523787	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523786	hsa-miR-5100	PAR-CLIP	23446348
MIRT523785	hsa-miR-450b-3p	PAR-CLIP	23446348
MIRT523784	hsa-miR-769-3p	PAR-CLIP	23446348
MIRT523783	hsa-miR-6728-5p	PAR-CLIP	23446348
MIRT523782	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT523781	hsa-miR-3942-3p	PAR-CLIP	23446348
MIRT523780	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT523779	hsa-miR-619-5p	PAR-CLIP	23446348

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016807	Function	Cysteine-type carboxypeptidase activity	IBA
GO:0016807	Function	Cysteine-type carboxypeptidase activity	IDA	27292798
GO:0036435	Function	K48-linked polyubiquitin modification-dependent protein binding	IDA	28082312
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IDA	28082312
GO:0071795	Function	K11-linked polyubiquitin modification-dependent protein binding	IDA	28082312
GO:0071796	Function	K6-linked polyubiquitin modification-dependent protein binding	IDA	28082312
GO:0071944	Component	Cell periphery	IBA
GO:1990380	Function	K48-linked deubiquitinase activity	IBA
GO:1990380	Function	K48-linked deubiquitinase activity	IDA	27292798
GO:1990380	Function	K48-linked deubiquitinase activity	IEA

MIM	HGNC	e!Ensembl
618408	26954	ENSG00000128923

Q8NBR6

Protein name

Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B)

Protein function

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). M

PDB

6Z49 , 6Z7V , 7NPI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04424	MINDY_DUB	272 → 395	MINDY deubiquitinase	Family

Sequence

MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVWAAETSGGNGLGAAAAR
RSLPDSASPAGSPEVPGPCSSSAGLDLKDSGLESPAAAEAPLRGQYKVTASPETAVAGVG
HELGTAGDAGARPDLAGTCQAELTAAGSEEPSSAGGLSSSCSDPSPPGESPSLDSLESFS
NLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLCKEEEGEETAQVLAASKERFPGQ
SVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLG
DYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDL
LDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGFVAEQFLNNTA
TQLTYHGLCELTSTVQEGELCVFFRNNHFSTMTKYKGQLYLLVTDQGFLTEEKVVWESLH
NVDGDGNFCDSEFHLRPPSDPETVYKGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGI
SDLELAKKLQEEEDRRASQYYQEQEQAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERK
RKEPREKDKEKEKEKNSCVIL

Sequence length

621

Interactions

View interactions

MINDY2 (MINDY lysine 48 deubiquitinase 2)