Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5462
Gene name	POU class 5 homeobox 1B
Gene symbol	POU5F1B
Synonyms (NCBI Gene)	OCT4-PG1OCT4PG1OTF3COTF3P1POU5F1P1POU5F1P4POU5FLC20POU5FLC8
Chromosome	8
Chromosome location	8q24.21
Summary	This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5

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miRTarBase ID	miRNA	Experiments	Reference
MIRT639980	hsa-miR-4318	HITS-CLIP	23824327
MIRT639979	hsa-miR-892a	HITS-CLIP	23824327
MIRT639978	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT639977	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT639976	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT639975	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT639974	hsa-miR-4433a-5p	HITS-CLIP	23824327
MIRT639973	hsa-miR-3657	HITS-CLIP	23824327
MIRT639972	hsa-miR-4669	HITS-CLIP	23824327
MIRT639971	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT639970	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT639969	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT526515	hsa-miR-4282	PAR-CLIP	22012620
MIRT526514	hsa-miR-5692a	PAR-CLIP	22012620
MIRT526513	hsa-miR-590-3p	PAR-CLIP	22012620
MIRT526512	hsa-miR-3163	PAR-CLIP	22012620
MIRT526511	hsa-miR-8063	PAR-CLIP	22012620
MIRT526510	hsa-miR-4698	PAR-CLIP	22012620
MIRT526509	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT526508	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT526507	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT526506	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT526505	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT526504	hsa-miR-3663-5p	PAR-CLIP	22012620
MIRT526503	hsa-miR-6843-3p	PAR-CLIP	22012620
MIRT526502	hsa-miR-6848-3p	PAR-CLIP	22012620
MIRT526501	hsa-miR-8485	PAR-CLIP	22012620
MIRT526500	hsa-miR-105-5p	PAR-CLIP	22012620
MIRT526499	hsa-miR-7853-5p	PAR-CLIP	22012620
MIRT639980	hsa-miR-4318	HITS-CLIP	23824327
MIRT639979	hsa-miR-892a	HITS-CLIP	23824327
MIRT639978	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT639977	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT639976	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT639975	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT639974	hsa-miR-4433a-5p	HITS-CLIP	23824327
MIRT639973	hsa-miR-3657	HITS-CLIP	23824327
MIRT639972	hsa-miR-4669	HITS-CLIP	23824327
MIRT639971	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT639970	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT639969	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT526515	hsa-miR-4282	PAR-CLIP	22012620
MIRT526514	hsa-miR-5692a	PAR-CLIP	22012620
MIRT526513	hsa-miR-590-3p	PAR-CLIP	22012620
MIRT526512	hsa-miR-3163	PAR-CLIP	22012620
MIRT526511	hsa-miR-8063	PAR-CLIP	22012620
MIRT526510	hsa-miR-4698	PAR-CLIP	22012620
MIRT526509	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT526508	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT526507	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT526506	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT526505	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT526504	hsa-miR-3663-5p	PAR-CLIP	22012620
MIRT526503	hsa-miR-6843-3p	PAR-CLIP	22012620
MIRT526502	hsa-miR-6848-3p	PAR-CLIP	22012620
MIRT526501	hsa-miR-8485	PAR-CLIP	22012620
MIRT526500	hsa-miR-105-5p	PAR-CLIP	22012620
MIRT526499	hsa-miR-7853-5p	PAR-CLIP	22012620
MIRT2456951	hsa-miR-3545-3p	CLIP-seq
MIRT2456952	hsa-miR-412	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	1408763
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	1408763
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA

MIM	HGNC	e!Ensembl
615739	9223	ENSG00000212993

Q06416

Protein name

POU domain, class 5, transcription factor 1B (Oct4-pg1) (Octamer-binding protein 3-like) (Octamer-binding transcription factor 3-like)

Protein function

Shows weak transcriptional activator activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00157	Pou	141 → 212	Pou domain - N-terminal to homeobox domain	Domain
PF00046	Homeodomain	231 → 286	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in epithelial cells of the prostate (at protein level) (PubMed:20017164). Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma) (PubMe

Sequence

MAGHLASDFAFSPPPGGGGDGPWGAEPGWVDPLTWLSFQGPPGGPGIGPGVGPGSEVWGI
PPCPPPYELCGGMAYCGPQVGVGLVPQGGLETSQPESEAGVGVESNSNGASPEPCTVPPG
AVKLEKEKLEQNPEKSQDIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFS
QKTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLMQARKRKRTSIENR
VRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAA
GSPFSGGPVSFPPAPGPHFGTPGYGSPHFTALYSSVPFPEGEVFPPVSVITLGSPMHSN

Sequence length

359

Interactions

View interactions

	KEGG
	Signaling pathways regulating pluripotency of stem cells

POU5F1B (POU class 5 homeobox 1B)