Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54606
Gene name	DEAD-box helicase 56
Gene symbol	DDX56
Synonyms (NCBI Gene)	DDX21DDX26NOH61
Chromosome	7
Chromosome location	7p13
Summary	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA second

Show/Hide all (24)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025272	hsa-miR-34a-5p	Proteomics	21566225
MIRT025272	hsa-miR-34a-5p	Proteomics	21566225
MIRT049377	hsa-miR-92a-3p	CLASH	23622248
MIRT043777	hsa-miR-328-3p	CLASH	23622248
MIRT043450	hsa-miR-331-3p	CLASH	23622248
MIRT042629	hsa-miR-423-3p	CLASH	23622248
MIRT1975610	hsa-miR-1914	CLIP-seq
MIRT2211093	hsa-miR-1202	CLIP-seq
MIRT2211094	hsa-miR-1267	CLIP-seq
MIRT2211095	hsa-miR-28-5p	CLIP-seq
MIRT2211096	hsa-miR-31	CLIP-seq
MIRT2211097	hsa-miR-3139	CLIP-seq
MIRT2211098	hsa-miR-3194-5p	CLIP-seq
MIRT2211099	hsa-miR-3972	CLIP-seq
MIRT2211100	hsa-miR-4453	CLIP-seq
MIRT2211101	hsa-miR-4480	CLIP-seq
MIRT2211102	hsa-miR-4509	CLIP-seq
MIRT2211103	hsa-miR-4538	CLIP-seq
MIRT2211104	hsa-miR-4633-3p	CLIP-seq
MIRT2211105	hsa-miR-4652-3p	CLIP-seq
MIRT2211106	hsa-miR-4688	CLIP-seq
MIRT2211107	hsa-miR-4778-5p	CLIP-seq
MIRT2211108	hsa-miR-610	CLIP-seq
MIRT2211109	hsa-miR-708	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IDA	8524823, 31340999
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0003724	Function	RNA helicase activity	TAS	10749921
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	31340999
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	33109765
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	TAS	10749921
GO:0005829	Component	Cytosol	IDA	33109765
GO:0006364	Process	RRNA processing	IEA
GO:0006606	Process	Protein import into nucleus	IDA	31340999
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0032480	Process	Negative regulation of type I interferon production	IDA	31340999
GO:0035613	Function	RNA stem-loop binding	IDA	33109765
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0044830	Process	Host-mediated perturbation of viral RNA genome replication	IMP	33109765
GO:0051607	Process	Defense response to virus	IDA	33109765
GO:0140311	Function	Protein sequestering activity	IDA	31340999

MIM	HGNC	e!Ensembl
608023	18193	ENSG00000136271

Q9NY93

Protein name

Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56)

Protein function

Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed:31340999, PubMed:33789112). Plays an essential role in maintaining nucleolar integrity in p

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	31 → 207	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	243 → 380	Helicase conserved C-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in heart, brain, liver, pancreas, placenta and lung.

Sequence

MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAA
YAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSA
AEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEEL
KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCET
EEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHI
ISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNF
DLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRM
EEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPL
HPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKF
RPTAKPS

Sequence length

547

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Uncertain significance	rs139810379	RCV005928967
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs139810379	RCV005928968

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alphavirus Infections	Associate	33109765
Carcinogenesis	Associate	28842590
Chikungunya Fever	Associate	33109765
Colorectal Neoplasms	Associate	26311743, 33328538
Drug Related Side Effects and Adverse Reactions	Associate	33657088
Infections	Inhibit	33109765
Infertility	Associate	25791297
Myelodysplastic Syndromes	Associate	31855738
Neoplasms	Associate	33328538
Prostatic Neoplasms	Associate	23349811
Squamous Cell Carcinoma of Head and Neck	Associate	27835882
Virus Diseases	Associate	29373715

DDX56 (DEAD-box helicase 56)