Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54584
Gene name Gene Name - the full gene name approved by the HGNC.	G protein subunit beta 1 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GNB1L
Synonyms (NCBI Gene) Gene synonyms aliases	DGCRK3, FKSG1, GY2, WDR14, WDVCF
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilit

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miRTarBase ID	miRNA	Experiments	Reference
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	20371350
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	20371350
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT529894	hsa-miR-3926	PAR-CLIP	22012620
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	22012620
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	22012620
MIRT483913	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT483911	hsa-miR-3197	PAR-CLIP	23592263
MIRT483909	hsa-miR-6087	PAR-CLIP	23592263
MIRT483910	hsa-miR-4252	PAR-CLIP	23592263
MIRT483908	hsa-miR-4316	PAR-CLIP	23592263
MIRT483907	hsa-miR-1294	PAR-CLIP	23592263
MIRT483906	hsa-miR-663b	PAR-CLIP	23592263
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT483904	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT489330	hsa-miR-4717-5p	PAR-CLIP	23592263
MIRT489329	hsa-miR-1321	PAR-CLIP	23592263
MIRT489327	hsa-miR-4739	PAR-CLIP	23592263
MIRT489328	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489326	hsa-miR-5690	PAR-CLIP	23592263
MIRT489325	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT489324	hsa-miR-6749-5p	PAR-CLIP	23592263
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	23592263
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	23592263
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	23592263
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT483913	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT483911	hsa-miR-3197	PAR-CLIP	23592263
MIRT483909	hsa-miR-6087	PAR-CLIP	23592263
MIRT483910	hsa-miR-4252	PAR-CLIP	23592263
MIRT483908	hsa-miR-4316	PAR-CLIP	23592263
MIRT483907	hsa-miR-1294	PAR-CLIP	23592263
MIRT483906	hsa-miR-663b	PAR-CLIP	23592263
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT483904	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	23592263
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	23592263
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	23592263
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT483907	hsa-miR-1294	PAR-CLIP	26701625
MIRT483907	hsa-miR-1294	PAR-CLIP	26701625
MIRT483913	hsa-miR-212-5p	PAR-CLIP	26701625
MIRT483913	hsa-miR-212-5p	PAR-CLIP	26701625
MIRT483911	hsa-miR-3197	PAR-CLIP	26701625
MIRT483911	hsa-miR-3197	PAR-CLIP	26701625
MIRT483910	hsa-miR-4252	PAR-CLIP	26701625
MIRT483910	hsa-miR-4252	PAR-CLIP	26701625
MIRT483908	hsa-miR-4316	PAR-CLIP	26701625
MIRT483908	hsa-miR-4316	PAR-CLIP	26701625
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	26701625
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	26701625
MIRT483909	hsa-miR-6087	PAR-CLIP	26701625
MIRT483909	hsa-miR-6087	PAR-CLIP	26701625
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	26701625
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	26701625
MIRT483907	hsa-miR-1294	PAR-CLIP	27292025
MIRT483913	hsa-miR-212-5p	PAR-CLIP	27292025
MIRT483911	hsa-miR-3197	PAR-CLIP	27292025
MIRT483910	hsa-miR-4252	PAR-CLIP	27292025
MIRT483908	hsa-miR-4316	PAR-CLIP	27292025
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	27292025
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	27292025
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	27292025
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	27292025
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	27292025
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	27292025
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	27292025
MIRT483909	hsa-miR-6087	PAR-CLIP	27292025
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	27292025
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	27292025
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	27292025
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	27292025
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	27292025
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	27292025
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	27292025
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	20371350
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	20371350
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	20371350
MIRT529894	hsa-miR-3926	PAR-CLIP	22012620
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	22012620
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	22012620
MIRT483913	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT483911	hsa-miR-3197	PAR-CLIP	23592263
MIRT483909	hsa-miR-6087	PAR-CLIP	23592263
MIRT483910	hsa-miR-4252	PAR-CLIP	23592263
MIRT483908	hsa-miR-4316	PAR-CLIP	23592263
MIRT483907	hsa-miR-1294	PAR-CLIP	23592263
MIRT483906	hsa-miR-663b	PAR-CLIP	23592263
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT483904	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT489330	hsa-miR-4717-5p	PAR-CLIP	23592263
MIRT489329	hsa-miR-1321	PAR-CLIP	23592263
MIRT489327	hsa-miR-4739	PAR-CLIP	23592263
MIRT489328	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489326	hsa-miR-5690	PAR-CLIP	23592263
MIRT489325	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT489324	hsa-miR-6749-5p	PAR-CLIP	23592263
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	23592263
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	23592263
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	23592263
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT483913	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT483912	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT483911	hsa-miR-3197	PAR-CLIP	23592263
MIRT483909	hsa-miR-6087	PAR-CLIP	23592263
MIRT483910	hsa-miR-4252	PAR-CLIP	23592263
MIRT483908	hsa-miR-4316	PAR-CLIP	23592263
MIRT483907	hsa-miR-1294	PAR-CLIP	23592263
MIRT483906	hsa-miR-663b	PAR-CLIP	23592263
MIRT483905	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT483904	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT483903	hsa-miR-4684-5p	PAR-CLIP	23592263
MIRT483901	hsa-miR-4768-5p	PAR-CLIP	23592263
MIRT483902	hsa-miR-6833-3p	PAR-CLIP	23592263
MIRT483900	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT1023869	hsa-miR-138	CLIP-seq
MIRT1023870	hsa-miR-1827	CLIP-seq
MIRT1023871	hsa-miR-2277-3p	CLIP-seq
MIRT1023872	hsa-miR-3189-3p	CLIP-seq
MIRT1023873	hsa-miR-4257	CLIP-seq
MIRT1023874	hsa-miR-4640-5p	CLIP-seq
MIRT1023875	hsa-miR-4652-5p	CLIP-seq
MIRT1023876	hsa-miR-4679	CLIP-seq
MIRT1023877	hsa-miR-4706	CLIP-seq
MIRT1023878	hsa-miR-4726-5p	CLIP-seq
MIRT1023879	hsa-miR-4749-5p	CLIP-seq
MIRT1023880	hsa-miR-4780	CLIP-seq
MIRT1023881	hsa-miR-4781-5p	CLIP-seq
MIRT1023882	hsa-miR-635	CLIP-seq
MIRT2540123	hsa-miR-1207-3p	CLIP-seq
MIRT2540124	hsa-miR-3128	CLIP-seq
MIRT2540123	hsa-miR-1207-3p	CLIP-seq
MIRT2540124	hsa-miR-3128	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	11072084
GO:0009898	Component	Cytoplasmic side of plasma membrane	NAS	11072084
GO:0035556	Process	Intracellular signal transduction	NAS	11072084

MIM	HGNC	e!Ensembl
610778	4397	ENSG00000185838

Protein

UniProt ID

Q9BYB4

Protein name

Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (DGCRK3) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF)

Protein function

Acts as a critical regulator of DNA damage response (DDR) signaling via specifically regulating phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	285 → 322	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart, liver, skeletal muscle, kidney, spleen, thymus and pancreas. Detected at low levels in lung, placenta and brain. {ECO:0000269|PubMed:11072084}.

Sequence

MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAV
TTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSI
LAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPL
LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ
QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC
VAFTADGLLAAGSKDQRISLWSLYPRA

Sequence length

327

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	22457764, 20538345, 18003636, 22095694

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Glaucoma	Glaucoma			GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
22q11 Deletion Syndrome	Associate	19011233
Autism Spectrum Disorder	Associate	22095694
Autistic Disorder	Associate	22095694
Bipolar Disorder	Associate	24831436
Carcinoma Hepatocellular	Associate	22326833
Chromosome Deletion	Associate	24831436
Glaucoma Open Angle	Associate	33726755
Heart Septal Defects Ventricular	Associate	19268070
Schizophrenia	Associate	19011233, 22095694, 24831436
Schizophrenia	Inhibit	19011233

GNB1L (G protein subunit beta 1 like)