EXOC6 (exocyst complex component 6)

Gene

• Entrez ID: 54536
• Gene name: Exocyst complex component 6
• Gene symbol: EXOC6
• Synonyms (NCBI Gene): EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p
• Chromosome: 10
• Chromosome location: 10q23.33
• Summary: The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex re

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019705	hsa-miR-375	Microarray	20215506
MIRT049903	hsa-miR-31-5p	CLASH	23622248
MIRT178387	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT639377	hsa-miR-1206	HITS-CLIP	23824327
MIRT639376	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT019705	hsa-miR-375	HITS-CLIP	23824327
MIRT639375	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT178387	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT639377	hsa-miR-1206	HITS-CLIP	23824327
MIRT019705	hsa-miR-375	HITS-CLIP	23824327
MIRT639375	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT178387	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT639377	hsa-miR-1206	HITS-CLIP	23824327
MIRT639376	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT019705	hsa-miR-375	HITS-CLIP	23824327
MIRT639375	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT178387	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT639377	hsa-miR-1206	HITS-CLIP	23824327
MIRT639376	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT019705	hsa-miR-375	HITS-CLIP	23824327
MIRT639375	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT178387	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT639377	hsa-miR-1206	HITS-CLIP	23824327
MIRT019705	hsa-miR-375	HITS-CLIP	23824327
MIRT639375	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT178387	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT639377	hsa-miR-1206	HITS-CLIP	23824327
MIRT639376	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT019705	hsa-miR-375	HITS-CLIP	23824327
MIRT639375	hsa-miR-6739-3p	HITS-CLIP	23824327
MIRT972813	hsa-miR-105	CLIP-seq
MIRT972814	hsa-miR-1178	CLIP-seq
MIRT972815	hsa-miR-1183	CLIP-seq
MIRT972816	hsa-miR-1243	CLIP-seq
MIRT972817	hsa-miR-1290	CLIP-seq
MIRT972818	hsa-miR-1305	CLIP-seq
MIRT972819	hsa-miR-2054	CLIP-seq
MIRT972820	hsa-miR-3065-5p	CLIP-seq
MIRT972821	hsa-miR-30a	CLIP-seq
MIRT972822	hsa-miR-30b	CLIP-seq
MIRT972823	hsa-miR-30c	CLIP-seq
MIRT972824	hsa-miR-30d	CLIP-seq
MIRT972825	hsa-miR-30e	CLIP-seq
MIRT972826	hsa-miR-3130-3p	CLIP-seq
MIRT972827	hsa-miR-3163	CLIP-seq
MIRT972828	hsa-miR-3167	CLIP-seq
MIRT972829	hsa-miR-3607-3p	CLIP-seq
MIRT972830	hsa-miR-3616-5p	CLIP-seq
MIRT972831	hsa-miR-3622a-3p	CLIP-seq
MIRT972832	hsa-miR-3622b-3p	CLIP-seq
MIRT972833	hsa-miR-3647-5p	CLIP-seq
MIRT972834	hsa-miR-3671	CLIP-seq
MIRT972835	hsa-miR-3686	CLIP-seq
MIRT972836	hsa-miR-410	CLIP-seq
MIRT972837	hsa-miR-421	CLIP-seq
MIRT972838	hsa-miR-4307	CLIP-seq
MIRT972839	hsa-miR-4320	CLIP-seq
MIRT972840	hsa-miR-4438	CLIP-seq
MIRT972841	hsa-miR-4463	CLIP-seq
MIRT972842	hsa-miR-4650-5p	CLIP-seq
MIRT972843	hsa-miR-4693-5p	CLIP-seq
MIRT972844	hsa-miR-4778-5p	CLIP-seq
MIRT972845	hsa-miR-4795-5p	CLIP-seq
MIRT972846	hsa-miR-5095	CLIP-seq
MIRT972847	hsa-miR-522	CLIP-seq
MIRT972848	hsa-miR-548u	CLIP-seq
MIRT972849	hsa-miR-573	CLIP-seq
MIRT972850	hsa-miR-587	CLIP-seq
MIRT972851	hsa-miR-600	CLIP-seq
MIRT972852	hsa-miR-605	CLIP-seq
MIRT972853	hsa-miR-607	CLIP-seq
MIRT972854	hsa-miR-876-5p	CLIP-seq
MIRT1988255	hsa-miR-23a	CLIP-seq
MIRT1988256	hsa-miR-23b	CLIP-seq
MIRT1988257	hsa-miR-23c	CLIP-seq
MIRT1988258	hsa-miR-4291	CLIP-seq
MIRT1988259	hsa-miR-4699-5p	CLIP-seq
MIRT1988260	hsa-miR-4719	CLIP-seq
MIRT1988261	hsa-miR-4756-3p	CLIP-seq
MIRT1988262	hsa-miR-4760-3p	CLIP-seq
MIRT1988263	hsa-miR-520a-5p	CLIP-seq
MIRT1988264	hsa-miR-525-5p	CLIP-seq
MIRT1988265	hsa-miR-550b	CLIP-seq
MIRT1988266	hsa-miR-889	CLIP-seq
MIRT2222724	hsa-miR-3180-5p	CLIP-seq
MIRT2222725	hsa-miR-4464	CLIP-seq
MIRT2222726	hsa-miR-4748	CLIP-seq
MIRT1988263	hsa-miR-520a-5p	CLIP-seq
MIRT1988264	hsa-miR-525-5p	CLIP-seq
MIRT2222727	hsa-miR-579	CLIP-seq
MIRT2526378	hsa-miR-3185	CLIP-seq
MIRT2526379	hsa-miR-4709-3p	CLIP-seq
MIRT2526380	hsa-miR-490-3p	CLIP-seq
MIRT2526381	hsa-miR-548a-5p	CLIP-seq
MIRT2526382	hsa-miR-548ab	CLIP-seq
MIRT2526383	hsa-miR-548ak	CLIP-seq
MIRT2526384	hsa-miR-548b-5p	CLIP-seq
MIRT2526385	hsa-miR-548c-5p	CLIP-seq
MIRT2526386	hsa-miR-548d-5p	CLIP-seq
MIRT2526387	hsa-miR-548h	CLIP-seq
MIRT2526388	hsa-miR-548i	CLIP-seq
MIRT2526389	hsa-miR-548j	CLIP-seq
MIRT2526390	hsa-miR-548w	CLIP-seq
MIRT2526391	hsa-miR-548y	CLIP-seq
MIRT2526392	hsa-miR-559	CLIP-seq
MIRT2526393	hsa-miR-649	CLIP-seq
MIRT2526378	hsa-miR-3185	CLIP-seq
MIRT2526379	hsa-miR-4709-3p	CLIP-seq
MIRT2526380	hsa-miR-490-3p	CLIP-seq
MIRT2526381	hsa-miR-548a-5p	CLIP-seq
MIRT2526382	hsa-miR-548ab	CLIP-seq
MIRT2526383	hsa-miR-548ak	CLIP-seq
MIRT2526384	hsa-miR-548b-5p	CLIP-seq
MIRT2526385	hsa-miR-548c-5p	CLIP-seq
MIRT2526386	hsa-miR-548d-5p	CLIP-seq
MIRT2526387	hsa-miR-548h	CLIP-seq
MIRT2526388	hsa-miR-548i	CLIP-seq
MIRT2526389	hsa-miR-548j	CLIP-seq
MIRT2526390	hsa-miR-548w	CLIP-seq
MIRT2526391	hsa-miR-548y	CLIP-seq
MIRT2526392	hsa-miR-559	CLIP-seq
MIRT2526393	hsa-miR-649	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000145	Component	Exocyst	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25556234, 27173435, 28514442, 32296183, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006887	Process	Exocytosis	IBA	21873635
GO:0006893	Process	Golgi to plasma membrane transport	IBA	21873635
GO:0006904	Process	Vesicle docking involved in exocytosis	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IBA	21873635
GO:0030426	Component	Growth cone	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0090543	Component	Flemming body	IEA

Other IDs

• MIM: 609672
• HGNC: 23196
• e!Ensembl: ENSG00000138190

Protein

• UniProt ID: Q8TAG9
• Protein name: Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)
• Protein function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membra
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04091	Sec15	456 → 762	Exocyst complex subunit Sec15-like	Family

• Sequence:

  MAENSESLGTVPEHERILQEIESTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDK
  EIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVHTEDIIRCRI
  QQRNITTVVEKLQLCLPVLEMYSKLKEQMSAKRYYSALKTMEQLENVYFPWVSQYRFCQL
  MIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQHQKTFSVSLQKQNKMKF
  GKNMYINRDRIPEERNETVLKHSLEEEDENEEEILTVQDLVDFSPVYRCLHIYSVLGDEE
  TFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAY
  TDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLTVIFADTLQGYGFPVNRLFDLLFEI
  RDQYNETLLKKWAGVFRDIFEEDNYSPIPVVNEEEYKIVISKFPFQDPDLEKQSFPKKFP
  MSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIRKP
  HIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGE
  IYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACM
  SACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFID
  LRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDR
  DKQKLIETVVKQLRSLVNGMSQHM

• Sequence length: 804

Pathways

Reactome:

Insulin processing
VxPx cargo-targeting to cilium

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	26818947

Unknown
Disease term	Disease name	Evidence	References	Source
Metabolic Syndrome	Metabolic Syndrome			GWAS
Diabetes	Diabetes			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Coronary artery disease	Coronary artery disease			GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS
Restless Legs Syndrome	Restless Legs Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	28798985, 35265226
Diabetes Gestational	Associate	38087213
Fibrocystic Breast Disease	Associate	28798985
Optic Nerve Aplasia Bilateral	Associate	21850183