MIER2 (MIER family member 2)

Gene

• Entrez ID: 54531
• Gene name: MIER family member 2
• Gene symbol: MIER2
• Synonyms (NCBI Gene): KIAA1193, Mi-er2
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051939	hsa-let-7b-5p	CLASH	23622248
MIRT044345	hsa-miR-106b-5p	CLASH	23622248
MIRT038143	hsa-miR-423-5p	CLASH	23622248
MIRT1148919	hsa-miR-1193	CLIP-seq
MIRT1148920	hsa-miR-1200	CLIP-seq
MIRT1148921	hsa-miR-128	CLIP-seq
MIRT1148922	hsa-miR-2110	CLIP-seq
MIRT1148923	hsa-miR-2682	CLIP-seq
MIRT1148924	hsa-miR-27a	CLIP-seq
MIRT1148925	hsa-miR-27b	CLIP-seq
MIRT1148926	hsa-miR-3074-5p	CLIP-seq
MIRT1148927	hsa-miR-3119	CLIP-seq
MIRT1148928	hsa-miR-3120-3p	CLIP-seq
MIRT1148929	hsa-miR-3126-5p	CLIP-seq
MIRT1148930	hsa-miR-3140-5p	CLIP-seq
MIRT1148931	hsa-miR-3179	CLIP-seq
MIRT1148932	hsa-miR-3189-3p	CLIP-seq
MIRT1148933	hsa-miR-3202	CLIP-seq
MIRT1148934	hsa-miR-34c-3p	CLIP-seq
MIRT1148935	hsa-miR-3616-5p	CLIP-seq
MIRT1148936	hsa-miR-3647-5p	CLIP-seq
MIRT1148937	hsa-miR-3671	CLIP-seq
MIRT1148938	hsa-miR-3714	CLIP-seq
MIRT1148939	hsa-miR-3922-5p	CLIP-seq
MIRT1148940	hsa-miR-3936	CLIP-seq
MIRT1148941	hsa-miR-4271	CLIP-seq
MIRT1148942	hsa-miR-4283	CLIP-seq
MIRT1148943	hsa-miR-4302	CLIP-seq
MIRT1148944	hsa-miR-4419a	CLIP-seq
MIRT1148945	hsa-miR-449c	CLIP-seq
MIRT1148946	hsa-miR-4510	CLIP-seq
MIRT1148947	hsa-miR-4710	CLIP-seq
MIRT1148948	hsa-miR-4725-3p	CLIP-seq
MIRT1148949	hsa-miR-4747-5p	CLIP-seq
MIRT1148950	hsa-miR-4762-5p	CLIP-seq
MIRT1148951	hsa-miR-4795-5p	CLIP-seq
MIRT1148952	hsa-miR-491-5p	CLIP-seq
MIRT1148953	hsa-miR-513a-5p	CLIP-seq
MIRT1148954	hsa-miR-541	CLIP-seq
MIRT1148955	hsa-miR-545	CLIP-seq
MIRT1148956	hsa-miR-573	CLIP-seq
MIRT1148957	hsa-miR-607	CLIP-seq
MIRT1148958	hsa-miR-654-5p	CLIP-seq
MIRT1148959	hsa-miR-7	CLIP-seq
MIRT1148960	hsa-miR-873	CLIP-seq
MIRT1556692	hsa-miR-4270	CLIP-seq
MIRT1556693	hsa-miR-4441	CLIP-seq
MIRT1556694	hsa-miR-4716-3p	CLIP-seq
MIRT2042361	hsa-miR-1204	CLIP-seq
MIRT2042362	hsa-miR-1236	CLIP-seq
MIRT2042363	hsa-miR-1285	CLIP-seq
MIRT2042364	hsa-miR-146b-3p	CLIP-seq
MIRT2042365	hsa-miR-1538	CLIP-seq
MIRT2042366	hsa-miR-1908	CLIP-seq
MIRT2042367	hsa-miR-1913	CLIP-seq
MIRT2042368	hsa-miR-214	CLIP-seq
MIRT2042369	hsa-miR-3173-5p	CLIP-seq
MIRT2042370	hsa-miR-3182	CLIP-seq
MIRT2042371	hsa-miR-3187-5p	CLIP-seq
MIRT2042372	hsa-miR-3193	CLIP-seq
MIRT2042373	hsa-miR-3194-3p	CLIP-seq
MIRT2042374	hsa-miR-324-3p	CLIP-seq
MIRT2042375	hsa-miR-342-5p	CLIP-seq
MIRT2042376	hsa-miR-3619-5p	CLIP-seq
MIRT2042377	hsa-miR-378g	CLIP-seq
MIRT2042378	hsa-miR-4268	CLIP-seq
MIRT2042379	hsa-miR-4435	CLIP-seq
MIRT2042380	hsa-miR-4486	CLIP-seq
MIRT2042381	hsa-miR-4514	CLIP-seq
MIRT2042382	hsa-miR-4530	CLIP-seq
MIRT2042383	hsa-miR-4651	CLIP-seq
MIRT2042384	hsa-miR-4664-5p	CLIP-seq
MIRT2042385	hsa-miR-4692	CLIP-seq
MIRT2042386	hsa-miR-4707-5p	CLIP-seq
MIRT2042387	hsa-miR-4745-3p	CLIP-seq
MIRT2042388	hsa-miR-608	CLIP-seq
MIRT2042389	hsa-miR-612	CLIP-seq
MIRT2042390	hsa-miR-622	CLIP-seq
MIRT2042391	hsa-miR-663	CLIP-seq
MIRT2042392	hsa-miR-760	CLIP-seq
MIRT2042393	hsa-miR-761	CLIP-seq
MIRT2042394	hsa-miR-874	CLIP-seq
MIRT2042395	hsa-miR-885-3p	CLIP-seq
MIRT2271989	hsa-miR-106a	CLIP-seq
MIRT2271990	hsa-miR-106b	CLIP-seq
MIRT1148919	hsa-miR-1193	CLIP-seq
MIRT1148921	hsa-miR-128	CLIP-seq
MIRT2042365	hsa-miR-1538	CLIP-seq
MIRT2271991	hsa-miR-17	CLIP-seq
MIRT2271992	hsa-miR-20a	CLIP-seq
MIRT2271993	hsa-miR-20b	CLIP-seq
MIRT1148924	hsa-miR-27a	CLIP-seq
MIRT1148925	hsa-miR-27b	CLIP-seq
MIRT1148929	hsa-miR-3126-5p	CLIP-seq
MIRT2271994	hsa-miR-3173-3p	CLIP-seq
MIRT1148932	hsa-miR-3189-3p	CLIP-seq
MIRT2042375	hsa-miR-342-5p	CLIP-seq
MIRT2271995	hsa-miR-3609	CLIP-seq
MIRT1148942	hsa-miR-4283	CLIP-seq
MIRT1148943	hsa-miR-4302	CLIP-seq
MIRT1148944	hsa-miR-4419a	CLIP-seq
MIRT2271996	hsa-miR-4447	CLIP-seq
MIRT2271997	hsa-miR-4472	CLIP-seq
MIRT1148946	hsa-miR-4510	CLIP-seq
MIRT2042383	hsa-miR-4651	CLIP-seq
MIRT2042384	hsa-miR-4664-5p	CLIP-seq
MIRT1148947	hsa-miR-4710	CLIP-seq
MIRT2042387	hsa-miR-4745-3p	CLIP-seq
MIRT2271998	hsa-miR-4796-3p	CLIP-seq
MIRT1148953	hsa-miR-513a-5p	CLIP-seq
MIRT2271999	hsa-miR-519d	CLIP-seq
MIRT1148954	hsa-miR-541	CLIP-seq
MIRT2272000	hsa-miR-548ah	CLIP-seq
MIRT2042388	hsa-miR-608	CLIP-seq
MIRT1148958	hsa-miR-654-5p	CLIP-seq
MIRT2042392	hsa-miR-760	CLIP-seq
MIRT2272001	hsa-miR-93	CLIP-seq
MIRT2390889	hsa-miR-1207-5p	CLIP-seq
MIRT2390890	hsa-miR-3160-3p	CLIP-seq
MIRT2390891	hsa-miR-3616-3p	CLIP-seq
MIRT1556692	hsa-miR-4270	CLIP-seq
MIRT2390892	hsa-miR-4300	CLIP-seq
MIRT1556693	hsa-miR-4441	CLIP-seq
MIRT2390893	hsa-miR-4721	CLIP-seq
MIRT2390894	hsa-miR-4763-3p	CLIP-seq
MIRT2390895	hsa-miR-486-3p	CLIP-seq
MIRT2390896	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0004407	Function	Histone deacetylase activity	IDA	28046085
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	28046085
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	28046085
GO:0032991	Component	Protein-containing complex	IDA	28046085
GO:0032991	Component	Protein-containing complex	IEA
GO:0042826	Function	Histone deacetylase binding	IBA
GO:0042826	Function	Histone deacetylase binding	IPI	28046085

Other IDs

• MIM: 620092
• HGNC: 29210
• e!Ensembl: ENSG00000105556

Protein

• UniProt ID: Q8N344
• Protein name: Mesoderm induction early response protein 2 (Mi-er2)
• Protein function: Transcriptional repressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01448	ELM2	197 → 247	ELM2 domain	Family
  PF00249	Myb_DNA-binding	300 → 345	Myb-like DNA-binding domain	Domain

• Sequence:

  MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGEC
  EEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMT
  LDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
  SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEE
  FLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLC
  AWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLG
  RRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDG
  LPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKEL
  PLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHC
  NVMTC

• Sequence length: 545

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Malignant tumor of esophagus	Uncertain significance	rs762665176	RCV005932669