Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54522
Gene name Gene Name - the full gene name approved by the HGNC.	Ankyrin repeat domain 16
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANKRD16
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p15.1

Show/Hide all(153)

miRTarBase ID	miRNA	Experiments
MIRT782893	hsa-miR-1254	CLIP-seq
MIRT782894	hsa-miR-1270	CLIP-seq
MIRT782895	hsa-miR-129-5p	CLIP-seq
MIRT782896	hsa-miR-197	CLIP-seq
MIRT782897	hsa-miR-1976	CLIP-seq
MIRT782898	hsa-miR-3116	CLIP-seq
MIRT782899	hsa-miR-3199	CLIP-seq
MIRT782900	hsa-miR-412	CLIP-seq
MIRT782901	hsa-miR-4258	CLIP-seq
MIRT782902	hsa-miR-4294	CLIP-seq
MIRT782903	hsa-miR-431	CLIP-seq
MIRT782904	hsa-miR-433	CLIP-seq
MIRT782905	hsa-miR-4438	CLIP-seq
MIRT782906	hsa-miR-4531	CLIP-seq
MIRT782907	hsa-miR-5095	CLIP-seq
MIRT782908	hsa-miR-617	CLIP-seq
MIRT782909	hsa-miR-620	CLIP-seq
MIRT782910	hsa-miR-661	CLIP-seq
MIRT782911	hsa-miR-924	CLIP-seq
MIRT1931036	hsa-miR-1193	CLIP-seq
MIRT1931037	hsa-miR-1200	CLIP-seq
MIRT1931038	hsa-miR-1234	CLIP-seq
MIRT782893	hsa-miR-1254	CLIP-seq
MIRT1931039	hsa-miR-150	CLIP-seq
MIRT782896	hsa-miR-197	CLIP-seq
MIRT782897	hsa-miR-1976	CLIP-seq
MIRT1931040	hsa-miR-2113	CLIP-seq
MIRT1931041	hsa-miR-2392	CLIP-seq
MIRT782898	hsa-miR-3116	CLIP-seq
MIRT782899	hsa-miR-3199	CLIP-seq
MIRT782901	hsa-miR-4258	CLIP-seq
MIRT1931042	hsa-miR-4307	CLIP-seq
MIRT1931043	hsa-miR-4324	CLIP-seq
MIRT782905	hsa-miR-4438	CLIP-seq
MIRT1931044	hsa-miR-4662a-5p	CLIP-seq
MIRT1931045	hsa-miR-4676-5p	CLIP-seq
MIRT1931046	hsa-miR-4735-5p	CLIP-seq
MIRT1931047	hsa-miR-4775	CLIP-seq
MIRT1931048	hsa-miR-4794	CLIP-seq
MIRT782907	hsa-miR-5095	CLIP-seq
MIRT1931049	hsa-miR-5096	CLIP-seq
MIRT1931050	hsa-miR-520g	CLIP-seq
MIRT1931051	hsa-miR-520h	CLIP-seq
MIRT1931052	hsa-miR-544b	CLIP-seq
MIRT1931053	hsa-miR-575	CLIP-seq
MIRT1931054	hsa-miR-590-3p	CLIP-seq
MIRT1931055	hsa-miR-599	CLIP-seq
MIRT782910	hsa-miR-661	CLIP-seq
MIRT1931056	hsa-miR-892a	CLIP-seq
MIRT2171614	hsa-miR-106a	CLIP-seq
MIRT2171615	hsa-miR-106b	CLIP-seq
MIRT2171616	hsa-miR-1179	CLIP-seq
MIRT1931037	hsa-miR-1200	CLIP-seq
MIRT2171617	hsa-miR-122	CLIP-seq
MIRT1931038	hsa-miR-1234	CLIP-seq
MIRT2171618	hsa-miR-124	CLIP-seq
MIRT782893	hsa-miR-1254	CLIP-seq
MIRT2171619	hsa-miR-1258	CLIP-seq
MIRT2171620	hsa-miR-1267	CLIP-seq
MIRT1931039	hsa-miR-150	CLIP-seq
MIRT2171621	hsa-miR-17	CLIP-seq
MIRT2171622	hsa-miR-1827	CLIP-seq
MIRT782897	hsa-miR-1976	CLIP-seq
MIRT2171623	hsa-miR-20a	CLIP-seq
MIRT2171624	hsa-miR-20b	CLIP-seq
MIRT2171625	hsa-miR-223	CLIP-seq
MIRT2171626	hsa-miR-2467-3p	CLIP-seq
MIRT2171627	hsa-miR-27a	CLIP-seq
MIRT2171628	hsa-miR-27b	CLIP-seq
MIRT2171629	hsa-miR-298	CLIP-seq
MIRT2171630	hsa-miR-302a	CLIP-seq
MIRT2171631	hsa-miR-302b	CLIP-seq
MIRT2171632	hsa-miR-302c	CLIP-seq
MIRT2171633	hsa-miR-302d	CLIP-seq
MIRT2171634	hsa-miR-302e	CLIP-seq
MIRT782898	hsa-miR-3116	CLIP-seq
MIRT2171635	hsa-miR-3127-5p	CLIP-seq
MIRT2171636	hsa-miR-3135b	CLIP-seq
MIRT2171637	hsa-miR-3194-3p	CLIP-seq
MIRT782899	hsa-miR-3199	CLIP-seq
MIRT2171638	hsa-miR-3652	CLIP-seq
MIRT2171639	hsa-miR-372	CLIP-seq
MIRT2171640	hsa-miR-373	CLIP-seq
MIRT2171641	hsa-miR-3918	CLIP-seq
MIRT782901	hsa-miR-4258	CLIP-seq
MIRT2171642	hsa-miR-4279	CLIP-seq
MIRT782902	hsa-miR-4294	CLIP-seq
MIRT782903	hsa-miR-431	CLIP-seq
MIRT2171643	hsa-miR-4310	CLIP-seq
MIRT1931043	hsa-miR-4324	CLIP-seq
MIRT2171644	hsa-miR-4328	CLIP-seq
MIRT782904	hsa-miR-433	CLIP-seq
MIRT2171645	hsa-miR-4423-3p	CLIP-seq
MIRT2171646	hsa-miR-4423-5p	CLIP-seq
MIRT2171647	hsa-miR-4430	CLIP-seq
MIRT2171648	hsa-miR-4436b-3p	CLIP-seq
MIRT782905	hsa-miR-4438	CLIP-seq
MIRT2171649	hsa-miR-4722-3p	CLIP-seq
MIRT2171650	hsa-miR-4731-5p	CLIP-seq
MIRT1931046	hsa-miR-4735-5p	CLIP-seq
MIRT2171651	hsa-miR-4772-5p	CLIP-seq
MIRT1931047	hsa-miR-4775	CLIP-seq
MIRT2171652	hsa-miR-4793-5p	CLIP-seq
MIRT1931048	hsa-miR-4794	CLIP-seq
MIRT2171653	hsa-miR-506	CLIP-seq
MIRT782907	hsa-miR-5095	CLIP-seq
MIRT2171654	hsa-miR-512-3p	CLIP-seq
MIRT2171655	hsa-miR-513a-5p	CLIP-seq
MIRT2171656	hsa-miR-519d	CLIP-seq
MIRT2171657	hsa-miR-520a-3p	CLIP-seq
MIRT2171658	hsa-miR-520b	CLIP-seq
MIRT2171659	hsa-miR-520c-3p	CLIP-seq
MIRT2171660	hsa-miR-520d-3p	CLIP-seq
MIRT2171661	hsa-miR-520e	CLIP-seq
MIRT1931050	hsa-miR-520g	CLIP-seq
MIRT1931051	hsa-miR-520h	CLIP-seq
MIRT1931052	hsa-miR-544b	CLIP-seq
MIRT1931054	hsa-miR-590-3p	CLIP-seq
MIRT782910	hsa-miR-661	CLIP-seq
MIRT782911	hsa-miR-924	CLIP-seq
MIRT2171662	hsa-miR-93	CLIP-seq
MIRT782893	hsa-miR-1254	CLIP-seq
MIRT782898	hsa-miR-3116	CLIP-seq
MIRT1931046	hsa-miR-4735-5p	CLIP-seq
MIRT1931047	hsa-miR-4775	CLIP-seq
MIRT1931048	hsa-miR-4794	CLIP-seq
MIRT1931054	hsa-miR-590-3p	CLIP-seq
MIRT782910	hsa-miR-661	CLIP-seq
MIRT782893	hsa-miR-1254	CLIP-seq
MIRT782895	hsa-miR-129-5p	CLIP-seq
MIRT782898	hsa-miR-3116	CLIP-seq
MIRT2474692	hsa-miR-3149	CLIP-seq
MIRT2171637	hsa-miR-3194-3p	CLIP-seq
MIRT782899	hsa-miR-3199	CLIP-seq
MIRT782905	hsa-miR-4438	CLIP-seq
MIRT1931046	hsa-miR-4735-5p	CLIP-seq
MIRT1931047	hsa-miR-4775	CLIP-seq
MIRT1931048	hsa-miR-4794	CLIP-seq
MIRT782907	hsa-miR-5095	CLIP-seq
MIRT1931054	hsa-miR-590-3p	CLIP-seq
MIRT782910	hsa-miR-661	CLIP-seq
MIRT1931038	hsa-miR-1234	CLIP-seq
MIRT782893	hsa-miR-1254	CLIP-seq
MIRT782895	hsa-miR-129-5p	CLIP-seq
MIRT782898	hsa-miR-3116	CLIP-seq
MIRT2474692	hsa-miR-3149	CLIP-seq
MIRT782901	hsa-miR-4258	CLIP-seq
MIRT782904	hsa-miR-433	CLIP-seq
MIRT1931046	hsa-miR-4735-5p	CLIP-seq
MIRT1931047	hsa-miR-4775	CLIP-seq
MIRT1931048	hsa-miR-4794	CLIP-seq
MIRT1931054	hsa-miR-590-3p	CLIP-seq
MIRT782910	hsa-miR-661	CLIP-seq

Show/Hide all(3)

GO ID	Ontology	Definition	Evidence
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0006400	Process	TRNA modification	ISS

MIM	HGNC	e!Ensembl
618017	23471	ENSG00000134461

Protein

UniProt ID

Q6P6B7

Protein name

Ankyrin repeat domain-containing protein 16

Protein function

Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	10 → 103	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	141 → 236	Ankyrin repeats (3 copies)	Repeat
PF13637	Ank_4	171 → 225		Repeat
PF13637	Ank_4	274 → 327		Repeat

Sequence

MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI
NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM
T

Sequence length

361

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Eczema	Eczema		GWAS
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Systemic lupus erythematosus	Systemic lupus erythematosus		GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	24177593
Glomerulonephritis IGA	Associate	31426789

ANKRD16 (ankyrin repeat domain 16)