Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	5452
Gene name	POU class 2 homeobox 2
Gene symbol	POU2F2
Synonyms (NCBI Gene)	OCT2OTF2Oct-2
Chromosome	19
Chromosome location	19q13.2
Summary	The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5`-ATTTGCAT-3`, a common transcription factor binding site in immunoglobulin gene promoters. Several tr

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Show/Hide all (239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000639	hsa-miR-9-5p	Luciferase reporter assay	19956200
MIRT720159	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT720158	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT720157	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT388051	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT388056	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT388055	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT720156	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT720155	hsa-miR-6839-3p	HITS-CLIP	19536157
MIRT521796	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT666873	hsa-miR-504-5p	HITS-CLIP	23824327
MIRT666872	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT666871	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT666870	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT666869	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT666868	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT666867	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT666866	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT666865	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT666864	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509446	hsa-miR-4307	PAR-CLIP	20371350
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509444	hsa-miR-6083	PAR-CLIP	20371350
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT521796	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT521795	hsa-miR-6832-3p	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521794	hsa-miR-623	PAR-CLIP	23446348
MIRT521793	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT521792	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT521791	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT521790	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT731733	hsa-miR-218-5p	ChIP-seqImmunofluorescenceImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26019213
MIRT731733	hsa-miR-218-5p	ChIP-seqImmunofluorescenceImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26019213
MIRT720156	hsa-miR-659-3p	HITS-CLIP	27418678
MIRT736663	hsa-miR-489-3p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCR	31649850
MIRT736664	hsa-miR-630	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCR	31649850
MIRT720159	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT720158	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT720157	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT388051	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT388056	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT388055	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT720156	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT720155	hsa-miR-6839-3p	HITS-CLIP	19536157
MIRT521796	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT666873	hsa-miR-504-5p	HITS-CLIP	23824327
MIRT666872	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT666871	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT666870	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT666869	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT666868	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT666867	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT666866	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT666865	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT666864	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509446	hsa-miR-4307	PAR-CLIP	20371350
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509444	hsa-miR-6083	PAR-CLIP	20371350
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT521796	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT521795	hsa-miR-6832-3p	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521794	hsa-miR-623	PAR-CLIP	23446348
MIRT521793	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT521792	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT521791	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT521790	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1250900	hsa-miR-3127-5p	CLIP-seq
MIRT1250901	hsa-miR-4261	CLIP-seq
MIRT1250902	hsa-miR-4270	CLIP-seq
MIRT1250903	hsa-miR-4441	CLIP-seq
MIRT1250904	hsa-miR-659	CLIP-seq
MIRT1250905	hsa-miR-1237	CLIP-seq
MIRT1250906	hsa-miR-1238	CLIP-seq
MIRT1250907	hsa-miR-1248	CLIP-seq
MIRT1250908	hsa-miR-1976	CLIP-seq
MIRT1250909	hsa-miR-223	CLIP-seq
MIRT1250910	hsa-miR-3150a-3p	CLIP-seq
MIRT1250911	hsa-miR-3175	CLIP-seq
MIRT1250912	hsa-miR-3180-5p	CLIP-seq
MIRT1250913	hsa-miR-320e	CLIP-seq
MIRT1250914	hsa-miR-370	CLIP-seq
MIRT1250915	hsa-miR-4277	CLIP-seq
MIRT1250916	hsa-miR-4287	CLIP-seq
MIRT1250917	hsa-miR-4419a	CLIP-seq
MIRT1250918	hsa-miR-4505	CLIP-seq
MIRT1250919	hsa-miR-4510	CLIP-seq
MIRT1250920	hsa-miR-4642	CLIP-seq
MIRT1250921	hsa-miR-4667-5p	CLIP-seq
MIRT1250922	hsa-miR-4685-3p	CLIP-seq
MIRT1250923	hsa-miR-4691-5p	CLIP-seq
MIRT1250924	hsa-miR-4700-5p	CLIP-seq
MIRT1250925	hsa-miR-4720-5p	CLIP-seq
MIRT1250926	hsa-miR-4728-5p	CLIP-seq
MIRT1250927	hsa-miR-4731-5p	CLIP-seq
MIRT1250928	hsa-miR-4780	CLIP-seq
MIRT1250929	hsa-miR-4799-3p	CLIP-seq
MIRT1250930	hsa-miR-483-3p	CLIP-seq
MIRT1250931	hsa-miR-520a-5p	CLIP-seq
MIRT1250932	hsa-miR-525-5p	CLIP-seq
MIRT1250933	hsa-miR-668	CLIP-seq
MIRT1250934	hsa-miR-939	CLIP-seq
MIRT1250935	hsa-miR-942	CLIP-seq
MIRT1552506	hsa-miR-3150b-3p	CLIP-seq
MIRT1552507	hsa-miR-4784	CLIP-seq
MIRT1250914	hsa-miR-370	CLIP-seq
MIRT2074066	hsa-miR-4492	CLIP-seq
MIRT2074067	hsa-miR-4498	CLIP-seq
MIRT1250927	hsa-miR-4731-5p	CLIP-seq
MIRT1250928	hsa-miR-4780	CLIP-seq
MIRT2074068	hsa-miR-762	CLIP-seq
MIRT2301015	hsa-miR-1287	CLIP-seq
MIRT2301016	hsa-miR-204	CLIP-seq
MIRT2301017	hsa-miR-211	CLIP-seq
MIRT2301018	hsa-miR-3135b	CLIP-seq
MIRT2301019	hsa-miR-3188	CLIP-seq
MIRT2301020	hsa-miR-331-3p	CLIP-seq
MIRT2301021	hsa-miR-3545-3p	CLIP-seq
MIRT2301022	hsa-miR-3612	CLIP-seq
MIRT2301023	hsa-miR-3661	CLIP-seq
MIRT1250914	hsa-miR-370	CLIP-seq
MIRT2301024	hsa-miR-4256	CLIP-seq
MIRT2301025	hsa-miR-4443	CLIP-seq
MIRT2301026	hsa-miR-4680-5p	CLIP-seq
MIRT2301027	hsa-miR-4725-5p	CLIP-seq
MIRT1250927	hsa-miR-4731-5p	CLIP-seq
MIRT1250928	hsa-miR-4780	CLIP-seq
MIRT2301028	hsa-miR-504	CLIP-seq
MIRT2301029	hsa-miR-631	CLIP-seq
MIRT2301030	hsa-miR-650	CLIP-seq
MIRT1250904	hsa-miR-659	CLIP-seq
MIRT2392858	hsa-miR-1267	CLIP-seq
MIRT2456923	hsa-miR-1185	CLIP-seq
MIRT2456924	hsa-miR-1255a	CLIP-seq
MIRT2456925	hsa-miR-1255b	CLIP-seq
MIRT2456926	hsa-miR-3605-5p	CLIP-seq
MIRT2456927	hsa-miR-3679-5p	CLIP-seq
MIRT2456928	hsa-miR-4709-3p	CLIP-seq
MIRT2456929	hsa-miR-765	CLIP-seq
MIRT2456926	hsa-miR-3605-5p	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
NFKB1	Unknown	9360945
RELA	Unknown	9360945

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	ISS
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	ISS
GO:0003700	Function	DNA-binding transcription factor activity	TAS	9442393
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	9242494
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006959	Process	Humoral immune response	TAS	9442393
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0043565	Function	Sequence-specific DNA binding	IDA	9242494
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0098586	Process	Cellular response to virus	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
164176	9213	ENSG00000028277

P09086

Protein name

POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)

Protein function

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to

PDB

1HDP , 9DZM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00157	Pou	198 → 269	Pou domain - N-terminal to homeobox domain	Domain
PF00046	Homeodomain	298 → 354	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. {ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:3072196}.

Sequence

MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS
HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP

Sequence length

479

Interactions

View interactions

	KEGG		Reactome
	Herpes simplex virus 1 infection Lipid and atherosclerosis		RNA polymerase II transcribes snRNA genes

POU2F2 (POU class 2 homeobox 2)