Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5452
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
POU class 2 homeobox 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
POU2F2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
OCT2, OTF2, Oct-2 |
Chromosome
Chromosome number
|
19 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
19q13.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5`-ATTTGCAT-3`, a common transcription factor binding site in immunoglobulin gene promoters. Several tr |
UniProt ID |
P09086
|
Protein name |
POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) |
Protein function |
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to |
PDB |
1HDP
,
9DZM
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00157
|
Pou |
198 → 269 |
Pou domain - N-terminal to homeobox domain |
Domain |
PF00046
|
Homeodomain |
298 → 354 |
Homeodomain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. {ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:3072196}. |
Sequence |
|
Sequence length |
479 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Prostate cancer |
Prostate cancer, familial |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
29892016 |
Prostate cancer, hereditary |
PROSTATE CANCER, HEREDITARY, 1 |
rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466 |
29892016 |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
|
29127420 |
Anodontia |
Associate
|
11154228, 8639794 |
Breast Neoplasms |
Associate
|
31420918, 39948777 |
Burkitt Lymphoma |
Associate
|
22346751 |
Carcinoma Non Small Cell Lung |
Associate
|
33300085 |
Carcinoma Renal Cell |
Associate
|
31088315 |
Choriocarcinoma |
Associate
|
11113121 |
Colorectal Neoplasms |
Associate
|
28992563 |
Diabetes Mellitus Type 2 |
Associate
|
32041280 |
Epstein Barr Virus Infections |
Associate
|
27009953 |
Hematologic Neoplasms |
Associate
|
26784514 |
Hereditary leiomyomatosis and renal cell cancer |
Associate
|
11154228, 15257313, 20016960, 8639794 |
Hodgkin Disease |
Associate
|
11154228, 16304050, 16648862, 19465900, 21424034, 8639794 |
Hodgkin Disease |
Inhibit
|
15257313 |
Huntington Disease |
Inhibit
|
11342448 |
Leukemia T Cell |
Associate
|
1717256 |
Lung Neoplasms |
Associate
|
24643204, 33832481 |
Lymphedema |
Associate
|
11841448 |
Lymphoma |
Associate
|
16778825, 25318949 |
Lymphoma B Cell |
Associate
|
1937571, 34461601 |
Lymphoma B Cell Marginal Zone |
Associate
|
16778825 |
Lymphoma Follicular |
Associate
|
24435047 |
Lymphoma Large B Cell Diffuse |
Associate
|
23292937, 28143608 |
Lymphoma Primary Effusion |
Associate
|
19224997 |
Mouth Neoplasms |
Associate
|
36170598 |
Multiple Myeloma |
Associate
|
11841448 |
Myelodysplastic Syndromes |
Associate
|
36629404 |
Neoplasms |
Associate
|
21706474, 33832481 |
Neoplasms |
Inhibit
|
26617867, 34461601 |
Neuroblastoma |
Associate
|
21314941, 23144874 |
Norrie disease |
Associate
|
32041280 |
Paraplegia |
Stimulate
|
15308563 |
Periodontitis |
Associate
|
27302879 |
Prostatic stromal proliferation of uncertain malignant potential |
Associate
|
36170598 |
Prostatitis |
Associate
|
28750683 |
Respiratory Tract Diseases |
Associate
|
37925496 |
Sarcoma Kaposi |
Associate
|
19224997 |
Testicular Germ Cell Tumor |
Associate
|
21706474 |
Testicular Neoplasms |
Associate
|
26784514 |
Uterine Cervical Neoplasms |
Associate
|
35616137 |
Waldenstrom Macroglobulinemia |
Associate
|
24801987, 32457988 |
|