Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	54510
Gene name	Protocadherin 18
Gene symbol	PCDH18
Synonyms (NCBI Gene)	PCDH68L
Chromosome	4
Chromosome location	4q28.3
Summary	This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical c

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Show/Hide all (169)

miRTarBase ID	miRNA	Experiments
MIRT1216809	hsa-miR-1271	CLIP-seq
MIRT1216810	hsa-miR-129-5p	CLIP-seq
MIRT1216811	hsa-miR-182	CLIP-seq
MIRT1216812	hsa-miR-2054	CLIP-seq
MIRT1216813	hsa-miR-3163	CLIP-seq
MIRT1216814	hsa-miR-345	CLIP-seq
MIRT1216815	hsa-miR-3613-5p	CLIP-seq
MIRT1216816	hsa-miR-4277	CLIP-seq
MIRT1216817	hsa-miR-4796-5p	CLIP-seq
MIRT1216818	hsa-miR-579	CLIP-seq
MIRT1216819	hsa-miR-96	CLIP-seq
MIRT1552132	hsa-miR-3175	CLIP-seq
MIRT2062564	hsa-miR-4670-3p	CLIP-seq
MIRT2062565	hsa-miR-4724-5p	CLIP-seq
MIRT2062566	hsa-miR-4766-5p	CLIP-seq
MIRT2062567	hsa-miR-4775	CLIP-seq
MIRT2062568	hsa-miR-488	CLIP-seq
MIRT2062569	hsa-miR-587	CLIP-seq
MIRT2291011	hsa-miR-1910	CLIP-seq
MIRT2291012	hsa-miR-3140-5p	CLIP-seq
MIRT2291013	hsa-miR-3145-3p	CLIP-seq
MIRT2291014	hsa-miR-4261	CLIP-seq
MIRT2291015	hsa-miR-4264	CLIP-seq
MIRT2291016	hsa-miR-4282	CLIP-seq
MIRT2291017	hsa-miR-455-3p	CLIP-seq
MIRT2291018	hsa-miR-4797-3p	CLIP-seq
MIRT2431908	hsa-miR-1297	CLIP-seq
MIRT2431909	hsa-miR-1299	CLIP-seq
MIRT2431910	hsa-miR-185	CLIP-seq
MIRT2431911	hsa-miR-26a	CLIP-seq
MIRT2431912	hsa-miR-26b	CLIP-seq
MIRT2431913	hsa-miR-3121-3p	CLIP-seq
MIRT2431914	hsa-miR-3125	CLIP-seq
MIRT2431915	hsa-miR-3143	CLIP-seq
MIRT1552132	hsa-miR-3175	CLIP-seq
MIRT2431916	hsa-miR-338-5p	CLIP-seq
MIRT2431917	hsa-miR-3662	CLIP-seq
MIRT2431918	hsa-miR-3916	CLIP-seq
MIRT2431919	hsa-miR-4280	CLIP-seq
MIRT2291016	hsa-miR-4282	CLIP-seq
MIRT2431920	hsa-miR-4306	CLIP-seq
MIRT2431921	hsa-miR-4453	CLIP-seq
MIRT2431922	hsa-miR-4465	CLIP-seq
MIRT2431923	hsa-miR-4538	CLIP-seq
MIRT2431924	hsa-miR-4644	CLIP-seq
MIRT2431925	hsa-miR-4662a-3p	CLIP-seq
MIRT2431926	hsa-miR-4698	CLIP-seq
MIRT2431927	hsa-miR-4729	CLIP-seq
MIRT2431928	hsa-miR-4782-5p	CLIP-seq
MIRT2431929	hsa-miR-4795-3p	CLIP-seq
MIRT2431930	hsa-miR-516b	CLIP-seq
MIRT2431931	hsa-miR-543	CLIP-seq
MIRT2431932	hsa-miR-633	CLIP-seq
MIRT2431933	hsa-miR-642b	CLIP-seq
MIRT2431934	hsa-miR-891b	CLIP-seq
MIRT2431927	hsa-miR-4729	CLIP-seq
MIRT2431933	hsa-miR-642b	CLIP-seq
MIRT2431934	hsa-miR-891b	CLIP-seq
MIRT2588638	hsa-miR-1229	CLIP-seq
MIRT1216809	hsa-miR-1271	CLIP-seq
MIRT1216810	hsa-miR-129-5p	CLIP-seq
MIRT2431909	hsa-miR-1299	CLIP-seq
MIRT1216811	hsa-miR-182	CLIP-seq
MIRT2431910	hsa-miR-185	CLIP-seq
MIRT2588639	hsa-miR-2116	CLIP-seq
MIRT2588640	hsa-miR-2392	CLIP-seq
MIRT2588641	hsa-miR-3127-5p	CLIP-seq
MIRT2431915	hsa-miR-3143	CLIP-seq
MIRT1216813	hsa-miR-3163	CLIP-seq
MIRT2588642	hsa-miR-3189-3p	CLIP-seq
MIRT2588643	hsa-miR-340	CLIP-seq
MIRT2588644	hsa-miR-3688-3p	CLIP-seq
MIRT2588645	hsa-miR-3692	CLIP-seq
MIRT2588646	hsa-miR-3910	CLIP-seq
MIRT2588647	hsa-miR-3935	CLIP-seq
MIRT2291014	hsa-miR-4261	CLIP-seq
MIRT1216816	hsa-miR-4277	CLIP-seq
MIRT2431919	hsa-miR-4280	CLIP-seq
MIRT2291016	hsa-miR-4282	CLIP-seq
MIRT2431920	hsa-miR-4306	CLIP-seq
MIRT2588648	hsa-miR-432	CLIP-seq
MIRT2431921	hsa-miR-4453	CLIP-seq
MIRT2588649	hsa-miR-4517	CLIP-seq
MIRT2588650	hsa-miR-452	CLIP-seq
MIRT2431923	hsa-miR-4538	CLIP-seq
MIRT2588651	hsa-miR-4633-5p	CLIP-seq
MIRT2431924	hsa-miR-4644	CLIP-seq
MIRT2431925	hsa-miR-4662a-3p	CLIP-seq
MIRT2588652	hsa-miR-4676-3p	CLIP-seq
MIRT2588653	hsa-miR-4677-5p	CLIP-seq
MIRT2588654	hsa-miR-4712-5p	CLIP-seq
MIRT2431927	hsa-miR-4729	CLIP-seq
MIRT2588655	hsa-miR-4773	CLIP-seq
MIRT2431928	hsa-miR-4782-5p	CLIP-seq
MIRT2588656	hsa-miR-4789-3p	CLIP-seq
MIRT2431929	hsa-miR-4795-3p	CLIP-seq
MIRT2588657	hsa-miR-4802-3p	CLIP-seq
MIRT2588658	hsa-miR-485-3p	CLIP-seq
MIRT2588659	hsa-miR-491-3p	CLIP-seq
MIRT2588660	hsa-miR-495	CLIP-seq
MIRT2588661	hsa-miR-502-5p	CLIP-seq
MIRT2431930	hsa-miR-516b	CLIP-seq
MIRT2431931	hsa-miR-543	CLIP-seq
MIRT2588662	hsa-miR-548c-3p	CLIP-seq
MIRT2588663	hsa-miR-562	CLIP-seq
MIRT2588664	hsa-miR-577	CLIP-seq
MIRT2062569	hsa-miR-587	CLIP-seq
MIRT2588665	hsa-miR-624	CLIP-seq
MIRT2431932	hsa-miR-633	CLIP-seq
MIRT2431933	hsa-miR-642b	CLIP-seq
MIRT2588666	hsa-miR-770-5p	CLIP-seq
MIRT2431934	hsa-miR-891b	CLIP-seq
MIRT2588667	hsa-miR-944	CLIP-seq
MIRT1216819	hsa-miR-96	CLIP-seq
MIRT2588638	hsa-miR-1229	CLIP-seq
MIRT1216809	hsa-miR-1271	CLIP-seq
MIRT1216810	hsa-miR-129-5p	CLIP-seq
MIRT2431909	hsa-miR-1299	CLIP-seq
MIRT1216811	hsa-miR-182	CLIP-seq
MIRT2431910	hsa-miR-185	CLIP-seq
MIRT2588639	hsa-miR-2116	CLIP-seq
MIRT2588640	hsa-miR-2392	CLIP-seq
MIRT2588641	hsa-miR-3127-5p	CLIP-seq
MIRT2431915	hsa-miR-3143	CLIP-seq
MIRT1216813	hsa-miR-3163	CLIP-seq
MIRT2588642	hsa-miR-3189-3p	CLIP-seq
MIRT2588643	hsa-miR-340	CLIP-seq
MIRT2588644	hsa-miR-3688-3p	CLIP-seq
MIRT2588645	hsa-miR-3692	CLIP-seq
MIRT2588646	hsa-miR-3910	CLIP-seq
MIRT2588647	hsa-miR-3935	CLIP-seq
MIRT2291014	hsa-miR-4261	CLIP-seq
MIRT1216816	hsa-miR-4277	CLIP-seq
MIRT2431919	hsa-miR-4280	CLIP-seq
MIRT2291016	hsa-miR-4282	CLIP-seq
MIRT2431920	hsa-miR-4306	CLIP-seq
MIRT2588648	hsa-miR-432	CLIP-seq
MIRT2431921	hsa-miR-4453	CLIP-seq
MIRT2588650	hsa-miR-452	CLIP-seq
MIRT2431923	hsa-miR-4538	CLIP-seq
MIRT2588651	hsa-miR-4633-5p	CLIP-seq
MIRT2431924	hsa-miR-4644	CLIP-seq
MIRT2431925	hsa-miR-4662a-3p	CLIP-seq
MIRT2687221	hsa-miR-4668-3p	CLIP-seq
MIRT2588652	hsa-miR-4676-3p	CLIP-seq
MIRT2588653	hsa-miR-4677-5p	CLIP-seq
MIRT2588654	hsa-miR-4712-5p	CLIP-seq
MIRT2431927	hsa-miR-4729	CLIP-seq
MIRT2588655	hsa-miR-4773	CLIP-seq
MIRT2431928	hsa-miR-4782-5p	CLIP-seq
MIRT2588656	hsa-miR-4789-3p	CLIP-seq
MIRT2431929	hsa-miR-4795-3p	CLIP-seq
MIRT2588657	hsa-miR-4802-3p	CLIP-seq
MIRT2588658	hsa-miR-485-3p	CLIP-seq
MIRT2588659	hsa-miR-491-3p	CLIP-seq
MIRT2588661	hsa-miR-502-5p	CLIP-seq
MIRT2431930	hsa-miR-516b	CLIP-seq
MIRT2431931	hsa-miR-543	CLIP-seq
MIRT2588662	hsa-miR-548c-3p	CLIP-seq
MIRT2588663	hsa-miR-562	CLIP-seq
MIRT2588664	hsa-miR-577	CLIP-seq
MIRT2062569	hsa-miR-587	CLIP-seq
MIRT2588665	hsa-miR-624	CLIP-seq
MIRT2431932	hsa-miR-633	CLIP-seq
MIRT2431933	hsa-miR-642b	CLIP-seq
MIRT2588666	hsa-miR-770-5p	CLIP-seq
MIRT2431934	hsa-miR-891b	CLIP-seq
MIRT2588667	hsa-miR-944	CLIP-seq
MIRT1216819	hsa-miR-96	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007420	Process	Brain development	IEA
GO:0007420	Process	Brain development	ISS
GO:0016020	Component	Membrane	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

MIM	HGNC	e!Ensembl
608287	14268	ENSG00000189184

Q9HCL0

Protein name

Protocadherin-18

Protein function

Potential calcium-dependent cell-adhesion protein.

PDB

6VFR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08266	Cadherin_2	29 → 113	Cadherin-like	Domain
PF00028	Cadherin	142 → 237	Cadherin domain	Domain
PF00028	Cadherin	251 → 345	Cadherin domain	Domain
PF00028	Cadherin	367 → 456	Cadherin domain	Domain
PF00028	Cadherin	470 → 567	Cadherin domain	Domain
PF00028	Cadherin	586 → 676	Cadherin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues, with highest expression in lung and ovary. {ECO:0000269|PubMed:11549318}.

Sequence

MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPN
PSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQL
FHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSAND
FFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSN
DNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKID
SERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMS
PGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTN
ATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSP
GAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQ
ITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHV
TRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQD
KGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLF
ATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPS
SSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQ
GQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEG
FSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQ
QHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSL
DTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQ
PSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS

Sequence length

1135

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colorectal Neoplasms	Associate	28588296	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	28588296	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	29888653	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	29888653	★★★★★ ★☆☆☆☆ Found in Text Mining only

PCDH18 (protocadherin 18)