Gene Gene information from NCBI Gene database.
Entrez ID 5451
Gene name POU class 2 homeobox 1
Gene symbol POU2F1
Synonyms (NCBI Gene)
OCT1OTF1Oct1Zoct-1B
Chromosome 1
Chromosome location 1q24.2
Summary The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA bindi
miRNA miRNA information provided by mirtarbase database.
1854
miRTarBase ID miRNA Experiments Reference
MIRT021477 hsa-miR-9-5p Microarray 17612493
MIRT024501 hsa-miR-215-5p Microarray 19074876
MIRT025581 hsa-miR-34a-5p Sequencing 20371350
MIRT026960 hsa-miR-192-5p Microarray 19074876
MIRT027386 hsa-miR-101-3p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
PPARG Activation 12881480
STAT3 Unknown 23172665
USF1 Unknown 18845576
USF2 Unknown 18845576
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 25802280
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP 10329190, 10541551, 11380252
GO:0000979 Function RNA polymerase II core promoter sequence-specific DNA binding IMP 10541551
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164175 9212 ENSG00000143190
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14859
Protein name POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1)
Protein function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactiv
PDB 1CQT , 1E3O , 1GT0 , 1HF0 , 1O4X , 1OCT , 1POG , 1POU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00157 Pou 283 354 Pou domain - N-terminal to homeobox domain Domain
PF00046 Homeodomain 380 436 Homeodomain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Isoform 2 is lymphocyte-specific.
Sequence
MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS
LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ
LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ
QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ
PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI
KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE
NLSSDS
SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK
EVIRVWFCNRRQKEKR
INPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP
VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA
SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP
SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV
FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ
NSLFTVASASGAASTTTTASKAQ
Sequence length 743
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Herpes simplex virus 1 infection
Lipid and atherosclerosis
  Interleukin-4 and Interleukin-13 signaling
RNA polymerase II transcribes snRNA genes
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression