POU2AF1 (POU class 2 homeobox associating factor 1)

Gene

• Entrez ID: 5450
• Gene name: POU class 2 homeobox associating factor 1
• Gene symbol: POU2AF1
• Synonyms (NCBI Gene): BOB1, OBF-1, OBF1, OCAB
• Chromosome: 11
• Chromosome location: 11q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439929	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT439928	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT439929	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT726902	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726901	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726900	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726899	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT439928	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT1250513	hsa-miR-1252	CLIP-seq
MIRT1250514	hsa-miR-1254	CLIP-seq
MIRT1250515	hsa-miR-1269	CLIP-seq
MIRT1250516	hsa-miR-1269b	CLIP-seq
MIRT1250517	hsa-miR-1275	CLIP-seq
MIRT1250518	hsa-miR-1288	CLIP-seq
MIRT1250519	hsa-miR-1321	CLIP-seq
MIRT1250520	hsa-miR-15a	CLIP-seq
MIRT1250521	hsa-miR-15b	CLIP-seq
MIRT1250522	hsa-miR-16	CLIP-seq
MIRT1250523	hsa-miR-186	CLIP-seq
MIRT1250524	hsa-miR-195	CLIP-seq
MIRT1250525	hsa-miR-2278	CLIP-seq
MIRT1250526	hsa-miR-2392	CLIP-seq
MIRT1250527	hsa-miR-24	CLIP-seq
MIRT1250528	hsa-miR-2467-5p	CLIP-seq
MIRT1250529	hsa-miR-3116	CLIP-seq
MIRT1250530	hsa-miR-3125	CLIP-seq
MIRT1250531	hsa-miR-3133	CLIP-seq
MIRT1250532	hsa-miR-3145-5p	CLIP-seq
MIRT1250533	hsa-miR-3154	CLIP-seq
MIRT1250534	hsa-miR-3173-3p	CLIP-seq
MIRT1250535	hsa-miR-3175	CLIP-seq
MIRT1250536	hsa-miR-3185	CLIP-seq
MIRT1250537	hsa-miR-3202	CLIP-seq
MIRT1250538	hsa-miR-3607-3p	CLIP-seq
MIRT1250539	hsa-miR-3690	CLIP-seq
MIRT1250540	hsa-miR-378	CLIP-seq
MIRT1250541	hsa-miR-378b	CLIP-seq
MIRT1250542	hsa-miR-378c	CLIP-seq
MIRT1250543	hsa-miR-378d	CLIP-seq
MIRT1250544	hsa-miR-378e	CLIP-seq
MIRT1250545	hsa-miR-378f	CLIP-seq
MIRT1250546	hsa-miR-378h	CLIP-seq
MIRT1250547	hsa-miR-378i	CLIP-seq
MIRT1250548	hsa-miR-3916	CLIP-seq
MIRT1250549	hsa-miR-3978	CLIP-seq
MIRT1250550	hsa-miR-422a	CLIP-seq
MIRT1250551	hsa-miR-424	CLIP-seq
MIRT1250552	hsa-miR-4269	CLIP-seq
MIRT1250553	hsa-miR-4271	CLIP-seq
MIRT1250554	hsa-miR-4284	CLIP-seq
MIRT1250555	hsa-miR-4311	CLIP-seq
MIRT1250556	hsa-miR-4419a	CLIP-seq
MIRT1250557	hsa-miR-4428	CLIP-seq
MIRT1250558	hsa-miR-4434	CLIP-seq
MIRT1250559	hsa-miR-4466	CLIP-seq
MIRT1250560	hsa-miR-4476	CLIP-seq
MIRT1250561	hsa-miR-4510	CLIP-seq
MIRT1250562	hsa-miR-4514	CLIP-seq
MIRT1250563	hsa-miR-4515	CLIP-seq
MIRT1250564	hsa-miR-4516	CLIP-seq
MIRT1250565	hsa-miR-4525	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT1250567	hsa-miR-4665-5p	CLIP-seq
MIRT1250568	hsa-miR-4679	CLIP-seq
MIRT1250569	hsa-miR-4692	CLIP-seq
MIRT1250570	hsa-miR-4722-5p	CLIP-seq
MIRT1250571	hsa-miR-4723-5p	CLIP-seq
MIRT1250572	hsa-miR-4725-3p	CLIP-seq
MIRT1250573	hsa-miR-4728-5p	CLIP-seq
MIRT1250574	hsa-miR-4739	CLIP-seq
MIRT1250575	hsa-miR-4740-5p	CLIP-seq
MIRT1250576	hsa-miR-4742-5p	CLIP-seq
MIRT1250577	hsa-miR-4746-3p	CLIP-seq
MIRT1250578	hsa-miR-4747-5p	CLIP-seq
MIRT1250579	hsa-miR-4756-5p	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT1250581	hsa-miR-497	CLIP-seq
MIRT1250582	hsa-miR-508-5p	CLIP-seq
MIRT1250583	hsa-miR-545	CLIP-seq
MIRT1250584	hsa-miR-548aa	CLIP-seq
MIRT1250585	hsa-miR-548p	CLIP-seq
MIRT1250586	hsa-miR-625	CLIP-seq
MIRT1250587	hsa-miR-661	CLIP-seq
MIRT1250588	hsa-miR-675	CLIP-seq
MIRT1250589	hsa-miR-767-5p	CLIP-seq
MIRT1250590	hsa-miR-940	CLIP-seq
MIRT1552504	hsa-miR-3689a-3p	CLIP-seq
MIRT1552505	hsa-miR-3689c	CLIP-seq
MIRT2073956	hsa-miR-1246	CLIP-seq
MIRT1250513	hsa-miR-1252	CLIP-seq
MIRT1250533	hsa-miR-3154	CLIP-seq
MIRT1250534	hsa-miR-3173-3p	CLIP-seq
MIRT2073957	hsa-miR-3921	CLIP-seq
MIRT2073958	hsa-miR-3926	CLIP-seq
MIRT2073959	hsa-miR-3929	CLIP-seq
MIRT2073960	hsa-miR-3974	CLIP-seq
MIRT2073961	hsa-miR-4251	CLIP-seq
MIRT2073962	hsa-miR-4320	CLIP-seq
MIRT2073963	hsa-miR-4329	CLIP-seq
MIRT2073964	hsa-miR-4419b	CLIP-seq
MIRT2073965	hsa-miR-4433	CLIP-seq
MIRT2073966	hsa-miR-4457	CLIP-seq
MIRT2073967	hsa-miR-4459	CLIP-seq
MIRT1250560	hsa-miR-4476	CLIP-seq
MIRT2073968	hsa-miR-4478	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT2073969	hsa-miR-4653-5p	CLIP-seq
MIRT1250568	hsa-miR-4679	CLIP-seq
MIRT2073970	hsa-miR-4714-5p	CLIP-seq
MIRT1250578	hsa-miR-4747-5p	CLIP-seq
MIRT2073971	hsa-miR-4767	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT2073972	hsa-miR-4786-5p	CLIP-seq
MIRT2073973	hsa-miR-4802-3p	CLIP-seq
MIRT2073974	hsa-miR-485-5p	CLIP-seq
MIRT2073975	hsa-miR-490-5p	CLIP-seq
MIRT2073976	hsa-miR-513b	CLIP-seq
MIRT2073977	hsa-miR-548s	CLIP-seq
MIRT2073978	hsa-miR-617	CLIP-seq
MIRT2073979	hsa-miR-624	CLIP-seq
MIRT2300879	hsa-miR-122	CLIP-seq
MIRT2300880	hsa-miR-125a-3p	CLIP-seq
MIRT2300881	hsa-miR-1285	CLIP-seq
MIRT2300882	hsa-miR-2116	CLIP-seq
MIRT1250527	hsa-miR-24	CLIP-seq
MIRT1250532	hsa-miR-3145-5p	CLIP-seq
MIRT2300883	hsa-miR-3183	CLIP-seq
MIRT2300884	hsa-miR-3187-5p	CLIP-seq
MIRT2300885	hsa-miR-3620	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2073958	hsa-miR-3926	CLIP-seq
MIRT2300887	hsa-miR-3934	CLIP-seq
MIRT2073960	hsa-miR-3974	CLIP-seq
MIRT2073961	hsa-miR-4251	CLIP-seq
MIRT1250554	hsa-miR-4284	CLIP-seq
MIRT2300888	hsa-miR-4287	CLIP-seq
MIRT2300889	hsa-miR-4300	CLIP-seq
MIRT2073965	hsa-miR-4433	CLIP-seq
MIRT2073966	hsa-miR-4457	CLIP-seq
MIRT2073967	hsa-miR-4459	CLIP-seq
MIRT1250559	hsa-miR-4466	CLIP-seq
MIRT2300890	hsa-miR-4469	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2300894	hsa-miR-4677-5p	CLIP-seq
MIRT1250568	hsa-miR-4679	CLIP-seq
MIRT2300895	hsa-miR-4685-3p	CLIP-seq
MIRT2300896	hsa-miR-4700-3p	CLIP-seq
MIRT2300897	hsa-miR-4713-5p	CLIP-seq
MIRT2073970	hsa-miR-4714-5p	CLIP-seq
MIRT2300898	hsa-miR-4723-3p	CLIP-seq
MIRT1250577	hsa-miR-4746-3p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT2073971	hsa-miR-4767	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT2073972	hsa-miR-4786-5p	CLIP-seq
MIRT1250582	hsa-miR-508-5p	CLIP-seq
MIRT2300900	hsa-miR-510	CLIP-seq
MIRT2073976	hsa-miR-513b	CLIP-seq
MIRT2073977	hsa-miR-548s	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2300902	hsa-miR-612	CLIP-seq
MIRT2073979	hsa-miR-624	CLIP-seq
MIRT1250587	hsa-miR-661	CLIP-seq
MIRT1250588	hsa-miR-675	CLIP-seq
MIRT2300903	hsa-miR-764	CLIP-seq
MIRT2300904	hsa-miR-766	CLIP-seq
MIRT1250589	hsa-miR-767-5p	CLIP-seq
MIRT2300905	hsa-miR-920	CLIP-seq
MIRT2456901	hsa-miR-10a	CLIP-seq
MIRT2456902	hsa-miR-10b	CLIP-seq
MIRT2300879	hsa-miR-122	CLIP-seq
MIRT2300881	hsa-miR-1285	CLIP-seq
MIRT2300884	hsa-miR-3187-5p	CLIP-seq
MIRT2456903	hsa-miR-34b	CLIP-seq
MIRT2456904	hsa-miR-3545-3p	CLIP-seq
MIRT2456905	hsa-miR-3614-5p	CLIP-seq
MIRT2300885	hsa-miR-3620	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2456906	hsa-miR-3672	CLIP-seq
MIRT1552504	hsa-miR-3689a-3p	CLIP-seq
MIRT1552505	hsa-miR-3689c	CLIP-seq
MIRT2456907	hsa-miR-412	CLIP-seq
MIRT1250552	hsa-miR-4269	CLIP-seq
MIRT1250562	hsa-miR-4514	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2456910	hsa-miR-4690-3p	CLIP-seq
MIRT1250569	hsa-miR-4692	CLIP-seq
MIRT1250570	hsa-miR-4722-5p	CLIP-seq
MIRT1250576	hsa-miR-4742-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT1250582	hsa-miR-508-5p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2300902	hsa-miR-612	CLIP-seq
MIRT1250587	hsa-miR-661	CLIP-seq
MIRT2300904	hsa-miR-766	CLIP-seq
MIRT1250590	hsa-miR-940	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2597647	hsa-miR-140-3p	CLIP-seq
MIRT2597648	hsa-miR-182	CLIP-seq
MIRT2597649	hsa-miR-3619-3p	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2597650	hsa-miR-3663-5p	CLIP-seq
MIRT2597651	hsa-miR-3689d	CLIP-seq
MIRT2073965	hsa-miR-4433	CLIP-seq
MIRT2073967	hsa-miR-4459	CLIP-seq
MIRT2597652	hsa-miR-4492	CLIP-seq
MIRT2597653	hsa-miR-4498	CLIP-seq
MIRT2597654	hsa-miR-4508	CLIP-seq
MIRT2597655	hsa-miR-4641	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT2597656	hsa-miR-4776-5p	CLIP-seq
MIRT2597657	hsa-miR-499a-5p	CLIP-seq
MIRT2597658	hsa-miR-501-3p	CLIP-seq
MIRT2597659	hsa-miR-502-3p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2597660	hsa-miR-626	CLIP-seq
MIRT2597661	hsa-miR-762	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2456906	hsa-miR-3672	CLIP-seq
MIRT1250560	hsa-miR-4476	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU2F1	Unknown	11847120

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002314	Process	Germinal center B cell differentiation	IEA
GO:0002314	Process	Germinal center B cell differentiation	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003712	Function	Transcription coregulator activity	TAS	7859290
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IMP	11380252
GO:0003713	Function	Transcription coactivator activity	ISS
GO:0003713	Function	Transcription coactivator activity	TAS	7859290
GO:0005515	Function	Protein binding	IPI	11483518, 28514442, 32296183, 33961781, 35512704
GO:0005634	Component	Nucleus	IEA
GO:0006959	Process	Humoral immune response	TAS	7859290
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	11380252
GO:0070974	Function	POU domain binding	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IDA	11380252
GO:0090575	Component	RNA polymerase II transcription regulator complex	IMP	10329190
GO:0098586	Process	Cellular response to virus	IEA
GO:0098586	Process	Cellular response to virus	ISS

Other IDs

• MIM: 601206
• HGNC: 9211
• e!Ensembl: ENSG00000110777

Protein

• UniProt ID: Q16633
• Protein name: POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
• Protein function: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It recognizes th
• PDB: 1CQT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09310	PD-C2-AF1	7 → 255	POU domain, class 2, associating factor 1	Domain

• Tissue specificity: TISSUE SPECIFICITY: B-cell specific (PubMed:7779176, PubMed:7859290). Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (PubMed:7779176, PubMed:7859290). {ECO:0000269|PubMed:7779176, ECO:0000269|PubMed:7859290
• Sequence:

  MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAAPAPTAVVLPHQPLATY
  TTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPWTPYTEYVPHEAVSCPYSA
  DMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPAVGPPLEGPEHQAPLTYFPWP
  QPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQDMEDPRRAASSLTIDKLLLEEE
  DSDAYALNHTLSVEGF

• Sequence length: 256