Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54498
Gene name Gene Name - the full gene name approved by the HGNC.
Spermine oxidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SMOX
Synonyms (NCBI Gene) Gene synonyms aliases
C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p13
Summary Summary of gene provided in NCBI Entrez Gene.
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, an
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT040277 hsa-miR-615-3p CLASH 23622248
MIRT457730 hsa-miR-370-5p PAR-CLIP 23592263
MIRT457729 hsa-miR-3677-5p PAR-CLIP 23592263
MIRT457728 hsa-miR-3135b PAR-CLIP 23592263
MIRT457727 hsa-miR-3689d PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA
GO:0005829 Component Cytosol TAS
GO:0006596 Process Polyamine biosynthetic process TAS
GO:0006598 Process Polyamine catabolic process IDA 12477380
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615854 15862 ENSG00000088826
Protein
UniProt ID Q9NWM0
Protein name Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)
Protein function Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important
PDB 7OXL , 7OY0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01593 Amino_oxidase 34 277 Flavin containing amine oxidoreductase Domain
PF01593 Amino_oxidase 304 544 Flavin containing amine oxidoreductase Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269|PubMed:18422650}.
Sequence
Sequence length 555
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Arginine and proline metabolism
beta-Alanine metabolism
Metabolic pathways
  PAOs oxidise polyamines to amines
Interconversion of polyamines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Panic Disorder Panic Disorder GWAS
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37334367
Asthma Associate 34456632
Carcinogenesis Associate 18302221, 18422650, 27041578, 35452470, 39305951
Carcinoma Non Small Cell Lung Associate 18422650
Carcinoma Renal Cell Associate 39993614
Colitis Ulcerative Associate 20127992
Colorectal Neoplasms Associate 27433286
DNA Virus Infections Associate 18422650
Gastritis Associate 27041578
Helicobacter Infections Stimulate 39305951