SMOX (spermine oxidase)

Gene

• Entrez ID: 54498
• Gene name: Spermine oxidase
• Gene symbol: SMOX
• Synonyms (NCBI Gene): C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO
• Chromosome: 20
• Chromosome location: 20p13
• Summary: Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040277	hsa-miR-615-3p	CLASH	23622248
MIRT457730	hsa-miR-370-5p	PAR-CLIP	23592263
MIRT457729	hsa-miR-3677-5p	PAR-CLIP	23592263
MIRT457728	hsa-miR-3135b	PAR-CLIP	23592263
MIRT457727	hsa-miR-3689d	PAR-CLIP	23592263
MIRT457726	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT457725	hsa-miR-6822-3p	PAR-CLIP	23592263
MIRT457724	hsa-miR-760	PAR-CLIP	23592263
MIRT457722	hsa-miR-3652	PAR-CLIP	23592263
MIRT457723	hsa-miR-4430	PAR-CLIP	23592263
MIRT457721	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT457720	hsa-miR-4460	PAR-CLIP	23592263
MIRT457719	hsa-miR-8057	PAR-CLIP	23592263
MIRT457730	hsa-miR-370-5p	PAR-CLIP	23592263
MIRT457729	hsa-miR-3677-5p	PAR-CLIP	23592263
MIRT457728	hsa-miR-3135b	PAR-CLIP	23592263
MIRT457727	hsa-miR-3689d	PAR-CLIP	23592263
MIRT457726	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT457725	hsa-miR-6822-3p	PAR-CLIP	23592263
MIRT457724	hsa-miR-760	PAR-CLIP	23592263
MIRT457722	hsa-miR-3652	PAR-CLIP	23592263
MIRT457723	hsa-miR-4430	PAR-CLIP	23592263
MIRT457721	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT457720	hsa-miR-4460	PAR-CLIP	23592263
MIRT457719	hsa-miR-8057	PAR-CLIP	23592263
MIRT1373807	hsa-miR-139-5p	CLIP-seq
MIRT1373808	hsa-miR-4668-3p	CLIP-seq
MIRT1373809	hsa-miR-4797-5p	CLIP-seq
MIRT1373810	hsa-miR-500a	CLIP-seq
MIRT1373811	hsa-miR-501-5p	CLIP-seq
MIRT1373812	hsa-miR-548c-3p	CLIP-seq
MIRT1373813	hsa-miR-577	CLIP-seq
MIRT1373814	hsa-miR-338-3p	CLIP-seq
MIRT1373815	hsa-miR-4257	CLIP-seq
MIRT1373816	hsa-miR-4530	CLIP-seq
MIRT1373817	hsa-miR-4713-3p	CLIP-seq
MIRT1373818	hsa-miR-95	CLIP-seq
MIRT2440578	hsa-miR-1178	CLIP-seq
MIRT2440579	hsa-miR-1224-3p	CLIP-seq
MIRT2440580	hsa-miR-1254	CLIP-seq
MIRT2440581	hsa-miR-3116	CLIP-seq
MIRT2440582	hsa-miR-4254	CLIP-seq
MIRT1373815	hsa-miR-4257	CLIP-seq
MIRT2440583	hsa-miR-4434	CLIP-seq
MIRT2440584	hsa-miR-4485	CLIP-seq
MIRT2440585	hsa-miR-4516	CLIP-seq
MIRT2440586	hsa-miR-4531	CLIP-seq
MIRT2440587	hsa-miR-767-3p	CLIP-seq
MIRT1373818	hsa-miR-95	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IDA	18422650
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	18422650
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006596	Process	Polyamine biosynthetic process	TAS
GO:0006598	Process	Polyamine catabolic process	IDA	12477380
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0046208	Process	Spermine catabolic process	IBA
GO:0046208	Process	Spermine catabolic process	IDA	18422650
GO:0046208	Process	Spermine catabolic process	IEA
GO:0046208	Process	Spermine catabolic process	IEA
GO:0046592	Function	Polyamine oxidase activity	IBA
GO:0046592	Function	Polyamine oxidase activity	IDA	12477380, 18422650
GO:0046592	Function	Polyamine oxidase activity	IEA
GO:0052901	Function	Spermine oxidase activity	IEA
GO:0052901	Function	Spermine oxidase activity	TAS

Other IDs

• MIM: 615854
• HGNC: 15862
• e!Ensembl: ENSG00000088826

Protein

• UniProt ID: Q9NWM0
• Protein name: Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)
• Protein function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important
• PDB: 7OXL, 7OY0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01593	Amino_oxidase	34 → 277	Flavin containing amine oxidoreductase	Domain
  PF01593	Amino_oxidase	304 → 544	Flavin containing amine oxidoreductase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269|PubMed:18422650}.
• Sequence:

  MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHI
  GGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGV
  ACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRI
  RNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFM
  RVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEP
  RGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRL
  GIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERY
  GHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRG
  SYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREA
  ARLIEMYRDLFQQGT

• Sequence length: 555

Pathways

KEGG:

Arginine and proline metabolism
beta-Alanine metabolism
Metabolic pathways

Reactome:

PAOs oxidise polyamines to amines
Interconversion of polyamines