Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54496
Gene name	Protein arginine methyltransferase 7
Gene symbol	PRMT7
Synonyms (NCBI Gene)	SBIDDS
Chromosome	16
Chromosome location	16q22.1
Summary	This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This

Show/Hide all (10)

SNP ID	Visualize variation	Clinical significance	Consequence
rs149170494	G>C	Pathogenic	Coding sequence variant, 5 prime UTR variant, non coding transcript variant, missense variant
rs201824659	G>T	Pathogenic	Splice acceptor variant
rs751670999	T>C	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs762515973	A>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs886039897	G>A	Pathogenic	Splice acceptor variant, intron variant
rs1014959895	G>C,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained, intron variant, non coding transcript variant
rs1251713297	C>A	Pathogenic	Non coding transcript variant, downstream transcript variant, stop gained, coding sequence variant, genic downstream transcript variant
rs1390386790	CT>-	Likely-pathogenic	Frameshift variant, non coding transcript variant, downstream transcript variant, genic downstream transcript variant, coding sequence variant
rs1567690011	AG>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs1567721991	->GCTCTCCG	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant, intron variant

Show/Hide all (73)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047476	hsa-miR-10b-5p	CLASH	23622248
MIRT046164	hsa-miR-30b-5p	CLASH	23622248
MIRT042041	hsa-miR-484	CLASH	23622248
MIRT535021	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT535020	hsa-miR-4323	PAR-CLIP	20371350
MIRT535019	hsa-miR-3943	PAR-CLIP	20371350
MIRT535018	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT570549	hsa-miR-361-3p	PAR-CLIP	20371350
MIRT570548	hsa-miR-3127-3p	PAR-CLIP	20371350
MIRT570547	hsa-miR-6756-3p	PAR-CLIP	20371350
MIRT535017	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT535016	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT535015	hsa-miR-24-1-5p	PAR-CLIP	20371350
MIRT535014	hsa-miR-24-2-5p	PAR-CLIP	20371350
MIRT535013	hsa-miR-6778-3p	PAR-CLIP	20371350
MIRT535012	hsa-miR-6791-3p	PAR-CLIP	20371350
MIRT535011	hsa-miR-6829-3p	PAR-CLIP	20371350
MIRT535010	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT535009	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT535008	hsa-miR-5001-3p	PAR-CLIP	20371350
MIRT535007	hsa-miR-6836-3p	PAR-CLIP	20371350
MIRT535021	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT535020	hsa-miR-4323	PAR-CLIP	22012620
MIRT535019	hsa-miR-3943	PAR-CLIP	22012620
MIRT535018	hsa-miR-6849-3p	PAR-CLIP	22012620
MIRT535017	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT535016	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT535015	hsa-miR-24-1-5p	PAR-CLIP	22012620
MIRT535014	hsa-miR-24-2-5p	PAR-CLIP	22012620
MIRT535013	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT535012	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT535011	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT535010	hsa-miR-6512-3p	PAR-CLIP	22012620
MIRT535009	hsa-miR-6720-5p	PAR-CLIP	22012620
MIRT535008	hsa-miR-5001-3p	PAR-CLIP	22012620
MIRT535007	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT449884	hsa-miR-656-3p	PAR-CLIP	22100165
MIRT449883	hsa-miR-7856-5p	PAR-CLIP	22100165
MIRT535021	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT535020	hsa-miR-4323	PAR-CLIP	20371350
MIRT535019	hsa-miR-3943	PAR-CLIP	20371350
MIRT535018	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT570549	hsa-miR-361-3p	PAR-CLIP	20371350
MIRT570548	hsa-miR-3127-3p	PAR-CLIP	20371350
MIRT570547	hsa-miR-6756-3p	PAR-CLIP	20371350
MIRT535017	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT535016	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT535015	hsa-miR-24-1-5p	PAR-CLIP	20371350
MIRT535014	hsa-miR-24-2-5p	PAR-CLIP	20371350
MIRT535013	hsa-miR-6778-3p	PAR-CLIP	20371350
MIRT535012	hsa-miR-6791-3p	PAR-CLIP	20371350
MIRT535011	hsa-miR-6829-3p	PAR-CLIP	20371350
MIRT535010	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT535009	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT535008	hsa-miR-5001-3p	PAR-CLIP	20371350
MIRT535007	hsa-miR-6836-3p	PAR-CLIP	20371350
MIRT535021	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT535020	hsa-miR-4323	PAR-CLIP	22012620
MIRT535019	hsa-miR-3943	PAR-CLIP	22012620
MIRT535018	hsa-miR-6849-3p	PAR-CLIP	22012620
MIRT535017	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT535016	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT535015	hsa-miR-24-1-5p	PAR-CLIP	22012620
MIRT535014	hsa-miR-24-2-5p	PAR-CLIP	22012620
MIRT535013	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT535012	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT535011	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT535010	hsa-miR-6512-3p	PAR-CLIP	22012620
MIRT535009	hsa-miR-6720-5p	PAR-CLIP	22012620
MIRT535008	hsa-miR-5001-3p	PAR-CLIP	22012620
MIRT535007	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT449884	hsa-miR-656-3p	PAR-CLIP	22100165
MIRT449883	hsa-miR-7856-5p	PAR-CLIP	22100165

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000387	Process	Spliceosomal snRNP assembly	IMP	17709427
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	28587924, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	15494416
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	15494416
GO:0005829	Component	Cytosol	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IDA	15044439
GO:0016274	Function	Protein-arginine N-methyltransferase activity	IBA
GO:0016274	Function	Protein-arginine N-methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018216	Process	Peptidyl-arginine methylation	IMP	17709427
GO:0030154	Process	Cell differentiation	IEA
GO:0032259	Process	Methylation	IEA
GO:0035241	Function	Protein-arginine omega-N monomethyltransferase activity	IDA	15044439, 19110445
GO:0035241	Function	Protein-arginine omega-N monomethyltransferase activity	IEA
GO:0035243	Function	Protein-arginine omega-N symmetric methyltransferase activity	IDA	15494416, 19110445
GO:0035243	Function	Protein-arginine omega-N symmetric methyltransferase activity	IEA
GO:0035243	Function	Protein-arginine omega-N symmetric methyltransferase activity	IMP	17709427
GO:0042054	Function	Histone methyltransferase activity	IBA
GO:0042393	Function	Histone binding	IDA	15494416
GO:0043021	Function	Ribonucleoprotein complex binding	IPI	17709427
GO:0044020	Function	Histone H4R3 methyltransferase activity	IEA
GO:0044020	Function	Histone H4R3 methyltransferase activity	ISS
GO:0071514	Process	Genomic imprinting	IEA
GO:0071514	Process	Genomic imprinting	ISS
GO:0140939	Function	Histone H4 methyltransferase activity	IDA	15494416
GO:0140939	Function	Histone H4 methyltransferase activity	IEA

MIM	HGNC	e!Ensembl
610087	25557	ENSG00000132600

Q9NVM4

Protein name

Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7)

Protein function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of argin

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06325	PrmA	54 → 149		Family

Sequence

MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVK
DRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVIN
KHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATV
YAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTV
LSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFW
AHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVR
QMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHH
LGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPF
FTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGF
DVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTV
ELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRA
LLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD

Sequence length

692

Interactions

View interactions

	Reactome
			RMTs methylate histone arginines

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Neurodevelopmental abnormality	Likely pathogenic; Pathogenic	rs201824659, rs2082897416	RCV001264712 RCV001264713
PRMT7-related disorder	Likely pathogenic; Pathogenic	rs201824659	RCV004754369
Short stature-brachydactyly-obesity-global developmental delay syndrome	Pathogenic; Likely pathogenic	rs2151732301, rs1597361540, rs2151827144, rs2151436426, rs2151701931, rs2151558358, rs1313637057, rs1339009950, rs2545118734, rs886039897, rs149170494, rs762515973, rs201824659, rs2086255627, rs768950720 View all (11 more)	RCV001420150 RCV001420151 RCV001544514 RCV001784880 RCV001806400 RCV001813607 RCV002260535 RCV002260536 RCV002510670 RCV000256479 RCV000256464 RCV000256485 RCV000256436 RCV003324206 RCV003990839 RCV003995191 RCV004515767 RCV004555312 RCV004594846 RCV000681524 RCV000681525 RCV000763383 RCV006249661 RCV000709800 RCV001199929 RCV001199406

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Epileptic encephalopathy	Conflicting classifications of pathogenicity	rs371698853	RCV001800167

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Brachydactyly	Associate	36348013
Brain Concussion	Inhibit	37196697
Brain Injuries Traumatic	Associate	37196697
Breast Neoplasms	Associate	30699057, 33782401
Carcinoma Hepatocellular	Associate	31732298, 35264579
Drug Related Side Effects and Adverse Reactions	Associate	19089452
Dwarfism Pituitary	Associate	36348013
Genetic Diseases Inborn	Associate	36348013
Growth Disorders	Associate	33270637, 36348013
Mitochondrial Diseases	Associate	37196697
Neoplasms	Associate	28874563, 33782401
Thoracic Outlet Syndrome	Inhibit	37196697
Thyroid Cancer Papillary	Associate	38092752

PRMT7 (protein arginine methyltransferase 7)