Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54487
Gene name Gene Name - the full gene name approved by the HGNC.	DGCR8 microprocessor complex subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DGCR8
Synonyms (NCBI Gene) Gene synonyms aliases	C22orf12, DGCRK6, Gy1, pasha
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the micr

Show/Hide all(187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051420	hsa-let-7e-5p	CLASH	23622248
MIRT048068	hsa-miR-197-3p	CLASH	23622248
MIRT044120	hsa-miR-30e-3p	CLASH	23622248
MIRT039550	hsa-miR-652-3p	CLASH	23622248
MIRT735015	hsa-miR-126-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), Immunofluorescence, qRT-PCR	33098220
MIRT735369	hsa-miR-451a	Microarray, Northern blotting, Immunoprecipitaion (IP), qRT-PCR	32302542
MIRT933748	hsa-miR-105	CLIP-seq
MIRT933749	hsa-miR-1226	CLIP-seq
MIRT933750	hsa-miR-1254	CLIP-seq
MIRT933751	hsa-miR-127-5p	CLIP-seq
MIRT933752	hsa-miR-128	CLIP-seq
MIRT933753	hsa-miR-1285	CLIP-seq
MIRT933754	hsa-miR-1292	CLIP-seq
MIRT933755	hsa-miR-1293	CLIP-seq
MIRT933756	hsa-miR-132	CLIP-seq
MIRT933757	hsa-miR-1324	CLIP-seq
MIRT933758	hsa-miR-190	CLIP-seq
MIRT933759	hsa-miR-190b	CLIP-seq
MIRT933760	hsa-miR-196a	CLIP-seq
MIRT933761	hsa-miR-196b	CLIP-seq
MIRT933762	hsa-miR-212	CLIP-seq
MIRT933763	hsa-miR-22	CLIP-seq
MIRT933764	hsa-miR-27a	CLIP-seq
MIRT933765	hsa-miR-27b	CLIP-seq
MIRT933766	hsa-miR-31	CLIP-seq
MIRT933767	hsa-miR-3116	CLIP-seq
MIRT933768	hsa-miR-3126-5p	CLIP-seq
MIRT933769	hsa-miR-3138	CLIP-seq
MIRT933770	hsa-miR-3158-5p	CLIP-seq
MIRT933771	hsa-miR-3166	CLIP-seq
MIRT933772	hsa-miR-3174	CLIP-seq
MIRT933773	hsa-miR-3187-5p	CLIP-seq
MIRT933774	hsa-miR-3201	CLIP-seq
MIRT933775	hsa-miR-323-5p	CLIP-seq
MIRT933776	hsa-miR-3612	CLIP-seq
MIRT933777	hsa-miR-3613-3p	CLIP-seq
MIRT933778	hsa-miR-377	CLIP-seq
MIRT933779	hsa-miR-3913-3p	CLIP-seq
MIRT933780	hsa-miR-3919	CLIP-seq
MIRT933781	hsa-miR-4252	CLIP-seq
MIRT933782	hsa-miR-4265	CLIP-seq
MIRT933783	hsa-miR-4296	CLIP-seq
MIRT933784	hsa-miR-4322	CLIP-seq
MIRT933785	hsa-miR-4417	CLIP-seq
MIRT933786	hsa-miR-4419a	CLIP-seq
MIRT933787	hsa-miR-4459	CLIP-seq
MIRT933788	hsa-miR-4471	CLIP-seq
MIRT933789	hsa-miR-4483	CLIP-seq
MIRT933790	hsa-miR-4506	CLIP-seq
MIRT933791	hsa-miR-4510	CLIP-seq
MIRT933792	hsa-miR-4514	CLIP-seq
MIRT933793	hsa-miR-4533	CLIP-seq
MIRT933794	hsa-miR-4635	CLIP-seq
MIRT933795	hsa-miR-4645-5p	CLIP-seq
MIRT933796	hsa-miR-4646-5p	CLIP-seq
MIRT933797	hsa-miR-4673	CLIP-seq
MIRT933798	hsa-miR-4687-3p	CLIP-seq
MIRT933799	hsa-miR-4692	CLIP-seq
MIRT933800	hsa-miR-4695-5p	CLIP-seq
MIRT933801	hsa-miR-4696	CLIP-seq
MIRT933802	hsa-miR-4704-3p	CLIP-seq
MIRT933803	hsa-miR-4709-5p	CLIP-seq
MIRT933804	hsa-miR-4733-3p	CLIP-seq
MIRT933805	hsa-miR-4747-5p	CLIP-seq
MIRT933806	hsa-miR-4771	CLIP-seq
MIRT933807	hsa-miR-4781-3p	CLIP-seq
MIRT933808	hsa-miR-4791	CLIP-seq
MIRT933809	hsa-miR-489	CLIP-seq
MIRT933810	hsa-miR-513a-5p	CLIP-seq
MIRT933811	hsa-miR-514	CLIP-seq
MIRT933812	hsa-miR-514b-3p	CLIP-seq
MIRT933813	hsa-miR-520a-5p	CLIP-seq
MIRT933814	hsa-miR-525-5p	CLIP-seq
MIRT933815	hsa-miR-548ae	CLIP-seq
MIRT933816	hsa-miR-548aj	CLIP-seq
MIRT933817	hsa-miR-548am	CLIP-seq
MIRT933818	hsa-miR-548c-3p	CLIP-seq
MIRT933819	hsa-miR-548q	CLIP-seq
MIRT933820	hsa-miR-548x	CLIP-seq
MIRT933821	hsa-miR-550a	CLIP-seq
MIRT933822	hsa-miR-612	CLIP-seq
MIRT933823	hsa-miR-650	CLIP-seq
MIRT933824	hsa-miR-661	CLIP-seq
MIRT933825	hsa-miR-876-3p	CLIP-seq
MIRT933826	hsa-miR-921	CLIP-seq
MIRT1976477	hsa-miR-138	CLIP-seq
MIRT1976478	hsa-miR-3117-5p	CLIP-seq
MIRT1976479	hsa-miR-3663-5p	CLIP-seq
MIRT933779	hsa-miR-3913-3p	CLIP-seq
MIRT933780	hsa-miR-3919	CLIP-seq
MIRT1976480	hsa-miR-4279	CLIP-seq
MIRT1976481	hsa-miR-4318	CLIP-seq
MIRT933802	hsa-miR-4704-3p	CLIP-seq
MIRT1976482	hsa-miR-483-5p	CLIP-seq
MIRT933809	hsa-miR-489	CLIP-seq
MIRT933811	hsa-miR-514	CLIP-seq
MIRT933812	hsa-miR-514b-3p	CLIP-seq
MIRT933813	hsa-miR-520a-5p	CLIP-seq
MIRT933814	hsa-miR-525-5p	CLIP-seq
MIRT933751	hsa-miR-127-5p	CLIP-seq
MIRT2211861	hsa-miR-1913	CLIP-seq
MIRT2211862	hsa-miR-3155	CLIP-seq
MIRT2211863	hsa-miR-3155b	CLIP-seq
MIRT2211864	hsa-miR-324-3p	CLIP-seq
MIRT2211865	hsa-miR-331-3p	CLIP-seq
MIRT2211866	hsa-miR-4438	CLIP-seq
MIRT933794	hsa-miR-4635	CLIP-seq
MIRT2211867	hsa-miR-4707-5p	CLIP-seq
MIRT1976482	hsa-miR-483-5p	CLIP-seq
MIRT2211868	hsa-miR-484	CLIP-seq
MIRT2386861	hsa-miR-4794	CLIP-seq
MIRT1976482	hsa-miR-483-5p	CLIP-seq
MIRT2448184	hsa-miR-1236	CLIP-seq
MIRT2448185	hsa-miR-4753-3p	CLIP-seq
MIRT2448186	hsa-miR-4768-5p	CLIP-seq
MIRT2515617	hsa-miR-1245b-3p	CLIP-seq
MIRT933750	hsa-miR-1254	CLIP-seq
MIRT2515618	hsa-miR-1305	CLIP-seq
MIRT2515619	hsa-miR-183	CLIP-seq
MIRT2515620	hsa-miR-1972	CLIP-seq
MIRT2515621	hsa-miR-2115	CLIP-seq
MIRT2515622	hsa-miR-3065-3p	CLIP-seq
MIRT2515623	hsa-miR-3065-5p	CLIP-seq
MIRT933767	hsa-miR-3116	CLIP-seq
MIRT2515624	hsa-miR-3130-3p	CLIP-seq
MIRT2515625	hsa-miR-370	CLIP-seq
MIRT2515626	hsa-miR-378	CLIP-seq
MIRT2515627	hsa-miR-378b	CLIP-seq
MIRT2515628	hsa-miR-378c	CLIP-seq
MIRT2515629	hsa-miR-378d	CLIP-seq
MIRT2515630	hsa-miR-378e	CLIP-seq
MIRT2515631	hsa-miR-378f	CLIP-seq
MIRT2515632	hsa-miR-378h	CLIP-seq
MIRT2515633	hsa-miR-378i	CLIP-seq
MIRT2515634	hsa-miR-3942-3p	CLIP-seq
MIRT2515635	hsa-miR-3977	CLIP-seq
MIRT2515636	hsa-miR-421	CLIP-seq
MIRT2515637	hsa-miR-422a	CLIP-seq
MIRT933781	hsa-miR-4252	CLIP-seq
MIRT2515638	hsa-miR-4254	CLIP-seq
MIRT2515639	hsa-miR-4436b-5p	CLIP-seq
MIRT2515640	hsa-miR-4462	CLIP-seq
MIRT2515641	hsa-miR-4493	CLIP-seq
MIRT2515642	hsa-miR-455-3p	CLIP-seq
MIRT2515643	hsa-miR-4639-5p	CLIP-seq
MIRT2515644	hsa-miR-4650-5p	CLIP-seq
MIRT2515645	hsa-miR-4742-5p	CLIP-seq
MIRT2515646	hsa-miR-4782-5p	CLIP-seq
MIRT2515647	hsa-miR-4793-3p	CLIP-seq
MIRT933810	hsa-miR-513a-5p	CLIP-seq
MIRT2515648	hsa-miR-516a-3p	CLIP-seq
MIRT933819	hsa-miR-548q	CLIP-seq
MIRT2515649	hsa-miR-552	CLIP-seq
MIRT2515650	hsa-miR-652	CLIP-seq
MIRT2515651	hsa-miR-764	CLIP-seq
MIRT2515617	hsa-miR-1245b-3p	CLIP-seq
MIRT2515621	hsa-miR-2115	CLIP-seq
MIRT2515624	hsa-miR-3130-3p	CLIP-seq
MIRT2679245	hsa-miR-3194-5p	CLIP-seq
MIRT2515626	hsa-miR-378	CLIP-seq
MIRT2515627	hsa-miR-378b	CLIP-seq
MIRT2515628	hsa-miR-378c	CLIP-seq
MIRT2515629	hsa-miR-378d	CLIP-seq
MIRT2515630	hsa-miR-378e	CLIP-seq
MIRT2515631	hsa-miR-378f	CLIP-seq
MIRT2515632	hsa-miR-378h	CLIP-seq
MIRT2515633	hsa-miR-378i	CLIP-seq
MIRT2679246	hsa-miR-3918	CLIP-seq
MIRT2515634	hsa-miR-3942-3p	CLIP-seq
MIRT2515635	hsa-miR-3977	CLIP-seq
MIRT2515637	hsa-miR-422a	CLIP-seq
MIRT2515640	hsa-miR-4462	CLIP-seq
MIRT2515641	hsa-miR-4493	CLIP-seq
MIRT2515642	hsa-miR-455-3p	CLIP-seq
MIRT2679247	hsa-miR-4640-5p	CLIP-seq
MIRT2679248	hsa-miR-4685-5p	CLIP-seq
MIRT2679249	hsa-miR-4726-5p	CLIP-seq
MIRT933804	hsa-miR-4733-3p	CLIP-seq
MIRT2515645	hsa-miR-4742-5p	CLIP-seq
MIRT2515646	hsa-miR-4782-5p	CLIP-seq
MIRT2515647	hsa-miR-4793-3p	CLIP-seq
MIRT933810	hsa-miR-513a-5p	CLIP-seq
MIRT2515648	hsa-miR-516a-3p	CLIP-seq
MIRT933819	hsa-miR-548q	CLIP-seq
MIRT2515649	hsa-miR-552	CLIP-seq
MIRT2515650	hsa-miR-652	CLIP-seq
MIRT2515651	hsa-miR-764	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003725	Function	Double-stranded RNA binding	IBA	21873635
GO:0003725	Function	Double-stranded RNA binding	IDA	17704815
GO:0005515	Function	Protein binding	IPI	15574589, 19626115, 22222205, 22796965, 23602568, 23995758, 24581491, 25416956, 26321680, 26496610
GO:0005634	Component	Nucleus	IDA	15574589
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0010586	Process	MiRNA metabolic process	TAS
GO:0016604	Component	Nuclear body	IDA
GO:0020037	Function	Heme binding	IDA	24449907, 24910438
GO:0031053	Process	Primary miRNA processing	IBA	21873635
GO:0031053	Process	Primary miRNA processing	IDA	15531877, 15574589, 24449907, 24910438
GO:0042802	Function	Identical protein binding	IPI	15574589, 17159994
GO:0042803	Function	Protein homodimerization activity	IDA	15574589
GO:0046872	Function	Metal ion binding	IEA
GO:0070877	Component	Microprocessor complex	IBA	21873635
GO:0070877	Component	Microprocessor complex	IDA	15574589
GO:0070878	Function	Primary miRNA binding	IBA	21873635
GO:0070878	Function	Primary miRNA binding	IDA	24910438
GO:0140517	Function	Protein-RNA adaptor activity	IDA	15574589

MIM	HGNC	e!Ensembl
609030	2847	ENSG00000128191

Protein

UniProt ID

Q8WYQ5

Protein name

Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)

Protein function

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcrip

PDB

1X47 , 2YT4 , 3LE4 , 5B16 , 6LXD , 6LXE , 6V5B , 6V5C , 7CNC , 9ASM , 9ASN , 9ASO , 9ASP , 9ASQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00035	dsrm	512 → 576	Double-stranded RNA binding motif	Domain
PF00035	dsrm	620 → 684	Double-stranded RNA binding motif	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12705904}.

Sequence

METDESPSPLPCGPAGEAVMESRARPFQALPREQSPPPPLQTSSGAEVMDVGSGGDGQSE
LPAEDPFNFYGASLLSKGSFSKGRLLIDPNCSGHSPRTARHAPAVRKFSPDLKLLKDVKI
SVSFTESCRSKDRKVLYTGAERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESAD
KKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFPYE
DDFDNDVDALLEEGLCAPKKRRTEEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPT
EPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKD
NEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAAPGAL
GQVKAKVEVCKDESVDLEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESER
PILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSE
PFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPKDSEELEYFNH
ISIEDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKH
TVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQ
YAKKNKPNLHILSKLQEEMKRLAEEREETRKKPKMSIVASAQPGGEPLCTVDV

Sequence length

773

Interactions

View interactions

	Reactome
			MicroRNA (miRNA) biogenesis

Show/Hide Causal Diseases (9)

Disease term	Disease name	dbSNP ID	References
Causal
Conotruncal anomaly face syndrome	CONOTRUNCAL ANOMALY FACE SYNDROME	rs28939675, rs1601294362
Digeorge syndrome	DiGeorge Syndrome	rs587776825, rs1555895466
Mental retardation	Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)
Microcephaly	Microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019 View all (280 more)
Nephroblastoma	Nephroblastoma	rs1553551874, rs1555913934, rs769116796	28825729
Pierre-robin syndrome	Pierre Robin Syndrome	rs1057519389, rs1057518986
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	23719809, 24904170, 23015298
Ventricular septal defect	Ventricular Septal Defects	rs104894073, rs387906775
Wilms tumor	Bilateral Wilms Tumor	rs121918261, rs2116574924, rs587776573, rs587776574, rs121907900, rs121907901, rs587776576, rs121907909, rs121907906, rs587776577, rs121907911, rs80359604, rs80358785, rs104894855, rs122453119 View all (13 more)	28825729

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Behavior disorders	Behavior Disorders	18469815	ClinVar
Specific learning disorder	Specific learning disability		ClinVar

Show/Hide Text Mining Associations (43)

Disease Name	Relationship Type	References
Associations from Text Mining
22q11 Deletion Syndrome	Associate	33581109
Acute Coronary Syndrome	Associate	27519051
Adenocarcinoma Follicular	Associate	34171097
Angina Stable	Associate	27519051
Autism Spectrum Disorder	Associate	31500805
Breast Neoplasms	Associate	22639842, 24574065, 28598829, 31858552, 32196606
Carcinogenesis	Associate	36499151
Carcinoma Hepatocellular	Associate	21319996, 23398123
Carcinoma Squamous Cell	Associate	26867589
Congenital Microtia	Associate	37107637
COVID 19	Associate	34715923
Diabetes Complications	Associate	31517606
Diabetes Gestational	Stimulate	25295740
DiGeorge Syndrome	Associate	24018986, 26221035, 27846841, 32989314, 33638978
DiGeorge Syndrome	Inhibit	25084529
Epilepsy Idiopathic Generalized	Associate	31805011
Esophageal Neoplasms	Associate	34257547
Glioblastoma	Associate	33758101
Glioma	Associate	33758101
Goiter Multinodular 2	Associate	31805011, 34171097
Hearing Loss Sudden	Associate	26240498
Heart Defects Congenital	Associate	36205932
Hyperglycemic Hyperosmolar Nonketotic Coma	Stimulate	31517606
Laryngeal Neoplasms	Associate	26688807, 28155978
Muscular Dystrophy Hemizygous Lethal Type	Associate	31805011
Neoplasm Metastasis	Associate	23135352, 32196606
Neoplasms	Associate	23322153, 25670082, 25670083, 26867589, 27107574, 31820118, 34188037, 36499151
Neurilemmoma	Associate	31805011
Ovarian Neoplasms	Associate	31841176
Pinealoma	Associate	31768671
Pneumonia	Associate	26991123
Prostatic Neoplasms	Associate	23135352
Purpura Thrombocytopenic Idiopathic	Associate	23360331
Schizophrenia	Associate	26173148, 26384369, 27846841, 31500805, 33581109
Schwannomatosis	Associate	31805011, 35723634
Stomach Neoplasms	Associate	36484990
Thyroid cancer follicular	Associate	36499151
Thyroid Cancer Papillary	Associate	31805011
Thyroid Diseases	Associate	36499151
Thyroid Neoplasms	Associate	36499151
Triple Negative Breast Neoplasms	Associate	32196606
Urinary Bladder Neoplasms	Associate	23322153
Wilms Tumor	Associate	25670082, 25670083, 28825729, 31805011, 31841180

DGCR8 (DGCR8 microprocessor complex subunit)