Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54487
Gene name Gene Name - the full gene name approved by the HGNC.	DGCR8 microprocessor complex subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DGCR8
Synonyms (NCBI Gene) Gene synonyms aliases	C22orf12, DGCRK6, Gy1, pasha
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the micr

Show/Hide all(187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051420	hsa-let-7e-5p	CLASH	23622248
MIRT048068	hsa-miR-197-3p	CLASH	23622248
MIRT044120	hsa-miR-30e-3p	CLASH	23622248
MIRT039550	hsa-miR-652-3p	CLASH	23622248
MIRT735015	hsa-miR-126-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), Immunofluorescence, qRT-PCR	33098220
MIRT735369	hsa-miR-451a	Microarray, Northern blotting, Immunoprecipitaion (IP), qRT-PCR	32302542
MIRT933748	hsa-miR-105	CLIP-seq
MIRT933749	hsa-miR-1226	CLIP-seq
MIRT933750	hsa-miR-1254	CLIP-seq
MIRT933751	hsa-miR-127-5p	CLIP-seq
MIRT933752	hsa-miR-128	CLIP-seq
MIRT933753	hsa-miR-1285	CLIP-seq
MIRT933754	hsa-miR-1292	CLIP-seq
MIRT933755	hsa-miR-1293	CLIP-seq
MIRT933756	hsa-miR-132	CLIP-seq
MIRT933757	hsa-miR-1324	CLIP-seq
MIRT933758	hsa-miR-190	CLIP-seq
MIRT933759	hsa-miR-190b	CLIP-seq
MIRT933760	hsa-miR-196a	CLIP-seq
MIRT933761	hsa-miR-196b	CLIP-seq
MIRT933762	hsa-miR-212	CLIP-seq
MIRT933763	hsa-miR-22	CLIP-seq
MIRT933764	hsa-miR-27a	CLIP-seq
MIRT933765	hsa-miR-27b	CLIP-seq
MIRT933766	hsa-miR-31	CLIP-seq
MIRT933767	hsa-miR-3116	CLIP-seq
MIRT933768	hsa-miR-3126-5p	CLIP-seq
MIRT933769	hsa-miR-3138	CLIP-seq
MIRT933770	hsa-miR-3158-5p	CLIP-seq
MIRT933771	hsa-miR-3166	CLIP-seq
MIRT933772	hsa-miR-3174	CLIP-seq
MIRT933773	hsa-miR-3187-5p	CLIP-seq
MIRT933774	hsa-miR-3201	CLIP-seq
MIRT933775	hsa-miR-323-5p	CLIP-seq
MIRT933776	hsa-miR-3612	CLIP-seq
MIRT933777	hsa-miR-3613-3p	CLIP-seq
MIRT933778	hsa-miR-377	CLIP-seq
MIRT933779	hsa-miR-3913-3p	CLIP-seq
MIRT933780	hsa-miR-3919	CLIP-seq
MIRT933781	hsa-miR-4252	CLIP-seq
MIRT933782	hsa-miR-4265	CLIP-seq
MIRT933783	hsa-miR-4296	CLIP-seq
MIRT933784	hsa-miR-4322	CLIP-seq
MIRT933785	hsa-miR-4417	CLIP-seq
MIRT933786	hsa-miR-4419a	CLIP-seq
MIRT933787	hsa-miR-4459	CLIP-seq
MIRT933788	hsa-miR-4471	CLIP-seq
MIRT933789	hsa-miR-4483	CLIP-seq
MIRT933790	hsa-miR-4506	CLIP-seq
MIRT933791	hsa-miR-4510	CLIP-seq
MIRT933792	hsa-miR-4514	CLIP-seq
MIRT933793	hsa-miR-4533	CLIP-seq
MIRT933794	hsa-miR-4635	CLIP-seq
MIRT933795	hsa-miR-4645-5p	CLIP-seq
MIRT933796	hsa-miR-4646-5p	CLIP-seq
MIRT933797	hsa-miR-4673	CLIP-seq
MIRT933798	hsa-miR-4687-3p	CLIP-seq
MIRT933799	hsa-miR-4692	CLIP-seq
MIRT933800	hsa-miR-4695-5p	CLIP-seq
MIRT933801	hsa-miR-4696	CLIP-seq
MIRT933802	hsa-miR-4704-3p	CLIP-seq
MIRT933803	hsa-miR-4709-5p	CLIP-seq
MIRT933804	hsa-miR-4733-3p	CLIP-seq
MIRT933805	hsa-miR-4747-5p	CLIP-seq
MIRT933806	hsa-miR-4771	CLIP-seq
MIRT933807	hsa-miR-4781-3p	CLIP-seq
MIRT933808	hsa-miR-4791	CLIP-seq
MIRT933809	hsa-miR-489	CLIP-seq
MIRT933810	hsa-miR-513a-5p	CLIP-seq
MIRT933811	hsa-miR-514	CLIP-seq
MIRT933812	hsa-miR-514b-3p	CLIP-seq
MIRT933813	hsa-miR-520a-5p	CLIP-seq
MIRT933814	hsa-miR-525-5p	CLIP-seq
MIRT933815	hsa-miR-548ae	CLIP-seq
MIRT933816	hsa-miR-548aj	CLIP-seq
MIRT933817	hsa-miR-548am	CLIP-seq
MIRT933818	hsa-miR-548c-3p	CLIP-seq
MIRT933819	hsa-miR-548q	CLIP-seq
MIRT933820	hsa-miR-548x	CLIP-seq
MIRT933821	hsa-miR-550a	CLIP-seq
MIRT933822	hsa-miR-612	CLIP-seq
MIRT933823	hsa-miR-650	CLIP-seq
MIRT933824	hsa-miR-661	CLIP-seq
MIRT933825	hsa-miR-876-3p	CLIP-seq
MIRT933826	hsa-miR-921	CLIP-seq
MIRT1976477	hsa-miR-138	CLIP-seq
MIRT1976478	hsa-miR-3117-5p	CLIP-seq
MIRT1976479	hsa-miR-3663-5p	CLIP-seq
MIRT933779	hsa-miR-3913-3p	CLIP-seq
MIRT933780	hsa-miR-3919	CLIP-seq
MIRT1976480	hsa-miR-4279	CLIP-seq
MIRT1976481	hsa-miR-4318	CLIP-seq
MIRT933802	hsa-miR-4704-3p	CLIP-seq
MIRT1976482	hsa-miR-483-5p	CLIP-seq
MIRT933809	hsa-miR-489	CLIP-seq
MIRT933811	hsa-miR-514	CLIP-seq
MIRT933812	hsa-miR-514b-3p	CLIP-seq
MIRT933813	hsa-miR-520a-5p	CLIP-seq
MIRT933814	hsa-miR-525-5p	CLIP-seq
MIRT933751	hsa-miR-127-5p	CLIP-seq
MIRT2211861	hsa-miR-1913	CLIP-seq
MIRT2211862	hsa-miR-3155	CLIP-seq
MIRT2211863	hsa-miR-3155b	CLIP-seq
MIRT2211864	hsa-miR-324-3p	CLIP-seq
MIRT2211865	hsa-miR-331-3p	CLIP-seq
MIRT2211866	hsa-miR-4438	CLIP-seq
MIRT933794	hsa-miR-4635	CLIP-seq
MIRT2211867	hsa-miR-4707-5p	CLIP-seq
MIRT1976482	hsa-miR-483-5p	CLIP-seq
MIRT2211868	hsa-miR-484	CLIP-seq
MIRT2386861	hsa-miR-4794	CLIP-seq
MIRT1976482	hsa-miR-483-5p	CLIP-seq
MIRT2448184	hsa-miR-1236	CLIP-seq
MIRT2448185	hsa-miR-4753-3p	CLIP-seq
MIRT2448186	hsa-miR-4768-5p	CLIP-seq
MIRT2515617	hsa-miR-1245b-3p	CLIP-seq
MIRT933750	hsa-miR-1254	CLIP-seq
MIRT2515618	hsa-miR-1305	CLIP-seq
MIRT2515619	hsa-miR-183	CLIP-seq
MIRT2515620	hsa-miR-1972	CLIP-seq
MIRT2515621	hsa-miR-2115	CLIP-seq
MIRT2515622	hsa-miR-3065-3p	CLIP-seq
MIRT2515623	hsa-miR-3065-5p	CLIP-seq
MIRT933767	hsa-miR-3116	CLIP-seq
MIRT2515624	hsa-miR-3130-3p	CLIP-seq
MIRT2515625	hsa-miR-370	CLIP-seq
MIRT2515626	hsa-miR-378	CLIP-seq
MIRT2515627	hsa-miR-378b	CLIP-seq
MIRT2515628	hsa-miR-378c	CLIP-seq
MIRT2515629	hsa-miR-378d	CLIP-seq
MIRT2515630	hsa-miR-378e	CLIP-seq
MIRT2515631	hsa-miR-378f	CLIP-seq
MIRT2515632	hsa-miR-378h	CLIP-seq
MIRT2515633	hsa-miR-378i	CLIP-seq
MIRT2515634	hsa-miR-3942-3p	CLIP-seq
MIRT2515635	hsa-miR-3977	CLIP-seq
MIRT2515636	hsa-miR-421	CLIP-seq
MIRT2515637	hsa-miR-422a	CLIP-seq
MIRT933781	hsa-miR-4252	CLIP-seq
MIRT2515638	hsa-miR-4254	CLIP-seq
MIRT2515639	hsa-miR-4436b-5p	CLIP-seq
MIRT2515640	hsa-miR-4462	CLIP-seq
MIRT2515641	hsa-miR-4493	CLIP-seq
MIRT2515642	hsa-miR-455-3p	CLIP-seq
MIRT2515643	hsa-miR-4639-5p	CLIP-seq
MIRT2515644	hsa-miR-4650-5p	CLIP-seq
MIRT2515645	hsa-miR-4742-5p	CLIP-seq
MIRT2515646	hsa-miR-4782-5p	CLIP-seq
MIRT2515647	hsa-miR-4793-3p	CLIP-seq
MIRT933810	hsa-miR-513a-5p	CLIP-seq
MIRT2515648	hsa-miR-516a-3p	CLIP-seq
MIRT933819	hsa-miR-548q	CLIP-seq
MIRT2515649	hsa-miR-552	CLIP-seq
MIRT2515650	hsa-miR-652	CLIP-seq
MIRT2515651	hsa-miR-764	CLIP-seq
MIRT2515617	hsa-miR-1245b-3p	CLIP-seq
MIRT2515621	hsa-miR-2115	CLIP-seq
MIRT2515624	hsa-miR-3130-3p	CLIP-seq
MIRT2679245	hsa-miR-3194-5p	CLIP-seq
MIRT2515626	hsa-miR-378	CLIP-seq
MIRT2515627	hsa-miR-378b	CLIP-seq
MIRT2515628	hsa-miR-378c	CLIP-seq
MIRT2515629	hsa-miR-378d	CLIP-seq
MIRT2515630	hsa-miR-378e	CLIP-seq
MIRT2515631	hsa-miR-378f	CLIP-seq
MIRT2515632	hsa-miR-378h	CLIP-seq
MIRT2515633	hsa-miR-378i	CLIP-seq
MIRT2679246	hsa-miR-3918	CLIP-seq
MIRT2515634	hsa-miR-3942-3p	CLIP-seq
MIRT2515635	hsa-miR-3977	CLIP-seq
MIRT2515637	hsa-miR-422a	CLIP-seq
MIRT2515640	hsa-miR-4462	CLIP-seq
MIRT2515641	hsa-miR-4493	CLIP-seq
MIRT2515642	hsa-miR-455-3p	CLIP-seq
MIRT2679247	hsa-miR-4640-5p	CLIP-seq
MIRT2679248	hsa-miR-4685-5p	CLIP-seq
MIRT2679249	hsa-miR-4726-5p	CLIP-seq
MIRT933804	hsa-miR-4733-3p	CLIP-seq
MIRT2515645	hsa-miR-4742-5p	CLIP-seq
MIRT2515646	hsa-miR-4782-5p	CLIP-seq
MIRT2515647	hsa-miR-4793-3p	CLIP-seq
MIRT933810	hsa-miR-513a-5p	CLIP-seq
MIRT2515648	hsa-miR-516a-3p	CLIP-seq
MIRT933819	hsa-miR-548q	CLIP-seq
MIRT2515649	hsa-miR-552	CLIP-seq
MIRT2515650	hsa-miR-652	CLIP-seq
MIRT2515651	hsa-miR-764	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	17704815
GO:0005515	Function	Protein binding	IPI	15574589, 19626115, 22222205, 22796965, 23602568, 23995758, 24581491, 25416956, 26321680, 26496610, 33961781, 35914814, 39251607
GO:0005634	Component	Nucleus	IDA	15574589
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006974	Process	DNA damage response	IDA	19500350
GO:0006974	Process	DNA damage response	IDA	34188037
GO:0014069	Component	Postsynaptic density	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0020037	Function	Heme binding	IDA	24449907, 24910438
GO:0020037	Function	Heme binding	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	34188037
GO:0031053	Process	Primary miRNA processing	IBA
GO:0031053	Process	Primary miRNA processing	IDA	15531877, 15574589
GO:0031053	Process	Primary miRNA processing	IDA	15574589, 24449907, 24910438
GO:0031053	Process	Primary miRNA processing	IEA
GO:0035861	Component	Site of double-strand break	IC	15574589
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	15574589, 17159994
GO:0042803	Function	Protein homodimerization activity	IDA	15574589
GO:0046872	Function	Metal ion binding	IEA
GO:0070877	Component	Microprocessor complex	IBA
GO:0070877	Component	Microprocessor complex	IDA	15574589
GO:0070877	Component	Microprocessor complex	IEA
GO:0070877	Component	Microprocessor complex	IPI	24581491
GO:0070878	Function	Primary miRNA binding	IBA
GO:0070878	Function	Primary miRNA binding	IDA	24910438
GO:0070878	Function	Primary miRNA binding	IEA
GO:0072091	Process	Regulation of stem cell proliferation	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0140517	Function	Protein-RNA adaptor activity	IDA	15574589
GO:2000633	Process	Positive regulation of pre-miRNA processing	IDA	15574589, 32926445

MIM	HGNC	e!Ensembl
609030	2847	ENSG00000128191

Protein

UniProt ID

Q8WYQ5

Protein name

Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)

Protein function

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcrip

PDB

1X47 , 2YT4 , 3LE4 , 5B16 , 6LXD , 6LXE , 6V5B , 6V5C , 7CNC , 9ASM , 9ASN , 9ASO , 9ASP , 9ASQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00035	dsrm	512 → 576	Double-stranded RNA binding motif	Domain
PF00035	dsrm	620 → 684	Double-stranded RNA binding motif	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12705904}.

Sequence

METDESPSPLPCGPAGEAVMESRARPFQALPREQSPPPPLQTSSGAEVMDVGSGGDGQSE
LPAEDPFNFYGASLLSKGSFSKGRLLIDPNCSGHSPRTARHAPAVRKFSPDLKLLKDVKI
SVSFTESCRSKDRKVLYTGAERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESAD
KKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFPYE
DDFDNDVDALLEEGLCAPKKRRTEEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPT
EPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKD
NEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAAPGAL
GQVKAKVEVCKDESVDLEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESER
PILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSE
PFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPKDSEELEYFNH
ISIEDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKH
TVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQ
YAKKNKPNLHILSKLQEEMKRLAEEREETRKKPKMSIVASAQPGGEPLCTVDV

Sequence length

773

Interactions

View interactions

	Reactome
			MicroRNA (miRNA) biogenesis

DGCR8 (DGCR8 microprocessor complex subunit)