RNF216 (ring finger protein 216)

Gene

• Entrez ID: 54476
• Gene name: Ring finger protein 216
• Gene symbol: RNF216
• Synonyms (NCBI Gene): CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
• Chromosome: 7
• Chromosome location: 7p22.1
• Summary: This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs141050143	G>A	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant, coding sequence variant, missense variant
rs148642312	T>A,C	Pathogenic	Coding sequence variant, missense variant
rs373785974	G>A,C	Pathogenic	5 prime UTR variant, missense variant, coding sequence variant, stop gained
rs387907368	G>A	Pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs387907369	A>T	Pathogenic	Coding sequence variant, stop gained
rs387907370	CT>-	Pathogenic	5 prime UTR variant, frameshift variant, coding sequence variant
rs794728000	C>T	Pathogenic	Coding sequence variant, missense variant
rs1562451985	C>G	Pathogenic	Splice acceptor variant, intron variant
rs1584549575	C>-	Pathogenic	5 prime UTR variant, coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044679	hsa-miR-320a	CLASH	23622248
MIRT037895	hsa-miR-455-3p	CLASH	23622248
MIRT706668	hsa-miR-3155a	HITS-CLIP	21572407
MIRT706667	hsa-miR-3155b	HITS-CLIP	21572407
MIRT706666	hsa-miR-484	HITS-CLIP	21572407
MIRT706665	hsa-miR-5693	HITS-CLIP	21572407
MIRT706664	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT706663	hsa-miR-3934-3p	HITS-CLIP	21572407
MIRT706662	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706661	hsa-miR-3140-3p	HITS-CLIP	21572407
MIRT706660	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT706659	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT706658	hsa-miR-3652	HITS-CLIP	21572407
MIRT706657	hsa-miR-4430	HITS-CLIP	21572407
MIRT706656	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706655	hsa-miR-891a-3p	HITS-CLIP	21572407
MIRT706654	hsa-miR-1178-3p	HITS-CLIP	21572407
MIRT706653	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT706652	hsa-miR-5698	HITS-CLIP	21572407
MIRT676530	hsa-miR-619-3p	HITS-CLIP	23824327
MIRT676529	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT676528	hsa-miR-8062	HITS-CLIP	23824327
MIRT676527	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT676526	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676525	hsa-miR-4324	HITS-CLIP	23824327
MIRT676524	hsa-miR-544b	HITS-CLIP	23824327
MIRT676523	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676522	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676521	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676520	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676519	hsa-miR-1976	HITS-CLIP	23824327
MIRT676518	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT676517	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT676516	hsa-miR-1911-5p	HITS-CLIP	23824327
MIRT676515	hsa-miR-1297	HITS-CLIP	23824327
MIRT676514	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT676513	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT676512	hsa-miR-4465	HITS-CLIP	23824327
MIRT676511	hsa-miR-1200	HITS-CLIP	23824327
MIRT676510	hsa-miR-4279	HITS-CLIP	23824327
MIRT676509	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT439759	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439758	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439757	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439759	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726728	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726726	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726727	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726725	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT726724	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726723	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT439758	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439757	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT706668	hsa-miR-3155a	HITS-CLIP	21572407
MIRT706667	hsa-miR-3155b	HITS-CLIP	21572407
MIRT706666	hsa-miR-484	HITS-CLIP	21572407
MIRT706665	hsa-miR-5693	HITS-CLIP	21572407
MIRT706664	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT706663	hsa-miR-3934-3p	HITS-CLIP	21572407
MIRT706662	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706661	hsa-miR-3140-3p	HITS-CLIP	21572407
MIRT706660	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT706659	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT706658	hsa-miR-3652	HITS-CLIP	21572407
MIRT706657	hsa-miR-4430	HITS-CLIP	21572407
MIRT706656	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706655	hsa-miR-891a-3p	HITS-CLIP	21572407
MIRT706654	hsa-miR-1178-3p	HITS-CLIP	21572407
MIRT706653	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT706652	hsa-miR-5698	HITS-CLIP	21572407
MIRT676530	hsa-miR-619-3p	HITS-CLIP	23824327
MIRT676529	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT676528	hsa-miR-8062	HITS-CLIP	23824327
MIRT676527	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT676526	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676525	hsa-miR-4324	HITS-CLIP	23824327
MIRT676524	hsa-miR-544b	HITS-CLIP	23824327
MIRT676523	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676522	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676521	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676520	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676519	hsa-miR-1976	HITS-CLIP	23824327
MIRT676518	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT676517	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT676516	hsa-miR-1911-5p	HITS-CLIP	23824327
MIRT676515	hsa-miR-1297	HITS-CLIP	23824327
MIRT676514	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT676513	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT676512	hsa-miR-4465	HITS-CLIP	23824327
MIRT676511	hsa-miR-1200	HITS-CLIP	23824327
MIRT676510	hsa-miR-4279	HITS-CLIP	23824327
MIRT676509	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT1312181	hsa-miR-23a	CLIP-seq
MIRT1312182	hsa-miR-23b	CLIP-seq
MIRT1312183	hsa-miR-23c	CLIP-seq
MIRT1312184	hsa-miR-3154	CLIP-seq
MIRT1312185	hsa-miR-3184	CLIP-seq
MIRT1312186	hsa-miR-423-5p	CLIP-seq
MIRT1312187	hsa-miR-4688	CLIP-seq
MIRT1312188	hsa-miR-4717-3p	CLIP-seq
MIRT1312189	hsa-miR-4728-5p	CLIP-seq
MIRT1312190	hsa-miR-4737	CLIP-seq
MIRT1312191	hsa-miR-486-3p	CLIP-seq
MIRT1312192	hsa-miR-1236	CLIP-seq
MIRT1312193	hsa-miR-124	CLIP-seq
MIRT1312194	hsa-miR-1246	CLIP-seq
MIRT1312195	hsa-miR-1254	CLIP-seq
MIRT1312196	hsa-miR-1302	CLIP-seq
MIRT1312197	hsa-miR-130a	CLIP-seq
MIRT1312198	hsa-miR-130b	CLIP-seq
MIRT1312199	hsa-miR-145	CLIP-seq
MIRT1312200	hsa-miR-19a	CLIP-seq
MIRT1312201	hsa-miR-19b	CLIP-seq
MIRT1312202	hsa-miR-204	CLIP-seq
MIRT1312203	hsa-miR-211	CLIP-seq
MIRT1312204	hsa-miR-2355-3p	CLIP-seq
MIRT1312181	hsa-miR-23a	CLIP-seq
MIRT1312182	hsa-miR-23b	CLIP-seq
MIRT1312183	hsa-miR-23c	CLIP-seq
MIRT1312205	hsa-miR-2682	CLIP-seq
MIRT1312206	hsa-miR-28-3p	CLIP-seq
MIRT1312207	hsa-miR-300	CLIP-seq
MIRT1312208	hsa-miR-301a	CLIP-seq
MIRT1312209	hsa-miR-301b	CLIP-seq
MIRT1312210	hsa-miR-302a	CLIP-seq
MIRT1312211	hsa-miR-302b	CLIP-seq
MIRT1312212	hsa-miR-302c	CLIP-seq
MIRT1312213	hsa-miR-302d	CLIP-seq
MIRT1312214	hsa-miR-302e	CLIP-seq
MIRT1312215	hsa-miR-3116	CLIP-seq
MIRT1312216	hsa-miR-3122	CLIP-seq
MIRT1312217	hsa-miR-3129-3p	CLIP-seq
MIRT1312184	hsa-miR-3154	CLIP-seq
MIRT1312218	hsa-miR-3155	CLIP-seq
MIRT1312219	hsa-miR-3183	CLIP-seq
MIRT1312185	hsa-miR-3184	CLIP-seq
MIRT1312220	hsa-miR-325	CLIP-seq
MIRT1312221	hsa-miR-3609	CLIP-seq
MIRT1312222	hsa-miR-3666	CLIP-seq
MIRT1312223	hsa-miR-3714	CLIP-seq
MIRT1312224	hsa-miR-371-5p	CLIP-seq
MIRT1312225	hsa-miR-372	CLIP-seq
MIRT1312226	hsa-miR-373	CLIP-seq
MIRT1312227	hsa-miR-381	CLIP-seq
MIRT1312228	hsa-miR-3910	CLIP-seq
MIRT1312229	hsa-miR-3913-5p	CLIP-seq
MIRT1312230	hsa-miR-3925-3p	CLIP-seq
MIRT1312231	hsa-miR-411	CLIP-seq
MIRT1312186	hsa-miR-423-5p	CLIP-seq
MIRT1312232	hsa-miR-4269	CLIP-seq
MIRT1312233	hsa-miR-4283	CLIP-seq
MIRT1312234	hsa-miR-4295	CLIP-seq
MIRT1312235	hsa-miR-4298	CLIP-seq
MIRT1312236	hsa-miR-4328	CLIP-seq
MIRT1312237	hsa-miR-4474-3p	CLIP-seq
MIRT1312238	hsa-miR-4477b	CLIP-seq
MIRT1312239	hsa-miR-4489	CLIP-seq
MIRT1312240	hsa-miR-449c	CLIP-seq
MIRT1312241	hsa-miR-4505	CLIP-seq
MIRT1312242	hsa-miR-4514	CLIP-seq
MIRT1312243	hsa-miR-454	CLIP-seq
MIRT1312244	hsa-miR-4645-5p	CLIP-seq
MIRT1312245	hsa-miR-4646-3p	CLIP-seq
MIRT1312246	hsa-miR-4652-5p	CLIP-seq
MIRT1312247	hsa-miR-4666-3p	CLIP-seq
MIRT1312248	hsa-miR-4673	CLIP-seq
MIRT1312249	hsa-miR-4675	CLIP-seq
MIRT1312187	hsa-miR-4688	CLIP-seq
MIRT1312250	hsa-miR-4692	CLIP-seq
MIRT1312251	hsa-miR-4707-3p	CLIP-seq
MIRT1312188	hsa-miR-4717-3p	CLIP-seq
MIRT1312252	hsa-miR-4722-5p	CLIP-seq
MIRT1312253	hsa-miR-4723-3p	CLIP-seq
MIRT1312189	hsa-miR-4728-5p	CLIP-seq
MIRT1312190	hsa-miR-4737	CLIP-seq
MIRT1312254	hsa-miR-4741	CLIP-seq
MIRT1312255	hsa-miR-4742-5p	CLIP-seq
MIRT1312256	hsa-miR-4789-5p	CLIP-seq
MIRT1312257	hsa-miR-4795-3p	CLIP-seq
MIRT1312258	hsa-miR-4800-3p	CLIP-seq
MIRT1312259	hsa-miR-483-5p	CLIP-seq
MIRT1312191	hsa-miR-486-3p	CLIP-seq
MIRT1312260	hsa-miR-506	CLIP-seq
MIRT1312261	hsa-miR-519a	CLIP-seq
MIRT1312262	hsa-miR-519b-3p	CLIP-seq
MIRT1312263	hsa-miR-519c-3p	CLIP-seq
MIRT1312264	hsa-miR-520a-3p	CLIP-seq
MIRT1312265	hsa-miR-520b	CLIP-seq
MIRT1312266	hsa-miR-520c-3p	CLIP-seq
MIRT1312267	hsa-miR-520d-3p	CLIP-seq
MIRT1312268	hsa-miR-520d-5p	CLIP-seq
MIRT1312269	hsa-miR-520e	CLIP-seq
MIRT1312270	hsa-miR-520g	CLIP-seq
MIRT1312271	hsa-miR-520h	CLIP-seq
MIRT1312272	hsa-miR-524-5p	CLIP-seq
MIRT1312273	hsa-miR-542-3p	CLIP-seq
MIRT1312274	hsa-miR-548ah	CLIP-seq
MIRT1312275	hsa-miR-548p	CLIP-seq
MIRT1312276	hsa-miR-578	CLIP-seq
MIRT1312277	hsa-miR-661	CLIP-seq
MIRT1312278	hsa-miR-665	CLIP-seq
MIRT1312279	hsa-miR-676	CLIP-seq
MIRT1312280	hsa-miR-766	CLIP-seq
MIRT1312281	hsa-miR-888	CLIP-seq
MIRT1312282	hsa-miR-940	CLIP-seq
MIRT2092787	hsa-miR-1178	CLIP-seq
MIRT2092788	hsa-miR-122	CLIP-seq
MIRT2092789	hsa-miR-1226	CLIP-seq
MIRT2092790	hsa-miR-1291	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092792	hsa-miR-1972	CLIP-seq
MIRT2092793	hsa-miR-24	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT1312218	hsa-miR-3155	CLIP-seq
MIRT2092796	hsa-miR-3160-3p	CLIP-seq
MIRT2092797	hsa-miR-3173-5p	CLIP-seq
MIRT2092798	hsa-miR-3189-3p	CLIP-seq
MIRT1312223	hsa-miR-3714	CLIP-seq
MIRT2092799	hsa-miR-378	CLIP-seq
MIRT2092800	hsa-miR-378b	CLIP-seq
MIRT2092801	hsa-miR-378c	CLIP-seq
MIRT2092802	hsa-miR-378d	CLIP-seq
MIRT2092803	hsa-miR-378e	CLIP-seq
MIRT2092804	hsa-miR-378f	CLIP-seq
MIRT2092805	hsa-miR-378h	CLIP-seq
MIRT2092806	hsa-miR-378i	CLIP-seq
MIRT2092807	hsa-miR-422a	CLIP-seq
MIRT2092808	hsa-miR-4284	CLIP-seq
MIRT1312236	hsa-miR-4328	CLIP-seq
MIRT2092809	hsa-miR-4438	CLIP-seq
MIRT2092810	hsa-miR-4487	CLIP-seq
MIRT2092811	hsa-miR-4520a-3p	CLIP-seq
MIRT2092812	hsa-miR-4525	CLIP-seq
MIRT2092813	hsa-miR-4638-3p	CLIP-seq
MIRT2092814	hsa-miR-4640-5p	CLIP-seq
MIRT2092815	hsa-miR-4650-5p	CLIP-seq
MIRT2092816	hsa-miR-4656	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT2092818	hsa-miR-4726-5p	CLIP-seq
MIRT2092819	hsa-miR-4755-3p	CLIP-seq
MIRT2092820	hsa-miR-4772-3p	CLIP-seq
MIRT2092821	hsa-miR-5095	CLIP-seq
MIRT2092822	hsa-miR-515-3p	CLIP-seq
MIRT2092823	hsa-miR-519e	CLIP-seq
MIRT2092824	hsa-miR-558	CLIP-seq
MIRT2092787	hsa-miR-1178	CLIP-seq
MIRT2317364	hsa-miR-1207-5p	CLIP-seq
MIRT2092788	hsa-miR-122	CLIP-seq
MIRT2092789	hsa-miR-1226	CLIP-seq
MIRT2317365	hsa-miR-1234	CLIP-seq
MIRT1312194	hsa-miR-1246	CLIP-seq
MIRT2317366	hsa-miR-1265	CLIP-seq
MIRT2317367	hsa-miR-1275	CLIP-seq
MIRT2317368	hsa-miR-1285	CLIP-seq
MIRT2092790	hsa-miR-1291	CLIP-seq
MIRT1312196	hsa-miR-1302	CLIP-seq
MIRT2317369	hsa-miR-136	CLIP-seq
MIRT2317370	hsa-miR-1911	CLIP-seq
MIRT2317371	hsa-miR-1913	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092792	hsa-miR-1972	CLIP-seq
MIRT2317372	hsa-miR-2392	CLIP-seq
MIRT2092793	hsa-miR-24	CLIP-seq
MIRT1312205	hsa-miR-2682	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT1312210	hsa-miR-302a	CLIP-seq
MIRT1312211	hsa-miR-302b	CLIP-seq
MIRT1312212	hsa-miR-302c	CLIP-seq
MIRT1312213	hsa-miR-302d	CLIP-seq
MIRT1312214	hsa-miR-302e	CLIP-seq
MIRT2317373	hsa-miR-3119	CLIP-seq
MIRT1312216	hsa-miR-3122	CLIP-seq
MIRT1312218	hsa-miR-3155	CLIP-seq
MIRT2092797	hsa-miR-3173-5p	CLIP-seq
MIRT2317374	hsa-miR-3178	CLIP-seq
MIRT2317375	hsa-miR-3187-5p	CLIP-seq
MIRT2092798	hsa-miR-3189-3p	CLIP-seq
MIRT2317376	hsa-miR-324-3p	CLIP-seq
MIRT2317377	hsa-miR-326	CLIP-seq
MIRT2317378	hsa-miR-328	CLIP-seq
MIRT2317379	hsa-miR-329	CLIP-seq
MIRT2317380	hsa-miR-330-5p	CLIP-seq
MIRT2317381	hsa-miR-331-3p	CLIP-seq
MIRT2317382	hsa-miR-362-3p	CLIP-seq
MIRT2317383	hsa-miR-3688-5p	CLIP-seq
MIRT1312224	hsa-miR-371-5p	CLIP-seq
MIRT1312225	hsa-miR-372	CLIP-seq
MIRT1312226	hsa-miR-373	CLIP-seq
MIRT2092799	hsa-miR-378	CLIP-seq
MIRT2092800	hsa-miR-378b	CLIP-seq
MIRT2092801	hsa-miR-378c	CLIP-seq
MIRT2092802	hsa-miR-378d	CLIP-seq
MIRT2092803	hsa-miR-378e	CLIP-seq
MIRT2092804	hsa-miR-378f	CLIP-seq
MIRT2317384	hsa-miR-378g	CLIP-seq
MIRT2092805	hsa-miR-378h	CLIP-seq
MIRT2092806	hsa-miR-378i	CLIP-seq
MIRT1312229	hsa-miR-3913-5p	CLIP-seq
MIRT2317385	hsa-miR-3941	CLIP-seq
MIRT2092807	hsa-miR-422a	CLIP-seq
MIRT1312232	hsa-miR-4269	CLIP-seq
MIRT2317386	hsa-miR-4281	CLIP-seq
MIRT2092808	hsa-miR-4284	CLIP-seq
MIRT2317387	hsa-miR-4291	CLIP-seq
MIRT2317388	hsa-miR-4297	CLIP-seq
MIRT1312235	hsa-miR-4298	CLIP-seq
MIRT2317389	hsa-miR-4437	CLIP-seq
MIRT2092809	hsa-miR-4438	CLIP-seq
MIRT2317390	hsa-miR-4486	CLIP-seq
MIRT1312240	hsa-miR-449c	CLIP-seq
MIRT1312242	hsa-miR-4514	CLIP-seq
MIRT2092811	hsa-miR-4520a-3p	CLIP-seq
MIRT2092812	hsa-miR-4525	CLIP-seq
MIRT2092813	hsa-miR-4638-3p	CLIP-seq
MIRT2317391	hsa-miR-4639-3p	CLIP-seq
MIRT2092815	hsa-miR-4650-5p	CLIP-seq
MIRT2317392	hsa-miR-4651	CLIP-seq
MIRT2317393	hsa-miR-466	CLIP-seq
MIRT2317394	hsa-miR-4660	CLIP-seq
MIRT2317395	hsa-miR-4665-5p	CLIP-seq
MIRT2317396	hsa-miR-4672	CLIP-seq
MIRT2317397	hsa-miR-4674	CLIP-seq
MIRT1312250	hsa-miR-4692	CLIP-seq
MIRT1312251	hsa-miR-4707-3p	CLIP-seq
MIRT2317398	hsa-miR-4723-5p	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT1312189	hsa-miR-4728-5p	CLIP-seq
MIRT2317399	hsa-miR-4731-5p	CLIP-seq
MIRT2317400	hsa-miR-4733-3p	CLIP-seq
MIRT1312255	hsa-miR-4742-5p	CLIP-seq
MIRT2317401	hsa-miR-4763-3p	CLIP-seq
MIRT2092820	hsa-miR-4772-3p	CLIP-seq
MIRT1312257	hsa-miR-4795-3p	CLIP-seq
MIRT2317402	hsa-miR-483-3p	CLIP-seq
MIRT1312191	hsa-miR-486-3p	CLIP-seq
MIRT2317403	hsa-miR-494	CLIP-seq
MIRT2317404	hsa-miR-498	CLIP-seq
MIRT2317405	hsa-miR-499-3p	CLIP-seq
MIRT2317406	hsa-miR-499a-3p	CLIP-seq
MIRT2092821	hsa-miR-5095	CLIP-seq
MIRT2317407	hsa-miR-515-5p	CLIP-seq
MIRT1312264	hsa-miR-520a-3p	CLIP-seq
MIRT1312265	hsa-miR-520b	CLIP-seq
MIRT1312266	hsa-miR-520c-3p	CLIP-seq
MIRT1312267	hsa-miR-520d-3p	CLIP-seq
MIRT1312268	hsa-miR-520d-5p	CLIP-seq
MIRT1312269	hsa-miR-520e	CLIP-seq
MIRT1312270	hsa-miR-520g	CLIP-seq
MIRT1312271	hsa-miR-520h	CLIP-seq
MIRT1312272	hsa-miR-524-5p	CLIP-seq
MIRT2317408	hsa-miR-545	CLIP-seq
MIRT2317409	hsa-miR-548aa	CLIP-seq
MIRT1312275	hsa-miR-548p	CLIP-seq
MIRT2317410	hsa-miR-603	CLIP-seq
MIRT2317411	hsa-miR-608	CLIP-seq
MIRT2317412	hsa-miR-612	CLIP-seq
MIRT2317413	hsa-miR-625	CLIP-seq
MIRT2317414	hsa-miR-651	CLIP-seq
MIRT1312281	hsa-miR-888	CLIP-seq
MIRT2317415	hsa-miR-935	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT2393830	hsa-miR-3180-5p	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT2092820	hsa-miR-4772-3p	CLIP-seq
MIRT2393831	hsa-miR-520a-5p	CLIP-seq
MIRT2393832	hsa-miR-525-5p	CLIP-seq
MIRT2317370	hsa-miR-1911	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092793	hsa-miR-24	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT2092808	hsa-miR-4284	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT2092820	hsa-miR-4772-3p	CLIP-seq
MIRT2317364	hsa-miR-1207-5p	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT2465980	hsa-miR-3150b-3p	CLIP-seq
MIRT1312223	hsa-miR-3714	CLIP-seq
MIRT2465981	hsa-miR-4253	CLIP-seq
MIRT2465982	hsa-miR-4689	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT2465983	hsa-miR-4761-3p	CLIP-seq
MIRT2317401	hsa-miR-4763-3p	CLIP-seq
MIRT2465984	hsa-miR-4784	CLIP-seq
MIRT2465985	hsa-miR-765	CLIP-seq
MIRT1312282	hsa-miR-940	CLIP-seq
MIRT2613222	hsa-miR-106a	CLIP-seq
MIRT2613223	hsa-miR-106b	CLIP-seq
MIRT2613224	hsa-miR-1207-3p	CLIP-seq
MIRT2092789	hsa-miR-1226	CLIP-seq
MIRT2317365	hsa-miR-1234	CLIP-seq
MIRT2613225	hsa-miR-1243	CLIP-seq
MIRT2317367	hsa-miR-1275	CLIP-seq
MIRT2092790	hsa-miR-1291	CLIP-seq
MIRT2317369	hsa-miR-136	CLIP-seq
MIRT2613226	hsa-miR-146a	CLIP-seq
MIRT2613227	hsa-miR-146b-5p	CLIP-seq
MIRT2613228	hsa-miR-150	CLIP-seq
MIRT2613229	hsa-miR-17	CLIP-seq
MIRT2613230	hsa-miR-1825	CLIP-seq
MIRT2317370	hsa-miR-1911	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092792	hsa-miR-1972	CLIP-seq
MIRT2613231	hsa-miR-20a	CLIP-seq
MIRT2613232	hsa-miR-20b	CLIP-seq
MIRT2613233	hsa-miR-2113	CLIP-seq
MIRT2613234	hsa-miR-218	CLIP-seq
MIRT1312181	hsa-miR-23a	CLIP-seq
MIRT1312182	hsa-miR-23b	CLIP-seq
MIRT1312183	hsa-miR-23c	CLIP-seq
MIRT2092793	hsa-miR-24	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT1312210	hsa-miR-302a	CLIP-seq
MIRT1312211	hsa-miR-302b	CLIP-seq
MIRT1312212	hsa-miR-302c	CLIP-seq
MIRT1312213	hsa-miR-302d	CLIP-seq
MIRT1312214	hsa-miR-302e	CLIP-seq
MIRT2613235	hsa-miR-3064-5p	CLIP-seq
MIRT2613236	hsa-miR-3065-3p	CLIP-seq
MIRT2092797	hsa-miR-3173-5p	CLIP-seq
MIRT2613237	hsa-miR-3177-3p	CLIP-seq
MIRT2092798	hsa-miR-3189-3p	CLIP-seq
MIRT2613238	hsa-miR-3195	CLIP-seq
MIRT2613239	hsa-miR-323b-5p	CLIP-seq
MIRT2613240	hsa-miR-361-3p	CLIP-seq
MIRT2613241	hsa-miR-3654	CLIP-seq
MIRT2613242	hsa-miR-3663-5p	CLIP-seq
MIRT2613243	hsa-miR-3667-5p	CLIP-seq
MIRT1312225	hsa-miR-372	CLIP-seq
MIRT1312226	hsa-miR-373	CLIP-seq
MIRT2613244	hsa-miR-3937	CLIP-seq
MIRT2613245	hsa-miR-4251	CLIP-seq
MIRT2465981	hsa-miR-4253	CLIP-seq
MIRT2092808	hsa-miR-4284	CLIP-seq
MIRT2317387	hsa-miR-4291	CLIP-seq
MIRT2317388	hsa-miR-4297	CLIP-seq
MIRT2613246	hsa-miR-4323	CLIP-seq
MIRT2613247	hsa-miR-4330	CLIP-seq
MIRT2092809	hsa-miR-4438	CLIP-seq
MIRT1312241	hsa-miR-4505	CLIP-seq
MIRT2092811	hsa-miR-4520a-3p	CLIP-seq
MIRT2092812	hsa-miR-4525	CLIP-seq
MIRT2613248	hsa-miR-4527	CLIP-seq
MIRT2613249	hsa-miR-4529-5p	CLIP-seq
MIRT2613250	hsa-miR-4532	CLIP-seq
MIRT2092813	hsa-miR-4638-3p	CLIP-seq
MIRT2613251	hsa-miR-4649-3p	CLIP-seq
MIRT2092815	hsa-miR-4650-5p	CLIP-seq
MIRT2317395	hsa-miR-4665-5p	CLIP-seq
MIRT2613252	hsa-miR-4677-3p	CLIP-seq
MIRT2613253	hsa-miR-4679	CLIP-seq
MIRT2613254	hsa-miR-4680-5p	CLIP-seq
MIRT1312251	hsa-miR-4707-3p	CLIP-seq
MIRT2613255	hsa-miR-4711-3p	CLIP-seq
MIRT1312188	hsa-miR-4717-3p	CLIP-seq
MIRT2317398	hsa-miR-4723-5p	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT1312189	hsa-miR-4728-5p	CLIP-seq
MIRT2317399	hsa-miR-4731-5p	CLIP-seq
MIRT2613256	hsa-miR-4758-3p	CLIP-seq
MIRT2465983	hsa-miR-4761-3p	CLIP-seq
MIRT2092820	hsa-miR-4772-3p	CLIP-seq
MIRT2317402	hsa-miR-483-3p	CLIP-seq
MIRT2092821	hsa-miR-5095	CLIP-seq
MIRT2613257	hsa-miR-512-3p	CLIP-seq
MIRT2613258	hsa-miR-512-5p	CLIP-seq
MIRT2317407	hsa-miR-515-5p	CLIP-seq
MIRT2613259	hsa-miR-519d	CLIP-seq
MIRT1312264	hsa-miR-520a-3p	CLIP-seq
MIRT1312265	hsa-miR-520b	CLIP-seq
MIRT1312266	hsa-miR-520c-3p	CLIP-seq
MIRT1312267	hsa-miR-520d-3p	CLIP-seq
MIRT1312269	hsa-miR-520e	CLIP-seq
MIRT2613260	hsa-miR-520f	CLIP-seq
MIRT1312270	hsa-miR-520g	CLIP-seq
MIRT1312271	hsa-miR-520h	CLIP-seq
MIRT2317408	hsa-miR-545	CLIP-seq
MIRT2613261	hsa-miR-564	CLIP-seq
MIRT2613262	hsa-miR-589	CLIP-seq
MIRT2613263	hsa-miR-619	CLIP-seq
MIRT2317413	hsa-miR-625	CLIP-seq
MIRT2613264	hsa-miR-767-3p	CLIP-seq
MIRT2613265	hsa-miR-93	CLIP-seq
MIRT1312282	hsa-miR-940	CLIP-seq
MIRT2613222	hsa-miR-106a	CLIP-seq
MIRT2613223	hsa-miR-106b	CLIP-seq
MIRT2613224	hsa-miR-1207-3p	CLIP-seq
MIRT2317365	hsa-miR-1234	CLIP-seq
MIRT2613225	hsa-miR-1243	CLIP-seq
MIRT2317367	hsa-miR-1275	CLIP-seq
MIRT2092790	hsa-miR-1291	CLIP-seq
MIRT2613226	hsa-miR-146a	CLIP-seq
MIRT2613227	hsa-miR-146b-5p	CLIP-seq
MIRT2613228	hsa-miR-150	CLIP-seq
MIRT2613229	hsa-miR-17	CLIP-seq
MIRT2317370	hsa-miR-1911	CLIP-seq
MIRT2092791	hsa-miR-1915	CLIP-seq
MIRT2092792	hsa-miR-1972	CLIP-seq
MIRT2613231	hsa-miR-20a	CLIP-seq
MIRT2613232	hsa-miR-20b	CLIP-seq
MIRT1312181	hsa-miR-23a	CLIP-seq
MIRT1312182	hsa-miR-23b	CLIP-seq
MIRT1312183	hsa-miR-23c	CLIP-seq
MIRT2092793	hsa-miR-24	CLIP-seq
MIRT2092794	hsa-miR-26a	CLIP-seq
MIRT2092795	hsa-miR-26b	CLIP-seq
MIRT1312210	hsa-miR-302a	CLIP-seq
MIRT1312211	hsa-miR-302b	CLIP-seq
MIRT1312212	hsa-miR-302c	CLIP-seq
MIRT1312213	hsa-miR-302d	CLIP-seq
MIRT1312214	hsa-miR-302e	CLIP-seq
MIRT2613235	hsa-miR-3064-5p	CLIP-seq
MIRT2613236	hsa-miR-3065-3p	CLIP-seq
MIRT2092797	hsa-miR-3173-5p	CLIP-seq
MIRT2613237	hsa-miR-3177-3p	CLIP-seq
MIRT2613239	hsa-miR-323b-5p	CLIP-seq
MIRT2613241	hsa-miR-3654	CLIP-seq
MIRT2613242	hsa-miR-3663-5p	CLIP-seq
MIRT1312225	hsa-miR-372	CLIP-seq
MIRT1312226	hsa-miR-373	CLIP-seq
MIRT2092799	hsa-miR-378	CLIP-seq
MIRT2092800	hsa-miR-378b	CLIP-seq
MIRT2092801	hsa-miR-378c	CLIP-seq
MIRT2092802	hsa-miR-378d	CLIP-seq
MIRT2092803	hsa-miR-378e	CLIP-seq
MIRT2092804	hsa-miR-378f	CLIP-seq
MIRT2092805	hsa-miR-378h	CLIP-seq
MIRT2092806	hsa-miR-378i	CLIP-seq
MIRT2092807	hsa-miR-422a	CLIP-seq
MIRT2613245	hsa-miR-4251	CLIP-seq
MIRT2092808	hsa-miR-4284	CLIP-seq
MIRT2317387	hsa-miR-4291	CLIP-seq
MIRT2317388	hsa-miR-4297	CLIP-seq
MIRT2613246	hsa-miR-4323	CLIP-seq
MIRT1312241	hsa-miR-4505	CLIP-seq
MIRT1312242	hsa-miR-4514	CLIP-seq
MIRT2092811	hsa-miR-4520a-3p	CLIP-seq
MIRT2092812	hsa-miR-4525	CLIP-seq
MIRT2613248	hsa-miR-4527	CLIP-seq
MIRT2613250	hsa-miR-4532	CLIP-seq
MIRT2092813	hsa-miR-4638-3p	CLIP-seq
MIRT1312244	hsa-miR-4645-5p	CLIP-seq
MIRT2613251	hsa-miR-4649-3p	CLIP-seq
MIRT2092815	hsa-miR-4650-5p	CLIP-seq
MIRT2317395	hsa-miR-4665-5p	CLIP-seq
MIRT1312248	hsa-miR-4673	CLIP-seq
MIRT1312250	hsa-miR-4692	CLIP-seq
MIRT1312251	hsa-miR-4707-3p	CLIP-seq
MIRT2613255	hsa-miR-4711-3p	CLIP-seq
MIRT1312188	hsa-miR-4717-3p	CLIP-seq
MIRT1312252	hsa-miR-4722-5p	CLIP-seq
MIRT2317398	hsa-miR-4723-5p	CLIP-seq
MIRT2092817	hsa-miR-4726-3p	CLIP-seq
MIRT2317399	hsa-miR-4731-5p	CLIP-seq
MIRT2613256	hsa-miR-4758-3p	CLIP-seq
MIRT2092820	hsa-miR-4772-3p	CLIP-seq
MIRT2613257	hsa-miR-512-3p	CLIP-seq
MIRT2613258	hsa-miR-512-5p	CLIP-seq
MIRT2613259	hsa-miR-519d	CLIP-seq
MIRT1312264	hsa-miR-520a-3p	CLIP-seq
MIRT1312265	hsa-miR-520b	CLIP-seq
MIRT1312266	hsa-miR-520c-3p	CLIP-seq
MIRT1312267	hsa-miR-520d-3p	CLIP-seq
MIRT1312269	hsa-miR-520e	CLIP-seq
MIRT1312270	hsa-miR-520g	CLIP-seq
MIRT1312271	hsa-miR-520h	CLIP-seq
MIRT2317408	hsa-miR-545	CLIP-seq
MIRT2613261	hsa-miR-564	CLIP-seq
MIRT2613262	hsa-miR-589	CLIP-seq
MIRT2317413	hsa-miR-625	CLIP-seq
MIRT2689872	hsa-miR-668	CLIP-seq
MIRT2613265	hsa-miR-93	CLIP-seq
MIRT1312282	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12600646, 15367624, 19893624, 32296183
GO:0005634	Component	Nucleus	IDA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032480	Process	Negative regulation of type I interferon production	TAS
GO:0032648	Process	Regulation of interferon-beta production	IDA	19893624
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	19893624
GO:0046872	Function	Metal ion binding	IEA
GO:0050691	Process	Regulation of defense response to virus by host	IDA	19893624
GO:0061630	Function	Ubiquitin protein ligase activity	EXP	19893624
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	19893624

Other IDs

• MIM: 609948
• HGNC: 21698
• e!Ensembl: ENSG00000011275

Protein

• UniProt ID: Q9NWF9
• Protein name: E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)
• Protein function: [Isoform 1]: E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination (PubMed:34998453). Plays a role in the regulation of antiviral responses
• PDB: 7M4M, 7M4N, 7M4O, 8EB0
• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.
• Sequence:

  MEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLD
  DDVILTEDDSEDDYGEFLDLGPPGISEFTKPSGQTEREPKPGPSHNQAANDIVNPRSEQK
  VIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHPYFQS
  LNQQPREITNQVVPQERQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQPAHPLG
  EFEDQQLASDDEEPGPAFPMQESQEPNLENIWGQEAAEVDQELVELLVKETEARFPDVAN
  GFIEEIIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKIDFFDY
  SKLTPLDQRCFIQAADLLMADFKVLSSQDIKWALHELKGHYAITRKALSDAIKKWQELSP
  ETSGKRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALLPAVQQEQE
  FYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKEC
  LIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYAD
  ELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYR
  TSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSP
  GAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQR
  VEALPRPVPQNLPQPQMPPYAFAHPPFPLPPVRPVFNNFPLNMGPIPAPYVPPLPNVRVN
  YDFGPIHMPLEHNLPMHFGPQPRHRF

• Sequence length: 866

Pathways

Reactome:

Negative regulators of DDX58/IFIH1 signaling

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cerebellar ataxia-hypogonadism syndrome	Likely pathogenic; Pathogenic	rs2128629356, rs200769983, rs374351343, rs1335215379, rs2534249263, rs794728000, rs373785974, rs1419567670, rs1562451985, rs387907368, rs387907369, rs387907370, rs1186852853	RCV001647236 RCV001647237 RCV005257986 RCV001845028 RCV002468775 RCV000180793 RCV000180794 RCV003153225 RCV000714821 RCV000043627 RCV000043628 RCV000043629 RCV006449380
Hypogonadotropic hypogonadism 7 with or without anosmia	Likely pathogenic	rs730882248	RCV000162188
Leukodystrophy	Likely pathogenic	rs730882248	RCV000162188

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Familial cancer of breast	Benign	rs138122142	RCV005907481
Gastric cancer	Benign	rs548642903	RCV005926726
Malignant tumor of esophagus	Uncertain significance	rs200838092	RCV005928487
Ovarian cancer	Likely benign	rs374263582	RCV005932071
Ovarian serous cystadenocarcinoma	Benign	rs201661241	RCV005926171
RNF216-related disorder	Likely benign; Benign; Uncertain significance	rs142641769, rs61753114, rs749862881, rs78387970, rs2534252023, rs779537129, rs139859373, rs145070983, rs141050143, rs115737075, rs141327139, rs140309187, rs148352106	RCV003900485 RCV003931060 RCV003911309 RCV003958622 RCV003414420 RCV003966422 RCV003964588 RCV003971988 RCV003903258 RCV003905965 RCV003968343 RCV003923293 RCV003943252
Rosette-forming glioneuronal tumor	Uncertain significance	rs761469213	RCV000487441
Thyroid cancer, nonmedullary, 1	Benign	rs138122142	RCV005907482

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	35820682
Anodontia	Associate	37161390
Ataxia	Associate	37161390
Autistic Disorder	Associate	20414355
Breast Neoplasms	Associate	26070530
Carcinogenesis	Associate	24690483
Cerebellar Ataxia and Hypogonadotropic Hypogonadism	Associate	32982993, 34998453, 37161390, 38377650
Cognition Disorders	Associate	37161390
Colitis Ulcerative	Stimulate	27037036
Demyelinating Diseases	Associate	37161390
Dystonia	Associate	37161390
Heredodegenerative Disorders Nervous System	Associate	38377650
Huntington Disease Like Syndrome	Associate	32358900, 37161390
Hypogonadism	Associate	25258038, 32982993, 37161390
Leukodystrophy Hypomyelinating with Hypodontia and Hypogonadotropic Hypogonadism	Associate	37161390
Neoplasms	Inhibit	24690483
Neurodegenerative Diseases	Associate	34998453
Parkinson Disease Secondary	Associate	37161390