NLE1 (notchless homolog 1)

Gene

• Entrez ID: 54475
• Gene name: Notchless homolog 1
• Gene symbol: NLE1
• Synonyms (NCBI Gene): HUSSY7, NLE, Rsa4
• Chromosome: 17
• Chromosome location: 17q12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019953	hsa-miR-375	Microarray	20215506
MIRT027611	hsa-miR-98-5p	Microarray	19088304
MIRT031827	hsa-miR-16-5p	Proteomics	18668040
MIRT032412	hsa-let-7b-5p	Proteomics	18668040
MIRT049402	hsa-miR-92a-3p	CLASH	23622248
MIRT048020	hsa-miR-30c-5p	CLASH	23622248
MIRT046828	hsa-miR-222-3p	CLASH	23622248
MIRT046828	hsa-miR-222-3p	CLASH	23622248
MIRT042382	hsa-miR-484	CLASH	23622248
MIRT1186615	hsa-miR-10a	CLIP-seq
MIRT1186616	hsa-miR-10b	CLIP-seq
MIRT1186617	hsa-miR-1207-5p	CLIP-seq
MIRT1186618	hsa-miR-1254	CLIP-seq
MIRT1186619	hsa-miR-1915	CLIP-seq
MIRT1186620	hsa-miR-296-5p	CLIP-seq
MIRT1186621	hsa-miR-3116	CLIP-seq
MIRT1186622	hsa-miR-34a	CLIP-seq
MIRT1186623	hsa-miR-34c-5p	CLIP-seq
MIRT1186624	hsa-miR-4256	CLIP-seq
MIRT1186625	hsa-miR-4436b-3p	CLIP-seq
MIRT1186626	hsa-miR-4446-3p	CLIP-seq
MIRT1186627	hsa-miR-449a	CLIP-seq
MIRT1186628	hsa-miR-449b	CLIP-seq
MIRT1186629	hsa-miR-450b-3p	CLIP-seq
MIRT1186630	hsa-miR-4530	CLIP-seq
MIRT1186631	hsa-miR-4656	CLIP-seq
MIRT1186632	hsa-miR-4680-5p	CLIP-seq
MIRT1186633	hsa-miR-4685-5p	CLIP-seq
MIRT1186634	hsa-miR-4713-3p	CLIP-seq
MIRT1186635	hsa-miR-4725-5p	CLIP-seq
MIRT1186636	hsa-miR-4733-5p	CLIP-seq
MIRT1186637	hsa-miR-4736	CLIP-seq
MIRT1186638	hsa-miR-4763-3p	CLIP-seq
MIRT1186639	hsa-miR-4797-5p	CLIP-seq
MIRT1186640	hsa-miR-486-5p	CLIP-seq
MIRT1186641	hsa-miR-504	CLIP-seq
MIRT1186642	hsa-miR-520f	CLIP-seq
MIRT1186643	hsa-miR-550a	CLIP-seq
MIRT1186644	hsa-miR-634	CLIP-seq
MIRT1186645	hsa-miR-636	CLIP-seq
MIRT1186646	hsa-miR-638	CLIP-seq
MIRT1186647	hsa-miR-661	CLIP-seq
MIRT1186648	hsa-miR-769-3p	CLIP-seq
MIRT1186649	hsa-miR-922	CLIP-seq
MIRT2283252	hsa-miR-1273e	CLIP-seq
MIRT2283253	hsa-miR-4420	CLIP-seq
MIRT2283254	hsa-miR-488	CLIP-seq
MIRT1186626	hsa-miR-4446-3p	CLIP-seq
MIRT1186630	hsa-miR-4530	CLIP-seq
MIRT1186631	hsa-miR-4656	CLIP-seq
MIRT1186632	hsa-miR-4680-5p	CLIP-seq
MIRT1186644	hsa-miR-634	CLIP-seq
MIRT1186649	hsa-miR-922	CLIP-seq
MIRT2581525	hsa-miR-1227	CLIP-seq
MIRT2581526	hsa-miR-149	CLIP-seq
MIRT2581527	hsa-miR-1908	CLIP-seq
MIRT2581528	hsa-miR-1914	CLIP-seq
MIRT2581529	hsa-miR-3064-3p	CLIP-seq
MIRT2581530	hsa-miR-3064-5p	CLIP-seq
MIRT2581531	hsa-miR-3153	CLIP-seq
MIRT2581532	hsa-miR-326	CLIP-seq
MIRT2581533	hsa-miR-330-5p	CLIP-seq
MIRT2581534	hsa-miR-342-5p	CLIP-seq
MIRT2581535	hsa-miR-376a	CLIP-seq
MIRT2581536	hsa-miR-376b	CLIP-seq
MIRT2581537	hsa-miR-3937	CLIP-seq
MIRT2581538	hsa-miR-4276	CLIP-seq
MIRT1186626	hsa-miR-4446-3p	CLIP-seq
MIRT2581539	hsa-miR-4455	CLIP-seq
MIRT2581540	hsa-miR-4462	CLIP-seq
MIRT2581541	hsa-miR-4480	CLIP-seq
MIRT2581542	hsa-miR-4504	CLIP-seq
MIRT1186630	hsa-miR-4530	CLIP-seq
MIRT2581543	hsa-miR-4648	CLIP-seq
MIRT2581544	hsa-miR-4651	CLIP-seq
MIRT2581545	hsa-miR-4654	CLIP-seq
MIRT1186631	hsa-miR-4656	CLIP-seq
MIRT2581546	hsa-miR-4664-5p	CLIP-seq
MIRT2581547	hsa-miR-4667-5p	CLIP-seq
MIRT2581548	hsa-miR-4668-5p	CLIP-seq
MIRT2581549	hsa-miR-4700-5p	CLIP-seq
MIRT2581550	hsa-miR-4706	CLIP-seq
MIRT2581551	hsa-miR-4749-5p	CLIP-seq
MIRT2581552	hsa-miR-4769-5p	CLIP-seq
MIRT2581553	hsa-miR-4794	CLIP-seq
MIRT2581554	hsa-miR-542-5p	CLIP-seq
MIRT2581555	hsa-miR-549	CLIP-seq
MIRT2581556	hsa-miR-602	CLIP-seq
MIRT2581557	hsa-miR-604	CLIP-seq
MIRT2581558	hsa-miR-608	CLIP-seq
MIRT1186644	hsa-miR-634	CLIP-seq
MIRT2581559	hsa-miR-637	CLIP-seq
MIRT2581560	hsa-miR-647	CLIP-seq
MIRT2581561	hsa-miR-663	CLIP-seq
MIRT2581562	hsa-miR-760	CLIP-seq
MIRT1186649	hsa-miR-922	CLIP-seq
MIRT2581525	hsa-miR-1227	CLIP-seq
MIRT2581526	hsa-miR-149	CLIP-seq
MIRT2686381	hsa-miR-151-5p	CLIP-seq
MIRT2686382	hsa-miR-151b	CLIP-seq
MIRT2581527	hsa-miR-1908	CLIP-seq
MIRT2581528	hsa-miR-1914	CLIP-seq
MIRT2581529	hsa-miR-3064-3p	CLIP-seq
MIRT2581530	hsa-miR-3064-5p	CLIP-seq
MIRT2686383	hsa-miR-3131	CLIP-seq
MIRT2581531	hsa-miR-3153	CLIP-seq
MIRT2581532	hsa-miR-326	CLIP-seq
MIRT2581533	hsa-miR-330-5p	CLIP-seq
MIRT2581534	hsa-miR-342-5p	CLIP-seq
MIRT2581537	hsa-miR-3937	CLIP-seq
MIRT2581538	hsa-miR-4276	CLIP-seq
MIRT1186626	hsa-miR-4446-3p	CLIP-seq
MIRT2581539	hsa-miR-4455	CLIP-seq
MIRT2581540	hsa-miR-4462	CLIP-seq
MIRT2581541	hsa-miR-4480	CLIP-seq
MIRT2581542	hsa-miR-4504	CLIP-seq
MIRT1186630	hsa-miR-4530	CLIP-seq
MIRT2581543	hsa-miR-4648	CLIP-seq
MIRT2581544	hsa-miR-4651	CLIP-seq
MIRT2581545	hsa-miR-4654	CLIP-seq
MIRT1186631	hsa-miR-4656	CLIP-seq
MIRT2686384	hsa-miR-4664-3p	CLIP-seq
MIRT2581546	hsa-miR-4664-5p	CLIP-seq
MIRT2581547	hsa-miR-4667-5p	CLIP-seq
MIRT2581548	hsa-miR-4668-5p	CLIP-seq
MIRT2581549	hsa-miR-4700-5p	CLIP-seq
MIRT2581550	hsa-miR-4706	CLIP-seq
MIRT2581551	hsa-miR-4749-5p	CLIP-seq
MIRT2581552	hsa-miR-4769-5p	CLIP-seq
MIRT2581553	hsa-miR-4794	CLIP-seq
MIRT2581554	hsa-miR-542-5p	CLIP-seq
MIRT2581555	hsa-miR-549	CLIP-seq
MIRT2581556	hsa-miR-602	CLIP-seq
MIRT2581558	hsa-miR-608	CLIP-seq
MIRT2686385	hsa-miR-611	CLIP-seq
MIRT1186644	hsa-miR-634	CLIP-seq
MIRT2581559	hsa-miR-637	CLIP-seq
MIRT2581561	hsa-miR-663	CLIP-seq
MIRT2581562	hsa-miR-760	CLIP-seq
MIRT1186649	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IBA	21873635
GO:0001756	Process	Somitogenesis	IEA
GO:0001822	Process	Kidney development	IEA
GO:0001826	Process	Inner cell mass cell differentiation	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA	21873635
GO:0005730	Component	Nucleolus	IDA
GO:0007219	Process	Notch signaling pathway	IBA	21873635
GO:0045930	Process	Negative regulation of mitotic cell cycle	IEA
GO:0048705	Process	Skeletal system morphogenesis	IEA
GO:0061484	Process	Hematopoietic stem cell homeostasis	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA
GO:2001268	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IEA

Other IDs

• MIM: 620924
• HGNC: 19889
• e!Ensembl: ENSG00000073536

Protein

• UniProt ID: Q9NVX2
• Protein name: Notchless protein homolog 1
• Protein function: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By sim
• PDB: 6WAJ, 8FL0, 8FL2, 8FL3, 8FL4, 8INK, 8IPD, 8IPX, 8IPY, 8IR1, 8IR3, 8RL2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08154	NLE	17 → 77	NLE (NUC135) domain	Domain
  PF00400	WD40	104 → 142	WD domain, G-beta repeat	Repeat
  PF00400	WD40	146 → 184	WD domain, G-beta repeat	Repeat
  PF00400	WD40	189 → 232	WD domain, G-beta repeat	Repeat
  PF00400	WD40	236 → 273	WD domain, G-beta repeat	Repeat
  PF00400	WD40	362 → 400	WD domain, G-beta repeat	Repeat
  PF00400	WD40	404 → 442	WD domain, G-beta repeat	Repeat
  PF00400	WD40	446 → 484	WD domain, G-beta repeat	Repeat

• Sequence:

  MAAAVPDEAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPL
  AFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISV
  AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI
  LLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCER
  ILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYA
  LRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE
  DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQI
  AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCL
  RIWRR

• Sequence length: 485

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Attention Deficit Disorder with Hyperactivity	Associate	32238911