KRT20 (keratin 20)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54474
Gene name Gene Name - the full gene name approved by the HGNC.
Keratin 20
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KRT20
Synonyms (NCBI Gene) Gene synonyms aliases
CD20, CK-20, CK20, K20, KRT21
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratin
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
miRTarBase ID miRNA Experiments Reference
MIRT1101200 hsa-miR-135a CLIP-seq
MIRT1101201 hsa-miR-135b CLIP-seq
MIRT1101202 hsa-miR-140-5p CLIP-seq
MIRT1101203 hsa-miR-150 CLIP-seq
MIRT1101204 hsa-miR-299-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
CDX1 Unknown 19188603
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005200 Function Structural constituent of cytoskeleton NAS 8359595
GO:0005515 Function Protein binding IPI 16189514, 16608857, 21516116, 25416956, 29892012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IDA 10973561
GO:0005829 Component Cytosol IDA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608218 20412 ENSG00000171431
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P35900
Protein name Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
Protein function Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12857878, ECO:000
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00038 Filament 69 → 380 Intermediate filament protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in
Sequence
Sequence length 424
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Estrogen signaling pathway
Staphylococcus aureus infection 		  Keratinization
Formation of the cornified envelope
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 15378696
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 15378696
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 15378696
Show/Hide Text Mining Associations (318)
Associations from Text Mining
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 19609205
Adenocarcinoma Associate 14631371, 15333652, 15710986, 17425380, 24696747, 25690258, 26603157, 26881627, 33268964, 36346458, 37164671
Adenocarcinoma Inhibit 30173239
Adenocarcinoma Mucinous Associate 16822880, 29698701
Adenocarcinoma of Lung Associate 16570563, 17606426, 30816121, 32556504
Adenoma Associate 24365748
Adenomatous Polyposis Coli Associate 35074964
Adjustment Disorders Associate 15871722
Adrenal Gland Neoplasms Associate 24322017
Adrenal Hyperplasia Congenital Associate 34616364