KRT20 (keratin 20)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 54474
Gene name Keratin 20
Gene symbol KRT20
Synonyms (NCBI Gene)
CD20CK-20CK20K20KRT21
Chromosome 17
Chromosome location 17q21.2
Summary The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratin
miRNA miRNA information provided by mirtarbase database.
19
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1101200 hsa-miR-135a CLIP-seq
MIRT1101201 hsa-miR-135b CLIP-seq
MIRT1101202 hsa-miR-140-5p CLIP-seq
MIRT1101203 hsa-miR-150 CLIP-seq
MIRT1101204 hsa-miR-299-5p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CDX1 Unknown 19188603
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002009 Process Morphogenesis of an epithelium IBA
GO:0005198 Function Structural molecule activity IEA
GO:0005200 Function Structural constituent of cytoskeleton NAS 8359595
GO:0005515 Function Protein binding IPI 16189514, 16608857, 21516116, 25416956, 29892012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IDA 10973561
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608218 20412 ENSG00000171431
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35900
Protein name Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
Protein function Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12857878, ECO:000
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00038 Filament 69 → 380 Intermediate filament protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in
Sequence
Sequence length 424
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Estrogen signaling pathway
Staphylococcus aureus infection 		  Keratinization
Formation of the cornified envelope
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
KRT20-related disorder Likely benign rs113823624 RCV003919655
Show/Hide Text Mining Associations (318)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 19609205
Adenocarcinoma Associate 14631371, 15333652, 15710986, 17425380, 24696747, 25690258, 26603157, 26881627, 33268964, 36346458, 37164671
Adenocarcinoma Inhibit 30173239
Adenocarcinoma Mucinous Associate 16822880, 29698701
Adenocarcinoma of Lung Associate 16570563, 17606426, 30816121, 32556504
Adenoma Associate 24365748
Adenomatous Polyposis Coli Associate 35074964
Adjustment Disorders Associate 15871722
Adrenal Gland Neoplasms Associate 24322017
Adrenal Hyperplasia Congenital Associate 34616364