TOLLIP (toll interacting protein)

Gene

• Entrez ID: 54472
• Gene name: Toll interacting protein
• Gene symbol: TOLLIP
• Synonyms (NCBI Gene): IL-1RAcPIP
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020158	hsa-miR-130b-3p	Sequencing	20371350
MIRT028044	hsa-miR-93-5p	Sequencing	20371350
MIRT041248	hsa-miR-193b-3p	CLASH	23622248
MIRT439404	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT439404	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT755361	hsa-miR-6870-3p	Luciferase reporter assay, Western blotting	36184551
MIRT1446152	hsa-miR-1179	CLIP-seq
MIRT1446153	hsa-miR-1202	CLIP-seq
MIRT1446154	hsa-miR-1253	CLIP-seq
MIRT1446155	hsa-miR-1273	CLIP-seq
MIRT1446156	hsa-miR-129-5p	CLIP-seq
MIRT1446157	hsa-miR-1302	CLIP-seq
MIRT1446158	hsa-miR-1304	CLIP-seq
MIRT1446159	hsa-miR-1343	CLIP-seq
MIRT1446160	hsa-miR-139-3p	CLIP-seq
MIRT1446161	hsa-miR-144	CLIP-seq
MIRT1446162	hsa-miR-185	CLIP-seq
MIRT1446163	hsa-miR-1915	CLIP-seq
MIRT1446164	hsa-miR-2110	CLIP-seq
MIRT1446165	hsa-miR-221	CLIP-seq
MIRT1446166	hsa-miR-222	CLIP-seq
MIRT1446167	hsa-miR-2682	CLIP-seq
MIRT1446168	hsa-miR-31	CLIP-seq
MIRT1446169	hsa-miR-3122	CLIP-seq
MIRT1446170	hsa-miR-3126-5p	CLIP-seq
MIRT1446171	hsa-miR-3130-3p	CLIP-seq
MIRT1446172	hsa-miR-3147	CLIP-seq
MIRT1446173	hsa-miR-3150a-3p	CLIP-seq
MIRT1446174	hsa-miR-3175	CLIP-seq
MIRT1446175	hsa-miR-3180-5p	CLIP-seq
MIRT1446176	hsa-miR-3189-3p	CLIP-seq
MIRT1446177	hsa-miR-3194-5p	CLIP-seq
MIRT1446178	hsa-miR-3195	CLIP-seq
MIRT1446179	hsa-miR-338-3p	CLIP-seq
MIRT1446180	hsa-miR-339-3p	CLIP-seq
MIRT1446181	hsa-miR-34a	CLIP-seq
MIRT1446182	hsa-miR-34c-5p	CLIP-seq
MIRT1446183	hsa-miR-3591-3p	CLIP-seq
MIRT1446184	hsa-miR-3622b-5p	CLIP-seq
MIRT1446185	hsa-miR-3665	CLIP-seq
MIRT1446186	hsa-miR-370	CLIP-seq
MIRT1446187	hsa-miR-3907	CLIP-seq
MIRT1446188	hsa-miR-3913-5p	CLIP-seq
MIRT1446189	hsa-miR-3934	CLIP-seq
MIRT1446190	hsa-miR-3972	CLIP-seq
MIRT1446191	hsa-miR-421	CLIP-seq
MIRT1446192	hsa-miR-4257	CLIP-seq
MIRT1446193	hsa-miR-4298	CLIP-seq
MIRT1446194	hsa-miR-4304	CLIP-seq
MIRT1446195	hsa-miR-4306	CLIP-seq
MIRT1446196	hsa-miR-4310	CLIP-seq
MIRT1446197	hsa-miR-4329	CLIP-seq
MIRT1446198	hsa-miR-4419a	CLIP-seq
MIRT1446199	hsa-miR-4422	CLIP-seq
MIRT1446200	hsa-miR-4425	CLIP-seq
MIRT1446201	hsa-miR-4428	CLIP-seq
MIRT1446202	hsa-miR-4462	CLIP-seq
MIRT1446203	hsa-miR-4474-3p	CLIP-seq
MIRT1446204	hsa-miR-4488	CLIP-seq
MIRT1446205	hsa-miR-449a	CLIP-seq
MIRT1446206	hsa-miR-449b	CLIP-seq
MIRT1446207	hsa-miR-449c	CLIP-seq
MIRT1446208	hsa-miR-4510	CLIP-seq
MIRT1446209	hsa-miR-4514	CLIP-seq
MIRT1446210	hsa-miR-4527	CLIP-seq
MIRT1446211	hsa-miR-4644	CLIP-seq
MIRT1446212	hsa-miR-4645-5p	CLIP-seq
MIRT1446213	hsa-miR-4673	CLIP-seq
MIRT1446214	hsa-miR-4681	CLIP-seq
MIRT1446215	hsa-miR-4692	CLIP-seq
MIRT1446216	hsa-miR-4696	CLIP-seq
MIRT1446217	hsa-miR-4697-5p	CLIP-seq
MIRT1446218	hsa-miR-4709-5p	CLIP-seq
MIRT1446219	hsa-miR-4726-3p	CLIP-seq
MIRT1446220	hsa-miR-4738-3p	CLIP-seq
MIRT1446221	hsa-miR-4768-3p	CLIP-seq
MIRT1446222	hsa-miR-4786-5p	CLIP-seq
MIRT1446223	hsa-miR-502-5p	CLIP-seq
MIRT1446224	hsa-miR-514	CLIP-seq
MIRT1446225	hsa-miR-514b-3p	CLIP-seq
MIRT1446226	hsa-miR-520a-5p	CLIP-seq
MIRT1446227	hsa-miR-524-3p	CLIP-seq
MIRT1446228	hsa-miR-525-3p	CLIP-seq
MIRT1446229	hsa-miR-525-5p	CLIP-seq
MIRT1446230	hsa-miR-548aa	CLIP-seq
MIRT1446231	hsa-miR-548ac	CLIP-seq
MIRT1446232	hsa-miR-548d-3p	CLIP-seq
MIRT1446233	hsa-miR-548u	CLIP-seq
MIRT1446234	hsa-miR-548v	CLIP-seq
MIRT1446235	hsa-miR-548z	CLIP-seq
MIRT1446236	hsa-miR-566	CLIP-seq
MIRT1446237	hsa-miR-574-5p	CLIP-seq
MIRT1446238	hsa-miR-602	CLIP-seq
MIRT1446239	hsa-miR-644	CLIP-seq
MIRT1446240	hsa-miR-657	CLIP-seq
MIRT1446241	hsa-miR-769-5p	CLIP-seq
MIRT1446242	hsa-miR-939	CLIP-seq
MIRT1446183	hsa-miR-3591-3p	CLIP-seq
MIRT1446216	hsa-miR-4696	CLIP-seq
MIRT1557208	hsa-miR-150	CLIP-seq
MIRT2133353	hsa-miR-1205	CLIP-seq
MIRT2133354	hsa-miR-1207-5p	CLIP-seq
MIRT2133355	hsa-miR-1234	CLIP-seq
MIRT1446154	hsa-miR-1253	CLIP-seq
MIRT2133356	hsa-miR-1254	CLIP-seq
MIRT2133357	hsa-miR-1268	CLIP-seq
MIRT2133358	hsa-miR-1268b	CLIP-seq
MIRT2133359	hsa-miR-1285	CLIP-seq
MIRT2133360	hsa-miR-1296	CLIP-seq
MIRT2133361	hsa-miR-1298	CLIP-seq
MIRT1446158	hsa-miR-1304	CLIP-seq
MIRT1446159	hsa-miR-1343	CLIP-seq
MIRT2133362	hsa-miR-1909	CLIP-seq
MIRT1446163	hsa-miR-1915	CLIP-seq
MIRT2133363	hsa-miR-1972	CLIP-seq
MIRT2133364	hsa-miR-1976	CLIP-seq
MIRT2133365	hsa-miR-205	CLIP-seq
MIRT2133366	hsa-miR-2909	CLIP-seq
MIRT1446168	hsa-miR-31	CLIP-seq
MIRT2133367	hsa-miR-3116	CLIP-seq
MIRT2133368	hsa-miR-3120-3p	CLIP-seq
MIRT1446170	hsa-miR-3126-5p	CLIP-seq
MIRT2133369	hsa-miR-3155	CLIP-seq
MIRT2133370	hsa-miR-3155b	CLIP-seq
MIRT2133371	hsa-miR-3187-5p	CLIP-seq
MIRT2133372	hsa-miR-361-3p	CLIP-seq
MIRT2133373	hsa-miR-3620	CLIP-seq
MIRT2133374	hsa-miR-3662	CLIP-seq
MIRT2133375	hsa-miR-3667-5p	CLIP-seq
MIRT2133376	hsa-miR-4284	CLIP-seq
MIRT2133377	hsa-miR-4292	CLIP-seq
MIRT2133378	hsa-miR-4297	CLIP-seq
MIRT2133379	hsa-miR-4314	CLIP-seq
MIRT1446198	hsa-miR-4419a	CLIP-seq
MIRT2133380	hsa-miR-4434	CLIP-seq
MIRT2133381	hsa-miR-4436b-3p	CLIP-seq
MIRT1446203	hsa-miR-4474-3p	CLIP-seq
MIRT1446208	hsa-miR-4510	CLIP-seq
MIRT2133382	hsa-miR-4516	CLIP-seq
MIRT2133383	hsa-miR-4531	CLIP-seq
MIRT2133384	hsa-miR-4640-5p	CLIP-seq
MIRT2133385	hsa-miR-4650-5p	CLIP-seq
MIRT2133386	hsa-miR-4672	CLIP-seq
MIRT2133387	hsa-miR-4722-3p	CLIP-seq
MIRT2133388	hsa-miR-4722-5p	CLIP-seq
MIRT2133389	hsa-miR-4726-5p	CLIP-seq
MIRT2133390	hsa-miR-4727-5p	CLIP-seq
MIRT1446220	hsa-miR-4738-3p	CLIP-seq
MIRT2133391	hsa-miR-4743	CLIP-seq
MIRT2133392	hsa-miR-4755-3p	CLIP-seq
MIRT2133393	hsa-miR-4758-3p	CLIP-seq
MIRT2133394	hsa-miR-4761-3p	CLIP-seq
MIRT2133395	hsa-miR-4763-3p	CLIP-seq
MIRT1446222	hsa-miR-4786-5p	CLIP-seq
MIRT2133396	hsa-miR-483-3p	CLIP-seq
MIRT2133397	hsa-miR-484	CLIP-seq
MIRT2133398	hsa-miR-518a-3p	CLIP-seq
MIRT2133399	hsa-miR-518b	CLIP-seq
MIRT2133400	hsa-miR-518c	CLIP-seq
MIRT2133401	hsa-miR-518d-3p	CLIP-seq
MIRT2133402	hsa-miR-518f	CLIP-seq
MIRT2133403	hsa-miR-545	CLIP-seq
MIRT1446233	hsa-miR-548u	CLIP-seq
MIRT1446237	hsa-miR-574-5p	CLIP-seq
MIRT2133404	hsa-miR-612	CLIP-seq
MIRT1446239	hsa-miR-644	CLIP-seq
MIRT2133405	hsa-miR-661	CLIP-seq
MIRT2133406	hsa-miR-665	CLIP-seq
MIRT1446241	hsa-miR-769-5p	CLIP-seq
MIRT2354533	hsa-miR-101	CLIP-seq
MIRT2354534	hsa-miR-106a	CLIP-seq
MIRT2354535	hsa-miR-106b	CLIP-seq
MIRT2354536	hsa-miR-1237	CLIP-seq
MIRT2354537	hsa-miR-1248	CLIP-seq
MIRT1446154	hsa-miR-1253	CLIP-seq
MIRT2354538	hsa-miR-1273f	CLIP-seq
MIRT2354539	hsa-miR-1276	CLIP-seq
MIRT1446156	hsa-miR-129-5p	CLIP-seq
MIRT1446158	hsa-miR-1304	CLIP-seq
MIRT1446160	hsa-miR-139-3p	CLIP-seq
MIRT2354540	hsa-miR-139-5p	CLIP-seq
MIRT1446161	hsa-miR-144	CLIP-seq
MIRT2354541	hsa-miR-17	CLIP-seq
MIRT1446162	hsa-miR-185	CLIP-seq
MIRT1446163	hsa-miR-1915	CLIP-seq
MIRT2354542	hsa-miR-20a	CLIP-seq
MIRT2354543	hsa-miR-20b	CLIP-seq
MIRT2354544	hsa-miR-214	CLIP-seq
MIRT2354545	hsa-miR-24	CLIP-seq
MIRT2354546	hsa-miR-3064-5p	CLIP-seq
MIRT1446168	hsa-miR-31	CLIP-seq
MIRT1446170	hsa-miR-3126-5p	CLIP-seq
MIRT2354547	hsa-miR-3144-5p	CLIP-seq
MIRT1446175	hsa-miR-3180-5p	CLIP-seq
MIRT2354548	hsa-miR-3184	CLIP-seq
MIRT2354549	hsa-miR-3191	CLIP-seq
MIRT2354550	hsa-miR-345	CLIP-seq
MIRT1446183	hsa-miR-3591-3p	CLIP-seq
MIRT2354551	hsa-miR-3609	CLIP-seq
MIRT2354552	hsa-miR-3611	CLIP-seq
MIRT2354553	hsa-miR-3614-5p	CLIP-seq
MIRT2354554	hsa-miR-3619-5p	CLIP-seq
MIRT2133375	hsa-miR-3667-5p	CLIP-seq
MIRT2354555	hsa-miR-3689a-3p	CLIP-seq
MIRT2354556	hsa-miR-3689c	CLIP-seq
MIRT2354557	hsa-miR-3692	CLIP-seq
MIRT2354558	hsa-miR-371-5p	CLIP-seq
MIRT2354559	hsa-miR-371b-5p	CLIP-seq
MIRT2354560	hsa-miR-3914	CLIP-seq
MIRT2354561	hsa-miR-3943	CLIP-seq
MIRT2354562	hsa-miR-423-5p	CLIP-seq
MIRT2354563	hsa-miR-4256	CLIP-seq
MIRT2354564	hsa-miR-4258	CLIP-seq
MIRT2354565	hsa-miR-4283	CLIP-seq
MIRT2354566	hsa-miR-4294	CLIP-seq
MIRT1446194	hsa-miR-4304	CLIP-seq
MIRT1446195	hsa-miR-4306	CLIP-seq
MIRT2133379	hsa-miR-4314	CLIP-seq
MIRT1446198	hsa-miR-4419a	CLIP-seq
MIRT1446201	hsa-miR-4428	CLIP-seq
MIRT2354567	hsa-miR-4437	CLIP-seq
MIRT2354568	hsa-miR-4447	CLIP-seq
MIRT2354569	hsa-miR-4457	CLIP-seq
MIRT2354570	hsa-miR-4472	CLIP-seq
MIRT2354571	hsa-miR-4493	CLIP-seq
MIRT1446208	hsa-miR-4510	CLIP-seq
MIRT1446211	hsa-miR-4644	CLIP-seq
MIRT2354572	hsa-miR-4652-5p	CLIP-seq
MIRT2354573	hsa-miR-4667-5p	CLIP-seq
MIRT2354574	hsa-miR-4668-3p	CLIP-seq
MIRT2354575	hsa-miR-4671-5p	CLIP-seq
MIRT1446216	hsa-miR-4696	CLIP-seq
MIRT2354576	hsa-miR-4700-5p	CLIP-seq
MIRT2354577	hsa-miR-4711-5p	CLIP-seq
MIRT2354578	hsa-miR-4717-5p	CLIP-seq
MIRT1446219	hsa-miR-4726-3p	CLIP-seq
MIRT2133393	hsa-miR-4758-3p	CLIP-seq
MIRT2354579	hsa-miR-4762-3p	CLIP-seq
MIRT1446221	hsa-miR-4768-3p	CLIP-seq
MIRT2354580	hsa-miR-4781-5p	CLIP-seq
MIRT1446222	hsa-miR-4786-5p	CLIP-seq
MIRT2354581	hsa-miR-4796-3p	CLIP-seq
MIRT2354582	hsa-miR-486-5p	CLIP-seq
MIRT2354583	hsa-miR-513a-3p	CLIP-seq
MIRT2354584	hsa-miR-513b	CLIP-seq
MIRT2354585	hsa-miR-513c	CLIP-seq
MIRT2354586	hsa-miR-514b-5p	CLIP-seq
MIRT2354587	hsa-miR-519a	CLIP-seq
MIRT2354588	hsa-miR-519b-3p	CLIP-seq
MIRT2354589	hsa-miR-519c-3p	CLIP-seq
MIRT2354590	hsa-miR-519d	CLIP-seq
MIRT1446226	hsa-miR-520a-5p	CLIP-seq
MIRT1446229	hsa-miR-525-5p	CLIP-seq
MIRT2354591	hsa-miR-544	CLIP-seq
MIRT2133403	hsa-miR-545	CLIP-seq
MIRT2354592	hsa-miR-548ah	CLIP-seq
MIRT2354593	hsa-miR-603	CLIP-seq
MIRT2354594	hsa-miR-637	CLIP-seq
MIRT2354595	hsa-miR-761	CLIP-seq
MIRT1446241	hsa-miR-769-5p	CLIP-seq
MIRT2354596	hsa-miR-873	CLIP-seq
MIRT2354597	hsa-miR-93	CLIP-seq
MIRT1446242	hsa-miR-939	CLIP-seq
MIRT2354598	hsa-miR-943	CLIP-seq
MIRT1446154	hsa-miR-1253	CLIP-seq
MIRT2462134	hsa-miR-767-3p	CLIP-seq
MIRT2466251	hsa-miR-3911	CLIP-seq
MIRT1446189	hsa-miR-3934	CLIP-seq
MIRT2466252	hsa-miR-4773	CLIP-seq
MIRT2466253	hsa-miR-501-3p	CLIP-seq
MIRT2466254	hsa-miR-502-3p	CLIP-seq
MIRT2466255	hsa-miR-552	CLIP-seq
MIRT2462134	hsa-miR-767-3p	CLIP-seq
MIRT2648423	hsa-miR-1184	CLIP-seq
MIRT2133353	hsa-miR-1205	CLIP-seq
MIRT2354536	hsa-miR-1237	CLIP-seq
MIRT2648424	hsa-miR-1247	CLIP-seq
MIRT2354537	hsa-miR-1248	CLIP-seq
MIRT2354538	hsa-miR-1273f	CLIP-seq
MIRT2648425	hsa-miR-184	CLIP-seq
MIRT1446162	hsa-miR-185	CLIP-seq
MIRT2133362	hsa-miR-1909	CLIP-seq
MIRT1446163	hsa-miR-1915	CLIP-seq
MIRT2354544	hsa-miR-214	CLIP-seq
MIRT2648426	hsa-miR-2467-3p	CLIP-seq
MIRT2648427	hsa-miR-3138	CLIP-seq
MIRT2648428	hsa-miR-3158-5p	CLIP-seq
MIRT1446174	hsa-miR-3175	CLIP-seq
MIRT2648429	hsa-miR-3180	CLIP-seq
MIRT2648430	hsa-miR-3180-3p	CLIP-seq
MIRT2648431	hsa-miR-3196	CLIP-seq
MIRT2354554	hsa-miR-3619-5p	CLIP-seq
MIRT2133373	hsa-miR-3620	CLIP-seq
MIRT2648432	hsa-miR-3678-3p	CLIP-seq
MIRT2354555	hsa-miR-3689a-3p	CLIP-seq
MIRT2354556	hsa-miR-3689c	CLIP-seq
MIRT2648433	hsa-miR-3690	CLIP-seq
MIRT2466251	hsa-miR-3911	CLIP-seq
MIRT2354560	hsa-miR-3914	CLIP-seq
MIRT1446189	hsa-miR-3934	CLIP-seq
MIRT2354561	hsa-miR-3943	CLIP-seq
MIRT2648434	hsa-miR-4254	CLIP-seq
MIRT2648435	hsa-miR-4270	CLIP-seq
MIRT1446195	hsa-miR-4306	CLIP-seq
MIRT2648436	hsa-miR-4441	CLIP-seq
MIRT1446211	hsa-miR-4644	CLIP-seq
MIRT2648437	hsa-miR-4691-5p	CLIP-seq
MIRT2133388	hsa-miR-4722-5p	CLIP-seq
MIRT1446221	hsa-miR-4768-3p	CLIP-seq
MIRT2466252	hsa-miR-4773	CLIP-seq
MIRT1446222	hsa-miR-4786-5p	CLIP-seq
MIRT2648438	hsa-miR-4800-5p	CLIP-seq
MIRT2648439	hsa-miR-4804-5p	CLIP-seq
MIRT2466253	hsa-miR-501-3p	CLIP-seq
MIRT2466254	hsa-miR-502-3p	CLIP-seq
MIRT2354591	hsa-miR-544	CLIP-seq
MIRT2466255	hsa-miR-552	CLIP-seq
MIRT2648440	hsa-miR-564	CLIP-seq
MIRT2354595	hsa-miR-761	CLIP-seq
MIRT1446241	hsa-miR-769-5p	CLIP-seq
MIRT2354596	hsa-miR-873	CLIP-seq
MIRT1446242	hsa-miR-939	CLIP-seq
MIRT2648423	hsa-miR-1184	CLIP-seq
MIRT2133353	hsa-miR-1205	CLIP-seq
MIRT2133355	hsa-miR-1234	CLIP-seq
MIRT2648424	hsa-miR-1247	CLIP-seq
MIRT2354538	hsa-miR-1273f	CLIP-seq
MIRT2133362	hsa-miR-1909	CLIP-seq
MIRT1446163	hsa-miR-1915	CLIP-seq
MIRT2648426	hsa-miR-2467-3p	CLIP-seq
MIRT2693851	hsa-miR-3150b-3p	CLIP-seq
MIRT2648428	hsa-miR-3158-5p	CLIP-seq
MIRT1446174	hsa-miR-3175	CLIP-seq
MIRT2133373	hsa-miR-3620	CLIP-seq
MIRT2648432	hsa-miR-3678-3p	CLIP-seq
MIRT2354555	hsa-miR-3689a-3p	CLIP-seq
MIRT2354556	hsa-miR-3689c	CLIP-seq
MIRT2648433	hsa-miR-3690	CLIP-seq
MIRT2354560	hsa-miR-3914	CLIP-seq
MIRT2354561	hsa-miR-3943	CLIP-seq
MIRT2648434	hsa-miR-4254	CLIP-seq
MIRT2648435	hsa-miR-4270	CLIP-seq
MIRT2648436	hsa-miR-4441	CLIP-seq
MIRT2693852	hsa-miR-4716-3p	CLIP-seq
MIRT2133388	hsa-miR-4722-5p	CLIP-seq
MIRT2693853	hsa-miR-4723-5p	CLIP-seq
MIRT2693854	hsa-miR-4779	CLIP-seq
MIRT2693855	hsa-miR-4784	CLIP-seq
MIRT1446222	hsa-miR-4786-5p	CLIP-seq
MIRT2133406	hsa-miR-665	CLIP-seq
MIRT1446241	hsa-miR-769-5p	CLIP-seq
MIRT2354596	hsa-miR-873	CLIP-seq
MIRT1446242	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005150	Function	Interleukin-1, type I receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	11397809, 14563850, 15047686, 16189514, 16412388, 16713569, 19060904, 19447967, 20936779, 21903422, 21988832, 25042851, 25416956, 25910212, 26320582, 31263572, 31515488, 32296183, 32814053, 33961781, 34524948, 35271311
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IC	11441107
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006914	Process	Autophagy	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IPI	11441107
GO:0016310	Process	Phosphorylation	IDA	1085432
GO:0016604	Component	Nuclear body	IEA
GO:0019897	Component	Extrinsic component of plasma membrane	IC	10854325
GO:0019900	Function	Kinase binding	IPI	10854325
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IBA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0032183	Function	SUMO binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	10854325
GO:0032991	Component	Protein-containing complex	IEA
GO:0033235	Process	Positive regulation of protein sumoylation	IEA
GO:0035325	Function	Toll-like receptor binding	IPI	11441107
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0035580	Component	Specific granule lumen	TAS
GO:0036010	Process	Protein localization to endosome	IDA	16412388
GO:0043130	Function	Ubiquitin binding	IBA
GO:0043130	Function	Ubiquitin binding	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045321	Process	Leukocyte activation	NAS	11441107
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0060090	Function	Molecular adaptor activity	IDA	10854325, 27368102
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	14625308
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	10854325
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IEA

Other IDs

• MIM: 606277
• HGNC: 16476
• e!Ensembl: ENSG00000078902

Protein

• UniProt ID: Q9H0E2
• Protein name: Toll-interacting protein
• Protein function: Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325). Inhibits IRAK1 phosphorylation
• PDB: 1WGL, 2N31
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	53 → 154	C2 domain	Domain
  PF02845	CUE	230 → 271	CUE domain	Domain

• Sequence:

  MATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAAQQLQYGGAVGTVGRLNITVV
  QAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIF
  DERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMV
  MPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALPPAAVNAQPRCSEEDLKAIQDM
  FPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP

• Sequence length: 274

Pathways

KEGG:

Toll-like receptor signaling pathway

Reactome:

Neutrophil degranulation
Interleukin-1 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC OBSTRUCTIVE AIRWAY DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic obstructive pulmonary disease	association; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Combined pulmonary fibrosis-emphysema syndrome	association; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC PULMONARY FIBROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Interstitial lung disease 2	association; Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Susceptibility to severe coronavirus disease (COVID-19)	association; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Airway Obstruction	Associate	35172835	★☆☆☆☆ Found in Text Mining only
Alveolitis Extrinsic Allergic	Associate	38309995	★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Associate	23300433	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	33993221	★☆☆☆☆ Found in Text Mining only
Asthma	Associate	35172835, 36946148	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Associate	33420630	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	17855441, 35441740	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	36499030	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Inhibit	26462859	★☆☆☆☆ Found in Text Mining only
Common Variable Immunodeficiency	Associate	29757592	★☆☆☆☆ Found in Text Mining only
Communicable Diseases	Associate	26107286	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Associate	36184551	★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	40076669	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Inhibit	26462859	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Inhibit	31813753	★☆☆☆☆ Found in Text Mining only
Dermatitis Atopic	Associate	17362526	★☆☆☆☆ Found in Text Mining only
Drug Related Side Effects and Adverse Reactions	Associate	25042851	★☆☆☆☆ Found in Text Mining only
HIV Infections	Associate	25915421, 34154540	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Associate	25042851	★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Associate	25275363, 26331942, 28648751, 29422061, 30635297, 33639995, 34370624, 34376770, 36514019	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic Pulmonary Fibrosis	Stimulate	29422061	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic Pulmonary Fibrosis	Inhibit	32596871	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Infections	Associate	25915421	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	17362526, 26107286, 29723847, 33420630, 36184551	★☆☆☆☆ Found in Text Mining only
Leishmaniasis Cutaneous	Associate	26107286	★☆☆☆☆ Found in Text Mining only
Leprosy	Associate	24294608	★☆☆☆☆ Found in Text Mining only
Leprosy Lepromatous	Associate	24294608	★☆☆☆☆ Found in Text Mining only
Lung Diseases Interstitial	Associate	30635297, 34376770, 36155967	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	36499030	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	17855441, 36499030	★☆☆☆☆ Found in Text Mining only
Neoplasms Adipose Tissue	Associate	36184551	★☆☆☆☆ Found in Text Mining only
Periodic fever familial autosomal dominant	Associate	31009059	★☆☆☆☆ Found in Text Mining only
Post Acute COVID 19 Syndrome	Associate	40076669	★☆☆☆☆ Found in Text Mining only
Primary Graft Dysfunction	Associate	26663441	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	23657238	★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Associate	33993221, 35532073	★☆☆☆☆ Found in Text Mining only
Sepsis	Associate	21219635	★☆☆☆☆ Found in Text Mining only
Status Asthmaticus	Associate	35172835	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	24935372	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	35920704	★☆☆☆☆ Found in Text Mining only
Tuberculosis	Stimulate	25887604	★☆☆☆☆ Found in Text Mining only