SPIN2A (spindlin family member 2A)

Gene

• Entrez ID: 54466
• Gene name: Spindlin family member 2A
• Gene symbol: SPIN2A
• Synonyms (NCBI Gene): DXF34, SPIN2, TDRD25, dJ323P24.1
• Chromosome: X
• Chromosome location: Xp11.21
• Summary: This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21. [provided by RefSeq, Nov 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1384250	hsa-miR-1227	CLIP-seq
MIRT1384251	hsa-miR-1283	CLIP-seq
MIRT1384252	hsa-miR-129-5p	CLIP-seq
MIRT1384253	hsa-miR-3618	CLIP-seq
MIRT1384254	hsa-miR-3692	CLIP-seq
MIRT1384255	hsa-miR-450b-5p	CLIP-seq
MIRT1384256	hsa-miR-455-5p	CLIP-seq
MIRT1384257	hsa-miR-4643	CLIP-seq
MIRT1384258	hsa-miR-4766-5p	CLIP-seq
MIRT1384259	hsa-miR-4789-5p	CLIP-seq
MIRT1384260	hsa-miR-488	CLIP-seq
MIRT1384261	hsa-miR-507	CLIP-seq
MIRT1384262	hsa-miR-548an	CLIP-seq
MIRT1384263	hsa-miR-557	CLIP-seq
MIRT1384264	hsa-miR-934	CLIP-seq
MIRT2337694	hsa-miR-361-5p	CLIP-seq
MIRT2337695	hsa-miR-4270	CLIP-seq
MIRT2337696	hsa-miR-4441	CLIP-seq
MIRT2337697	hsa-miR-587	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29061846
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0007276	Process	Gamete generation	IEA
GO:0140002	Function	Histone H3K4me3 reader activity	IDA	29061846

Other IDs

• MIM: 300621
• HGNC: 20694
• e!Ensembl: ENSG00000147059

Protein

• UniProt ID: Q99865
• Protein name: Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A)
• Protein function: May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02513	Spin-Ssty	50 → 99	Spin/Ssty Family	Repeat
  PF02513	Spin-Ssty	129 → 178	Spin/Ssty Family	Repeat
  PF02513	Spin-Ssty	210 → 255	Spin/Ssty Family	Repeat

• Sequence:

  MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQPRRNIVGCRISHGWKE
  GDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDERVLSLKILSDRVASSHIS
  DANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKAWFYITYEKDPVLYMYQLLDD
  YKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTKEDGSKRIGMVIHQVETKPSVYF
  IKFDDDFHIYVYDLVKKS

• Sequence length: 258

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations