XRN1 (5'-3' exoribonuclease 1)

Gene

• Entrez ID: 54464
• Gene name: 5'-3' exoribonuclease 1
• Gene symbol: XRN1
• Synonyms (NCBI Gene): Sep-01
• Chromosome: 3
• Chromosome location: 3q23
• Summary: This gene encodes a member of the 5`-3` exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a simi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017527	hsa-miR-335-5p	Microarray	18185580
MIRT025425	hsa-miR-34a-5p	Sequencing	20371350
MIRT025621	hsa-miR-10a-5p	Sequencing	20371350
MIRT032310	hsa-let-7b-5p	Proteomics	18668040
MIRT520100	hsa-miR-6507-5p	HITS-CLIP	21572407
MIRT520101	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520098	hsa-miR-4747-3p	HITS-CLIP	21572407
MIRT520099	hsa-miR-1295b-3p	HITS-CLIP	21572407
MIRT520097	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT520096	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT520095	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT520101	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT520097	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT520096	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520095	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT520100	hsa-miR-6507-5p	PAR-CLIP	23446348
MIRT520101	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT520098	hsa-miR-4747-3p	PAR-CLIP	23446348
MIRT520099	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT520097	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT520096	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520095	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT726092	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726090	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726091	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT520100	hsa-miR-6507-5p	HITS-CLIP	21572407
MIRT520101	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520098	hsa-miR-4747-3p	HITS-CLIP	21572407
MIRT520099	hsa-miR-1295b-3p	HITS-CLIP	21572407
MIRT520097	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT520096	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT520095	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT520101	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT520097	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT520096	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520095	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT520100	hsa-miR-6507-5p	PAR-CLIP	23446348
MIRT520101	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT520098	hsa-miR-4747-3p	PAR-CLIP	23446348
MIRT520099	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT520097	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT520096	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520095	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1497506	hsa-miR-1289	CLIP-seq
MIRT1497507	hsa-miR-1291	CLIP-seq
MIRT1497508	hsa-miR-1299	CLIP-seq
MIRT1497509	hsa-miR-142-5p	CLIP-seq
MIRT1497510	hsa-miR-1910	CLIP-seq
MIRT1497511	hsa-miR-3173-5p	CLIP-seq
MIRT1497512	hsa-miR-338-3p	CLIP-seq
MIRT1497513	hsa-miR-3613-3p	CLIP-seq
MIRT1497514	hsa-miR-3658	CLIP-seq
MIRT1497515	hsa-miR-3662	CLIP-seq
MIRT1497516	hsa-miR-3663-3p	CLIP-seq
MIRT1497517	hsa-miR-370	CLIP-seq
MIRT1497518	hsa-miR-374c	CLIP-seq
MIRT1497519	hsa-miR-4251	CLIP-seq
MIRT1497520	hsa-miR-4310	CLIP-seq
MIRT1497521	hsa-miR-4420	CLIP-seq
MIRT1497522	hsa-miR-4432	CLIP-seq
MIRT1497523	hsa-miR-4503	CLIP-seq
MIRT1497524	hsa-miR-452	CLIP-seq
MIRT1497525	hsa-miR-455-3p	CLIP-seq
MIRT1497526	hsa-miR-4663	CLIP-seq
MIRT1497527	hsa-miR-4668-3p	CLIP-seq
MIRT1497528	hsa-miR-4676-3p	CLIP-seq
MIRT1497529	hsa-miR-4698	CLIP-seq
MIRT1497530	hsa-miR-4699-5p	CLIP-seq
MIRT1497531	hsa-miR-4719	CLIP-seq
MIRT1497532	hsa-miR-4775	CLIP-seq
MIRT1497533	hsa-miR-4782-5p	CLIP-seq
MIRT1497534	hsa-miR-499-5p	CLIP-seq
MIRT1497535	hsa-miR-5096	CLIP-seq
MIRT1497536	hsa-miR-513b	CLIP-seq
MIRT1497537	hsa-miR-516b	CLIP-seq
MIRT1497538	hsa-miR-520d-5p	CLIP-seq
MIRT1497539	hsa-miR-524-5p	CLIP-seq
MIRT1497540	hsa-miR-539	CLIP-seq
MIRT1497541	hsa-miR-590-3p	CLIP-seq
MIRT1497542	hsa-miR-634	CLIP-seq
MIRT1497543	hsa-miR-654-3p	CLIP-seq
MIRT1497544	hsa-miR-655	CLIP-seq
MIRT1497545	hsa-miR-875-3p	CLIP-seq
MIRT1497546	hsa-let-7a	CLIP-seq
MIRT1497547	hsa-let-7b	CLIP-seq
MIRT1497548	hsa-let-7c	CLIP-seq
MIRT1497549	hsa-let-7d	CLIP-seq
MIRT1497550	hsa-let-7e	CLIP-seq
MIRT1497551	hsa-let-7f	CLIP-seq
MIRT1497552	hsa-let-7g	CLIP-seq
MIRT1497553	hsa-let-7i	CLIP-seq
MIRT1497554	hsa-miR-106a	CLIP-seq
MIRT1497555	hsa-miR-106b	CLIP-seq
MIRT1497556	hsa-miR-1273f	CLIP-seq
MIRT1497507	hsa-miR-1291	CLIP-seq
MIRT1497557	hsa-miR-143	CLIP-seq
MIRT1497558	hsa-miR-17	CLIP-seq
MIRT1497559	hsa-miR-181a	CLIP-seq
MIRT1497560	hsa-miR-181b	CLIP-seq
MIRT1497561	hsa-miR-181c	CLIP-seq
MIRT1497562	hsa-miR-181d	CLIP-seq
MIRT1497563	hsa-miR-202	CLIP-seq
MIRT1497564	hsa-miR-205	CLIP-seq
MIRT1497565	hsa-miR-208a	CLIP-seq
MIRT1497566	hsa-miR-208b	CLIP-seq
MIRT1497567	hsa-miR-20a	CLIP-seq
MIRT1497568	hsa-miR-20b	CLIP-seq
MIRT1497569	hsa-miR-25	CLIP-seq
MIRT1497570	hsa-miR-3135b	CLIP-seq
MIRT1497571	hsa-miR-3145-3p	CLIP-seq
MIRT1497511	hsa-miR-3173-5p	CLIP-seq
MIRT1497572	hsa-miR-32	CLIP-seq
MIRT1497573	hsa-miR-33a	CLIP-seq
MIRT1497574	hsa-miR-33b	CLIP-seq
MIRT1497575	hsa-miR-3609	CLIP-seq
MIRT1497513	hsa-miR-3613-3p	CLIP-seq
MIRT1497576	hsa-miR-363	CLIP-seq
MIRT1497577	hsa-miR-3652	CLIP-seq
MIRT1497514	hsa-miR-3658	CLIP-seq
MIRT1497578	hsa-miR-367	CLIP-seq
MIRT1497579	hsa-miR-3671	CLIP-seq
MIRT1497517	hsa-miR-370	CLIP-seq
MIRT1497518	hsa-miR-374c	CLIP-seq
MIRT1497580	hsa-miR-3978	CLIP-seq
MIRT1497519	hsa-miR-4251	CLIP-seq
MIRT1497581	hsa-miR-4261	CLIP-seq
MIRT1497582	hsa-miR-4262	CLIP-seq
MIRT1497583	hsa-miR-4275	CLIP-seq
MIRT1497584	hsa-miR-4325	CLIP-seq
MIRT1497585	hsa-miR-4430	CLIP-seq
MIRT1497522	hsa-miR-4432	CLIP-seq
MIRT1497586	hsa-miR-4458	CLIP-seq
MIRT1497587	hsa-miR-4461	CLIP-seq
MIRT1497588	hsa-miR-4474-5p	CLIP-seq
MIRT1497589	hsa-miR-4500	CLIP-seq
MIRT1497526	hsa-miR-4663	CLIP-seq
MIRT1497527	hsa-miR-4668-3p	CLIP-seq
MIRT1497590	hsa-miR-4708-5p	CLIP-seq
MIRT1497531	hsa-miR-4719	CLIP-seq
MIRT1497591	hsa-miR-4770	CLIP-seq
MIRT1497592	hsa-miR-4796-3p	CLIP-seq
MIRT1497593	hsa-miR-489	CLIP-seq
MIRT1497594	hsa-miR-494	CLIP-seq
MIRT1497534	hsa-miR-499-5p	CLIP-seq
MIRT1497536	hsa-miR-513b	CLIP-seq
MIRT1497595	hsa-miR-519a	CLIP-seq
MIRT1497596	hsa-miR-519b-3p	CLIP-seq
MIRT1497597	hsa-miR-519c-3p	CLIP-seq
MIRT1497598	hsa-miR-519d	CLIP-seq
MIRT1497538	hsa-miR-520d-5p	CLIP-seq
MIRT1497539	hsa-miR-524-5p	CLIP-seq
MIRT1497540	hsa-miR-539	CLIP-seq
MIRT1497599	hsa-miR-548ah	CLIP-seq
MIRT1497600	hsa-miR-556-3p	CLIP-seq
MIRT1497601	hsa-miR-576-3p	CLIP-seq
MIRT1497602	hsa-miR-586	CLIP-seq
MIRT1497603	hsa-miR-607	CLIP-seq
MIRT1497604	hsa-miR-627	CLIP-seq
MIRT1497544	hsa-miR-655	CLIP-seq
MIRT1497605	hsa-miR-924	CLIP-seq
MIRT1497606	hsa-miR-92a	CLIP-seq
MIRT1497607	hsa-miR-92b	CLIP-seq
MIRT1497608	hsa-miR-93	CLIP-seq
MIRT1497609	hsa-miR-98	CLIP-seq
MIRT1557315	hsa-miR-214	CLIP-seq
MIRT1557316	hsa-miR-3619-5p	CLIP-seq
MIRT1557317	hsa-miR-761	CLIP-seq
MIRT1497546	hsa-let-7a	CLIP-seq
MIRT1497547	hsa-let-7b	CLIP-seq
MIRT1497548	hsa-let-7c	CLIP-seq
MIRT1497549	hsa-let-7d	CLIP-seq
MIRT1497550	hsa-let-7e	CLIP-seq
MIRT1497551	hsa-let-7f	CLIP-seq
MIRT1497552	hsa-let-7g	CLIP-seq
MIRT1497553	hsa-let-7i	CLIP-seq
MIRT1497508	hsa-miR-1299	CLIP-seq
MIRT1497509	hsa-miR-142-5p	CLIP-seq
MIRT1497559	hsa-miR-181a	CLIP-seq
MIRT1497560	hsa-miR-181b	CLIP-seq
MIRT1497561	hsa-miR-181c	CLIP-seq
MIRT1497562	hsa-miR-181d	CLIP-seq
MIRT2149846	hsa-miR-1827	CLIP-seq
MIRT1497510	hsa-miR-1910	CLIP-seq
MIRT1497563	hsa-miR-202	CLIP-seq
MIRT2149847	hsa-miR-302a	CLIP-seq
MIRT2149848	hsa-miR-302b	CLIP-seq
MIRT2149849	hsa-miR-302c	CLIP-seq
MIRT2149850	hsa-miR-302d	CLIP-seq
MIRT2149851	hsa-miR-302e	CLIP-seq
MIRT2149852	hsa-miR-3064-5p	CLIP-seq
MIRT2149853	hsa-miR-3148	CLIP-seq
MIRT2149854	hsa-miR-3156-5p	CLIP-seq
MIRT2149855	hsa-miR-3163	CLIP-seq
MIRT2149856	hsa-miR-3194-3p	CLIP-seq
MIRT2149857	hsa-miR-3646	CLIP-seq
MIRT1497577	hsa-miR-3652	CLIP-seq
MIRT1497579	hsa-miR-3671	CLIP-seq
MIRT2149858	hsa-miR-372	CLIP-seq
MIRT2149859	hsa-miR-373	CLIP-seq
MIRT2149860	hsa-miR-421	CLIP-seq
MIRT1497582	hsa-miR-4262	CLIP-seq
MIRT1497583	hsa-miR-4275	CLIP-seq
MIRT2149861	hsa-miR-4311	CLIP-seq
MIRT1497521	hsa-miR-4420	CLIP-seq
MIRT1497585	hsa-miR-4430	CLIP-seq
MIRT1497586	hsa-miR-4458	CLIP-seq
MIRT1497589	hsa-miR-4500	CLIP-seq
MIRT2149862	hsa-miR-4505	CLIP-seq
MIRT2149863	hsa-miR-4517	CLIP-seq
MIRT1497525	hsa-miR-455-3p	CLIP-seq
MIRT2149864	hsa-miR-4643	CLIP-seq
MIRT2149865	hsa-miR-466	CLIP-seq
MIRT1497529	hsa-miR-4698	CLIP-seq
MIRT1497531	hsa-miR-4719	CLIP-seq
MIRT2149866	hsa-miR-4742-3p	CLIP-seq
MIRT1497532	hsa-miR-4775	CLIP-seq
MIRT1497533	hsa-miR-4782-5p	CLIP-seq
MIRT2149867	hsa-miR-4789-3p	CLIP-seq
MIRT2149868	hsa-miR-4789-5p	CLIP-seq
MIRT2149869	hsa-miR-4795-3p	CLIP-seq
MIRT1497593	hsa-miR-489	CLIP-seq
MIRT1497537	hsa-miR-516b	CLIP-seq
MIRT2149870	hsa-miR-520a-3p	CLIP-seq
MIRT2149871	hsa-miR-520b	CLIP-seq
MIRT2149872	hsa-miR-520c-3p	CLIP-seq
MIRT2149873	hsa-miR-520d-3p	CLIP-seq
MIRT2149874	hsa-miR-520e	CLIP-seq
MIRT2149875	hsa-miR-548a-3p	CLIP-seq
MIRT2149876	hsa-miR-548c-3p	CLIP-seq
MIRT2149877	hsa-miR-548e	CLIP-seq
MIRT2149878	hsa-miR-548f	CLIP-seq
MIRT1497541	hsa-miR-590-3p	CLIP-seq
MIRT1497603	hsa-miR-607	CLIP-seq
MIRT2149879	hsa-miR-642b	CLIP-seq
MIRT2149880	hsa-miR-646	CLIP-seq
MIRT2149881	hsa-miR-767-3p	CLIP-seq
MIRT1497545	hsa-miR-875-3p	CLIP-seq
MIRT2149882	hsa-miR-935	CLIP-seq
MIRT2149883	hsa-miR-944	CLIP-seq
MIRT1497609	hsa-miR-98	CLIP-seq
MIRT1497546	hsa-let-7a	CLIP-seq
MIRT1497547	hsa-let-7b	CLIP-seq
MIRT1497548	hsa-let-7c	CLIP-seq
MIRT1497549	hsa-let-7d	CLIP-seq
MIRT1497550	hsa-let-7e	CLIP-seq
MIRT1497551	hsa-let-7f	CLIP-seq
MIRT1497552	hsa-let-7g	CLIP-seq
MIRT1497553	hsa-let-7i	CLIP-seq
MIRT1497554	hsa-miR-106a	CLIP-seq
MIRT1497555	hsa-miR-106b	CLIP-seq
MIRT2369972	hsa-miR-1183	CLIP-seq
MIRT1497556	hsa-miR-1273f	CLIP-seq
MIRT1497506	hsa-miR-1289	CLIP-seq
MIRT1497508	hsa-miR-1299	CLIP-seq
MIRT2369973	hsa-miR-134	CLIP-seq
MIRT2369974	hsa-miR-138	CLIP-seq
MIRT1497557	hsa-miR-143	CLIP-seq
MIRT1497558	hsa-miR-17	CLIP-seq
MIRT1497559	hsa-miR-181a	CLIP-seq
MIRT1497560	hsa-miR-181b	CLIP-seq
MIRT1497561	hsa-miR-181c	CLIP-seq
MIRT1497562	hsa-miR-181d	CLIP-seq
MIRT2149846	hsa-miR-1827	CLIP-seq
MIRT2369975	hsa-miR-1911	CLIP-seq
MIRT1497563	hsa-miR-202	CLIP-seq
MIRT1497564	hsa-miR-205	CLIP-seq
MIRT1497567	hsa-miR-20a	CLIP-seq
MIRT1497568	hsa-miR-20b	CLIP-seq
MIRT2369976	hsa-miR-2277-3p	CLIP-seq
MIRT2369977	hsa-miR-2467-5p	CLIP-seq
MIRT1497569	hsa-miR-25	CLIP-seq
MIRT2369978	hsa-miR-3065-5p	CLIP-seq
MIRT2369979	hsa-miR-3118	CLIP-seq
MIRT2369980	hsa-miR-3121-3p	CLIP-seq
MIRT1497571	hsa-miR-3145-3p	CLIP-seq
MIRT2369981	hsa-miR-3149	CLIP-seq
MIRT2369982	hsa-miR-3158-3p	CLIP-seq
MIRT2149855	hsa-miR-3163	CLIP-seq
MIRT2369983	hsa-miR-3166	CLIP-seq
MIRT2369984	hsa-miR-3183	CLIP-seq
MIRT2369985	hsa-miR-3188	CLIP-seq
MIRT2369986	hsa-miR-3199	CLIP-seq
MIRT1497572	hsa-miR-32	CLIP-seq
MIRT1497512	hsa-miR-338-3p	CLIP-seq
MIRT1497573	hsa-miR-33a	CLIP-seq
MIRT1497574	hsa-miR-33b	CLIP-seq
MIRT1497575	hsa-miR-3609	CLIP-seq
MIRT1497576	hsa-miR-363	CLIP-seq
MIRT2149857	hsa-miR-3646	CLIP-seq
MIRT1497514	hsa-miR-3658	CLIP-seq
MIRT1497516	hsa-miR-3663-3p	CLIP-seq
MIRT1497578	hsa-miR-367	CLIP-seq
MIRT2369987	hsa-miR-3675-3p	CLIP-seq
MIRT2369988	hsa-miR-3689a-5p	CLIP-seq
MIRT2369989	hsa-miR-3689b	CLIP-seq
MIRT2369990	hsa-miR-3689e	CLIP-seq
MIRT2369991	hsa-miR-3689f	CLIP-seq
MIRT1497518	hsa-miR-374c	CLIP-seq
MIRT2369992	hsa-miR-3910	CLIP-seq
MIRT2369993	hsa-miR-3975	CLIP-seq
MIRT2369994	hsa-miR-409-3p	CLIP-seq
MIRT2369995	hsa-miR-411	CLIP-seq
MIRT2149860	hsa-miR-421	CLIP-seq
MIRT1497582	hsa-miR-4262	CLIP-seq
MIRT2369996	hsa-miR-4288	CLIP-seq
MIRT1497520	hsa-miR-4310	CLIP-seq
MIRT2149861	hsa-miR-4311	CLIP-seq
MIRT2369997	hsa-miR-4316	CLIP-seq
MIRT2369998	hsa-miR-4318	CLIP-seq
MIRT1497584	hsa-miR-4325	CLIP-seq
MIRT1497522	hsa-miR-4432	CLIP-seq
MIRT1497586	hsa-miR-4458	CLIP-seq
MIRT2369999	hsa-miR-4469	CLIP-seq
MIRT2370000	hsa-miR-4484	CLIP-seq
MIRT2370001	hsa-miR-4495	CLIP-seq
MIRT2370002	hsa-miR-4496	CLIP-seq
MIRT1497589	hsa-miR-4500	CLIP-seq
MIRT1497523	hsa-miR-4503	CLIP-seq
MIRT2370003	hsa-miR-4509	CLIP-seq
MIRT2370004	hsa-miR-4522	CLIP-seq
MIRT1497525	hsa-miR-455-3p	CLIP-seq
MIRT2370005	hsa-miR-455-5p	CLIP-seq
MIRT2370006	hsa-miR-4659a-3p	CLIP-seq
MIRT2370007	hsa-miR-4659b-3p	CLIP-seq
MIRT2370008	hsa-miR-4679	CLIP-seq
MIRT2370009	hsa-miR-4693-5p	CLIP-seq
MIRT1497529	hsa-miR-4698	CLIP-seq
MIRT2370010	hsa-miR-4708-3p	CLIP-seq
MIRT1497590	hsa-miR-4708-5p	CLIP-seq
MIRT2370011	hsa-miR-4712-3p	CLIP-seq
MIRT1497531	hsa-miR-4719	CLIP-seq
MIRT2370012	hsa-miR-4723-3p	CLIP-seq
MIRT2370013	hsa-miR-4735-5p	CLIP-seq
MIRT2370014	hsa-miR-4740-3p	CLIP-seq
MIRT2370015	hsa-miR-4765	CLIP-seq
MIRT1497591	hsa-miR-4770	CLIP-seq
MIRT1497532	hsa-miR-4775	CLIP-seq
MIRT2370016	hsa-miR-4778-3p	CLIP-seq
MIRT1497533	hsa-miR-4782-5p	CLIP-seq
MIRT2149869	hsa-miR-4795-3p	CLIP-seq
MIRT1497592	hsa-miR-4796-3p	CLIP-seq
MIRT2370017	hsa-miR-485-5p	CLIP-seq
MIRT1497593	hsa-miR-489	CLIP-seq
MIRT2370018	hsa-miR-495	CLIP-seq
MIRT1497534	hsa-miR-499-5p	CLIP-seq
MIRT1497536	hsa-miR-513b	CLIP-seq
MIRT1497537	hsa-miR-516b	CLIP-seq
MIRT1497595	hsa-miR-519a	CLIP-seq
MIRT1497596	hsa-miR-519b-3p	CLIP-seq
MIRT1497597	hsa-miR-519c-3p	CLIP-seq
MIRT1497598	hsa-miR-519d	CLIP-seq
MIRT1497538	hsa-miR-520d-5p	CLIP-seq
MIRT1497539	hsa-miR-524-5p	CLIP-seq
MIRT1497540	hsa-miR-539	CLIP-seq
MIRT2370019	hsa-miR-548ae	CLIP-seq
MIRT1497599	hsa-miR-548ah	CLIP-seq
MIRT2370020	hsa-miR-548aj	CLIP-seq
MIRT2370021	hsa-miR-548am	CLIP-seq
MIRT2370022	hsa-miR-548an	CLIP-seq
MIRT2149876	hsa-miR-548c-3p	CLIP-seq
MIRT2370023	hsa-miR-548t	CLIP-seq
MIRT2370024	hsa-miR-548v	CLIP-seq
MIRT2370025	hsa-miR-548x	CLIP-seq
MIRT2370026	hsa-miR-550b	CLIP-seq
MIRT2370027	hsa-miR-576-5p	CLIP-seq
MIRT1497602	hsa-miR-586	CLIP-seq
MIRT1497541	hsa-miR-590-3p	CLIP-seq
MIRT2370028	hsa-miR-632	CLIP-seq
MIRT2370029	hsa-miR-642a	CLIP-seq
MIRT2149879	hsa-miR-642b	CLIP-seq
MIRT2149880	hsa-miR-646	CLIP-seq
MIRT2370030	hsa-miR-653	CLIP-seq
MIRT1497543	hsa-miR-654-3p	CLIP-seq
MIRT1497544	hsa-miR-655	CLIP-seq
MIRT2370031	hsa-miR-888	CLIP-seq
MIRT2370032	hsa-miR-892a	CLIP-seq
MIRT1497606	hsa-miR-92a	CLIP-seq
MIRT1497607	hsa-miR-92b	CLIP-seq
MIRT1497608	hsa-miR-93	CLIP-seq
MIRT2149882	hsa-miR-935	CLIP-seq
MIRT2370033	hsa-miR-942	CLIP-seq
MIRT1497609	hsa-miR-98	CLIP-seq
MIRT2369976	hsa-miR-2277-3p	CLIP-seq
MIRT2397110	hsa-miR-3942-3p	CLIP-seq
MIRT2370024	hsa-miR-548v	CLIP-seq
MIRT2149879	hsa-miR-642b	CLIP-seq
MIRT2149880	hsa-miR-646	CLIP-seq
MIRT2370030	hsa-miR-653	CLIP-seq
MIRT2434873	hsa-miR-320a	CLIP-seq
MIRT2434874	hsa-miR-320b	CLIP-seq
MIRT2434875	hsa-miR-320c	CLIP-seq
MIRT2434876	hsa-miR-320d	CLIP-seq
MIRT2434877	hsa-miR-4291	CLIP-seq
MIRT1497520	hsa-miR-4310	CLIP-seq
MIRT2434878	hsa-miR-4429	CLIP-seq
MIRT2149876	hsa-miR-548c-3p	CLIP-seq
MIRT1497570	hsa-miR-3135b	CLIP-seq
MIRT2369981	hsa-miR-3149	CLIP-seq
MIRT2369982	hsa-miR-3158-3p	CLIP-seq
MIRT2369995	hsa-miR-411	CLIP-seq
MIRT2370013	hsa-miR-4735-5p	CLIP-seq
MIRT1497532	hsa-miR-4775	CLIP-seq
MIRT1497541	hsa-miR-590-3p	CLIP-seq
MIRT2149857	hsa-miR-3646	CLIP-seq
MIRT2149861	hsa-miR-4311	CLIP-seq
MIRT1497527	hsa-miR-4668-3p	CLIP-seq
MIRT2663776	hsa-miR-1227	CLIP-seq
MIRT2663777	hsa-miR-1251	CLIP-seq
MIRT2663778	hsa-miR-1261	CLIP-seq
MIRT2663779	hsa-miR-1269	CLIP-seq
MIRT2663780	hsa-miR-1269b	CLIP-seq
MIRT2663781	hsa-miR-1279	CLIP-seq
MIRT2663782	hsa-miR-1287	CLIP-seq
MIRT2663783	hsa-miR-145	CLIP-seq
MIRT1497559	hsa-miR-181a	CLIP-seq
MIRT1497560	hsa-miR-181b	CLIP-seq
MIRT1497561	hsa-miR-181c	CLIP-seq
MIRT1497562	hsa-miR-181d	CLIP-seq
MIRT2149846	hsa-miR-1827	CLIP-seq
MIRT2369975	hsa-miR-1911	CLIP-seq
MIRT2663784	hsa-miR-218	CLIP-seq
MIRT2663785	hsa-miR-2276	CLIP-seq
MIRT2369976	hsa-miR-2277-3p	CLIP-seq
MIRT2663786	hsa-miR-23a	CLIP-seq
MIRT2663787	hsa-miR-23b	CLIP-seq
MIRT2663788	hsa-miR-23c	CLIP-seq
MIRT2369977	hsa-miR-2467-5p	CLIP-seq
MIRT2663789	hsa-miR-28-3p	CLIP-seq
MIRT2369980	hsa-miR-3121-3p	CLIP-seq
MIRT2663790	hsa-miR-3121-5p	CLIP-seq
MIRT1497570	hsa-miR-3135b	CLIP-seq
MIRT2663791	hsa-miR-3146	CLIP-seq
MIRT2149853	hsa-miR-3148	CLIP-seq
MIRT2369981	hsa-miR-3149	CLIP-seq
MIRT2149855	hsa-miR-3163	CLIP-seq
MIRT2663792	hsa-miR-3174	CLIP-seq
MIRT2369985	hsa-miR-3188	CLIP-seq
MIRT2663793	hsa-miR-340	CLIP-seq
MIRT2663794	hsa-miR-3591-3p	CLIP-seq
MIRT1497575	hsa-miR-3609	CLIP-seq
MIRT1497513	hsa-miR-3613-3p	CLIP-seq
MIRT2149857	hsa-miR-3646	CLIP-seq
MIRT2663795	hsa-miR-3647-3p	CLIP-seq
MIRT1497577	hsa-miR-3652	CLIP-seq
MIRT1497515	hsa-miR-3662	CLIP-seq
MIRT1497516	hsa-miR-3663-3p	CLIP-seq
MIRT2369987	hsa-miR-3675-3p	CLIP-seq
MIRT2663796	hsa-miR-3680	CLIP-seq
MIRT2663797	hsa-miR-377	CLIP-seq
MIRT2369993	hsa-miR-3975	CLIP-seq
MIRT2369994	hsa-miR-409-3p	CLIP-seq
MIRT1497582	hsa-miR-4262	CLIP-seq
MIRT2369997	hsa-miR-4316	CLIP-seq
MIRT1497585	hsa-miR-4430	CLIP-seq
MIRT2663798	hsa-miR-4433	CLIP-seq
MIRT2663799	hsa-miR-4438	CLIP-seq
MIRT2663800	hsa-miR-4520b-3p	CLIP-seq
MIRT2663801	hsa-miR-4529-3p	CLIP-seq
MIRT2370005	hsa-miR-455-5p	CLIP-seq
MIRT2663802	hsa-miR-4653-3p	CLIP-seq
MIRT1497527	hsa-miR-4668-3p	CLIP-seq
MIRT2663803	hsa-miR-4668-5p	CLIP-seq
MIRT1497529	hsa-miR-4698	CLIP-seq
MIRT1497531	hsa-miR-4719	CLIP-seq
MIRT2370013	hsa-miR-4735-5p	CLIP-seq
MIRT2370015	hsa-miR-4765	CLIP-seq
MIRT2663804	hsa-miR-4772-3p	CLIP-seq
MIRT2663805	hsa-miR-4773	CLIP-seq
MIRT1497532	hsa-miR-4775	CLIP-seq
MIRT2149867	hsa-miR-4789-3p	CLIP-seq
MIRT2663806	hsa-miR-4798-3p	CLIP-seq
MIRT2370017	hsa-miR-485-5p	CLIP-seq
MIRT1497593	hsa-miR-489	CLIP-seq
MIRT1497594	hsa-miR-494	CLIP-seq
MIRT2663807	hsa-miR-500a	CLIP-seq
MIRT2663808	hsa-miR-501-5p	CLIP-seq
MIRT2663809	hsa-miR-502-5p	CLIP-seq
MIRT2663810	hsa-miR-507	CLIP-seq
MIRT2663811	hsa-miR-5095	CLIP-seq
MIRT2663812	hsa-miR-513c	CLIP-seq
MIRT2663813	hsa-miR-514b-5p	CLIP-seq
MIRT1497595	hsa-miR-519a	CLIP-seq
MIRT1497596	hsa-miR-519b-3p	CLIP-seq
MIRT1497597	hsa-miR-519c-3p	CLIP-seq
MIRT1497538	hsa-miR-520d-5p	CLIP-seq
MIRT1497539	hsa-miR-524-5p	CLIP-seq
MIRT2663814	hsa-miR-544	CLIP-seq
MIRT2149875	hsa-miR-548a-3p	CLIP-seq
MIRT2663815	hsa-miR-548ad	CLIP-seq
MIRT1497599	hsa-miR-548ah	CLIP-seq
MIRT2149876	hsa-miR-548c-3p	CLIP-seq
MIRT2149877	hsa-miR-548e	CLIP-seq
MIRT2149878	hsa-miR-548f	CLIP-seq
MIRT2370023	hsa-miR-548t	CLIP-seq
MIRT2370024	hsa-miR-548v	CLIP-seq
MIRT2663816	hsa-miR-557	CLIP-seq
MIRT2663817	hsa-miR-570	CLIP-seq
MIRT2663818	hsa-miR-582-5p	CLIP-seq
MIRT1497541	hsa-miR-590-3p	CLIP-seq
MIRT2663819	hsa-miR-600	CLIP-seq
MIRT2149879	hsa-miR-642b	CLIP-seq
MIRT2149880	hsa-miR-646	CLIP-seq
MIRT2370030	hsa-miR-653	CLIP-seq
MIRT2370031	hsa-miR-888	CLIP-seq
MIRT2149882	hsa-miR-935	CLIP-seq
MIRT2663776	hsa-miR-1227	CLIP-seq
MIRT2663777	hsa-miR-1251	CLIP-seq
MIRT2663778	hsa-miR-1261	CLIP-seq
MIRT2663781	hsa-miR-1279	CLIP-seq
MIRT1497506	hsa-miR-1289	CLIP-seq
MIRT2663783	hsa-miR-145	CLIP-seq
MIRT1497559	hsa-miR-181a	CLIP-seq
MIRT1497560	hsa-miR-181b	CLIP-seq
MIRT1497561	hsa-miR-181c	CLIP-seq
MIRT1497562	hsa-miR-181d	CLIP-seq
MIRT2149846	hsa-miR-1827	CLIP-seq
MIRT2369975	hsa-miR-1911	CLIP-seq
MIRT2369976	hsa-miR-2277-3p	CLIP-seq
MIRT2663786	hsa-miR-23a	CLIP-seq
MIRT2663787	hsa-miR-23b	CLIP-seq
MIRT2663788	hsa-miR-23c	CLIP-seq
MIRT2369977	hsa-miR-2467-5p	CLIP-seq
MIRT2663789	hsa-miR-28-3p	CLIP-seq
MIRT2663790	hsa-miR-3121-5p	CLIP-seq
MIRT1497570	hsa-miR-3135b	CLIP-seq
MIRT2663791	hsa-miR-3146	CLIP-seq
MIRT2369981	hsa-miR-3149	CLIP-seq
MIRT2149855	hsa-miR-3163	CLIP-seq
MIRT2369985	hsa-miR-3188	CLIP-seq
MIRT2663793	hsa-miR-340	CLIP-seq
MIRT2663794	hsa-miR-3591-3p	CLIP-seq
MIRT1497513	hsa-miR-3613-3p	CLIP-seq
MIRT2149857	hsa-miR-3646	CLIP-seq
MIRT2663795	hsa-miR-3647-3p	CLIP-seq
MIRT1497516	hsa-miR-3663-3p	CLIP-seq
MIRT2369987	hsa-miR-3675-3p	CLIP-seq
MIRT2663796	hsa-miR-3680	CLIP-seq
MIRT2663797	hsa-miR-377	CLIP-seq
MIRT2369993	hsa-miR-3975	CLIP-seq
MIRT2369994	hsa-miR-409-3p	CLIP-seq
MIRT1497582	hsa-miR-4262	CLIP-seq
MIRT2369997	hsa-miR-4316	CLIP-seq
MIRT2663798	hsa-miR-4433	CLIP-seq
MIRT2663799	hsa-miR-4438	CLIP-seq
MIRT2370005	hsa-miR-455-5p	CLIP-seq
MIRT1497527	hsa-miR-4668-3p	CLIP-seq
MIRT1497529	hsa-miR-4698	CLIP-seq
MIRT2370013	hsa-miR-4735-5p	CLIP-seq
MIRT2695388	hsa-miR-4742-5p	CLIP-seq
MIRT2370015	hsa-miR-4765	CLIP-seq
MIRT1497532	hsa-miR-4775	CLIP-seq
MIRT2663806	hsa-miR-4798-3p	CLIP-seq
MIRT2370017	hsa-miR-485-5p	CLIP-seq
MIRT1497593	hsa-miR-489	CLIP-seq
MIRT2663807	hsa-miR-500a	CLIP-seq
MIRT2663808	hsa-miR-501-5p	CLIP-seq
MIRT2663810	hsa-miR-507	CLIP-seq
MIRT2663811	hsa-miR-5095	CLIP-seq
MIRT1497538	hsa-miR-520d-5p	CLIP-seq
MIRT1497539	hsa-miR-524-5p	CLIP-seq
MIRT2370024	hsa-miR-548v	CLIP-seq
MIRT1497600	hsa-miR-556-3p	CLIP-seq
MIRT2663816	hsa-miR-557	CLIP-seq
MIRT1497541	hsa-miR-590-3p	CLIP-seq
MIRT2149879	hsa-miR-642b	CLIP-seq
MIRT2149880	hsa-miR-646	CLIP-seq
MIRT2370030	hsa-miR-653	CLIP-seq
MIRT2370031	hsa-miR-888	CLIP-seq
MIRT2149882	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IEA
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IBA
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IEA
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IMP	17545563
GO:0002151	Function	G-quadruplex RNA binding	ISS
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004534	Function	5'-3' RNA exonuclease activity	IBA
GO:0004534	Function	5'-3' RNA exonuclease activity	IEA
GO:0004534	Function	5'-3' RNA exonuclease activity	IMP	26950371
GO:0004534	Function	5'-3' RNA exonuclease activity	ISS
GO:0005515	Function	Protein binding	IPI	15687258, 20584987, 21876179, 23125361, 23756462, 24510189, 25220460, 29033321, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0008409	Function	5'-3' exonuclease activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016070	Process	RNA metabolic process	IEA
GO:0016075	Process	RRNA catabolic process	IBA
GO:0016075	Process	RRNA catabolic process	IMP	20368444
GO:0016787	Function	Hydrolase activity	IEA
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030425	Component	Dendrite	IEA
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IC	26950371
GO:0033574	Process	Response to testosterone	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0051880	Function	G-quadruplex DNA binding	ISS
GO:0070034	Function	Telomerase RNA binding	IPI	26950371
GO:0071028	Process	Nuclear mRNA surveillance	IMP	17545563
GO:0071044	Process	Histone mRNA catabolic process	IMP	18172165
GO:0071409	Process	Cellular response to cycloheximide	IEA
GO:1905795	Process	Cellular response to puromycin	IEA

Other IDs

• MIM: 607994
• HGNC: 30654
• e!Ensembl: ENSG00000114127

Protein

• UniProt ID: Q8IZH2
• Protein name: 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)
• Protein function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tet
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03159	XRN_N	1 → 227		Family
  PF17846	XRN_M	272 → 610	Xrn1 helical domain	Domain
  PF18332	XRN1_D1	647 → 845	Exoribonuclease Xrn1 D1 domain	Domain
  PF18334	XRN1_D2_D3	848 → 935	Exoribonuclease Xrn1 D2/D3 domain	Domain
  PF18129	SH3_12	1101 → 1171	Xrn1 SH3-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269|PubMed:12426100}.
• Sequence:

  MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKI
  FTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGE
  TLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHK
  IMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
  PEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHL
  HINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKW
  FESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDET
  EDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWY
  YPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSP
  IIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLM
  CWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFP
  TLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWP
  HLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEH
  YLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFD
  SRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDAL
  IQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFN
  KKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGEN
  ENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTV
  KPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLF
  EVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSS
  SSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVL
  PQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIEN
  FLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQI
  ANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVS
  TPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALF
  ALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSS
  HLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFEN
  KEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHH
  KSTPISSSRRKSRKLAVNFGVSKPSE

• Sequence length: 1706

Pathways

KEGG:

Ribosome biogenesis in eukaryotes
RNA degradation

Reactome:

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Osteosarcoma	Inhibit	34266995	★☆☆☆☆ Found in Text Mining only