Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	54460
Gene name	Mitochondrial ribosomal protein S21
Gene symbol	MRPS21
Synonyms (NCBI Gene)	MDS016MRP-S21RPMS21bS21m
Chromosome	1
Chromosome location	1q21.2
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT695025	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT695024	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT695023	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT695022	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT695021	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT695020	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT695019	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT695018	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT695016	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT695017	hsa-miR-612	HITS-CLIP	23313552
MIRT695014	hsa-miR-6860	HITS-CLIP	23313552
MIRT695015	hsa-miR-4290	HITS-CLIP	23313552
MIRT695013	hsa-miR-661	HITS-CLIP	23313552
MIRT695012	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT695011	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT695010	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT459235	hsa-miR-3123	PAR-CLIP	23592263
MIRT459234	hsa-miR-4496	PAR-CLIP	23592263
MIRT459233	hsa-miR-25-3p	PAR-CLIP	23592263
MIRT459232	hsa-miR-32-5p	PAR-CLIP	23592263
MIRT459231	hsa-miR-363-3p	PAR-CLIP	23592263
MIRT459230	hsa-miR-367-3p	PAR-CLIP	23592263
MIRT459229	hsa-miR-92a-3p	PAR-CLIP	23592263
MIRT459228	hsa-miR-92b-3p	PAR-CLIP	23592263
MIRT459227	hsa-miR-3919	PAR-CLIP	23592263
MIRT459226	hsa-miR-3607-5p	PAR-CLIP	23592263
MIRT459225	hsa-miR-4790-3p	PAR-CLIP	23592263
MIRT459224	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT459223	hsa-miR-3166	PAR-CLIP	23592263
MIRT459222	hsa-miR-4771	PAR-CLIP	23592263
MIRT459221	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT459220	hsa-miR-5093	PAR-CLIP	23592263
MIRT459219	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT459218	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT459217	hsa-miR-137	PAR-CLIP	23592263
MIRT459216	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT459215	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT459214	hsa-miR-5089-5p	PAR-CLIP	23592263
MIRT459213	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT459212	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT459211	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT459210	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT459209	hsa-miR-8070	PAR-CLIP	23592263
MIRT459208	hsa-miR-8081	PAR-CLIP	23592263
MIRT459212	hsa-let-7a-2-3p	PAR-CLIP	27292025
MIRT459213	hsa-let-7c-3p	PAR-CLIP	27292025
MIRT459211	hsa-let-7g-3p	PAR-CLIP	27292025
MIRT459216	hsa-miR-1273h-3p	PAR-CLIP	27292025
MIRT459217	hsa-miR-137	PAR-CLIP	27292025
MIRT459221	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT459233	hsa-miR-25-3p	PAR-CLIP	27292025
MIRT459235	hsa-miR-3123	PAR-CLIP	27292025
MIRT459223	hsa-miR-3166	PAR-CLIP	27292025
MIRT459232	hsa-miR-32-5p	PAR-CLIP	27292025
MIRT459226	hsa-miR-3607-5p	PAR-CLIP	27292025
MIRT459231	hsa-miR-363-3p	PAR-CLIP	27292025
MIRT459230	hsa-miR-367-3p	PAR-CLIP	27292025
MIRT459215	hsa-miR-3678-3p	PAR-CLIP	27292025
MIRT459227	hsa-miR-3919	PAR-CLIP	27292025
MIRT459234	hsa-miR-4496	PAR-CLIP	27292025
MIRT459222	hsa-miR-4771	PAR-CLIP	27292025
MIRT459225	hsa-miR-4790-3p	PAR-CLIP	27292025
MIRT459210	hsa-miR-493-5p	PAR-CLIP	27292025
MIRT459224	hsa-miR-508-3p	PAR-CLIP	27292025
MIRT459214	hsa-miR-5089-5p	PAR-CLIP	27292025
MIRT459220	hsa-miR-5093	PAR-CLIP	27292025
MIRT459219	hsa-miR-520d-5p	PAR-CLIP	27292025
MIRT459218	hsa-miR-524-5p	PAR-CLIP	27292025
MIRT459209	hsa-miR-8070	PAR-CLIP	27292025
MIRT459208	hsa-miR-8081	PAR-CLIP	27292025
MIRT459229	hsa-miR-92a-3p	PAR-CLIP	27292025
MIRT459228	hsa-miR-92b-3p	PAR-CLIP	27292025
MIRT695025	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT695024	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT695023	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT695022	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT695021	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT695020	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT695019	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT695018	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT695016	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT695017	hsa-miR-612	HITS-CLIP	23313552
MIRT695014	hsa-miR-6860	HITS-CLIP	23313552
MIRT695015	hsa-miR-4290	HITS-CLIP	23313552
MIRT695013	hsa-miR-661	HITS-CLIP	23313552
MIRT695012	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT695011	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT695010	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT459235	hsa-miR-3123	PAR-CLIP	23592263
MIRT459234	hsa-miR-4496	PAR-CLIP	23592263
MIRT459233	hsa-miR-25-3p	PAR-CLIP	23592263
MIRT459232	hsa-miR-32-5p	PAR-CLIP	23592263
MIRT459231	hsa-miR-363-3p	PAR-CLIP	23592263
MIRT459230	hsa-miR-367-3p	PAR-CLIP	23592263
MIRT459229	hsa-miR-92a-3p	PAR-CLIP	23592263
MIRT459228	hsa-miR-92b-3p	PAR-CLIP	23592263
MIRT459227	hsa-miR-3919	PAR-CLIP	23592263
MIRT459226	hsa-miR-3607-5p	PAR-CLIP	23592263
MIRT459225	hsa-miR-4790-3p	PAR-CLIP	23592263
MIRT459224	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT459223	hsa-miR-3166	PAR-CLIP	23592263
MIRT459222	hsa-miR-4771	PAR-CLIP	23592263
MIRT459221	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT459220	hsa-miR-5093	PAR-CLIP	23592263
MIRT459219	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT459218	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT459217	hsa-miR-137	PAR-CLIP	23592263
MIRT459216	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT459215	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT459214	hsa-miR-5089-5p	PAR-CLIP	23592263
MIRT459213	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT459212	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT459211	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT459210	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT459209	hsa-miR-8070	PAR-CLIP	23592263
MIRT459208	hsa-miR-8081	PAR-CLIP	23592263
MIRT1159957	hsa-miR-1245b-5p	CLIP-seq
MIRT1159958	hsa-miR-1248	CLIP-seq
MIRT1159959	hsa-miR-1255a	CLIP-seq
MIRT1159960	hsa-miR-1255b	CLIP-seq
MIRT1159961	hsa-miR-185	CLIP-seq
MIRT1159962	hsa-miR-25	CLIP-seq
MIRT1159963	hsa-miR-3142	CLIP-seq
MIRT1159964	hsa-miR-32	CLIP-seq
MIRT1159965	hsa-miR-3612	CLIP-seq
MIRT1159966	hsa-miR-363	CLIP-seq
MIRT1159967	hsa-miR-367	CLIP-seq
MIRT1159968	hsa-miR-4443	CLIP-seq
MIRT1159969	hsa-miR-4455	CLIP-seq
MIRT1159970	hsa-miR-548e	CLIP-seq
MIRT1159971	hsa-miR-548f	CLIP-seq
MIRT1159972	hsa-miR-609	CLIP-seq
MIRT1159973	hsa-miR-650	CLIP-seq
MIRT1159974	hsa-miR-92a	CLIP-seq
MIRT1159975	hsa-miR-92b	CLIP-seq
MIRT1159959	hsa-miR-1255a	CLIP-seq
MIRT1159960	hsa-miR-1255b	CLIP-seq
MIRT1159961	hsa-miR-185	CLIP-seq
MIRT1159962	hsa-miR-25	CLIP-seq
MIRT1159964	hsa-miR-32	CLIP-seq
MIRT1159966	hsa-miR-363	CLIP-seq
MIRT1159967	hsa-miR-367	CLIP-seq
MIRT1159970	hsa-miR-548e	CLIP-seq
MIRT1159971	hsa-miR-548f	CLIP-seq
MIRT1159974	hsa-miR-92a	CLIP-seq
MIRT1159975	hsa-miR-92b	CLIP-seq
MIRT1159957	hsa-miR-1245b-5p	CLIP-seq
MIRT1159958	hsa-miR-1248	CLIP-seq
MIRT1159959	hsa-miR-1255a	CLIP-seq
MIRT1159960	hsa-miR-1255b	CLIP-seq
MIRT1159961	hsa-miR-185	CLIP-seq
MIRT1159962	hsa-miR-25	CLIP-seq
MIRT1159963	hsa-miR-3142	CLIP-seq
MIRT1159964	hsa-miR-32	CLIP-seq
MIRT1159965	hsa-miR-3612	CLIP-seq
MIRT1159966	hsa-miR-363	CLIP-seq
MIRT1159967	hsa-miR-367	CLIP-seq
MIRT1159968	hsa-miR-4443	CLIP-seq
MIRT1159969	hsa-miR-4455	CLIP-seq
MIRT1159970	hsa-miR-548e	CLIP-seq
MIRT1159971	hsa-miR-548f	CLIP-seq
MIRT1159972	hsa-miR-609	CLIP-seq
MIRT1159973	hsa-miR-650	CLIP-seq
MIRT1159974	hsa-miR-92a	CLIP-seq
MIRT1159975	hsa-miR-92b	CLIP-seq
MIRT1159958	hsa-miR-1248	CLIP-seq
MIRT1159962	hsa-miR-25	CLIP-seq
MIRT1159964	hsa-miR-32	CLIP-seq
MIRT1159966	hsa-miR-363	CLIP-seq
MIRT1159967	hsa-miR-367	CLIP-seq
MIRT1159974	hsa-miR-92a	CLIP-seq
MIRT1159975	hsa-miR-92b	CLIP-seq
MIRT1159962	hsa-miR-25	CLIP-seq
MIRT1159964	hsa-miR-32	CLIP-seq
MIRT1159966	hsa-miR-363	CLIP-seq
MIRT1159967	hsa-miR-367	CLIP-seq
MIRT1159974	hsa-miR-92a	CLIP-seq
MIRT1159975	hsa-miR-92b	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0003735	Function	Structural constituent of ribosome	NAS	11279123
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	11279123
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	25838379
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11279123
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611984	14046	ENSG00000266472

P82921

Protein name

Small ribosomal subunit protein bS21m (28S ribosomal protein S21, mitochondrial) (MRP-S21) (S21mt)

PDB

3J9M , 6NU2 , 6NU3 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01165	Ribosomal_S21	11 → 64	Ribosomal protein S21	Family

Sequence

MAKHLKFIARTVMVQEGNVESAYRTLNRILTMDGLIEDIKHRRYYEKPCCRRQRESYERC
RRIYNMEMARKINFLMRKNRADPWQGC

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenoma Islet Cell	Associate	33154504	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Associate	33154504	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPS21 (mitochondrial ribosomal protein S21)