CYTL1 (cytokine like 1)

Gene

• Entrez ID: 54360
• Gene name: Cytokine like 1
• Gene symbol: CYTL1
• Synonyms (NCBI Gene): C17, C4orf4
• Chromosome: 4
• Chromosome location: 4p16.2
• Summary: C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016797	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002062	Process	Chondrocyte differentiation	IEA
GO:0005102	Function	Signaling receptor binding	TAS	10857752
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	TAS	10857752
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0007165	Process	Signal transduction	TAS	10857752
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048839	Process	Inner ear development	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IEA
GO:1990079	Process	Cartilage homeostasis	IEA

Other IDs

• MIM: 607930
• HGNC: 24435
• e!Ensembl: ENSG00000170891

Protein

• UniProt ID: Q9NRR1
• Protein name: Cytokine-like protein 1 (Protein C17)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15153	CYTL1	7 → 133	Cytokine-like protein 1	Family

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in CD34+ hematopoietic cells. {ECO:0000269|PubMed:10857752}.
• Sequence:

  MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSEPCVRYLPR
  LYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTIMNSFCRRDLVFLLDDCNA
  LEYPIPVTTVLPDRQR

• Sequence length: 136

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE THYROID DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMMON VARIABLE IMMUNODEFICIENCY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE IDIOPATHIC ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adrenal Gland Neoplasms	Associate	21521926	★☆☆☆☆ Found in Text Mining only
Asymptomatic Infections	Associate	21521926	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Inhibit	35115484, 38211443	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	22011669	★☆☆☆☆ Found in Text Mining only
Cartilage Diseases	Associate	33892138	★☆☆☆☆ Found in Text Mining only
Coxa Magna	Associate	33892138	★☆☆☆☆ Found in Text Mining only
Epidermolysis Bullosa Junctional	Associate	35490295	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Associate	35589822	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	35115484	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	17853492, 36825034	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	35115484, 38211443	★☆☆☆☆ Found in Text Mining only
Osteoarthritis Knee	Associate	33903094	★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Associate	36472318	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	36825034	★☆☆☆☆ Found in Text Mining only