POLH (DNA polymerase eta)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 5429 |
| Gene name | DNA polymerase eta |
| Gene symbol | POLH |
| Synonyms (NCBI Gene) |
RAD30RAD30AXP-VXPV
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| Chromosome | 6 |
| Chromosome location | 6p21.1 |
| Summary | This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymeras |
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SNPs
SNP information provided by dbSNP.
15
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miRNA
miRNA information provided by mirtarbase database.
1239
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
1
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9Y253 | ||||||||||||||||||||
| Protein name | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | ||||||||||||||||||||
| Protein function | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, | ||||||||||||||||||||
| PDB | 2I5O , 2LSK , 3JAA , 3MR2 , 3MR3 , 3MR5 , 3MR6 , 3SI8 , 3TQ1 , 3WUP , 4DL2 , 4DL3 , 4DL4 , 4DL5 , 4DL6 , 4DL7 , 4ECQ , 4ECR , 4ECS , 4ECT , 4ECU , 4ECV , 4ECW , 4ECX , 4ECY , 4ECZ , 4ED0 , 4ED1 , 4ED2 , 4ED3 , 4ED6 , 4ED7 , 4ED8 , 4EEY , 4J9K , 4J9L , 4J9M , 4J9N , 4J9O , 4J9P , 4J9Q , 4J9R , 4J9S , 4O3N , 4O3O , 4O3P , 4O3Q , 4O3R , 4O3S , 4Q8E , 4Q8F | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 713 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
342
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