Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5423
Gene name Gene Name - the full gene name approved by the HGNC.	DNA polymerase beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	POLB
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p11.21
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA dam

Show/Hide all(2)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051150	hsa-miR-16-5p	CLASH	23622248
MIRT035975	hsa-miR-1301-3p	CLASH	23622248

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
ATF2	Activation	10518804

Show/Hide all(45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA	21873635
GO:0003887	Function	DNA-directed DNA polymerase activity	IDA	9207062, 16600869
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	TAS
GO:0005515	Function	Protein binding	IPI	9207062, 15520167, 25260657, 25416956, 25910212, 26496610, 28514442, 31515488, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19713937, 21362556
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	15725623, 19713937, 21362556
GO:0005874	Component	Microtubule	IDA	15725623
GO:0005876	Component	Spindle microtubule	IDA	15725623
GO:0006261	Process	DNA-dependent DNA replication	TAS	8168825
GO:0006281	Process	DNA repair	TAS	8168825
GO:0006284	Process	Base-excision repair	IBA	21873635
GO:0006284	Process	Base-excision repair	IDA	16600869
GO:0006284	Process	Base-excision repair	IMP	21362556
GO:0006286	Process	Base-excision repair, base-free sugar-phosphate removal	TAS
GO:0006287	Process	Base-excision repair, gap-filling	IEA
GO:0006288	Process	Base-excision repair, DNA ligation	TAS
GO:0006290	Process	Pyrimidine dimer repair	IEA
GO:0006297	Process	Nucleotide-excision repair, DNA gap filling	IMP	20227374
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	IBA	21873635
GO:0006954	Process	Inflammatory response	IEA
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	21362556
GO:0007435	Process	Salivary gland morphogenesis	IEA
GO:0007568	Process	Aging	IEA
GO:0008017	Function	Microtubule binding	IDA	15725623
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:0010332	Process	Response to gamma radiation	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016829	Function	Lyase activity	IDA	16600869
GO:0019899	Function	Enzyme binding	IPI	16600869, 19713937, 21362556
GO:0032991	Component	Protein-containing complex	IDA	25378300
GO:0045471	Process	Response to ethanol	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048535	Process	Lymph node development	IEA
GO:0048536	Process	Spleen development	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0055093	Process	Response to hyperoxia	IEA
GO:0071707	Process	Immunoglobulin heavy chain V-D-J recombination	IEA
GO:0071897	Process	DNA biosynthetic process	IEA

MIM	HGNC	e!Ensembl
174760	9174	ENSG00000070501

Protein

UniProt ID

P06746

Protein name

DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)

Protein function

Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an

PDB

1BPX , 1BPY , 1BPZ , 1MQ2 , 1MQ3 , 1TV9 , 1TVA , 1ZJM , 1ZJN , 1ZQA , 1ZQB , 1ZQC , 1ZQD , 1ZQE , 1ZQF , 1ZQG , 1ZQH , 1ZQI , 1ZQJ , 1ZQK , 1ZQL , 1ZQM , 1ZQN , 1ZQO , 1ZQP , 1ZQQ , 1ZQR , 1ZQS , 1ZQT , 2FMP , 2FMQ , 2FMS , 2I9G , 2ISO , 2ISP , 2P66 , 2PXI , 3C2K , 3C2L , 3C2M , 3GDX , 3ISB , 3ISC , 3ISD , 3JPN , 3JPO , 3JPP , 3JPQ , 3JPR , 3JPS , 3JPT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14716	HHH_8	12 → 78	Helix-hairpin-helix domain	Domain
PF10391	DNA_pol_lambd_f	98 → 147	Fingers domain of DNA polymerase lambda	Domain
PF14792	DNA_pol_B_palm	149 → 262	DNA polymerase beta palm	Domain
PF14791	DNA_pol_B_thumb	268 → 334	DNA polymerase beta thumb	Family

Sequence

MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE

Sequence length

335

Interactions

View interactions

	KEGG		Reactome
	Base excision repair Human T-cell leukemia virus 1 infection Viral carcinogenesis		POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PCNA-Dependent Long Patch Base Excision Repair Ub-specific processing proteases Abasic sugar-phosphate removal via the single-nucleotide replacement pathway

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	25030372

Show/Hide Text Mining Associations (61)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma Mucinous	Associate	22799326
Adenocarcinoma of Lung	Associate	27655641
Alzheimer Disease	Associate	17065437, 17704129, 27234294, 31415677
Aneuploidy	Associate	33673690
Argininosuccinic Aciduria	Associate	18039710
Brain Neoplasms	Associate	8692923
Breast Neoplasms	Associate	12064574, 18477668, 24462520, 9294209
Breast Neoplasms	Inhibit	34406589
Carcinogenesis	Associate	24382701, 26238022, 33314687
Carcinoma Ductal Breast	Associate	34406589
Carcinoma Hepatocellular	Associate	34045188
Carcinoma Intraductal Noninfiltrating	Associate	34406589
Carcinoma Ovarian Epithelial	Associate	33674744
Carcinoma Renal Cell	Associate	12064574
Cell Transformation Neoplastic	Associate	12064574
Colonic Neoplasms	Associate	22650412, 28945359
Colorectal Neoplasms	Associate	24259968, 25030372, 25933036, 26649135, 9294209
Crohn Disease	Inhibit	40527798
Diabetes Gestational	Inhibit	27019630
Diabetes Mellitus	Stimulate	27019630
Drug Related Side Effects and Adverse Reactions	Associate	20068071, 21377995
Esophageal Neoplasms	Associate	16094698, 25015190, 26527528
Esophageal Squamous Cell Carcinoma	Associate	23749489, 23959474
Fragile X Syndrome	Associate	7592950
Glioma	Associate	21377995
Immunologic Deficiency Syndromes	Inhibit	20227038
Inflammation	Associate	36624848
Lead Poisoning Nervous System	Associate	25933036
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	16739313
Lung Neoplasms	Associate	22382497, 33314687
Lupus Erythematosus Systemic	Associate	27569236
Lymphatic Metastasis	Associate	25561897
Mosaic variegated aneuploidy syndrome	Associate	33673690, 36624848
Myotonic Dystrophy	Inhibit	27019630
Myotonic Dystrophy	Associate	7592950
Necrosis	Inhibit	34406589
Neoplasm Metastasis	Associate	37240218
Neoplasms	Associate	10782890, 12064574, 12087186, 18039710, 19167932, 21107011, 21305655, 21377995, 22650412, 22901161, 23877444, 24133209, 25015190, 25205036, 25237188 View all (14 more)
Neoplasms	Inhibit	24462520
Neoplasms Squamous Cell	Associate	33673690
Neurodegenerative Diseases	Associate	36982964
Neuromuscular Diseases	Associate	14654691
Non Muscle Invasive Bladder Neoplasms	Stimulate	33004944
Ovarian Diseases	Associate	22799326, 23144153
Ovarian Neoplasms	Associate	22799326, 22901161, 23098424, 23144153, 26745057, 29524322, 33674744
Pancreatic Neoplasms	Associate	17230526
Personality Disorders	Associate	24462520
Personality Disorders	Inhibit	34406589
Prostatic Neoplasms	Associate	12064574, 18623241, 21305655, 23877444
Prostatitis	Associate	12064574, 21305655, 23877444
Radiation Injuries	Associate	17705630
Retinoblastoma	Associate	28976878
Squamous Cell Carcinoma of Head and Neck	Associate	27906459, 31981740
Squamous Cell Carcinoma of Head and Neck	Stimulate	28415784
Stomach Neoplasms	Associate	18039710, 23144153, 25561897, 26090616
Tertiary Lymphoid Structures	Associate	33673690
Thymus Hyperplasia	Associate	33314687
Triple Negative Breast Neoplasms	Associate	26267318
Urinary Bladder Neoplasms	Associate	24382701
Varicocele	Associate	3181490
Xeroderma Pigmentosum	Associate	866172

POLB (DNA polymerase beta)